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Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions

  • Herein the optimization of the physicochemical properties and surface biocompatibility of polyelectrolyte multilayers of the natural, biocompatible and biodegradable, linear polysaccharides hyaluronan and chitosan by Hofmeister anions was systematically investigated. We demonstrated that there is an interconnection between the bulk and surface properties of HA/Chi multilayers both varying in accordance with the arrangement of the anions in the Hofmeister series. Kosmotropic anions increased the hydration, thickness, micro- and macro-roughness, and hydrophilicity and improved the biocompatibility of the films by reduction (2 orders of magnitude) of the films stiffness and complete anti-thrombogenicity.

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Name:Krastev, Rumen
Erschienen in:Journal of materials chemistry. - B. Materials for biology and medicine
Publisher:The Royal Society of Chemistry
Place of publication:Cambridge
Document Type:Article
Year of Publication:2016
First Page:7092
Last Page:7100
Dewey Decimal Classification:540 Chemie
Open Access:Nein