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Impact of porosity and surface functionalization of hard templates on the preparation of mesoporous silica microspheres

  • Mesoporous silica microspheres (MPSMs) find broad application as separation materials in high liquid chromatography (HPLC). A promising preparation strategy uses p(GMA-co-EDMA) as hard templates to control the pore properties and a narrow size distribution of the MPMs. Here six hard templates were prepared which differ in their porosity and surface functionalization. This was achieved by altering the ratio of GMA to EDMA and by adjusting the proportion of monomer and porogen in the polymerization process. The various amounts of GMA incorporated into the polymer network of P1-6 lead to different numbers of tetraethylene pentamine in the p(GMA-co-EDMA) template. This was established by a partial least squares regression (PLS-R) model, based on FTIR spectra of the templates. Deposition of silica nanoparticles (SNP) into the template under Stoeber conditions and subsequent removal of the polymer by calcination result in MPSM1-6. The size of the SNPs and their incorporation depends on the pore parameters of the template and degree of TEPA functionalization. Moreover, the incorporated SNPs construct the silica network and control the pore parameters of the MPSMs. Functionalization of the MPSMs with trimethoxy (octadecyl) silane allows their use as a stationary phase for the separation of biomolecules. The pore characteristics and the functionalization of the template determine the pore structure of the silica particles and, consequently, their separation properties.

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Metadaten
Author of HS ReutlingenFait, Fabio; Steinbach, Julia; Kandelbauer, Andreas
URN:urn:nbn:de:bsz:rt2-opus4-47748
DOI:https://doi.org/10.1016/j.micromeso.2023.112482
ISSN:1387-1811
Erschienen in:Microporous and mesoporous materials
Publisher:Elsevier
Place of publication:Amsterdam
Document Type:Journal article
Language:English
Publication year:2023
Tag:ethylenglycol dimethacrylate (EDMA); glycidylmethacrylate (GMA); hard template method; high performance liquid chromatography (HPLC); mesoporous silica microspheres (MPSM)
Volume:351
Page Number:9
First Page:1
Last Page:9
Article Number:112482
PPN:Im Katalog der Hochschule Reutlingen ansehen
DDC classes:530 Physik
Open access?:Ja
Licence (German):License Logo  Creative Commons - CC BY - Namensnennung 4.0 International