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Composite polyelectrolyte multilayers for biofunctionalization of medical devices

  • Polyelectrolyte multilayer coatings (PEM) are prepared by alternative layer-by-layer deposition of cationic and anionic polyelectrolyte monolayers on charged surfaces. The thickness of the coatings ranges from nm to few μm. Their properties such as roughness, stiffness, surface charge and surface energy can be precisely tuned to fulfil different technical or biological requirements. The coating process is based on self-assembly of polyelectrolytes. Advantages of these coatings are their easy handling, no harsh chemistry and the possibility for coatings on complex geometries. The PEM coatings can be prepared from a variety of suitable polyelectrolytes. Their stability varies from very durable PEM coatings that are only soluble in strong solvents to quickly degradable, which may be applied as drug release system. One example of such a degradable PEM system is the one based on the polyelectrolyte pair Hyaluronan (HA) and Chitosan (CHI). These biopolymers originate from natural sources and show low toxicity towards human cells. However, HA/CHI multilayers show only weak adhesiveness for human umbilical vein endothelial cells (HUVEC). In this article, we summarize our approaches to enhance the HA/CHI multilayer by incorporation of a non-polymer substance –graphene oxide– to improve the cell adhesion and keep such properties as low cytotoxicity and biodegradability. Different approaches for incorporation of graphene oxide were performed and the cellular adhesion was tested by metabolic assay.

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Metadaten
Author of HS ReutlingenRudt, Alexander; Andreeva, Tonya; Krastev, Rumen
URN:urn:nbn:de:bsz:rt2-opus4-30258
DOI:https://doi.org/10.1515/cdbme-2020-3110
ISSN:2364-5504
Erschienen in:Current directions in biomedical engineering
Publisher:de Gruyter
Place of publication:Berlin
Document Type:Article
Language:English
Year of Publication:2020
Tag:biocompatibility; cell adhesion; composite films; graphene oxide; polyelectrolyte multilayers
Volume:6
Issue:3
Page Number:4
First Page:1
Last Page:4
Article Number:20203110
DDC classes:570 Biowissenschaften, Biologie
Open Access?:Ja
Licence (German):License Logo  Creative Commons - CC BY - Namensnennung 4.0 International