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Understanding the effects of mature adipocytes and endothelial cells on fatty acid metabolism and vascular tone in physiological fatty tissue for vascularized adipose tissue engineering

  • Engineering of large vascularized adipose tissue constructs is still a challenge for the treatment of extensive high-graded burns or the replacement of tissue after tumor removal. Communication between mature adipocytes and endothelial cells is important for homeostasis and the maintenance of adipose tissue mass but, to date, is mainly neglected in tissue engineering strategies. Thus, new coculture strategies are needed to integrate adipocytes and endothelial cells successfully into a functional construct. This review focuses on the cross-talk of mature adipocytes and endothelial cells and considers their influence on fatty acid metabolism and vascular tone. In addition, the properties and challenges with regard to these two cell types for vascularized tissue engineering are highlighted.

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Author of HS ReutlingenKluger, Petra; Volz, Ann-Cathrin
Erschienen in:Cell & tissue research
Place of publication:Berlin, Heidelberg
Document Type:Article
Year of Publication:2015
Tag:co-culture; cross-talk; endothelial cells; mature adipocytes; vascularized fatty tissue engineering
Page Number:11
First Page:269
Last Page:279
DDC classes:570 Biowissenschaften, Biologie
Open Access?:Nein
Licence (German):License Logo  Lizenzbedingungen Springer