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Surface modification of Polydimethylsiloxane by hydrogels for microfluidic applications

  • In vitro, hydrogel-based ECMs for functionalizing surfaces of various material have played an essential role in mimicking native tissue matrix. Polydimethylsiloxane (PDMS) is widely used to build microfluidic or organ-on-chip devices compatible with cells due to its easy handling in cast replication. Despite such advantages, the limitation of PDMS is its hydrophobic surface property. To improve wettability of PDMS-based devices, alginate, a naturally derived polysaccharide, was covalently bound to the PDMS surface. This alginate then crosslinked further hydrogel onto the PDMS surface in desired layer thickness. Hydrogel-modified PDMS was used for coating a topography chip system and in vitro investigation of cell growth on the surfaces. Moreover, such hydrophilic hydrogel-coated PDMS is utilized in a microfluidic device to prevent unspecific absorption of organic solutions. Hence, in both exemplary studies, PDMS surface properties were modified leading to improved devices.

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Metadaten
Name:Yang, Linxiao; Athanasopulu, Kiriaki; Frey, Kerstin; Cui, Zhishan; Kemkemer, Ralf
URN:urn:nbn:de:bsz:rt2-opus4-23949
DOI:https://doi.org/10.1515/cdbme-2019-0024
ISSN:2364-5504
Erschienen in:Current directions in biomedical engineering
Publisher:De Gruyter
Place of publication:Berlin
Document Type:Article
Language:English
Year of Publication:2019
Tag:PDMS; alginate; cell culture; hydrogel; microfluidic chips
Volume:5
Issue:1
Pagenumber:4
First Page:93
Last Page:96
Dewey Decimal Classification:570 Biowissenschaften, Biologie
Open Access:Ja
Licence (German):License Logo  Creative Commons - CC BY - Namensnennung 4.0 International