Two different approaches for pharmacokinetic modeling of exhaled drug concentrations
- Online measurement of drug concentrations in patient's breath is a promising approach for individualized dosage. A direct transfer from breath- to blood-concentrations is not possible. Measured exhaled concentrations are following the blood-concentration with a delay in non-steady-state situations. Therefore, it is necessary to integrate the breath-concentration into a pharmacological model. Two different approaches for pharmacokinetic modelling are presented. Usually a 3-compartment model is used for pharmacokinetic calculations of blood concentrations. This 3-compartment model is extended with a 2-compartment model based on the first compartment of the 3-compartment model and a new lung compartment. The second approach is to calculate a time delay of changes in the concentration of the first compartment to describe the lung-concentration. Exemplarily both approaches are used for modelling of exhaled propofol. Based on time series of exhaled propofol measurements using an ion-mobility-spectrometer every minute for 346 min a correlation of calculated plasma and the breath concentration was used for modelling to deliver R2 = 0.99 interdependencies. Including the time delay modelling approach the new compartment coefficient ke0lung was calculated to ke0lung = 0.27 min−1 with R2 = 0.96. The described models are not limited to propofol. They could be used for any kind of drugs, which are measurable in patient's breath.
Author of HS Reutlingen | Baumbach, Jörg Ingo |
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URN: | urn:nbn:de:bsz:rt2-opus4-139 |
DOI: | https://doi.org/10.1038/srep05423 |
eISSN: | 2045-2322 |
Erschienen in: | Scientific Reports |
Publisher: | Nature Publishing Group |
Place of publication: | London |
Document Type: | Journal article |
Language: | English |
Publication year: | 2014 |
Volume: | 4 |
Page Number: | 6 |
First Page: | 1 |
Last Page: | 6 |
DDC classes: | 610 Medizin, Gesundheit |
Open access?: | Ja |
Licence (German): | Creative Commons - Namensnennung |