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Increasingly volatile market conditions and manufacturing environments combined with a rising demand for highly personalized products, the emergence of new technologies like cyber-physical systems and additive manufacturing as well as an increasing cross-linking of different entities (Industrie 4.0) will result in fundamental changes of future work and logistics systems. The place of production, the logistical network and the respective production system will underlie the requirements of constant changes and therefore sources and sinks of logistical networks have to obey the versatility of (cyber-physical) production systems. To cope with the arising complexity to control and monitor changeable production and logistics systems, decentralized control systems are the mean of choice since centralized systems are pushed to their limits in this regard. This paradigm shift will affect the overall concept under which production and logistics is planned, managed and controlled and how companies interact and collaborate within the emerging value chains by using dynamic methods to generate and execute the created network and to allocate available resources to fulfill the demand for customized products. In this field of research learning factories, like the ESB Logistics Learning Factory at ESB Business School (Reutlingen University), provide a great potential as a risk free test bed to develop new methods and technical solutions, to investigate new technologies regarding their practical use and to transfer the latest state of knowledge and specific competences into the training of students and professionals. Keeping with these guiding principles ESB Business School is transferring its existing production system into a cyber-physical production system to investigate innovative solutions for the design of human-machine collaboration and technical assistance systems as wells as to develop decentralized control methods for intralogistics systems following the requirements of changeable work systems including the respective design of dynamic inbound and outbound logistic networks.