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Flame-retardant finishing of cotton fabrics using DOPO functionalized alkoxy- and amido alkoxysilane
(2023)
In the present study, DOPO-based alkoxysilane (DOPO-ETES) and amido alkoxysilane (DOPO-AmdPTES) were synthesized by one-step and without by-products as halogen-free flame retardants. The flame retardants were applied on cotton fabric utilizing sol–gel method and pad-dry-cure finishing process. The flame retardancy, the thermal stability and the combustion ehaviour of treated cotton were evaluated by surface and bottom edge ignition flame test (according to EN ISO 15025), thermogravimetric analysis (TGA) and micro-scale combustion calorimeter (MCC). Unlike CO/DOPO-ETES sample, cotton treated with DOPO-AmdPTES nanosols exhibits self-extinguishing ehaviour with high char residue, an improvement of the LOI value and a significant reduction of the PHRR, HRC and THR compared to pristine cotton. Cotton finished with DOPO-AmdPTES reveals a semi-durability after ten laundering cycles keeping the flame-retardant properties unchanged. According to the results obtained from TGA-FTIR, Py-GC/MS and XPS, the major activity of flame retardant occurs in the condensed phase via catalytic induced char formation as physical barrier along with the activity in the gas phase derived mainly from the dilution effect. The early degradation of CO/DOPO-AmdPTES compared to CO/DOPO-ETES, triggered by the cleavage of the weak bond between P and C=O, as the DFT study indicated, provides the beneficial effect of this flame retardant on the fire resistance of cellulose.
In our initial DaMoN paper, we set out the goal to revisit the results of “Starring into the Abyss [...] of Concurrency Control with [1000] Cores” (Yu in Proc. VLDB Endow 8: 209-220, 2014). Against their assumption, today we do not see single-socket CPUs with 1000 cores. Instead, multi-socket hardware is prevalent today and in fact offers over 1000 cores. Hence, we evaluated concurrency control (CC) schemes on a real (Intel-based) multi-socket platform. To our surprise, we made interesting findings opposing results of the original analysis that we discussed in our initial DaMoN paper. In this paper, we further broaden our analysis, detailing the effect of hardware and workload characteristics via additional real hardware platforms (IBM Power8 and 9) and the full TPC-C transaction mix. Among others, we identified clear connections between the performance of the CC schemes and hardware characteristics, especially concerning NUMA and CPU cache. Overall, we conclude that no CC scheme can efficiently make use of large multi-socket hardware in a robust manner and suggest several directions on how CC schemes and overall OLTP DBMS should evolve in future.
Glioblastoma WHO IV belongs to a group of brain tumors that are still incurable. A promising treatment approach applies photodynamic therapy (PDT) with hypericin as a photosensitizer. To generate a comprehensive understanding of the photosensitizer-tumor interactions, the first part of our study is focused on investigating the distribution and penetration behavior of hypericin in glioma cell spheroids by fluorescence microscopy. In the second part, fluorescence lifetime imaging microscopy (FLIM) was used to correlate fluorescence lifetime (FLT) changes of hypericin to environmental effects inside the spheroids. In this context, 3D tumor spheroids are an excellent model system since they consider 3D cell–cell interactions and the extracellular matrix is similar to tumors in vivo. Our analytical approach considers hypericin as probe molecule for FLIM and as photosensitizer for PDT at the same time, making it possible to directly draw conclusions of the state and location of the drug in a biological system. The knowledge of both state and location of hypericin makes a fundamental understanding of the impact of hypericin PDT in brain tumors possible. Following different incubation conditions, the hypericin distribution in peripheral and central cryosections of the spheroids were analyzed. Both fluorescence microscopy and FLIM revealed a hypericin gradient towards the spheroid core for short incubation periods or small concentrations. On the other hand, a homogeneous hypericin distribution is observed for long incubation times and high concentrations. Especially, the observed FLT change is crucial for the PDT efficiency, since the triplet yield, and hence the O2 activation, is directly proportional to the FLT. Based on the FLT increase inside spheroids, an incubation time 30 min is required to achieve most suitable conditions for an effective PDT.
The early detection of head and neck cancer is a prolonged challenging task. It requires a precise and accurate identification of tissue alterations as well as a distinct discrimination of cancerous from healthy tissue areas. A novel approach for this purpose uses microspectroscopic techniques with special focus on hyperspectral imaging (HSI) methods. Our proof-of-principle study presents the implementation and application of darkfield elastic light scattering spectroscopy (DF ELSS) as a non-destructive, high-resolution, and fast imaging modality to distinguish lingual healthy from altered tissue regions in a mouse model. The main aspect of our study deals with the comparison of two varying HSI detection principles, which are a point-by-point and line scanning imaging, and whether one might be more appropriate in differentiating several tissue types. Statistical models are formed by deploying a principal component analysis (PCA) with the Bayesian discriminant analysis (DA) on the elastic light scattering (ELS) spectra. Overall accuracy, sensitivity, and precision values of 98% are achieved for both models whereas the overall specificity results in 99%. An additional classification of model-unknown ELS spectra is performed. The predictions are verified with histopathological evaluations of identical HE-stained tissue areas to prove the model’s capability of tissue distinction. In the context of our proof-of-principle study, we assess the Pushbroom PCA-DA model to be more suitable for tissue type differentiations and thus tissue classification. In addition to the HE-examination in head and neck cancer diagnosis, the usage of HSI-based statistical models might be conceivable in a daily clinical routine.
Der Girlboss Mythos : die gesellschaftlichen und ökonomischen Perspektiven der Gender-Debatte
(2019)
Faktisch sind Frauen heute gleichberechtigt. Sie haben die gleichen Chancen, Rechte und Möglichkeiten wie Männer. Dennoch weisen maßgebliche Studien darauf hin, dass die Anzahl von Frauen auf allen Führungsebenen stagniert oder nur im Schneckentempo wächst. In der medialen Diskussion rund um das Thema Frauen im Management ist die Welt auf den ersten Blick in zwei Lager geteilt. Ein Lager stellt ernüchtert fest, dass Frauen selbst Schuld sind an ihrer Situation. Oft werden hier gerade erfolgreiche Frauen zitiert, die ihren Geschlechtsgenossinnen den nötigen Erfolgswillen oder die Opferbereitschaft absprechen. Das andere Lager scheint die Sachlage genau entgegengesetzt zu beurteilen. Überall gut ausgebildete, hochmotivierte Frauen, die an Glasdecken stoßen oder denen von der Gesellschaft im Allgemeinen und Männern im Besonderen die Türen versperrt werden. Dieses Buch trägt zu einer wissenschaftlich nüchternen Diskussion bei, um die aktuelle gesellschaftspolitische Situation differenzierter und abseits von abgegriffenen Dogmen zu betrachten.
Die meisten Innovationsprojekte in Unternehmen scheitern nicht am Mangel an Ideen, Kreativität oder am Umsetzungswillen, sondern an vielen kleinen Hürden, die die Projekte massiv entschleunigen. So verlieren Initiativen an der Dynamik, die dafür sorgt, dass sich zügig Erfolge einstellen. Ein Bereich, in dem unkonventionell, agil und schnell Ergebnisse erzielt werden, ist das Guerilla Marketing. Was können Innovations-, Forschungs- und Projektleiter aus dem Methodenbaukasten lernen? Wie können konkrete Taktiken aus dem Marketing auch Innovationsprojekten zu mehr Viralität und Schwung verhelfen, um die Eigendynamik der Initiativen „unbremsbar“ zu machen? Das erfahren Sie in diesem essential.
Hybride Arbeitsmodelle gelten als Zukunft der Arbeit. Demnach beschäftigt sich die vorliegende Forschungsarbeit mit der Untersuchung hybrider Arbeitsmodelle im Hinblick auf deutsche kleine und mittlere Unternehmen (KMU) im Vergleich zu Großbetrieben. Mithilfe einer multi-methodischen Studie, bestehend aus einer Umfrage und qualitativen Experteninterviews, wird evaluiert, in welchem Maß hybride Arbeitsmodelle in KMU bereits etabliert sind und welche Herausforderungen sie dabei bewältigen müssen. Zusätzlich wird betrachtet, ob soziodemografische Faktoren wie Alter, Geschlecht oder Rolle im Unternehmen einen Einfluss auf hybrides Arbeiten haben.Die Ergebnisse zeigen, dass die Etablierung von hybriden Arbeitsmodellen in KMU im Gegensatz zu Großbetrieben weniger vorangeschritten ist. KMUs stehen vor vielfältigen Herausforderungen, die beispielsweise auf unzureichende Digitalisierung oder traditionellere Strukturen zurückzuführen sind. Insbesondere die Unternehmenskultur sowie die Rolle im Unternehmen und der Einfluss der Führungskraft spielen eine wichtige Rolle.Praktische Relevanz: Der Großteil vorliegender Literatur zum Thema New Work und Hybride Arbeit legt den Fokus auf die Gesamtbetrachtung aller Unternehmensgrößen oder auf Großbetriebe. Aufgrund der spezifischen Merkmale, wie beispielsweise eingeschränkter Ressourcenzugang, können Ergebnisse von Großbetrieben kaum auf KMU übertragen werden. Demnach gibt diese Arbeit eine Orientierung, wie hybride Arbeitsmodelle in KMU sinnvoll und gewinnbringend umgesetzt werden und welche Herausforderungen auftreten.
Forecasting demand is challenging. Various products exhibit different demand patterns. While demand may be constant and regular for one product, it may be sporadic for another, as well as when demand occurs, it may fluctuate significantly. Forecasting errors are costly and result in obsolete inventory or unsatisfied demand. Methods from statistics, machine learning, and deep learning have been used to predict such demand patterns. Nevertheless, it is not clear for what demand pattern, which algorithm would achieve the best forecast. Therefore, even today a large number of models are used to forecast on a test period. The model with the best result on the test period is used for the actual forecast. This approach is computationally and time intensive and, in most cases, uneconomical. In our paper we show the possibility to use a machine learning classification algorithm, which predicts the best possible model based on the characteristics of a time series. The approach was developed and evaluated on a dataset from a B2B-technical-retailer. The machine learning classification algorithm achieves a mean ROC-AUC of 89%, which emphasizes the skill of the model.
The basic idea behind a wearable robotic grasp assistancesystem is to support people that suffer from severe motor impairments in daily activities. Such a system needs to act mostly autonomously and according to the user’s intent. Vision-based hand pose estimation could be an integral part of a larger control and assistance framework. In this paper we evaluate the performance of egocentric monocular hand pose estimation for a robot-controlled hand exoskeleton in a simulation. For hand pose estimation we adopt a Convolutional Neural Network (CNN). We train and evaluate this network with computer graphics, created by our own data generator. In order to guide further design decisions we focus in our experiments on two egocentric camera viewpoints tested on synthetic data with the help of a 3D-scanned hand model, with and without an exoskeleton attached to it.We observe that hand pose estimation with a wrist-mounted camera performs more accurate than with a head-mounted camera in the context of our simulation. Further, a grasp assistance system attached to the hand alters visual appearance and can improve hand pose estimation. Our experiment provides useful insights for the integration of sensors into a context sensitive analysis framework for intelligent assistance.
Additive Manufacturing is increasingly used in the industrial sector as a result of continuous development. In the Production Planning and Control (PPC) system, AM enables an agile response in the area of detailed and process planning, especially for a large number of plants. For this purpose, a concept for a PPC system for AM is presented, which takes into account the requirements for integration into the operational enterprise software system. The technical applicability will be demonstrated by individual implemented sections. The presented solution approach promises a more efficient utilization of the plants and a more elastic use.