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Self-organization and surface properties of hBest1 in models of biological membranes

  • The transmembrane Ca2+ − activated Cl− channel - human bestrophin-1 (hBest1) is expressed in retinal pigment epithelium and mutations of BEST1 gene cause ocular degenerative diseases colectivelly referred to as “bestrophinopathies”. A large number of genetical, biochemical, biophysical and molecular biological studies have been performed to understand the relationship between structure and function of the hBest1 protein and its pathophysiological significance. Here, we review the current understanding of hBest1 surface organization, interactions with membrane lipids in model membranes, and its association with microdomains of cellular membranes. These highlights are significant for modulation of channel activity in cells.

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Metadaten
Author of HS ReutlingenAndreeva, Tonya
DOI:https://doi.org/10.1016/j.cis.2022.102619
ISSN:0001-8686
eISSN:1873-3727
Erschienen in:Advances in colloid and interface science
Publisher:Elsevier
Place of publication:New York
Document Type:Journal article
Language:English
Publication year:2022
Tag:POPC; hBest1; lipid rafts; sphingomielin; surface films
Volume:302
Article Number:102619
DDC classes:540 Chemie
Open access?:Nein
Licence (German):License Logo  In Copyright - Urheberrechtlich geschützt