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Current clinical practice is often unable to identify the causes of conductive hearing loss in the middle ear with sufficient certainty without exploratory surgery. Besides the large uncertainties due to interindividual variances, only partially understood cause–effect principles are a major reason for the hesitant use of objective methods such as wideband tympanometry in diagnosis, despite their high sensitivity to pathological changes. For a better understanding of objective metrics of the middle ear, this study presents a model that can be used to reproduce characteristic changes in metrics of the middle ear by altering local physical model parameters linked to the anatomical causes of a pathology. A finite-element model is, therefore, fitted with an adaptive parameter identification algorithm to results of a temporal bone study with stepwise and systematically prepared pathologies. The fitted model is able to reproduce well the measured quantities reflectance, impedance, umbo and stapes transfer function for normal ears and ears with otosclerosis, malleus fixation, and disarticulation. In addition to a good representation of the characteristic influences of the pathologies in the measured quantities, a clear assignment of identified model parameters and pathologies consistent with previous studies is achieved. The identification results highlight the importance of the local stiffness and damping values in the middle ear for correct mapping of pathological characteristics and address the challenges of limited measurement data and wide parameter ranges from the literature. The great sensitivity of the model with respect to pathologies indicates a high potential for application in model-based diagnosis.
Global, competitive markets which are characterised by mass customisation and rapidly changing customer requirements force major changes in production styles and the configuration of manufacturing systems. As a result, factories may need to be regularly adapted and optimised to meet short-term requirements. One way to optimise the production process is the adaptation of the plant layout to the current or expected order situation. To determine whether a layout change is reasonable, a model of the current layout is needed. It is used to perform simulations and in the case of a layout change it serves as a basis for the reconfiguration process. To aid the selection of possible measurement systems, a requirements analysis was done to identify the important parameters for the creation of a digital shadow of a plant layout. Based on these parameters, a method is proposed for defining limit values and specifying exclusion criteria. The paper thus contributes to the development and application of systems that enable an automatic synchronisation of the real layout with the digital layout.
Cross-linked thermoplastics
(2022)
Cross-linked thermoplastics represent an important class of materials for numerous applications such as heat-shrinkable tubing, rotational molded parts, and polyolefin foams. By cross-linking olefins, their mechanical performance can be significantly enhanced. This chapter covers the three main methods for the cross-linking of thermoplastics: radiation cross-linking, chemical cross-linking with organic peroxides, and cross-linking using silane-grafting agents. It also considers the major effects of the cross-linking procedure on the performance of the thermoplastic materials discussed.
Silicones
(2022)
Silicones are found in a variety of applications with requirements that range from long life at elevated temperatures to fluidity at low temperatures. This chapter first considers silicone elastomers and their application in room temperature vulcanizing (RTV) and heat curing systems (HTV). Also, new technologies for UV curing are introduced. Coverage of RTVs includes both one-component and two-component systems and the different cure chemistries of each and is followed by a separate discussion of silicone laminates. Due to the high importance of silicone fluids, they are also discussed. Fluids include polishes, release agents, surfactants, and dielectric fluids.
Cyanate ester resins
(2022)
Cyanate ester resins are an important class of thermosetting compounds that experience an ever-increasing interest as matrix systems for advanced polymer composite materials, which among other application fields are especially suitable for highly demanding applications in the aerospace or microelectronics industries. Other names for cyanate ester resins are cyanate resins, cyanic esters, or triazine resins. The various types of cyanate ester monomers share the –OCN functional group that trimerizes in the course of resin formation to yield a highly branched heterocyclic polymeric network based on the substituted triazine core structure.
Process analysis and process control have attracted increasing interest in recent years. The development and application of process analytical methods are a prerequisite for the knowledge-based manufacturing of industrial goods and allow for the production of high-value products of defined, constantly good quality. Discussed in this chapter are the measurement principle and some relevant aspects and illustrative examples of online monitoring tools as the basis for process control in the manufacturing and processing of thermosetting resins. Optical spectroscopy is featured as one of the main process analytical methods applicable to, among other applications, online monitoring of resin synthesis. In combination with chemometric methods for multivariate data analysis, powerful process models can be generated within the framework of feedback and feed-forward control concepts. Other analytical methods covered in this chapter are those frequently used to control further processing of thermosets to the final parts, including dielectric analysis, ultrasonics, fiber optics, and Fiber Bragg Grating sensors.
Self-healing thermosets
(2022)
This chapter discusses the basic extrinsic, intrinsic, and combined extrinsic/intrinsic strategies for equipping thermosetting polymers with self-healing properties. The main focus will be on the presentation of a holistic optimization of thermosetting materials, that is, on a simultaneous optimization of both self-healing and other, specialized material properties. Due to their very rigid, highly cross-linked three-dimensional structure, thermosetting polymers require special chemical strategies to achieve self-healing properties. The main chemical strategies available for this will be briefly outlined. The examples given illustrate interesting and/or typical procedures and serve as an inspiration to find solutions for your own applications. They summarize important recent development in research and technology aiming toward multifunctional truly smart self-healing thermosetting materials. An important aspect in this topic area is also how precisely the self-healing effects are analytically checked, quantified, and evaluated. A range of measuring methods is available for this purpose. In this chapter, the most important analytical tools for testing self-healing properties are briefly introduced and highlighted with some illustrative examples.
From the perspective of manufacturing companies, the political, media and economic discourse on decarbonisation in the recent years manifests itself as an increasing social expectation of action. In Germany, in particular, this discourse is also being driven forward by powerful companies, respectively sectors, most notably the automotive industry. Against this background, the present paper examines how German manufacturing companies react to rising societal pressure and emerging policies. It examines which measures the companies have taken or plan to take to reduce their carbon footprint, which aspirations are associated with this and the structural characteristics (company size, energy intensity, and sector) by which these are influenced. A mix methods approach is applied, utilising data gathered from approx. 900 companies in context of the Energy Efficiency Index of German Industry (EEI), along with media research focusing on the announced decarbonisation plans and initiatives. We demonstrate that one-size-serves-all approaches are not suitable to decarbonise industry, as the situation and ambitions differ considerably depending on size, energy intensity and sector. Even though the levels of ambition and urgency are high, micro and energy intensive companies, in particular, are challenged. The present research uncovers a series of questions that call for attention to materialise the ambitions and address the challenges outlined.
Monitoring tautomerization of single hypericin molecules in a tunable optical λ/2 microcavity
(2022)
Hypericin tautomerization that involves the migration of the labile protons is believed to be the primary photophysical process relevant to its light-activated antiviral activity. Despite the difficulty in isolating individual tautomers, it can be directly observed in single-molecule experiments. We show that the tautomerization of single hypericin molecules in free space is observed as an abrupt flipping of the image pattern accompanied with fluorescence intensity fluctuations, which are not correlated with lifetime changes. Moreover, the study can be extended to a λ/2 Fabry–Pérot microcavity. The modification of the local photonic environment by a microcavity is well simulated with a theoretical model that shows good agreement with the experimental data. Inside a microcavity, the excited state lifetime and fluorescence intensity of single hypericin molecules are correlated, and a distinct jump of the lifetime and fluorescence intensity reveals the temporal behavior of the tautomerization with high sensitivity and high temporal resolution. The observed changes are also consistent with time-dependent density functional theory calculations. Our approach paves the way to monitor and even control reactions for a wider range of molecules at the single molecule level.
Repräsentativ zur Erkenntnis
(2022)
In einer immer komplexeren Welt wird es zunehmend schwierig, den Blick aufs große Ganze zu bewahren. Trainingsprofis können Führungskräfte und Teams dabei unterstützen -etwas mit einer speziellen Aufstellungstechnik, der prototypischen Strukturaufstellung. Kerstin Reich erklärt anhand eines Praxisbeispiels, wie sie funktioniert.
In dem Beitrag wurden exemplarisch Möglichkeiten aufgezeigt, die mittels der Verknüpfung unterschiedlicher Technologien zur Steigerung von Genauigkeit und Effizienz bei der Bearbeitung genutzt werden können. Dabei sind Kenntnisse aus unterschiedlichen Bereichen erforderlich. Dies sind sowohl Bearbeitungs- und Prozesstechnologie, die Konstruktion von Maschinen, Vorrichtungen und Werkzeugen, sowie Mess- und Steuerungstechnik. Daneben sind auch neue Geschäftsmodelle und Technologien für die Nutzung und Verfügbarmachung von Daten und Informationen erforderlich.
Das Buch untersucht die Umsetzung der Seidenstraßeninitiative (BRI) in Ostafrika. Die BRI gilt als das zentrale geopolitische und geoökonomische Vorhaben Chinas in der Ära von Präsident Xi Jinping. Durch die Arbeit soll ein Beitrag zur Schließung einiger Forschungslücken geleistet werden, etwa die mangelnde Tiefe von Untersuchungen einzelner BRI-Projekte und die Unterberücksichtigung von Verarbeitungsnarrativen in den teilnehmenden Ländern. Die Leitfrage ist, inwiefern die BRI ein politisches bzw. hegemoniales Projekt des von der KPCh gelenkten Staats-Zivilgesellschafts-Komplexes in Ostafrika ist. Zu deren Beantwortung werden Datenbanken internationaler Organisationen und Policy-Dokumente ausgewertet. Außerdem führt der Verfasser eine qualitative Inhaltsanalyse von Zeitungsartikeln lokaler Medienhäuser in den Ländern Äthiopien, Kenia und Tansania durch, um drei Infrastrukturprojekte zu untersuchen. Die Arbeit verdeutlicht, dass die BRI zur Steigerung der Konnektivität in Ostafrika beiträgt. Gleichzeitig führen die Verdichtung der ökonomischen Beziehungen und die Implementierung der Infrastrukturvorhaben in Ostafrika zu zahlreichen Konsequenzen und konturieren ein hegemoniales Projekt.
Die additive Fertigung hat sich in den vergangenen Jahren wesentlich weiterentwickelt. Dabei wurde die Prozesstechnologie, Anlagen und die Werkstoffe optimiert. Für die industrielle Anwendung auch bei größeren Stückzahlen in der flexiblen Fertigung fehlen noch automatisierte Lösungen für die gesamte Prozesskette. In diesem Beitrag werden Werkzeuge und Technologie für die Reinigung interner Strukturelemente dargestellt.
Background
Although teledermatology has been proven internationally to be an effective and safe addition to the care of patients in primary care, there are few pilot projects implementing teledermatology in routine outpatient care in Germany. The aim of this cluster randomized controlled trial was to evaluate whether referrals to dermatologists are reduced by implementing a store-and-forward teleconsultation system in general practitioner practices.
Methods
Eight counties were cluster randomized to the intervention and control conditions. During the 1-year intervention period between July 2018 and June 2019, 46 general practitioner practices in the 4 intervention counties implemented a store-and-forward teledermatology system with Patient Data Management System interoperability. It allowed practice teams to initiate teleconsultations for patients with dermatologic complaints. In the four control counties, treatment as usual was performed. As primary outcome, number of referrals was calculated from routine health care data. Poisson regression was used to compare referral rates between the intervention practices and 342 control practices.
Results
The primary analysis revealed no significant difference in referral rates (relative risk = 1.02; 95% confidence interval = 0.911–1.141; p = .74). Secondary analyses accounting for sociodemographic and practice characteristics but omitting county pairing resulted in significant differences of referral rates between intervention practices and control practices. Matched county pair, general practitioner age, patient age, and patient sex distribution in the practices were significantly related to referral rates.
Conclusions
While a store-and-forward teleconsultation system was successfully implemented in the German primary health care setting, the intervention's effect was superimposed by regional factors. Such regional factors should be considered in future teledermatology research.
The requirements for textiles differ greatly depending on the area of application, whereby it often does not remain with only one required functionality. For example, in the field of functional clothing or protective clothing/PPE, it is necessary to protect the textile’s wearers from UV radiation. At the same time, self-cleaning effects offer certain advantages in that field. In addition, an antimicrobial effect in functional clothing can reduce the formation of unpleasant odors, and in PPE – especially in the healthcare sector – can contribute to the interruption of the chain of infection. One way to achieve these 3 desired functions in just one finishing step is to immobilize titanium dioxide (TiO2). However, TiO2 is viewed critically for application in the textile sector due to a REACH listing. Another disadvantage is that it only takes effect under UV radiation and is therefore not suitable for indoor use. Alternatively, photocatalysts such as doped zinc oxides (ZnO) can be used, which also exhibit catalytic activity through activation by visible light, which can lead to the killing of microorganisms and the degradation of organic soiling.
Schweißerschutzkleidung muss unterschiedlichen Anforderungen genügen. Sie muss u.a. flammfest sein, den Schweißer vor Metallspritzern schützen, die beim Schweißen entstehen, und auch einen Schutz vor UV-Licht sicherstellen, das im Schweißbogen entsteht. Besonders der Schutz vor Metallspritzern wird durch das Flächengewicht der Textilien bestimmt. Der entsprechende Schutzfaktor wird durch Tropfen flüssigen Eisens bestimmt, die auf ein Gewebe fallen. Dabei gilt: je höher das Flächengewicht, desto höher der Schutz vor Schweißspritzern. Jedoch gilt auch: je höher das Flächengewicht, desto schlechter ist der Tragekomfort und desto wärmender ist die Kleidung und damit die körperliche Belastung des Trägers. Durch die Applikation von Nanopartikeln ist es möglich, das benötigte Flächengewicht der Kleidung zu reduzieren.
Schweißerschutzkleidung muss unterschiedlichen Anforderungen genügen. Sie muss u.a. flammfest sein, den Schweißer vor Metallspritzern schützen, die beim Schweißen entstehen, und auch einen Schutz vor UV-Licht sicherstellen, das im Schweißbogen entsteht. Besonders der Schutz vor Metallspritzern wird durch das Flächengewicht der Textilien bestimmt. Der entsprechende Schutzfaktor wird durch Tropfen flüssigen Eisens bestimmt, die auf ein Gewebe fallen. Dabei gilt: je höher das Flächengewicht, desto höher der Schutz vor Schweißspritzern. Jedoch gilt auch: je höher das Flächengewicht, desto schlechter ist der Tragekomfort und desto wärmender ist die Kleidung und damit die körperliche Belastung des Trägers. Durch die Applikation von Nanopartikeln ist es möglich, das benötigte Flächengewicht der Kleidung zu reduzieren.
We address the problem of 3D face recognition based on either 3D sensor data, or on a 3D face reconstructed from a 2D face image. We focus on 3D shape representation in terms of a mesh of surface normal vectors. The first contribution of this work is an evaluation of eight different 3D face representations and their multiple combinations. An important contribution of the study is the proposed implementation, which allows these representations to be computed directly from 3D meshes, instead of point clouds. This enhances their computational efficiency. Motivated by the results of the comparative evaluation, we propose a 3D face shape descriptor, named Evolutional Normal Maps, that assimilates and optimises a subset of six of these approaches. The proposed shape descriptor can be modified and tuned to suit different tasks. It is used as input for a deep convolutional network for 3D face recognition. An extensive experimental evaluation using the Bosphorus 3D Face, CASIA 3D Face and JNU-3D Face datasets shows that, compared to the state of the art methods, the proposed approach is better in terms of both computational cost and recognition accuracy.
For collision and obstacle avoidance as well as trajectory planning, robots usually generate and use a simple 2D costmap without any semantic information about the detected obstacles. Thus a robot’s path planning will simply adhere to an arbitrarily large safety margin around obstacles. A more optimal approach is to adjust this safety margin according to the class of an obstacle. For class prediction, an image processing convolutional neural network can be trained. One of the problems in the development and training of any neural network is the creation of a training dataset. The first part of this work describes methods and free open source software, allowing a fast generation of annotated datasets. Our pipeline can be applied to various objects and environment settings and is extremely easy to use to anyone for synthesising training data from 3D source data. We create a fully synthetic industrial environment dataset with 10 k physically-based rendered images and annotations. Our da taset and sources are publicly available at https://github.com/LJMP/synthetic-industrial-dataset. Subsequently, we train a convolutional neural network with our dataset for costmap safety class prediction. We analyse different class combinations and show that learning the safety classes end-to-end directly with a small dataset, instead of using a class lookup table, improves the quantity and precision of the predictions.
Allyls
(2022)
This chapter addresses the importance and usage of the commercially low-volume thermoset plastics group known as allyls. The three significant subelements of this group are poly(diallylphthalates), poly(diallylisophthalates), and poly(allyldiglycol carbonate). Chemistry, processing, and properties are also described. Allyl polymers are synthesized by radical polymerizations of allyl monomers that usually do not produce high-molecular-mass macromolecules. Therefore only a few specific monomers can produce thermosetting materials. Diallyldiglycolcarbonate (CR-39) and diallylphthalates are the most significant examples that have considerably improved our everyday life.
Unsaturated polyester resins (UPR) and vinyl ester resins (VER) are among the most commercially important thermosetting matrix materials for composites. Although comparatively low cost, their technological performance is suitable for a wide range of applications, such as fiber-reinforced plastics, artificial marble or onyx, polymer concrete, or gel coats. The main areas of UPR consumption include the wind energy, marine, pipe and tank, transportation, and construction industries.
This chapter discusses basic UPR and VER chemistry and technology of manufacturing, and consequent applications. Some important properties and performance characteristics are discussed, such as shrinkage behavior, flame retardance, and property modification by nanoparticles. Also briefly introduced and described are the practical aspects of UPR and VER processing, with special emphasis on the most widely used technological approaches, such as hand and spray layup, resin infusion, resin transfer molding, sheet and bulk molding, pultrusion, winding, and centrifugal casting.
Lehrbuch zur CAD-Software Creo Parametric und zur Produktdatenverwaltung mit Windchill.
3D-Volumenmodellierung, 3D-Flächenmodellierung, Blechmodellierung, Baugruppen- und Zeichnungserstellung, Definition von Normteilen, Erstellen von Animationen und dynamischen Analysen.
Verfahren zum Umgang mit großen Baugruppen und zur flexiblen Modellierung, Konstruk-tionsvarianten "Top-Down" und "Bottom-Up", Organisation von Konstruktionsprojekten über Skeletttechnik.
Neu: Konstruktion von und mit Mehrkörperobjekten, Rahmenkonstruktion in der Profilumgebung (AFX), intelligente Verbindungen (IFX), Live Simulation und Generatives Design.
Die Informatics Inside ist seit über 13 Jahren ein fester Bestandteil des akademischen Jahres an der Fakultät für Informatik der Hochschule Reutlingen. Die Konferenz wird von Studierenden des Masterstudiengangs Human-Centered Computing selbstständig organisiert und bildet einen wichtigen Teil der wissenschaftlichen Ausbildung. Die Studierenden haben ihre Themen selbst gewählt und nicht selten sind es Fragen, die sie bereits durch das ganze Studium begleiten. Sie bereiten diese im Format einer wissenschaftlichen Ausarbeitung auf, wobei Inhalt, Vollständigkeit und Nachvollziehbarkeit entscheidende Faktoren sind. Die Ergebnisse dieser vertieften Auseinandersetzung mit relevanten Anwendungsthemen der Informatik können Sie in diesem Tagungsband nachlesen. Die Anwendungsdomänen reichen von der Medizin über Wirtschaft bis zu den Medien. Dabei werden aktuelle Fragestellungen des menschzentrierten Einsatzes von künstlicher Intelligenz, Softwaretechnik, Datenanalyse und Kommunikation sowie der digitalen Transformation behandelt. Es wird deutlich, dass der Nutzen von IT-Lösungen für den Menschen im Mittelpunkt der Veranstaltung steht. Das Motto der Veranstaltung „IT´s Future“ ist Programm und macht die Relevanz der Informatik für alle Lebensbereiche sowie die zukünftige Innovations- und Wettbewerbsfähigkeit von Industrie und Forschung deutlich.
This study examines the relevance of integrated reporting quality (IRQ) to capital markets. We investigate whether IRQ benefits capital market participants by improving a firm's information environment, using analyst earnings forecast accuracy as a proxy. Our study focuses specifically on companies that publish integrated reports on a voluntary basis. Based on a scoring model, we assess IRQ and its effects with data from 2015 to 2019 of 101 companies. The results indicate no significant relationship between IRQ and analyst earnings forecast accuracy. Thus, IRQ does not appear to improve a firm's information environment, at least not currently in a voluntary setting. Drawing on previous literature in the field, this study further concludes that integrated reporting (IR) in general has not yet reached its full potential in benefitting capital markets. Potential implications of our results are that the standard setters should work to improve the specificity and rigor of their guidelines, and analysts should become more involved in developing IR guidelines to make them more relevant to their information needs. IR seems to unfold its benefits better in mandatory settings, which could call for regulators to make IR mandatory.
Die Charakterisierung und Beschreibung der komplexen Wechselwirkungen an der Zerspanstelle eines Bearbeitungszentrums beeinflusst die Qualität der hergestellten Bauteile. In diesem Beitrag wird die Messung und Beschreibung der Eigenfrequenzen unterschiedlicher Bearbeitungszentren in Abhängigkeit der bei der Bearbeitung verwendeten Werkzeuge und Bearbeitungsstrategien bezüglich der Auswirkungen auf die Stabilität hergeleitet. Dazu werden die gestellseitigen Resonanzfrequenzen analysiert. Ziel der Untersuchungen ist eine Beschreibung der dynamischen Eigenschaften zur Optimierung der NC-Programmierung.
The blockchain technology represents a decentralized database that stores information securely in immutable data blocks. Regarding supply chain management, these characteristics offer potentials in increasing supply chain transparency, visibility, automation, and efficiency. In this context, first token-based mapping approaches exist to transfer certain manufacturing processes to the blockchain, such as the creation or assembly of parts as well as their transfer of ownership. However, the decentralized and immutable structure of blockchain technology also creates challenges when applying these token-based approaches to dynamic manufacturing processes. As a first step, this paper investigates existing mapping approaches and exemplifies weaknesses regarding their suitability for products with changeable configurations. Secondly, a concept is proposed to overcome these weaknesses by introducing logically coupled tokens embedded into a flexible smart contract structure. Finally, a concept for a token-based architecture is introduced to map manufacturing processes of products with changeable configurations.
This study empirically analyzes and compares return data from developed and emerging market data based on the Fama French five-factor model and compares it to previous results from the Fama French three-factor model by Kostin, Runge and Adams (2021). It researches whether the addition of the profitability and investment pattern factors show superior results in the assessment of emerging markets during the COVID-19 pandemic compared to developed markets. We use panel data covering eight indices of developed and emerging countries as well as a selection of eight companies from these markets, covering a period from 2000 to 2020. Our findings suggest that emerging markets do not generally outperform developed markets. The results underscore the need to reconsider the assumption that adding more factors to regression models automatically yields results that are more reliable. Our study contributes to the extant literature by broadening this research area. It is the first study to compare the performance of the Fama French three-factor model and the Fama French five-factor model in the cost of equity calculation for developed and emerging countries during the COVID-19 pandemic and other crisis events of the past two decades.
Gewinn, Profitabilität und Wachstum eines Unternehmens sind untrennbar mit dem Arbeitseinsatz und der Mitarbeiterperformance verbunden (Birri, 2014; Bligh et al., 2006). Arbeitseinsatz und Performance wiederum erwachsen maßgeblich aus den grundlegenden intrinsischen und extrinsischen Motivationstreibern. Also müssen Unternehmen zur Sicherung ihres Erfolgs mit geeigneten Werkzeugen gezielt auf diese Treiber einwirken. Ein zentrales Werkzeug hierfür sind die Vergütungssysteme der Unternehmen.
Die additive Fertigung hat sich in den vergangenen Jahren wesentlich weiter entwickelt. Dabei wurde die Prozesstechnologie, Anlagen und die Werkstoffe optimiert. Für die industrielle Anwendung auch bei größeren Stückzahlen in der flexiblen Fertigung fehlen noch automatisierte Lösungen für die gesamte Prozesskette. In diesem Beitrag werden Werkzeuge und Technologie für die Reinigung interner Strukturelemente dargestellt.
This article explores the question of how sustainability and labour law are interrelated. The modern world of work is characterised by the growing social and environmental responsibility of companies. Especially in the post-COVID era, sustainability also plays an increasingly important role in the corporate context, which is also noticeable in the so-called ‘war for talent’. Achieving personal career goals is no longer enough for employees today. Corporate values and in particular the so-called ESG criteria (Environment, Social, Governance) are thus also becoming increasingly important in the employment relationship and in corporate reporting requirements. In terms of social sustainability, labour law instruments can, for example, promote the creation of a discrimination-free working environment, the introduction of flexible working time models or the protection of whistleblowers. From an ecological perspective, labour regulations are also suitable for implementing ‘green mobility’ and other measures to reduce companies’ ecological footprints. Working from home, which experienced a huge boom during the COVID-19 pandemic, is also sustainable, especially from an ecological point of view. Appropriate consideration of these sustainable work tools in future corporate social responsibility (CSR) strategies not only creates a competitive advantage but can also be beneficial in recruitment.
The functionality of existing cyber-physical production systems generally focuses on mapping technologic specifications derived from production requirements. Consequently, such systems base their conception on a structurally mechanistic paradigm. Insofar as these approaches have considered humans, their conception likewise is based on the structurally identical paradigm. Due to the fundamental reorientation towards explicitly human-centered approaches, the fact that essential aspects of the dimension "human" remain unconsidered by the previous paradigm becomes more and more apparent. To overcome such limitations, mapping the "social" dimension requires a structurally different approach. In this paper, an anthropocentric approach is developed based on possible conceptions of the human being, enabling a structural integration of the human being in an extended dimension. Through the model, extending concepts for better integration of the human being in the sense of human-centered approaches, as envisioned in the Industrie 5.0 conception, is possible.
Artificial intelligence is a field of research that is seen as a means of realization regarding digitalization and industry 4.0. It is considered as the critical technology needed to drive the future evolution of manufacturing systems. At the same time, autonomous guided vehicles (AGV) developed as an essential part due to the flexibility they contribute to the whole manufacturing process within manufacturing systems. However, there are still open challenges in the intelligent control of these vehicles on the factory floor. Especially when considering dynamic environments where resources should be controlled in such a way, that they can be adjusted to turbulences efficiently. Therefore, this paper aimed to develop a conceptual framework for addressing a catalog of criteria that considers several machine learning algorithms to find the optimal algorithm for the intelligent control of AGVs. By applying the developed framework, an algorithm is automatically selected that is most suitable for the current operation of the AGV in order to enable efficient control within the factory environment. In future work, this decision-making framework can be transferred to even more scenarios with multiple AGV systems, including internal communication along with AGV fleets. With this study, the automatic selection of the optimal machine learning algorithm for the AGV improves the performance in such a way, that computational power is distributed within a hybrid system linking the AGV and cloud storage in an efficient manner.
Physicians in interventional radiology are exposed to high physical stress. To avoid negative long-term effects resulting from unergonomic working conditions, we demonstrated the feasibility of a system that gives feedback about unergonomic
situations arising during the intervention based on the Azure Kinect camera. The overall feasibility of the approach could be shown.
The proper selection of a demand forecasting method is directly linked to the success of supply chain management (SCM). However, today’s manufacturing companies are confronted with uncertain and dynamic markets. Consequently, classical statistical methods are not always appropriate for accurate and reliable forecasting. Algorithms of Artificial intelligence (AI) are currently used to improve statistical methods. Existing literature only gives a very general overview of the AI methods used in combination with demand forecasting. This paper provides an analysis of the AI methods published in the last five years (2017-2021). Furthermore, a classification is presented by clustering the AI methods in order to define the trend of the methods applied. Finally, a classification of the different AI methods according to the dimensionality of data, volume of data, and time horizon of the forecast is presented. The goal is to support the selection of the appropriate AI method to optimize demand forecasting.
Towards a model for holistic mapping of supply chains by means of tracking and tracing technologies
(2022)
The usage of tracking and tracing technologies not only enables transparency and visibility of supply chains but also offers far-reaching advantages for companies, such as ensuring product quality or reducing supplier risks. Increasing the amount of shared information supports both internal and external planning processes as well as the stability and resilience of globally operating value chains. This paper aims to differentiate and define the functionalities of tracking and tracing technologies that are frequently used interchangeably in literature. Furthermore, this paper incorporates influencing factors impacting a sequencing of the connected world in Industry4.0 supply chain networks. This includes legal influences, the embedment of supply chain-related standards, and new possibilities of emerging technologies. Finally, the results are summarized in a model for the holistic mapping of supply chains by means of tracking and tracing technologies. The resulting technological solutions that can be derived from the model enable companies to address missing elements in order to enable the holistic mapping of supply chain events as well as the transparent representation of a digital shadow throughout the entire supply chain.
The fifth mobile communications generation (5G) offers the deployment scenario of licensed 5G standalone non-public networks (NPNs). Standalone NPNs are locally restricted 5G networks based on 5G New Radio technology which are fully isolated from public networks. NPNs operate on their dedicated core network and offer organizations high data security and customizability for intrinsic network control. Especially in networked and cloud manufacturing, 5G is seen as a promising enabler for delay-sensitive applications such as autonomous mobile robots and robot motion control based on the tactile internet that requires wireless communication with deterministic traffic and strict cycling times. However, currently available industrial standalone NPNs do not meet the performance parameters defined in the 5G specification and standardization process. Current research lacks in performance measurements of download, upload, and time delays of 5G standalone-capable end-devices in NPNs with currently available software and hardware in industrial settings. Therefore, this paper presents initial measurements of the data rate and the round-trip delay in standalone NPNs with various end-devices to generate a first performance benchmark for 5G-based applications. In addition, five end-devices are compared to gain insights into the performance of currently available standalone-capable 5G chipsets. To validate the data rate, three locally hosted measurement methods, namely iPerf3, LibreSpeed and OpenSpeedTest, are used. Locally hosted Ping and LibreSpeed have been executed to validate the time delay. The 5G standalone NPN of Reutlingen University uses licensed frequencies between 3.7-3.8 GHz and serves as the testbed for this study.
Von den Covid-19-Restriktionen wurden im Automobilsektor die Zulieferer wesentlich stärker getroffen als die Fahrzeughersteller. Vor allem die Entwicklung des Working Capitals im ersten Pandemie-Jahr erwies sich als kritisch. Der Beitrag gibt einen Überblick über mögliche Lösungen für eine allseits vorteilhaftere, stabile Supply-Chain-Finanzierung in künftigen Krisen.
Einige Ideen, Erfahrungen und Realitäten für die Studierenden und Bürger in Reutlingen. Zusammengestellt von 50 Studierenden 2020/21 und aus Beiträgen von 40 Institutionen und Unternehmen in und um Reutlingen.
Ein Versuch, sehr konkret am Tatsächlichen zu erklären, was zu mehr Nachhaltigkeit führt, in Reutlingen. Dabei bleibt nicht aus, auch auf Schwachstellen hinzuweisen.
Wenn Studierende und Bürger in den nächsten Jahren bewusst zu mehr Nachhaltigkeit bereit sind, so sind sie mit den Ideen und Realitäten in diesem Projekt auf einem guten Weg.
In our initial DaMoN paper, we set out the goal to revisit the results of “Starring into the Abyss [...] of Concurrency Control with [1000] Cores” (Yu in Proc. VLDB Endow 8: 209-220, 2014). Against their assumption, today we do not see single-socket CPUs with 1000 cores. Instead, multi-socket hardware is prevalent today and in fact offers over 1000 cores. Hence, we evaluated concurrency control (CC) schemes on a real (Intel-based) multi-socket platform. To our surprise, we made interesting findings opposing results of the original analysis that we discussed in our initial DaMoN paper. In this paper, we further broaden our analysis, detailing the effect of hardware and workload characteristics via additional real hardware platforms (IBM Power8 and 9) and the full TPC-C transaction mix. Among others, we identified clear connections between the performance of the CC schemes and hardware characteristics, especially concerning NUMA and CPU cache. Overall, we conclude that no CC scheme can efficiently make use of large multi-socket hardware in a robust manner and suggest several directions on how CC schemes and overall OLTP DBMS should evolve in future.
Current data-intensive systems suffer from scalability as they transfer massive amounts of data to the host DBMS to process it there. Novel near-data processing (NDP) DBMS architectures and smart storage can provably reduce the impact of raw data movement. However, transferring the result-set of an NDP operation may increase the data movement, and thus, the performance overhead. In this paper, we introduce a set of in-situ NDP result-set management techniques, such as spilling, materialization, and reuse. Our evaluation indicates a performance improvement of 1.13 × to 400 ×.
For a long time, most discrete accelerators have been attached to host systems using various generations of the PCI Express interface. However, with its lack of support for coherency between accelerator and host caches, fine-grained interactions require frequent cache-flushes, or even the use of inefficient uncached memory regions. The Cache Coherent Interconnect for Accelerators (CCIX) was the first multi-vendor standard for enabling cache-coherent host-accelerator attachments, and already is indicative of the capabilities of upcoming standards such as Compute Express Link (CXL). In our work, we compare and contrast the use of CCIX with PCIe when interfacing an ARM-based host with two generations of CCIX-enabled FPGAs. We provide both low-level throughput and latency measurements for accesses and address translation, as well as examine an application-level use-case of using CCIX for fine-grained synchronization in an FPGA-accelerated database system. We can show that especially smaller reads from the FPGA to the host can benefit from CCIX by having roughly 33% shorter latency than PCIe. Small writes to the host have a latency roughly 32% higher than PCIe, though, since they carry a higher coherency overhead. For the database use-case, the use of CCIX allowed to maintain a constant synchronization latency even with heavy host-FPGA parallelism.
Even though near-data processing (NDP) can provably reduce data transfers and increase performance, current NDP is solely utilized in read-only settings. Slow or tedious to implement synchronization and invalidation mechanisms between host and smart storage make NDP support for data-intensive update operations difficult. In this paper, we introduce a low-latency cache-coherent shared lock table for update NDP settings in disaggregated memory environments. It utilizes the novel CCIX interconnect technology and is integrated in neoDBMS, a near-data processing DBMS for smart storage. Our evaluation indicates end-to-end lock latencies of ∼80-100ns and robust performance under contention.
Due to its wide-ranging endocrine functions, adipose tissue influences the whole body’s metabolism. Engineering long-term stable and functional human adipose tissue is still challenging due to the limited availability of suitable biomaterials and adequate cell maturation. We used gellan gum (GG) to create manual and bioprinted adipose tissue models because of its similarities to the native extracellular matrix and its easily tunable properties. Gellan gum itself was neither toxic nor monocyte activating. The resulting hydrogels exhibited suitable viscoelastic properties for soft tissues and were stable for 98 days in vitro. Encapsulated human primary adipose-derived stem cells (ASCs) were adipogenically differentiated for 14 days and matured for an additional 84 days. Live-dead staining showed that encapsulated cells stayed viable until day 98, while intracellular lipid staining showed an increase over time and a differentiation rate of 76% between days 28 and 56. After 4 weeks of culture, adipocytes had a univacuolar morphology, expressed perilipin A, and secreted up to 73% more leptin. After bioprinting establishment, we demonstrated that the cells in printed hydrogels had high cell viability and exhibited an adipogenic phenotype and function. In summary, GG-based adipose tissue models show long-term stability and allow ASCs maturation into functional, univacuolar adipocytes.
Hybrid project management is an approach that combines traditional and agile project management techniques. The goal is to benefit from the strengths of each approach, and, at the same time avoid the weaknesses. However, due to the variety of hybrid methodologies that have been presented in the meantime, it is not easy to understand the differences or similarities of the methodologies, as well as, the advantages or disadvantages of the hybrid approach in general. Additionally, there is only fragmented knowledge about prerequisites and success factors for successfully implementing hybrid project management in organizations. Hence, the aim of this study is to provide a structured overview of the current state of research regarding the topic. To address this aim, we have conducted a systematic literature review focusing on a set of specific research questions. As a result, four different hybrid methodologies are discussed, as well as, the definition, benefits, challenges, suitability and prerequisites of hybrid project management. Our study contributes to knowledge by synthesizing and structuring prior work in this growing area of research, which serves as a basis for purposeful and targeted research in the future.
Purpose
Artificial intelligence (AI), in particular deep neural networks, has achieved remarkable results for medical image analysis in several applications. Yet the lack of explainability of deep neural models is considered the principal restriction before applying these methods in clinical practice.
Methods
In this study, we propose a NeuroXAI framework for explainable AI of deep learning networks to increase the trust of medical experts. NeuroXAI implements seven state-of-the-art explanation methods providing visualization maps to help make deep learning models transparent.
Results
NeuroXAI has been applied to two applications of the most widely investigated problems in brain imaging analysis, i.e., image classification and segmentation using magnetic resonance (MR) modality. Visual attention maps of multiple XAI methods have been generated and compared for both applications. Another experiment demonstrated that NeuroXAI can provide information flow visualization on internal layers of a segmentation CNN.
Conclusion
Due to its open architecture, ease of implementation, and scalability to new XAI methods, NeuroXAI could be utilized to assist radiologists and medical professionals in the detection and diagnosis of brain tumors in the clinical routine of cancer patients. The code of NeuroXAI is publicly accessible at https://github.com/razeineldin/NeuroXAI.
Purpose
Context awareness in the operating room (OR) is important to realize targeted assistance to support actors during surgery. A situation recognition system (SRS) is used to interpret intraoperative events and derive an intraoperative situation from these. To achieve a modular system architecture, it is desirable to de-couple the SRS from other system components. This leads to the need of an interface between such an SRS and context-aware systems (CAS). This work aims to provide an open standardized interface to enable loose coupling of the SRS with varying CAS to allow vendor-independent device orchestrations.
Methods
A requirements analysis investigated limiting factors that currently prevent the integration of CAS in today's ORs. These elicited requirements enabled the selection of a suitable base architecture. We examined how to specify this architecture with the constraints of an interoperability standard. The resulting middleware was integrated into a prototypic SRS and our system for intraoperative support, the OR-Pad, as exemplary CAS for evaluating whether our solution can enable context-aware assistance during simulated orthopedical interventions.
Results
The emerging Service-oriented Device Connectivity (SDC) standard series was selected to specify and implement a middleware for providing the interpreted contextual information while the SRS and CAS are loosely coupled. The results were verified within a proof of concept study using the OR-Pad demonstration scenario. The fulfillment of the CAS’ requirements to act context-aware, conformity to the SDC standard series, and the effort for integrating the middleware in individual systems were evaluated. The semantically unambiguous encoding of contextual information depends on the further standardization process of the SDC nomenclature. The discussion of the validity of these results proved the applicability and transferability of the middleware.
Conclusion
The specified and implemented SDC-based middleware shows the feasibility of loose coupling an SRS with unknown CAS to realize context-aware assistance in the OR.
The transmembrane Ca2+ − activated Cl− channel - human bestrophin-1 (hBest1) is expressed in retinal pigment epithelium and mutations of BEST1 gene cause ocular degenerative diseases colectivelly referred to as “bestrophinopathies”. A large number of genetical, biochemical, biophysical and molecular biological studies have been performed to understand the relationship between structure and function of the hBest1 protein and its pathophysiological significance. Here, we review the current understanding of hBest1 surface organization, interactions with membrane lipids in model membranes, and its association with microdomains of cellular membranes. These highlights are significant for modulation of channel activity in cells.
The paper describes how eye-tracking can be used to explore electronic patient records (EPR) in a sterile environment. As an information display, we used a system that we developed for the presentation of patient data and for supporting surgical hand disinfection. The eye-tracking was performed using the Tobii Eye Tracker 4C, and the connection between the eye-tracker and the HTML website was realized using the Tobii EyeX Chrome Extension. Interactions with the EPR are triggered by fixations of icons. The interaction was working as intended, but test persons reported a high mental load while using the system.
Ultra wideband real-time locating system for tracking people and devices in the operating room
(2022)
Position tracking within the OR could be one possible input for intraoperative situation recognition. Our approach demonstrates a Real-time Locating System (RTLS) using the Ultra Wideband (UWB) technology to determine the position of people or objects. The UWB RTLS was integrated into the research OR at Reutlingen University and the system’s settings were optimized regarding the four factors accuracy, susceptibility to interference, range, and latency. Therefore, different parameters were adapted and the effects on the factors were compared. Goodtracking quality could be achieved under optimal settings. These results indicate that a UWB RTLS is well suited to determine the position of people and devices in our setting. The feasibility of the system needsto be evaluated under real OR conditions.
With the progress of technology in modern hospitals, an intelligent perioperative situation recognition will gain more relevance due to its potential to substantially improve surgical workflows by providing situation knowledge in real-time. Such knowledge can be extracted from image data by machine learning techniques but poses a privacy threat to the staff’s and patients’ personal data. De-identification is a possible solution for removing visual sensitive information. In this work, we developed a YOLO v3 based prototype to detect sensitive areas in the image in real-time. These are then deidentified using common image obfuscation techniques. Our approach shows that it is principle suitable for de-identifying sensitive data in OR images and contributes to a privacyrespectful way of processing in the context of situation recognition in the OR.
Intraoperative imaging can assist neurosurgeons to define brain tumours and other surrounding brain structures. Interventional ultrasound (iUS) is a convenient modality with fast scan times. However, iUS data may suffer from noise and artefacts which limit their interpretation during brain surgery. In this work, we use two deep learning networks, namely UNet and TransUNet, to make automatic and accurate segmentation of the brain tumour in iUS data. Experiments were conducted on a dataset of 27 iUS volumes. The outcomes show that using a transformer with UNet is advantageous providing an efficient segmentation modelling long-range dependencies between each iUS image. In particular, the enhanced TransUNet was able to predict cavity segmentation in iUS data with an inference rate of more than 125 FPS. These promising results suggest that deep learning networks can be successfully deployed to assist neurosurgeons in the operating room.
Recently, blockchain-based tokens have earned an important role in fields such as the art market or online gaming. First approaches exist, which adopt the potentials of blockchain tokens in supply chain management to increase transparency, visibility, automation, and disintermediation of supply chains. In context, the tokenization of assets in supply chains refers to the practice of creating virtual representations of physical assets on the blockchain. Solutions in supply chain management based on the tokenization of assets vary in terms of application objectives, token types, asset characteristics, as well as the complexities of supply chain events to be mapped on the blockchain. Currently, however, no review exists that summarizes the characteristics of blockchain-based tokens and their scope of applications. This paper provides a clear terminological distinction of existing blockchain token types and therefore distinguishes between fungible tokens, non-fungible tokens, smart non-fungible tokens, and dynamic smart non-fungible tokens. Subsequently, the token types are classified regarding their traceability, modifiability, and authorization to evaluate suitability for mapping assets in supply chains. Given the potential of blockchain in supply chain management, the results of the review serve as a foundation for a practical guide supporting the selection process of suitable token types for industrial applications.
One of the key challenges for automatic assistance is the support of actors in the operating room depending on the status of the procedure. Therefore, context information collected in the operating room is used to gain knowledge about the current situation. In literature, solutions already exist for specific use cases, but it is doubtful to what extent these approaches can be transferred to other conditions. We conducted a comprehensive literature research on existing situation recognition systems for the intraoperative area, covering 274 articles and 95 cross-references published between 2010 and 2019. We contrasted and compared 58 identified approaches based on defined aspects such as used sensor data or application area. In addition, we discussed applicability and transferability. Most of the papers focus on video data for recognizing situations within laparoscopic and cataract surgeries. Not all of the approaches can be used online for real-time recognition. Using different methods, good results with recognition accuracies above 90% could be achieved. Overall, transferability is less addressed. The applicability of approaches to other circumstances seems to be possible to a limited extent. Future research should place a stronger focus on adaptability. The literature review shows differences within existing approaches for situation recognition and outlines research trends. Applicability and transferability to other conditions are less addressed in current work.
Purpose: Interpretive research in management accounting and control provides rich insights from empirically based studies, but it has been criticised for lacking generalisability and potential subjectivity. On the latter, triangulation is useful, and this paper aims to offer some insights on a triangulation technique thus far not commonly reported in management accounting/control research.
Design/methodology/approach: Drawing on a study of the roles of management accountants in performance management systems, this paper offers some insights from empirical experiences on the use of concept maps as a tool to assist triangulation and improve understanding of complex empirical phenomena.
Findings: The concept maps as utilised revealed additional insights which were not recounted by interviewees during the normal interview time. This is a potentially important finding for consideration of future researchers.
Practical implications: In this paper, how concept maps were used is detailed, and it is hoped that future researchers will find their use beneficial in interview settings.
Originality/value: Thus far, concept maps seem under-utilised in management accounting and control research. This paper gives some initial insights on how they may be used in case study settings.
Motivation: Aim of this project is the automatic classification of total hip endoprosthesis (THEP) components in 2D Xray images. Revision surgeries of total hip arthroplasty (THA) are common procedures in orthopedics and trauma surgery. Currently, around 400.000 procedures per year are performed in the United States (US) alone. To achieve the best possible result, preoperative planning is crucial. Especially if parts of the current THEP system are to be retained.
Methods: First, a ground truth based on 76 X-ray images was created: We used an image processing pipeline consisting of a segmentation step performed by a convolutional neural network and a classification step performed by a support vector machine (SVM). In total, 11 classes (5 pans and 6 shafts) shall be classified.
Results: The ground truth generated was of good quality even though the initial segmentation was performed by technicians. The best segmentation results were achieved using a U-net architecture. For classification, SVM architectures performed much better than additional neural networks.
Conclusions: The overall image processing pipeline performed well, but the ground truth needs to be extended to include a broader variability of implant types and more examples per training class.
Recognition of sleep and wake states is one of the relevant parts of sleep analysis. Performing this measurement in a contactless way increases comfort for the users. We present an approach evaluating only movement and respiratory signals to achieve recognition, which can be measured non-obtrusively. The algorithm is based on multinomial logistic regression and analyses features extracted out of mentioned above signals. These features were identified and developed after performing fundamental research on characteristics of vital signals during sleep. The achieved accuracy of 87% with the Cohen’s kappa of 0.40 demonstrates the appropriateness of a chosen method and encourages continuing research on this topic.
Monodisperse porous poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) particles are widely applied in different fields, as their pore properties can be influenced and functionalization of the epoxy group is versatile. However, the adjustment of parameters which control morphology and pore properties such as pore volume, pore size and specific surface area is scarcely available. In this work, the effects of the process factors monomer:porogen ratio, GMA:EDMA ratio and composition of the porogen mixture on the response variables pore volume, pore size and specific surface area are investigated using a face centered central composite design. Non-linear effects of the process factors and second order interaction effects between them were identified. Despite the complex interplay of the process factors, targeted control of the pore properties was possible. For each response a response surface model was derived with high predictive power (all R2 predicted > 0.85). All models were tested by four external validation experiments and their validity and predictive power was demonstrated.
This article explores the determinants of people’s growth prospects in survey data as well as the impact of the European recovery fund to future growth. The focus is on the aftermath of the Corona pandemic, which is a natural limit to the sample size. We use Eurobarometer survey data and macroeconomic variables, such as GDP, unemployment, public deficit, inflation, bond yields, and fiscal spending data. We estimate a variety of panel regression models and develop a new simulation-regression methodology due to limitation of the sample size. We find the major determinant of people’s growth prospect is domestic GDP per capita, while European fiscal aid does not significantly matter. In addition, we exhibit with the simulation-regression method novel scientific insights, significant outcomes, and a policy conclusion alike.
The vast majority of state-of-the-art integrated circuits are mixed-signal chips. While the design of the digital parts of the ICs is highly automated, the design of the analog circuitry is largely done manually; it is very time-consuming; and prone to error. Among the reasons generally listed for this is often the attitude of the analog designer. The fact is that many analog designers are convinced that human experience and intuition are needed for good analog design. This is why they distrust the automated synthesis tools. This observation is quite correct, but this is only a symptom of the real problem. This paper shows that this phenomenon is caused by very concrete technical (and thus very rational) issues. These issues lie in the mode of operation of the typical optimization processes employed for the synthesizing tasks. I will show that the dilemma that arises in analog design with these optimizers is the root cause of the low level of automation in analog design. The paper concludes with a review of proposals for automating analog design
Bioenergy production is a new and promising industry in Ecuador. However, a confusing variety of laws, which are spread among different regulating institutions, regulate the agricultural sector. Such dispersion makes it difficult for farmers and businesses to understand applicable rights, duties, regulations and agricultural policies. Moreover, this rather young industry lacks important experience. In the first section of this work, the existing Ecuadorian legislation on bioenergy is presented and analyzed. Then, a brief, thorough analysis and comparison are carried out for experiences not only in developed countries, but also with similar cultural frameworks and comparable climatic conditions. The results are summarized as specific recommendations that have been handed to the National Agricultural Chamber of Ecuador from academia for the proposal of a Unified Agricultural Code established in the Ecuadorian legal hierarchy as an Organic Law.
Continuous manufacturing is becoming more important in the biopharmaceutical industry. This processing strategy is favorable, as it is more efficient, flexible, and has the potential to produce higher and more consistent product quality. At the same time, it faces some challenges, especially in cell culture. As a steady state has to be maintained over a prolonged time, it is unavoidable to implement advanced process analytical technologies to control the relevant process parameters in a fast and precise manner. One such analytical technology is Raman spectroscopy, which has proven its advantages for process monitoring and control mostly in (fed-) batch cultivations. In this study, an in-line flow cell for Raman spectroscopy is included in the cell-free harvest stream of a perfusion process. Quantitative models for glucose and lactate were generated based on five cultivations originating from varying bioreactor scales. After successfully validating the glucose model (Root Mean Square Error of Prediction (RMSEP) of ∼0.2 g/L), it was employed for control of an external glucose feed in cultivation with a glucose-free perfusion medium. The generated model was successfully applied to perform process control at 4 g/L and 1.5 g/L glucose over several days, respectively, with variability of ±0.4 g/L. The results demonstrate the high potential of Raman spectroscopy for advanced process monitoring and control of a perfusion process with a bioreactor and scale-independent measurement method.
Multi-versioning and MVCC are the foundations of many modern DBMSs. Under mixed workloads and large datasets, the creation of the transactional snapshot can become very expensive, as long-running analytical transactions may request old versions, residing on cold storage, for reasons of transactional consistency. Furthermore, analytical queries operate on cold data, stored on slow persistent storage. Due to the poor data locality, snapshot creation may cause massive data transfers and thus lower performance. Given the current trend towards computational storage and near-data processing, it has become viable to perform such operations in-storage to reduce data transfers and improve scalability. neoDBMS is a DBMS designed for near-data processing and computational storage. In this paper, we demonstrate how neoDBMS performs snapshot computation in-situ. We showcase different interactive scenarios, where neoDBMS outperforms PostgreSQL 12 by up to 5×.
Near-data processing in database systems on native computational storage under HTAP workloads
(2022)
Today’s Hybrid Transactional and Analytical Processing (HTAP) systems, tackle the ever-growing data in combination with a mixture of transactional and analytical workloads. While optimizing for aspects such as data freshness and performance isolation, they build on the traditional data-to-code principle and may trigger massive cold data transfers that impair the overall performance and scalability. Firstly, in this paper we show that Near-Data Processing (NDP) naturally fits in the HTAP design space. Secondly, we propose an NDP database architecture, allowing transactionally consistent in-situ executions of analytical operations in HTAP settings. We evaluate the proposed architecture in state-of-the-art key/value-stores and multi-versioned DBMS. In contrast to traditional setups, our approach yields robust, resource- and cost-effcient performance.
Database management systems and K/V-Stores operate on updatable datasets – massively exceeding the size of available main memory. Tree-based K/V storage management structures became particularly popular in storage engines. B+ -Trees [1, 4] allow constant search performance, however write-heavy workloads yield in inefficient write patterns to secondary storage devices and poor performance characteristics. LSM-Trees [16, 23] overcome this issue by horizontal partitioning fractions of data – small enough to fully reside in main memory, but require frequent maintenance to sustain search performance.
Firstly, we propose Multi-Version Partitioned BTrees (MV-PBT) as sole storage and index management structure in key-sorted storage engines like K/V-Stores. Secondly, we compare MV-PBT against LSM-Trees. The logical horizontal partitioning in MV-PBT allows leveraging recent advances in modern B+ -Tree techniques in a small transparent and memory resident portion of the structure. Structural properties sustain steady read performance, yielding efficient write patterns and reducing write amplification.
We integrated MV-PBT in the WiredTiger [15] KV storage engine. MV-PBT offers an up to 2× increased steady throughput in comparison to LSM-Trees and several orders of magnitude in comparison to B+ -Trees in a YCSB [5] workload.
Switched reluctance motors are particularly attractive due to their simple structure. The control of this machine type requires the instants, to switch the currents in the motor phases in an appropriate sequence. These switching instants are determined either based on a position sensor, or on signals generated by a sensorless method. A very simple sensorless method uses the switching frequency of the hysteresis controllers used for phase current control. This paper first presents an automatic commissioning method for this sensorless method and second a startup procedure, thus enhancing this approach towards an application in industry.
The purpose of this paper sought to develop a collaborative framework that provides wine bottling facilities, wine cellars and their direct supply chain partner guidelines to facilitate a collaborative partnership – aiming to aid responsive decision making and improve reliability. The framework was developed using a triangulation approach, consisting of an in-depth literature review, 14 semi-structured interviews with industry experts and a theoretical case study. The developed framework was presented to wine bottling facilities and their supply chain stakeholders. Indication are that the proposed wine industry collaborative framework should enhance supply chain collaboration and will contribute towards the guidance and facilitation in developing collaboration platforms to align supply chain operations, while improving bottling responsiveness and meeting demand requirements.
A premise guaranteeing the successful interdisciplinary teamwork in product design is a mutual understanding of both professional and academic communities of the different design expertise and the role they play in the process. It appears that the open compound word industrial design is open to interpretation in European education. This ambiguity had a negative impact on the labour policies of some European countries, which have labelled some professions with incorrect names. Therefore, this terminological inconsistency urges for clarification within the design community. This work analyses the term industrial design, it presents historical developments in European industrial design education, in particular in Germany and in the Netherlands, and discusses how the education to the industrial design profession was positioned towards product development. This paper suggests that the causes for the observed lack of clarity about the meaning of the term industrial design are of an etymological and disciplinary kind. In order to act as a bridge between the professional and academic communities, universities should create the premises for interdisciplinary collaboration between designers and engineers through standardized communication, ultimately contributing for a sustainable future in both design and engineering education.
Social-Customer-Relationship-Management zeichnet sich vor allem durch die Möglichkeit eines zentralen, überregionalen Kundendialogs mit der Option einer inhaltlichen Segmentierung aus. Obwohl Wissenschaftler schon seit Längerem die Vorteile von Social CRM als ganzheitliche Marketingstrategie betonen, versuchen nur wenig Unternehmen eine ernsthafte Etablierung. Dabei eignet sich dieser Ansatz insbesondere für größere Firmen, die eine Palette unterschiedlicher Produkte überregional unter einem Markennamen vertreiben. Hier könnte Social CRM eine sinnvolle Bereicherung für das CRM-Instrumentarium darstellen und je nach Art der vertriebenen Produkte auch zum Qualitätsmanagement beitragen.
Human retinal pigment epithelial (RPE) cells express the transmembrane Ca2+-dependent Cl− channel bestrophin-1 (hBest1) of the plasma membrane. Mutations in the hBest1 protein are associated with the development of distinct pathological conditions known as bestrophinopathies. The interactions between hBest1 and plasma membrane lipids (cholesterol (Chol), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and sphingomyelin (SM)) determine its lateral organization and surface dynamics, i.e., their miscibility or phase separation. Using the surface pressure/mean molecular area (π/A) isotherms, hysteresis and compressibility moduli (Cs−1) of hBest1/POPC/Chol and hBest1/SM/Chol composite Langmuir monolayers, we established that the films are in an LE (liquid-expanded) or LE-LC (liquid-condensed) state, the components are well-mixed and the Ca2+ ions have a condensing effect on the surface molecular organization. Cholesterol causes a decrease in the elasticity of both films and a decrease in the ΔGmixπ values (reduction of phase separation) of hBest1/POPC/Chol films. For the hBest1/SM/Chol monolayers, the negative values of ΔGmixπ are retained and equalized with the values of ΔGmixπ in the hBest1/POPC/Chol films. Shifts in phase separation/miscibility by cholesterol can lead to changes in the structure and localization of hBest1 in the lipid rafts and its channel functions.
Purpose
Returnable transport packaging (RTP) solutions have found increasing attention in the recent past. It is not clear, however, under what conditions an RTP system improves a company's financial performance. This paper investigates the operational factors that influence the financial attractiveness of an RTP solution in a manufacturing environment and discusses how these factors are related to each other.
Design/methodology/approach
The paper presents the results of five empirical RTP use cases and compares the case study findings with the results found in literature in order to develop a taxonomy of RTP cost effects. Drawing on the concept of value-based management (VBM), the operational drivers of these RTP cost effects are systematized and categorized in a value driver model that relates RTP cost effects to overall economic value added (EVA).
Findings
Based on the use case findings, additional cost factors are identified that have not been previously discussed in literature. The amended taxonomy of influence factors is further operationalized in a value driver model.
Originality/value
The present paper is the first one providing a taxonomy of RTP cost effects and putting these effects in a conceptual framework that can be used for decision-making and performance benchmarking.
This article illustrates a method for sensorless control of a switched reluctance motor. The detection of the time instants for switching between the working phases is determined based on the evaluation of the switching frequency of the hysteresis current controllers for appropriately selected sensing phases. This enables a simple and cost efficient implementation. The method is compared with a pulse injection method in terms of efficiency and resolution.
Glioblastomas are the most aggressive fast-growing primary brain cancer which originate in the glial cells of the brain. Accurate identification of the malignant brain tumor and its sub-regions is still one of the most challenging problems in medical image segmentation. The Brain Tumor Segmentation Challenge (BraTS) has been a popular benchmark for automatic brain glioblastomas segmentation algorithms since its initiation. In this year, BraTS 2021 challenge provides the largest multi-parametric (mpMRI) dataset of 2,000 pre-operative patients. In this paper, we propose a new aggregation of two deep learning frameworksnamely, DeepSeg and nnU-Net for automatic glioblastoma recognition in pre-operative mpMRI. Our ensemble method obtains Dice similarity scores of 92.00, 87.33, and 84.10 and Hausdorff Distances of 3.81, 8.91, and 16.02 for the enhancing tumor, tumor core, and whole tumor regions, respectively, on the BraTS 2021 validation set, ranking us among the top ten teams. These experimental findings provide evidence that it can be readily applied clinically and thereby aiding in the brain cancer prognosis, therapy planning, and therapy response monitoring. A docker image for reproducing our segmentation results is available online at (https://hub.docker.com/r/razeineldin/deepseg21).
Der Beitrag befasst sich mit den wirtschaftlichen Auswirkungen auf Unternehmen der deutschen Automobilbranche in Folge der behördlichen Restriktionen im Rahmen der Corona-Pandemie. Untersuchungszeitraum ist das Jahr 2020 auf Quartalsebene. Unsere Auswertung zeigt, dass die Zulieferer von der Pandemie wesentlich stärker getroffen wurden als die Hersteller der Branche. Ebenso konnte eine zeitliche Wellenbewegung der Negativentwicklung entlang der Wertschöpfungskette festgestellt werden. Der Beitrag zeigt Instrumente der Supply-Chain-Finanzierung auf, die sowohl kurzfristige Erleichterungen in Krisenzeiten als auch langfristige Möglichkeiten der Working Capital Optimierung darstellen.
What might the attendee be able to do after being in your session?
Our work shows how to connect intra-operative devices via IEEE 11073 Service-oriented Device Connectivity (SDC).
Description of the Problem or Gap
Standardized device communication is essential for interoperability, availability of device data, and therefore for the intelligent operating room (OR) and arising solutions. The SDC standard was developed to make information from medical devices available in a uniform manner and enable interoperability. Existing devices are rarely SDC-capable and need interfaces to be interoperable via SDC.
Methods: What did you do to address the problem or gap?
We conceived an SDC-based architecture consisting of a service provider and service consumer. In our concept, the service provider is connected to the medical device and capable to translate the proprietary protocol of the device into SDC and vice versa. The service consumer is used to request or send information via the SDC protocol to the service provider and can function as a uniform bidirectional interface (e.g. for displaying or controlling). This concept was exemplarily demonstrated with the patient monitor MX800 of Philips to retrieve the device data (e.g. vital parameters) via SDC and partly for the operating light marLED X of KLS Martin Group.
Results: What was the outcome(s) of what you did to address the problem or gap?
The patient monitor MX800 was connected to a Raspberry Pi (RPi) via LAN, on which the service provider is running. The python script on the RPi establishes a connection to the monitor and translates incoming and outgoing messages from the proprietary protocol to SDC and vice versa to/from the service consumer. The service consumer is running on a laptop and acts as a simulation for different kinds of systems that want to get vital parameters or other information from the patient monitor. The operating light marLED X was connected to an RPi via USB-to-RS232. A python script on the RPi establishes a connection to the light and makes it possible via proprietary commands to get information of the light (e.g. status) and to control it (e.g. toggle the light, increment the intensity). A translation to SDC is not integrated yet.
Discussion of Results
Our practical implementation shows that medical devices can be accessed via external connections to get device data and control the device via commands. The example SDC implementation of the patient monitor MX800 makes it possible to request its data via the standardized communication protocol SDC. This is also possible for the operating light marLED X if its proprietary protocol is analyzed to be translatable to/from SDC. This would allow to control the device from an external system, or automatically depending on the status of the ongoing procedure. The advantage is, that existing intra-operative devices can be extended by a service provider which is capable of translating the proprietary protocol of the device in SDC and vice versa. This enables interoperability and an intelligent OR that, for example, is aware of all devices, their status, and data and can use this information to optimally support the surgeons and their team (e.g. provision of information, automated documentation). This interoperability allows that future innovations merely need to understand the SDC protocol instead of all vendor-dependent communication protocols.
Conclusion
Standardized device communication is essential to reach interoperability, and therefore intelligent ORs. Our contribution addresses the possibility of subsequently making medical devices SDC-capable. This may eliminate the need of understanding all the different proprietary protocols when developing new innovative solutions for the OR.
Affordable Luxury Sports Cars in Germany : Investigating the Determinants of Customer Experience
(2022)
The article discusses the factors affecting the customer experience when buying affordable luxury sports cars in Germany by identifying differences between first-time and experienced buyers. It emphasizes the need for the creation of two different customer journeys based on different customer experience clusters, a touchpoint analysis from the customer perspective identified differences in purchase stages, and staff behaviour and brand trust for customer satisfaction and brand identification.
Since project managers still face problems in managing interorganizational R&D projects, it is a promising approach to manage these projects project-culturally-aware. However, an important prerequisite for a project-culture-aware management is that the involved individual organizations pursue a collaborative strategy. Therefore, our article provides a conceptual approach including a new tool, the Collaborative Iron Triangle, which supports both project sponsors and managers in different phases of the collaboration process to pursue a collaborative strategy in interorganizational R&D projects.
For a holistic assessment of the interaction between the human body and tight fitted clothing, it is necessary to consider the mechanical properties of the body. Default avatars in CAD software are usually solid and do not take this interaction into account. For this purpose, a solid avatar is converted to a deformable one by using the soft body physics implementation in the simulation program Blender. The fit of a 3D garment on both avatars are compared, which allows a first evaluation of the differences between these approaches.
When wearing compressive garments, the tissue of the human body is altered in relation to its natural shape by the properties of the applied material and by the pattern construction used.
To check the fit of garments, both construction and selected materials can be virtually simulated in 3D on avatars in corresponding CAD programs before fabrication.
The software Blender allows the modelling of an avatar and to generate in respective to the different tissue zones with their specific properties to adjust them with soft body physics according to the testing of real soft tissue but the models in Blender are mainly using linear springs.
The scoring of sleep stages is an essential part of sleep studies. The main objective of this research is to provide an algorithm for the automatic classification of sleep stages using signals that may be obtained in a non-obtrusive way. After reviewing the relevant research, the authors selected a multinomial logistic regression as the basis for their approach. Several parameters were derived from movement and breathing signals, and their combinations were investigated to develop an accurate and stable algorithm. The algorithm was implemented to produce successful results: the accuracy of the recognition of Wake/NREM/REM stages is equal to 73%, with Cohen's kappa of 0.44 for the analyzed 19324 sleep epochs of 30 seconds each. This approach has the advantage of using the only movement and breathing signals, which can be recorded with less effort than heart or brainwave signals, and requiring only four derived parameters for the calculations. Therefore, the new system is a significant improvement for non-obtrusive sleep stage identification compared to existing approaches.
Due to its availability and minimal invasive harvesting human adipose tissue-derived extracellular matrix (dECM) is often used as a biomaterial in various tissue engineering and healthcare applications. Next to dECM, cell-derived ECM (cdECM) can be generated by and isolated from in vitro cultured cells. So far both types of ECM were investigated extensively toward their application as (bio)material in tissue engineering and healthcare. However, a systematic characterization and comparison of soft tissue dECM and cdECM is still missing. In this study, we characterized dECM from human adipose tissue, as well as cdECM from human adipose-derived stem cells, toward their molecular composition, structural characteristics, and biological purity. The dECM was found to exhibit higher levels of collagens and lower levels of sulfated glycosaminoglycans compared with cdECMs. Structural characteristics revealed an immature state of the fibrous part of cdECM samples. By the identified differences, we aim to support researchers in the selection of a suitable ECM-based biomaterial for their specific application and the interpretation of obtained results.
Enterprises and societies currently face crucial challenges, while Society 5.0 can contribute to a supersmart society, especially for manufacturing and healthcare, and Industry 4.0 becomes important in the global manufacturing industry. Smart energy digital platforms are architected to manage energy supply efficiently. Furthermore, the above digital platforms are expected to collect various kinds of data and analyze Big Data for the trends in the sharing economy in ecosystems. The adaptive integrated digital architecture framework (AIDAF) for Design Thinking Approach with Risk Management is expected to make an alignment with digital IT strategy. In this paper, we propose that various energy management systems and related digital platforms are designed and implemented in an alignment to digital IT strategy for sharing economy toward Society 5.0, with the AIDAF framework for Design Thinking Approach with Risk Management. The vision of AIDAF applications to enable sharing economy and digital platforms is explained and extended in the context of Society 5.0. In addition, challenges and future activities for this area are discussed that cover the directions of smart energy for Society 5.0.
The volume includes papers presented at the International KES Conference on Human Centred Intelligent Systems 2022 (KES HCIS 2022), held in Rhodes, Greece on June 20–22, 2022. This book highlights new trends and challenges in intelligent systems, which play an important part in the digital transformation of many areas of science and practice. It includes papers offering a deeper understanding of the human-centred perspective on artificial intelligence, of intelligent value co-creation, ethics, value-oriented digital models, transparency, and intelligent digital architectures and engineering to support digital services and intelligent systems, the transformation of structures in digital businesses and intelligent systems based on human practices, as well as the study of interaction and the co-adaptation of humans and systems.
The respiratory rate is a vital sign indicating breathing illness. It is necessary to analyze the mechanical oscillations of the patient's body arising from chest movements. An inappropriate holder on which the sensor is mounted, or an inappropriate sensor position is some of the external factors which should be minimized during signal registration. This paper considers using a non-invasive device placed under the bed mattress and evaluates the respiratory rate. The aim of the work is the development of an accelerometer sensor holder for this system. The normal and deep breathing signals were analyzed, corresponding to the relaxed state and when taking deep breaths. The evaluation criterion for the holder's model is its influence on the patient's respiratory signal amplitude for each state. As a result, we offer a non-invasive system of respiratory rate detection, including the mechanical component providing the most accurate values of mentioned respiratory rate.
Over the last decades, a tremendous change toward using information technology in almost every daily routine of our lives can be perceived in our society, entailing an incredible growth of data collected day-by-day on Web, IoT, and AI applications.
At the same time, magneto-mechanical HDDs are being replaced by semiconductor storage such as SSDs, equipped with modern Non-Volatile Memories, like Flash, which yield significantly faster access latencies and higher levels of parallelism. Likewise, the execution speed of processing units increased considerably as nowadays server architectures comprise up to multiple hundreds of independently working CPU cores along with a variety of specialized computing co-processors such as GPUs or FPGAs.
However, the burden of moving the continuously growing data to the best fitting processing unit is inherently linked to today’s computer architecture that is based on the data-to-code paradigm. In the light of Amdahl's Law, this leads to the conclusion that even with today's powerful processing units, the speedup of systems is limited since the fraction of parallel work is largely I/O-bound.
Therefore, throughout this cumulative dissertation, we investigate the paradigm shift toward code-to-data, formally known as Near-Data Processing (NDP), which relieves the contention on the I/O bus by offloading processing to intelligent computational storage devices, where the data is originally located.
Firstly, we identified Native Storage Management as the essential foundation for NDP due to its direct control of physical storage management within the database. Upon this, the interface is extended to propagate address mapping information and to invoke NDP functionality on the storage device. As the former can become very large, we introduce Physical Page Pointers as one novel NDP abstraction for self-contained immutable database objects.
Secondly, the on-device navigation and interpretation of data are elaborated. Therefore, we introduce cross-layer Parsers and Accessors as another NDP abstraction that can be executed on the heterogeneous processing capabilities of modern computational storage devices. Thereby, the compute placement and resource configuration per NDP request is identified as a major performance criteria. Our experimental evaluation shows an improvement in the execution durations of 1.4x to 2.7x compared to traditional systems. Moreover, we propose a framework for the automatic generation of Parsers and Accessors on FPGAs to ease their application in NDP.
Thirdly, we investigate the interplay of NDP and modern workload characteristics like HTAP. Therefore, we present different offloading models and focus on an intervention-free execution. By propagating the Shared State with the latest modifications of the database to the computational storage device, it is able to process data with transactional guarantees. Thus, we achieve to extend the design space of HTAP with NDP by providing a solution that optimizes for performance isolation, data freshness, and the reduction of data transfers. In contrast to traditional systems, we experience no significant drop in performance when an OLAP query is invoked but a steady and 30% faster throughput.
Lastly, in-situ result-set management and consumption as well as NDP pipelines are proposed to achieve flexibility in processing data on heterogeneous hardware. As those produce final and intermediary results, we continue investigating their management and identified that an on-device materialization comes at a low cost but enables novel consumption modes and reuse semantics. Thereby, we achieve significant performance improvements of up to 400x by reusing once materialized results multiple times.
Job advertisements are important means of communicating role expectations for management accountants to the labor market. They provide information about which roles of management accountants are sought by companies or which roles are expected. However, which roles are communicated in job advertisements is unknown so far. Using a large sample of 889 job ads and a text-mining approach, we show an apparent mix of different role types with a strong focus on a rather classic role: the watchdog role. However, individuals with business partner characteristics are more often sought for leadership positions or in family businesses and small and medium-sized enterprises (SMEs). The results challenge the current role discussion for management accountants as business partners in practice and some academic fields.
Context: Nowadays the market environment is characterized by high uncertainties due to high market dynamics, confronting companies with new challenges in creating and updating product roadmaps. Most companies are still using traditional approaches which typically fail in such environments. Therefore, companies are seeking opportunities for new product roadmapping approaches.
Objective: This paper presents good practices to support companies better understand what factors are required to conduct a successful product roadmapping in a dynamic and uncertain market environment.
Method: Based on a grey literature review, essential aspects for conducting product roadmapping in a dynamic and uncertain market environment were identified. Expert workshops were then held with two researchers and three practitioners to develop best practices and the proposed approach for an outcome-driven roadmap. These results were then given to another set of practitioners and their perceptions were gathered through interviews.
Results: The study results in the development of 9 good practices that provide practitioners with insights into what aspects are crucial for product roadmapping in a dynamic and uncertain market environment. Moreover, we propose an approach to product roadmapping that includes providing a flexible structure and focusing on delivering value to the customer and the business. To ensure the latter, this approach consists of the main items outcome hypothesis, validated outcomes, and discovered outputs.
Providing a digital infrastructure, platform technologies foster interfirm collaboration between loosely coupled companies, enabling the formation of ecosystems and building the organizational structure for value co-creation. Despite the known potential, the development of platform ecosystems creates new sources of complexity and uncertainty due to the involvement of various independent actors. For a platform ecosystem to succeed, it is essential that the platform ecosystem participants are aligned, coordinated, and given a common direction. Traditionally, product roadmaps have served these purposes during product development. A systematic mapping study was conducted to better understand how product roadmapping could be used in the dynamic environment of platform ecosystems. One result of the study is that there are hardly any concrete approaches for product roadmapping in platform ecosystems so far. However, many challenges on the topic are described in the literature from different perspectives. Based on the results of the systematic mapping study, a research agenda for product roadmapping in platform ecosystems is derived and presented.
Cell migration plays an essential role in wound healing and inflammatory processes inside the human body. Peripheral blood neutrophils, a type of polymorphonuclear leukocyte (PMN), are the first cells to be activated during inflammation and subsequently migrate toward an injured tissue or infection site. This response is dependent on both biochemical signaling and the extracellular environment, one aspect of which includes increased temperature in the tissues surrounding the inflammation site. In our study, we analyzed temperature-dependent neutrophil migration using differentiated HL-60 cells. The migration speed of differentiated HL-60 cells was found to correlate positively with temperature from 30 to 42 °C, with higher temperatures inducing a concomitant increase in cell detachment. The migration persistence time of differentiated HL-60 cells was higher at lower temperatures (30–33 °C), while the migration persistence length stayed constant throughout the temperature range. Coupled with the increased speed observed at high temperatures, this suggests that neutrophils are primed to migrate more effectively at the elevated temperatures characteristic of inflammation. Temperature gradients exist on both cell and tissue scales. Taking this into consideration, we also investigated the ability of differentiated HL-60 cells to sense and react to the presence of temperature gradients, a process known as thermotaxis. Using a two-dimensional temperature gradient chamber with a range of 27–43 °C, we observed a migration bias parallel to the gradient, resulting in both positive and negative thermotaxis. To better mimic the extracellular matrix (ECM) environment in vivo, a three-dimensional collagen temperature gradient chamber was constructed, allowing observation of biased neutrophil-like differentiated HL-60 migration toward the heat source.
Purpose
Artificial intelligence (AI), in particular deep learning (DL), has achieved remarkable results for medical image analysis in several applications. Yet the lack of human-like explanations of such systems is considered the principal restriction before utilizing these methods in clinical practice (Yang, Ye, & Xia, 2022).
Methods
Explainable Artificial Intelligence (XAI) provides a human-explainable and interpretable description of the “black-box” nature of DL (Gulum, Trombley, & Kantardzic, 2021). An effective XAI diagnosis generator, namely NeuroXAI (refer to Fig. 1), has been developed to extract 3D explanations from convolutional neural networks (CNN) models of brain gliomas (Zeineldin et al., 2022). By providing visual justification maps, NeuroXAI can help make DL models transparent and thus increase the trust of medical experts.
Results
NeuroXAI has been applied to two applications of the most widely investigated problems in brain imaging analysis, i.e. image classification and segmentation using magnetic resonance imaging (MRI). Visual attention maps of multiple XAI methods have been generated and compared for both applications, which could help to provide transparency about the performance of DL systems.
Conclusion
NeuroXAI helps to understand the prediction process of 3D CNN networks for brain glioma using human-understandable explanations. Results revealed that the investigated DL models behave in a logical human-like manner and can improve the analytical process of the MRI images systematically. Due to its open architecture, ease of implementation, and scalability to new XAI methods, NeuroXAI could be utilized to assist medical professionals in the detection and diagnosis of brain tumors. NeuroXAI code is publicly accessible at https://github.com/razeineldin/NeuroXAI
Gender pay gaps are commonly studied in populations with already completed educational careers. We focus on an earlier stage by investigating the gender pay gap among university students working alongside their studies. With data from five cohorts of a large-scale student survey from Germany, we use regression and wage decomposition techniques to describe gender pay gaps and potential explanations. We find that female students earn about 6% less on average than male students, which reduces to 4.1% when accounting for a rich set of explanatory variables. The largest explanatory factor is the type of jobs male and female students pursue.
Im Kampf gegen die Ausbreitung des Corona-Virus waren flächendeckende Schulschließungen seit Ausbruch der Pandemie eine zentrale politische Maßnahme. Infolgedessen kam es zu erheblichen Lernzeiteinbußen unter allen Schüler*innen, worunter insbesondere Kinder und Jugendliche aus benachteiligten Verhältnissen immer noch leiden. Über die Auswirkungen der Corona-Pandemie auf das deutsche Bildungssystem wird diskutiert und Maßnahmen zu deren Eindämmung aufgesetzt.
Early exposure makes the entrepreneur: how economics education in school influences entrepreneurship
(2022)
Many countries that seek to boost their economy share the goal of promoting entrepreneurship. Whereas there is ample research on the predictors of entrepreneurship during adulthood, we know little about how pre-adulthood experience influences entrepreneurship later in life. Using a natural experiment, this paper examines whether introducing economics classes in school enhances entrepreneurial behavior in adulthood. Our difference-in-differences approach exploits curricula reforms across German states that introduced compulsory economics education classes in secondary schools. Using information on school and labor market careers for more than 10,000 individuals from 1984 to 2019, we find that the reform increases students’ entrepreneurial activities by three percentage points. Examining gender differences, we find that economics classes equally benefit female and male students. Our results advance our understanding of how pre-adulthood experiences shape individuals’ entrepreneurial behavior.
Bioactive cations, including calcium, copper and magnesium, have shown the potential to become the alternative to protein growth factor-based therapeutics for bone healing. Ion substitutions are less costly, more stable, and more effective at low concentrations. Although they have been shown to be effective in providing bone grafts with more biological functions, the precise control of ion release kinetics is still a challenge. Moreover, the synergistic effect of three or more metal ions on bone regeneration has rarely been studied. In this study, vaterite-calcite CaCO3 particles were loaded with copper (Cu2+) and magnesium (Mg2+). The polyelectrolyte multilayer (PEM) was deposited on CaCuMg-CO3 particles via layer-by-layer technique to further improve the stability and biocompatibility of the particles and to enable controlled release of multiple metal ions. The PEM coated microcapsules were successfully combined with collagen at the outmost layer, providing a further stimulating microenvironment for bone regeneration. The in vitro release studies showed remarkably stable release of Cu2+ in 2 months without initial burst release. Mg2+ was released in relatively low concentration in the first 7 days. Cell culture studies showed that CaCuMg-PEM-Col microcapsules stimulated cell proliferation, extracellular maturation and mineralization more effectively than blank control and other microcapsules without collagen adsorption (Ca-PEM, CaCu-PEM, CaMg-PEM, CaCuMg-PEM). In addition, the CaCuMg-PEM-Col microcapsules showed positive effects on osteogenesis and angiogenesis in gene expression studies. The results indicate that such a functional and controllable delivery system of multiple bioactive ions might be a safer, simpler and more efficient alternative of protein growth factor-based therapeutics for bone regeneration. It also provides an effective method for functionalizing bone grafts for bone tissue engineering.
User innovators follow multiple diffusion and adoption pathways for their self-developed innovations. Users may choose to commercialize their self-developed products on the marketplace by becoming entrepreneurs. Few studies exist that focus on understanding personal and interpersonal factors that affect some user innovators’ entrepreneurial decision-making. Hence, this paper focuses on how user innovators make key decisions relating to opportunity recognition and evaluation and when opportunity evaluation leads to subsequent entrepreneurial action in the entrepreneurial process. We conducted an exploratory study using a multi-grounded theory methodology as the user entrepreneurship phenomenon embodies complex social processes. We collected data through the netnography approach that targeted 18 entrepreneurs with potentially relevant differences through crowdfunding platforms. We integrated self-determination, human capital, and social capital theory to address the phenomena under study. This study’s significant findings posit that users’ motives are dissatisfaction with existing goods, interest in innovation, altruism, social recognition, desire for independence, and economic benefits. Besides, use-related experience, product-related knowledge, product diffusion, and iterative feedback positively impact innovative users’ entrepreneurial decision-making.