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A cellulose-based material for vascularized adipose tissue engineering

  • Artificial adipose tissue (AT) constructs are urgently needed to treat severe wounds, to replace removed tissue, or for the use as in vitro model to screen for potential drugs or study metabolic pathways. The clinical translation of products is mostly prevented by the absence of a vascular component that would allow a sustainable maintenance and an extension of the construct to a relevant size. With this study, we aimed to evaluate the suitability of a novel material based on bacterial cellulose (CBM) on the defined adipogenic differentiation of human adipose-derived stem cells (ASCs) and the maintenance of the received adipocytes (diffASCs) and human microvascular endothelial cells (mvECs) in mono- and coculture. A slight acceleration of adipogenic differentiation over regular tissue culture polystyrene (TCPS) was seen on CBM under defined conditions, whereas on the maintenance of the generated adipocytes, comparable effects were detected for both materials. CBM facilitated the formation of vascular like structures in monoculture of mvECs, which was not observed on TCPS. By contrast, vascular-like structures were detected in CBM and TCPS in coculture by the presence of diffASCs. Concluding, CBM represents a promising material in vascularized AT engineering with the potential to speed up and simplify the in vitro setup of engineered products.

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Metadaten
Name:Volz, Ann-Cathrin; Hack, Larissa; Kluger, Petra
DOI:https://doi.org/10.1002/jbm.b.34235
ISSN:1552-4973
eISSN:1552-4981
Erschienen in:Journal of biomedical materials research. - Part B, Applied biomaterials
Publisher:Wiley
Place of publication:Hoboken, NJ
Document Type:Article
Language:English
Year of Publication:2019
Volume:107
Issue:5
Pagenumber:9
First Page:1431
Last Page:1439
Dewey Decimal Classification:570 Biowissenschaften, Biologie
Open Access:Nein
Licence (German):License Logo  Lizenzbedingungen Wiley