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Modification of polyelectrolyte multilayer coatings using nanoparticles to optimize adhesion and proliferation of different cell types

  • Adapting characteristics of biomaterials specifically for in vitro and in vivo applications is becoming increasingly important in order to control interactions between material and biological systems. These complex interactions are influenced by surface properties like chemical composition, charge, mechanical and topographic attributes. In many cases it is not useful or even not possible to alter the base material but changing surface, to improve biocompatibility or to make surfaces bioactive, may be achieved by thin coatings. An already established method is the coating with polyelectrolyte multilayers (PEM). To adjust adhesion, proliferation and improve vitality of certain cell types, we modified the roughness of PEM coatings. We included different types nanoparticles (NP’s) in different concentrations into PEM coatings for controlling surface roughness. Surface properties were characterized and the reaction of 3 different cell types on these coatings was tested.

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Author of HS ReutlingenKemkemer, Ralf; Krastev, Rumen; Athanasopulu, Kiriaki; Rudt, Alexander; Gittel, Bianca
Erschienen in:Bionanomaterials : journal of functional materials, biomechanics, and tissue engineering
Publisher:De Gruyter
Place of publication:Berlin
Document Type:Journal article
Publication year:2016
Page Number:1
First Page:123
DDC classes:660 Technische Chemie
Open access?:Ja
Licence (German):License Logo  Open Access