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Adipose-derived stem cell differentiation as a basic tool for vascularized adipose tissue engineering

  • The development of in vitro adipose tissue constructs is highly desired to cope with the increased demand for substitutes to replace damaged soft tissue after high graded burns, deformities or tumor removal. To achieve clinically relevant dimensions, vascularization of soft tissue constructs becomes inevitable but still poses a challenge. Adipose-derived stem cells (ASCs) represent a promising cell source for the setup of vascularized fatty tissue constructs as they can be differentiated into adipocytes and endothelial cells in vitro and are thereby available in sufficiently high cell numbers. This review summarizes the currently known characteristics of ASCs and achievements in adipogenic and endothelial differentiation in vitro. Further, the interdependency of adipogenesis and angiogenesis based on the crosstalk of endothelial cells, stem cells and adipocytes is addressed at the molecular level. Finally, achievements and limitations of current co-culture conditions for the construction of vascularized adipose tissue are evaluated.

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Metadaten
Name:Volz, Ann-Cathrin; Kluger, Petra
DOI:https://doi.org/10.1016/j.diff.2016.02.003
ISSN:0301-4681
eISSN:1432-0436
Erschienen in:Differentiation : the journal of the International Society of Differentiation
Publisher:Elsevier
Place of publication:New York, NY
Document Type:Article
Language:English
Year of Publication:2016
Tag:adipose-derived stem cells; co-culture; crosstalk; differentiation; endothelial cells; vascularized adipose tissue engineering
Volume:92
Issue:1-2
Pagenumber:13
First Page:52
Last Page:64
Dewey Decimal Classification:570 Biowissenschaften, Biologie
Open Access:Nein
Licence (German):License Logo  Lizenzbedingungen Elsevier