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Increasing concerns regarding the world´s natural resources and sustainability continue to be a major issue for global development. As a result several political initiatives and strategies for green or resource-efficient growth both on national and international levels have been proposed. A core element of these initiatives is the promotion of an increase of resource or material productivity. This dissertation examines material productivity developments in the OECD and BRICS countries between 1980 and 2008. By applying the concept of convergence stemming from economic growth theory to material productivity the analysis provides insights into both aspects: material productivity developments in general as well potentials for accelerated improvements in material productivity which consequently may allow a reduction of material use globally. The results of the convergence analysis underline the importance of policy-making with regard to technology and innovation policy enabling the production of resource-efficient products and services as well as technology transfer and diffusion.
Long-term stability of membranes in membrane distillation operation is a problem nowadays which prevents the industrial breakthrough of this separation process. Fouling or slow pore wetting are the basic reasons for this.
Membrane distillation membranes were made by NIPS process rendering the membrane asymmetrically to achieve low permeation resistance and pores which can be over coated with polyelectrolyte polymers thus leading to thermopervaporation membranes. Those membranes prohibit pore wetting and may strongly reduce resorption of organic substances on for membrane distillation typically used hydrophobic surfaces thus leading to longterm operation stability in dewatering including stable membrane cleaning.
Asymmetric PVDF membranes have been coated with cation exchange polyelectrolyte leading to a very thin, defect-free layer which has a high permeation rate for water due to the domain structure of phase-separated hydrophilic and hydrophobic three-dimensional structures.
One of strategically important issues of energy security of Ukraine and the countries of Europe today is to reduce the consumption of natural gas. This task is particularly relevant in winter, when a significant amount of natural gas is consumed for heating premises. Therefore, one can predict that in the nearest future, in Ukraine and European countries, premises will be heated more frequently by electrical energy.
A massive transition to electric heating of premises under conditions of the implementation of national objective in Ukraine and the countries of Europe related to a significant reduction in energy consumption necessitates to rethink the process of control over electric heating of premises. It is required that the algorithms that control power supply to premises should include mechanisms for planning the amount of electric energy consumed by an individual. This is especially true of such energy-intensive processes like heating the premises.
Therefore, it is an important task for Ukraine and the countries of Europe to work out an approach for creating systems to control electric heating of premises in a house or apartment that would take into consideration not only information about the desired temperature regime, but also information on the desired amount of electricity needed for heating.
Drug-induced liver toxicity is one of the most common reasons for the failure of drugs in clinical trials and frequent withdrawal from the market. Reasons for such failures include the low predictive power of in vivo studies, that is mainly caused by metabolic differences between humans and animals, and intraspecific variances. In addition to factors such as age and genetic background, changes in drug metabolism can also be caused by disease-related changes in the liver. Such metabolic changes have also been observed in clinical settings, for example, in association with a change in liver stiffness, a major characteristic of an altered fibrotic liver. For mimicking these changes in an in vitro model, this study aimed to develop scaffolds that represent the rigidity of healthy and fibrotic liver tissue. We observed that liver cells plated on scaffolds representing the stiffness of healthy livers showed a higher metabolic activity compared to cells plated on stiffer scaffolds. Additionally, we detected a positive effect of a scaffold pre-coated with fetal calf serum (FCS)-containing media. This pre-incubation resulted in increased cell adherence during cell seeding onto the scaffolds. In summary, we developed a scaffold-based 3D model that mimics liver stiffness-dependent changes in drug metabolism that may more easily predict drug interaction in diseased livers.
Health monitoring in a home environment can have broader use since it may provide continuous control of health parameters with relatively minor intrusiveness into regular life. This work aims to verify if it is possible to replace the typical in some sleep medicine areas subjective questioning by an objective measurement using electronic devices. For this purpose, a study was conducted with ten subjects, in which objective and subjective measurement of relevant sleep parameters took place. The results of both measurement methods were evaluated and analyzed. The results showed that while for some measures, such as Total Time in Bed, there is a high agreement between objective and subjective measurements, for others, such as sleep quality, there are significant differences. For this reason, currently, a combination of both measurement methods may be beneficial and provide the most detailed results, while a partial replacement can already reduce the number of questions at the subjective measurement by measurement through electronic devices.
Development of an IoT-based inventory management solution and training module using smart bins
(2023)
Flexibility, transparency and changeability of warehouse environments are playing an increasingly important role to achieve a cost-efficient production of small batch sizes. This results in increasing requirements for warehouses in terms of flexibility, scalability, reconfigurability and transparency of material and information flows to deal with large number of different components and variable material and information flows due to small batch sizes. Therefore, an IoT-based inventory management solution and training module has been developed, implemented and validated at Werk150 – the Factory on campus of the ESB Business School. Key elements of the developed solution are smart bins using weight mats to track the bin’s content and additional sensors and buttons which are connected to an IoT – Hub to collect data of material consumption and manual handling operations. The use of weight mats for the smart bins offers the possibility to measure the container content independent of the specific component geometry and thus for a variety of components based on the specific component weights. The developed solution enables focusing on key for success elements of the system to provide synchronization of the flow of materials and information resulting an increase of flexibility and significantly higher transparency of the material flow. AIbased algorithms are applied to analyse the gathered data and to initiate process optimizations by providing the logistics decision makers a profound and transparent basis for decision making. In order to provide students and industry visitors of the learning factory with the necessary competences and to support the transfer into practice, a training module on IoT-based inventory management was developed and implemented.
Manufacturing companies are confronted with external (e.g. short-term change of product configuration by the customer) and internal (e.g. production process deviations) turbulences which are affecting the performance of production. Predefined, centrally controlled logistics processes are limiting the possibilities of production to initiate countermeasures to react in an optimized way to these turbulences. The autonomous control of intralogistics offers a great potential to cope with these turbulences by using the respective flexibility corridors of production systems and applying intelligent logistic objects with decentralized decision and process execution capabilities to maintain a target-optimized production. A method for AI-based storage-location- and material-handling-optimization to achieve performance-optimized intralogistics system through continuous monitoring of performance-relevant parameters and influencing factors by using AI (e.g. for pattern recognition) has been developed. To provide the basis to investigate and demonstrate the potentials of autonomously controlled intralogistics in connection with turbulences of production and in combination with AI, an intelligent warehouse involving an indoor localization system, smart bins, manual, semi-automated/collaborative and autonomous transport systems has been developed and implemented at Werk150, the factory on campus of ESB Business School (Reutlingen University). This scenario, which has been integrated into graduate training modules, allows the analysis and demonstration of different measures of intralogistics to cope with turbulences in production involving amongst others storage and material provision processes. The target fulfilment of the applied intralogistics measures to master arising turbulences is assessed based on the overall performance of production considering lead times and adherence to delivery dates. By applying artificial intelligence (AI) algorithms the intelligent logistical objects (smart bin, transport systems, etc.) as well as the entire logistics system should be enabled to improve their decision and process execution capabilities to master short-term turbulences in the production system autonomously.
Development of an indoor positioning system to create a digital shadow of production plant layouts
(2023)
The objective of this dissertation is to develop an indoor positioning system that allows the creation of a digital shadow of the plant layout in order to continuously represent the actual state of the physical layout in the virtual space. In order to define the requirements for such a system, potential stakeholders who could benefit from a digital shadow in the context of the plant layout were analysed. In order to generate added value for their work, the requirements were derived from their perspective. As the core of an indoor positioning system is the sensory aspect to capture the physical layout parameters, different potential technologies were compared and evaluated in terms of their suitability for this particular application. Derived from this analysis, the selected concept is based on the use of a pan-tilt-zoom (PTZ) camera in combination with fiducial markers. In order to determine specific camera parameters, a series of experiments were conducted which were necessary to develop the measurement method as well as the mathematical calculation method and coordinate transformation for the determination of poses (positions and angular orientations) of the respective facilities in the plant. In addition, an experimental validation was performed to ensure that the limit values for individual parameters determined in the requirements analysis can be met.
Development of an expert system to overpass citizens technological barriers on smart home and living
(2023)
Adopting new technologies can be overwhelming, even for people with experience in the field. For the general public, learning about new implementations, releases, brands, and enhancements can cause them to lose interest. There is a clear need to create point sources and platforms that provide helpful information about the novel and smart technologies, assisting users, technicians, and providers with products and technologies. The purpose of these platforms is twofold, as they can gather and share information on interests common to manufacturers and vendors. This paper presents the ”Finde-Dein-SmartHome” tool. Developed in association with the Smart Home & Living competence center [5] to help users learn about, understand, and purchase available technologies that meet their home automation needs. This tool aims to lower the usability barrier and guide potential customers to clear their doubts about privacy and pricing. Communities can use the information provided by this tool to identify market trends that could eventually lower costs for providers and incentivize access to innovative home technologies and devices supporting long-term care.
Process risks are omnipresent in the corporate world and repeatedly present organizations with the challenge of how to deal with these risks. Efforts in trying to analyze and prevent these risks are costly and require many resources, which do not always bring the desired added value. The goal of this work is to determine how a benefit-oriented resource allocation can be made for risk-oriented process management. For this purpose, the following research question is posed: "How can systematic prioritization decisions regarding risk-oriented process management be made?” To answer it, an evaluation procedure is developed which assesses processes based on their characteristics regarding potential risk disposition as well as entrepreneurial relevance. For this purpose, requirements for such a procedure are first collected and used to define selection criteria for it. After the detailed analysis of known selection and evaluation procedures, one of them is selected and used for further development. Next steps include the definition of relevant criteria for the evaluation of the processes by examining process characteristics regarding their suitability for process evaluation. The focus here lies on characteristics that provide indications of the risk disposition and business relevance of processes. The result of this approach is a scoring model with a criteria catalog consisting of 15 criteria according to which a process is evaluated. The evaluation result is presented both numerically and in a matrix. This enables the comparison of several processes and a derived prioritization of those for a more in-depth risk analysis. The application of this approach will ensure a benefit-oriented allocation of resources in the management of process risks and increased process reliability.