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Sulfated hyaluronan coating of polyurethanebased implant materials

  • Thermoplastic polycarbonate urethane elastomers (TPCU) are potential implant materials for treating degenerative joint diseases thanks to their adjustable rubber-like properties, their toughness, and their durability. We developed a water-containing high-molecular-weight sulfated hyaluronic acid-coating to improve the interaction of TPCU with the synovial fluid. It is suggested that trapped synovial fluid can act as a lubricant that reduces the friction forces and thus provides an enhanced abrasion resistance of TPCU implants. Aims of this work were (i) the development of a coating method for novel soft TPCU with high-molecular sulfated hyaluronic acid to increase the biocompatibility and (ii) the in vitro validation of the functionalized TPCUs in cell culture experiments.

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Metadaten
Author of HS ReutlingenAthanasopulu, Kiriaki; Caltzidou, Dimitra; Kutuzova, Larysa; Lorenz, Günter; Kemkemer, Ralf
URN:urn:nbn:de:bsz:rt2-opus4-30116
DOI:https://doi.org/10.1515/cdbme-2020-3115
ISSN:2364-5504
Erschienen in:Current directions in biomedical engineering
Publisher:De Gruyter
Place of publication:Berlin
Document Type:Article
Language:English
Year of Publication:2020
Tag:PURs; implant coating; sulfated hyaluronic acid; surface modification
Volume:6
Issue:3
Page Number:4
First Page:1
Last Page:4
Article Number:20203115
DDC classes:570 Biowissenschaften, Biologie
Open Access?:Ja
Licence (German):License Logo  Creative Commons - CC BY - Namensnennung 4.0 International