Open Access

Weltweit und in Deutschland erreicht das Thema Inflation neue Höchststände in der Aufmerksamkeit (Google-Trends 2022). Nach einer vielbeachteten und millionenfach angesehenen Online-Weihnachtsvorlesung aus dem Jahre 2020 hat der Ökonomieprofessor Hans-Werner Sinn das Buch mit gleichnamigem Titel „Die wundersame Geldvermehrung“ veröffentlicht. Abermals könnte es dem Autor gelingen die politische Öffentlichkeit damit aufzurütteln.

The aim of this paper is to show to what extent Artificial Intelligence can be used to optimize forecasting capability in procurement as well as to compare AI with traditional statistic methods. At the same time this article presents the status quo of the research project ANIMATE. The project applies Artificial Intelligence to forecast customer orders in medium-sized companies. Precise forecasts are essential for companies. For planning, decision making and controlling. Forecasts are applied, e.g. in the areas of supply chain, production or purchasing. Medium-sized companies have major challenges in using suitable methods to improve their forecasting ability. Companies often use proven methods such as classical statistics as the ARIMA algorithm. However, simple statistics often fail while applied for complex non-linear predictions. Initial results show that even a simple MLP ANN produces better results than traditional statistic methods. Furthermore, a baseline (Implicit Sales Expectation) of the company was used to compare the performance. This comparison also shows that the proposed AI method is superior. Until the developed method becomes part of corporate practice, it must be further optimized. The model has difficulties with strong declines, for example due to holidays. The authors are certain that the model can be further improved. For example, through more advanced methods, such as a FilterNet, but also through more data, such as external data on holiday periods.

Intracranial brain tumors are one of the ten most common malignant cancers and account for substantial morbidity and mortality. The largest histological category of primary brain tumors is the gliomas which occur with an ultimate heterogeneous appearance and can be challenging to discern radiologically from other brain lesions. Neurosurgery is mostly the standard of care for newly diagnosed glioma patients and may be followed by radiation therapy and adjuvant temozolomide chemotherapy. However, brain tumor surgery faces fundamental challenges in achieving maximal tumor removal while avoiding postoperative neurologic deficits. Two of these neurosurgical challenges are presented as follows. First, manual glioma delineation, including its sub-regions, is considered difficult due to its infiltrative nature and the presence of heterogeneous contrast enhancement. Second, the brain deforms its shape, called “brain shift,” in response to surgical manipulation, swelling due to osmotic drugs, and anesthesia, which limits the utility of pre-operative imaging data for guiding the surgery. Image-guided systems provide physicians with invaluable insight into anatomical or pathological targets based on modern imaging modalities such as magnetic resonance imaging (MRI) and Ultrasound (US). The image-guided toolkits are mainly computer-based systems, employing computer vision methods to facilitate the performance of peri-operative surgical procedures. However, surgeons still need to mentally fuse the surgical plan from pre-operative images with real-time information while manipulating the surgical instruments inside the body and monitoring target delivery. Hence, the need for image guidance during neurosurgical procedures has always been a significant concern for physicians. This research aims to develop a novel peri-operative image-guided neurosurgery (IGN) system, namely DeepIGN, that can achieve the expected outcomes of brain tumor surgery, thus maximizing the overall survival rate and minimizing post-operative neurologic morbidity. In the scope of this thesis, novel methods are first proposed for the core parts of the DeepIGN system of brain tumor segmentation in MRI and multimodal pre-operative MRI to the intra-operative US (iUS) image registration using the recent developments in deep learning. Then, the output prediction of the employed deep learning networks is further interpreted and examined by providing human-understandable explainable maps. Finally, open-source packages have been developed and integrated into widely endorsed software, which is responsible for integrating information from tracking systems, image visualization, image fusion, and displaying real-time updates of the instruments relative to the patient domain. The components of DeepIGN have been validated in the laboratory and evaluated in the simulated operating room. For the segmentation module, DeepSeg, a generic decoupled deep learning framework for automatic glioma delineation in brain MRI, achieved an accuracy of 0.84 in terms of the dice coefficient for the gross tumor volume. Performance improvements were observed when employing advancements in deep learning approaches such as 3D convolutions over all slices, region-based training, on-the-fly data augmentation techniques, and ensemble methods. To compensate for brain shift, an automated, fast, and accurate deformable approach, iRegNet, is proposed for registering pre-operative MRI to iUS volumes as part of the multimodal registration module. Extensive experiments have been conducted on two multi-location databases: the BITE and the RESECT. Two expert neurosurgeons conducted additional qualitative validation of this study through overlaying MRI-iUS pairs before and after the deformable registration. Experimental findings show that the proposed iRegNet is fast and achieves state-of-the-art accuracies. Furthermore, the proposed iRegNet can deliver competitive results, even in the case of non-trained images, as proof of its generality and can therefore be valuable in intra-operative neurosurgical guidance. For the explainability module, the NeuroXAI framework is proposed to increase the trust of medical experts in applying AI techniques and deep neural networks. The NeuroXAI includes seven explanation methods providing visualization maps to help make deep learning models transparent. Experimental findings showed that the proposed XAI framework achieves good performance in extracting both local and global contexts in addition to generating explainable saliency maps to help understand the prediction of the deep network. Further, visualization maps are obtained to realize the flow of information in the internal layers of the encoder-decoder network and understand the contribution of MRI modalities in the final prediction. The explainability process could provide medical professionals with additional information about tumor segmentation results and therefore aid in understanding how the deep learning model is capable of processing MRI data successfully. Furthermore, an interactive neurosurgical display has been developed for interventional guidance, which supports the available commercial hardware such as iUS navigation devices and instrument tracking systems. The clinical environment and technical requirements of the integrated multi-modality DeepIGN system were established with the ability to incorporate: (1) pre-operative MRI data and associated 3D volume reconstructions, (2) real-time iUS data, and (3) positional instrument tracking. This system's accuracy was tested using a custom agar phantom model, and its use in a pre-clinical operating room is simulated. The results of the clinical simulation confirmed that system assembly was straightforward, achievable in a clinically acceptable time of 15 min, and performed with a clinically acceptable level of accuracy. In this thesis, a multimodality IGN system has been developed using the recent advances in deep learning to accurately guide neurosurgeons, incorporating pre- and intra-operative patient image data and interventional devices into the surgical procedure. DeepIGN is developed as open-source research software to accelerate research in the field, enable ease of sharing between multiple research groups, and continuous developments by the community. The experimental results hold great promise for applying deep learning models to assist interventional procedures - a crucial step towards improving the surgical treatment of brain tumors and the corresponding long-term post-operative outcomes.

This paper reviews suggestions for changes to database technology coming from the work of many researchers, particularly those working with evolving big data. We discuss new approaches to remote data access and standards that better provide for durability and auditability in settings including business and scientific computing. We propose ways in which the language standards could evolve, with proof-of-concept implementations on Github.

We study whether compulsory religious education in schools affects students' religiosity as adults. We exploit the staggered termination of compulsory religious education across German states in models with state and cohort fixed effects. Using three different datasets, we find that abolishing compulsory religious education significantly reduced religiosity of affected students in adulthood. It also reduced the religious actions of personal prayer, church-going, and church membership. Beyond religious attitudes, the reform led to more equalized gender roles, fewer marriages and children, and higher labor-market participation and earnings. The reform did not affect ethical and political values or non-religious school outcomes.

Die Lohnlücke zwischen Frauen und Männern (der sogenannte Gender Pay Gap) wird üblicherweise in Bevölkerungsgruppen untersucht, die ihre Bildungslaufbahn bereits abgeschlossen haben. In diesem Beitrag betrachten wir eine frühere Phase der Berufstätigkeit, indem wir den Gender Pay Gap unter Studierenden, die neben ihrem Studium arbeiten, analysieren. Anhand von Daten aus fünf Kohorten einer Studierendenbefragung in Deutschland beschreiben wir den Gender Pay Gap und diskutieren mögliche Erklärungen. Die Ergebnisse zeigen, dass Studentinnen im Durchschnitt etwa 6% weniger verdienen als Studenten. Nach Berücksichtigung verschiedener entlohnungsrelevanter Faktoren verringert sich die Lücke auf 4,1%. Einer der Hauptgründe für die Differenz in der Entlohnung sind die unterschiedlichen Beschäftigungen, die männliche und weibliche Studierende ausüben.

Im Kampf gegen die Ausbreitung des Corona-Virus waren flächendeckende Schulschließungen seit Ausbruch der Pandemie eine zentrale politische Maßnahme. Infolgedessen kam es zu erheblichen Lernzeiteinbußen unter allen Schüler*innen, worunter insbesondere Kinder und Jugendliche aus benachteiligten Verhältnissen immer noch leiden. Über die Auswirkungen der Corona-Pandemie auf das deutsche Bildungssystem wird diskutiert und Maßnahmen zu deren Eindämmung aufgesetzt.

Gender pay gaps are commonly studied in populations with already completed educational careers. We focus on an earlier stage by investigating the gender pay gap among university students working alongside their studies. With data from five cohorts of a large-scale student survey from Germany, we use regression and wage decomposition techniques to describe gender pay gaps and potential explanations. We find that female students earn about 6% less on average than male students, which reduces to 4.1% when accounting for a rich set of explanatory variables. The largest explanatory factor is the type of jobs male and female students pursue.

Uncontrolled movement of instruments in laparoscopic surgery can lead to inadvertent tissue damage, particularly when the dissecting or electrosurgical instrument is located outside the field of view of the laparoscopic camera. The incidence and relevance of such events are currently unknown. The present work aims to identify and quantify potentially dangerous situations using the example of laparoscopic cholecystectomy (LC). Twenty-four final year medical students were prompted to each perform four consecutive LC attempts on a well-established box trainer in a surgical training environment following a standardized protocol in a porcine model. The following situation was defined as a critical event (CE): the dissecting instrument was inadvertently located outside the laparoscopic camera’s field of view. Simultaneous activation of the electrosurgical unit was defined as a highly critical event (hCE). Primary endpoint was the incidence of CEs. While performing 96 LCs, 2895 CEs were observed. Of these, 1059 (36.6%) were hCEs. The median number of CEs per LC was 20.5 (range: 1–125; IQR: 33) and the median number of hCEs per LC was 8.0 (range: 0–54, IQR: 10). Mean total operation time was 34.7 min (range: 15.6–62.5 min, IQR: 14.3 min). Our study demonstrates the significance of CEs as a potential risk factor for collateral damage during LC. Further studies are needed to investigate the occurrence of CE in clinical practice, not just for laparoscopic cholecystectomy but also for other procedures. Systematic training of future surgeons as well as technical solutions address this safety issue.

Industrial practice is characterized by random events, also referred to as internal and external turbulences, which disturb the target-oriented planning and execution of production and logistics processes. Methods of probabilistic forecasting, in contrast to single value predictions, allow an estimation of the probability of various future outcomes of a random variable in the form of a probability density function instead of predicting the probability of a specific single outcome. Probabilistic forecasting methods, which are embedded into the analytics process to gain insights for the future based on historical data, therefore offer great potential for incorporating uncertainty into planning and control in industrial environments. In order to familiarize students with these potentials, a training module on the application of probabilistic forecasting methods in production and intralogistics was developed in the learning factory 'Werk150' of the ESB Business School (Reutlingen University). The theoretical introduction to the topic of analytics, probabilistic forecasting methods and the transition to the application domain of intralogistics is done based on examples from other disciplines such as weather forecasting and energy consumption forecasting. In addition, data sets of the learning factory are used to familiarize the students with the steps of the analytics process in a practice-oriented manner. After this, the students are given the task of identifying the influencing factors and required information to capture intralogistics turbulences based on defined turbulence scenarios (e.g. failure of a logistical resource) in the learning factory. Within practical production scenario runs, the students apply probabilistic forecasting using and comparing different probabilistic forecasting methods. The graduate training module allows the students to experience the potentials of using probabilistic forecasting methods to improve production and intralogistics processes in context with turbulences and to build up corresponding professional and methodological competencies.

Context: Companies that operate in the software-intensive business are confronted with high market dynamics, rapidly evolving technologies as well as fast-changing customer behavior. Traditional product roadmapping practices, such as fixed-time-based charts including detailed planned features, products, or services typically fail in such environments. Until now, the underlying reasons for the failure of product roadmaps in a dynamic and uncertain market environment are not widely analyzed and understood. Objective: This paper aims to identify current challenges and pitfalls practitioners face when developing and handling product roadmaps in a dynamic and uncertain market environment. Method: To reach our objective we conducted a grey literature review (GLR). Results: Overall, we identified 40 relevant papers, from which we could extract 11 challenges of the application of product roadmapping in a dynamic and uncertain market environment. The analysis of the articles showed that the major challenges for practitioners originate from overcoming a feature-driven mindset, not including a lot of details in the product roadmap, and ensuring that the content of the roadmap is not driven by management or expert opinion.

Eine zukunftsfähige Ausrichtung der betrieblichen Abläufe nach den Prinzipien des nachhaltigen Wirtschaftens erhöht die Wettbewerbsfähigkeit, die Innovationskraft und die Glaubwürdigkeit des Unternehmens bei allen Interessengruppen. Zudem zeigt die Praxis, dass Unternehmen damit nicht nur ökologische und soziale Aspekte angehen können, sondern auch ökonomisch besser aufgestellt sind, zum Beispiel durch Einsparungen an Ressourcen, einer höheren Akzeptanz im Markt und in der Gesellschaft oder einer besseren Mitarbeitermotivation. In der VDI 4070 Blatt 1 wurde eine Handlungsanleitung gegeben und eine strukturierte Vorgehensweise beschrieben, um Betriebe systematisch an ein nachhaltiges Wirtschaften heranzuführen. In Ergänzung dazu werden in Blatt 2 beispielhafte Methoden sowie bewährte und innovative Instrumente vorgestellt und praktische Anwendungshilfen und Beispiele aufgezeigt. Die Richtlinie richtet sich an Behörden, Beratungsunternehmen, kleine und mittelständische Unternehmen.

Context: Nowadays the market environment is characterized by high uncertainties due to high market dynamics, confronting companies with new challenges in creating and updating product roadmaps. Most companies are still using traditional approaches which typically fail in such environments. Therefore, companies are seeking opportunities for new product roadmapping approaches. Objective: This paper presents good practices to support companies better understand what factors are required to conduct a successful product roadmapping in a dynamic and uncertain market environment. Method: Based on a grey literature review, essential aspects for conducting product roadmapping in a dynamic and uncertain market environment were identified. Expert workshops were then held with two researchers and three practitioners to develop best practices and the proposed approach for an outcome-driven roadmap. These results were then given to another set of practitioners and their perceptions were gathered through interviews. Results: The study results in the development of 9 good practices that provide practitioners with insights into what aspects are crucial for product roadmapping in a dynamic and uncertain market environment. Moreover, we propose an approach to product roadmapping that includes providing a flexible structure and focusing on delivering value to the customer and the business. To ensure the latter, this approach consists of the main items outcome hypothesis, validated outcomes, and discovered outputs.

Machine learning (ML) has played an important role in research in recent years. For companies that want to use ML, finding the algorithms and models that fit for their business is tedious. A review of the available literature on this problem indicates only a few research papers. Given this gap, the aim of this paper is to design an effective and easy-to-use ML service repository. The corresponding research is based on a multi-vocal literature analysis combined with design science research, addressing three research questions: (1) How is current white and gray literature on ML services structured with respect to repositories? (2) Which features are relevant for an effective ML service repository? (3) How is a prototype for an effective ML service repository conceptualized? Findings are relevant for the explanation of user acceptance of ML repositories. This is essential for corporate practice in order to create and use ML repositories effectively.

Today, companies face increasing market dynamics, rapidly evolving technologies, and rapid changes in customer behavior. Traditional approaches to product development typically fail in such environments and require companies to transform their often feature-driven mindset into a product-led mindset. A promising first step on the way to a product-led company is a better understanding of how product planning can be adapted to the requirements of an increasingly dynamic and uncertain market environment in the sense of product roadmapping. The authors developed the DEEP product roadmap assessment tool to help companies evaluate their current product roadmap practices and identify appropriate actions to transition to a more product-led company. Objective: The goal of this paper is to gain insight into the applicability and usefulness of version 1.1 of the DEEP model. In addition, the benefits, and implications of using the DEEP model in corporate contexts will be explored. Method: We conducted a multiple case study in which participants were observed using the DEEP model. We then interviewed each participant to understand their perceptions of the DEEP model. In addition, we conducted interviews with each company's product management department to learn how the application of the DEEP model influenced their attitudes toward product roadmapping. Results: The study showed that by applying the DEEP model, participants better understood which artifacts and methods were critical to product roadmapping success in a dynamic and uncertain market environment. In addition, the application of the DEEP model helped convince management and other stakeholders of the need to change current product roadmapping practices. The application also proved to be a suitable starting point for the transformation in the participating companies.

Startups in the field of Industry 4.0 could be a huge driver of innovation for many industry sectors such as manufacturing. However, there is a lack of education programs to ensure a sufficient number of well-trained founders and thus a supply of such startups. Therefore, this study presents the design, implementation, and evaluation of a university course tailored to the characteristics of Industry 4.0 entrepreneurship. Educational design-based research was applied with a focus on content and teaching concept. The study program was first implemented in 2021 at a German university of applied sciences with 25 students, of which 22 participated in the evaluation. The evaluation of the study program was conducted with a pretest–posttest-design targeting three areas: (1) knowledge about the application domain, (2) entrepreneurial intention and (3) psychological characteristics. The entrepreneurial intention was measured based on the theory of planned behavior. For measuring psychological characteristics, personality traits associated with entrepreneurship were used. Considering the study context and the limited external validity of the study, the following can be identified in particular: The results show that a university course can improve participants' knowledge of this particular area. In addition, perceived behavioral control of starting an Industry 4.0 startup was enhanced. However, the results showed no significant effects on psychological characteristics.

The rapid development and growth of knowledge has resulted in a rich stream of literature on various topics. Information systems (IS) research is becoming increasingly extensive, complex, and heterogeneous. Therefore, a proper understanding and timely analysis of the existing body of knowledge are important to identify emerging topics and research gaps. Despite the advances of information technology in the context of big data, machine learning, and text mining, the implementation of systematic literature reviews (SLRs) is in most cases still a purely manual task. This might lead to serious shortcomings of SLRs in terms of quality and time. The outlined approach in this paper supports the process of SLRs with machine learning techniques. For this purpose, we develop a framework with embedded steps of text mining, cluster analysis, and network analysis to analyze and structure a large amount of research literature. Although the framework is presented using IS research as an example, it is not limited to the IS field but can also be applied to other research areas.

Data governance have been relevant for companies for a long time. Yet, in the broad discussion on smart cities, research on data governance in particular is scant, even though data governance plays an essential role in an environment with multiple stakeholders, complex IT structures and heterogeneous processes. Indeed, not only can a city benefit from the existing body of knowledge on data governance, but it can also make the appropriate adjustments for its digital transformation. Therefore, this literature review aims to spark research on urban data governance by providing an initial perspective for future studies. It provides a comprehensive overview of data governance and the relevant facets embedded in this strand of research. Furthermore, it provides a fundamental basis for future research on the development of an urban data governance framework.

Startups play a key role in software-based innovation. They make an important contribution to an economy’s ability to compete and innovate, and their importance will continue to grow due to increasing digitalization. However, the success of a startup depends primarily on market needs and the ability to develop a solution that is attractive enough for customers to choose. A sophisticated technical solution is usually not critical, especially in the early stages of a startup. It is not necessary to be an experienced software engineer to start a software startup. However, this can become problematic as the solution matures and software complexity increases. Based on a proposed solution for systematic software development for early-stage startups, in this paper, we present the key findings of a survey study to identify the methodological and technical priorities of software startups. Among other things, we found that requirements engineering and architecture pose challenges for startups. In addition, we found evidence that startups’ software development approaches do not tend to change over time. An early investment in a more scalable development approach could help avoid long-term software problems. To support such an investment, we propose an extended model for Entrepreneurial Software Engineering that provides a foundation for future research.

The concept of digital twins (DTs) is receiving increasing attention in research and management practice. However, various facets around the concept are blurry, including conceptualization, application areas, and reference architectures for DTs. A review of preliminary results regarding the emerging research output on DTs is required to promote further research and implementation in organizations. To do so, this paper asks four research questions: (1) How is the concept of DTs defined? (2) Which application areas are relevant for the implementation of DTs? (3) How is a reference architecture for DTs conceptualized? and (4) Which directions are relevant for further research on DTs? With regard to research methods, we conduct a meta-review of 14 systematic literature reviews on DTs. The results yield important insights for the current state of conceptualization, application areas, reference architecture, and future research directions on DTs.

This research briefing describes the organizational capability of scaling at scale, which we define as enabling multiple digital innovation initiatives to realize bottom-line value from their innovation by leveraging shared resources. We illustrate this concept with a case study from global multi-energy company Repsol, which implemented scaling at scale to cultivate a portfolio of more than 450 initiatives and helped over seventy percent of initiatives to reach the scale-up stage. As a result, over five years Repsol realized €800 million of bottom-line value from digital innovations.

Artificial intelligence is considered to be a significant technology for driving the future evolution of smart manufacturing environments. At the same time, automated guided vehicles (AGVs) play an essential role in manufacturing systems due to their potential to improve internal logistics by increasing production flexibility. Thereby, the productivity of the entire system relies on the quality of the schedule, which can achieve production cost savings by minimizing delays and the total makespan. However, traditional scheduling algorithms often have difficulties in adapting to changing environment conditions, and the performance of a selected algorithm depends on the individual scheduling problem. Therefore, this paper aimed to analyze the scheduling problem classes of AGVs by applying design science research to develop an algorithm selection approach. The designed artifact addressed a catalogue of characteristics that used several machine learning algorithms to find the optimal solution strategy for the intended scheduling problem. The contribution of this paper is the creation of an algorithm selection method that automatically selects a scheduling algorithm, depending on the problem class and the algorithm space. In this way, production efficiency can be increased by dynamically adapting the AGV schedules. A computational study with benchmark literature instances unveiled the successful implementation of constraint programming solvers for solving JSSP and FJSSP scheduling problems and machine learning algorithms for predicting the most promising solver. The performance of the solvers strongly depended on the given problem class and the problem instance. Consequently, the overall production performance increased by selecting the algorithms per instance. A field experiment in the learning factory at Reutlingen University enabled the validation of the approach within a running production scenario.

Especially, if the potential of technical and organizational measures for ergonomic workplace design is limited, exoskeletons can be considered as innovative ergonomic aids to reduce the physical workload of workers. Recent scientific findings from ergonomic analyses with and without exoskeletons are indicating that strain reduction can be achieved, particularly at workplaces with lifting, holding, and carrying processes. Currently, a work system design method is under development incorporating criteria and characteristics for the design of work systems in which a human worker is supported by an exoskeleton. Based on the properties of common passive and active exoskeletons, factors influencing the human on which an exoskeleton can have a positive or negative effect (e.g. additional weight) were derived. The method will be validated by the conceptualization and setup of several work system demonstrators at Werk150, the factory of ESB Business School on campus of Reutlingen University, to prove the positive ergonomic effect on humans and the supporting process to choose the suitable exoskeleton. The developed method and demonstrators enable the user to experience the positive ergonomic effects of exoskeletal support in lifting, holding and carrying processes in logistics and production. The new work system design method will contribute to the fact that employees can pursue their professional activity longer without substantial injuries or can be used more flexibly at different work stations. Also new work concepts, strategies and scenarios are opened up to reduce the risk of occupational accidents and to promote the compatibility of work for employees. A training module is being developed and evaluated with participants from industry and master students to build up competence.

Over the last decades, a tremendous change toward using information technology in almost every daily routine of our lives can be perceived in our society, entailing an incredible growth of data collected day-by-day on Web, IoT, and AI applications. At the same time, magneto-mechanical HDDs are being replaced by semiconductor storage such as SSDs, equipped with modern Non-Volatile Memories, like Flash, which yield significantly faster access latencies and higher levels of parallelism. Likewise, the execution speed of processing units increased considerably as nowadays server architectures comprise up to multiple hundreds of independently working CPU cores along with a variety of specialized computing co-processors such as GPUs or FPGAs. However, the burden of moving the continuously growing data to the best fitting processing unit is inherently linked to today’s computer architecture that is based on the data-to-code paradigm. In the light of Amdahl's Law, this leads to the conclusion that even with today's powerful processing units, the speedup of systems is limited since the fraction of parallel work is largely I/O-bound. Therefore, throughout this cumulative dissertation, we investigate the paradigm shift toward code-to-data, formally known as Near-Data Processing (NDP), which relieves the contention on the I/O bus by offloading processing to intelligent computational storage devices, where the data is originally located. Firstly, we identified Native Storage Management as the essential foundation for NDP due to its direct control of physical storage management within the database. Upon this, the interface is extended to propagate address mapping information and to invoke NDP functionality on the storage device. As the former can become very large, we introduce Physical Page Pointers as one novel NDP abstraction for self-contained immutable database objects. Secondly, the on-device navigation and interpretation of data are elaborated. Therefore, we introduce cross-layer Parsers and Accessors as another NDP abstraction that can be executed on the heterogeneous processing capabilities of modern computational storage devices. Thereby, the compute placement and resource configuration per NDP request is identified as a major performance criteria. Our experimental evaluation shows an improvement in the execution durations of 1.4x to 2.7x compared to traditional systems. Moreover, we propose a framework for the automatic generation of Parsers and Accessors on FPGAs to ease their application in NDP. Thirdly, we investigate the interplay of NDP and modern workload characteristics like HTAP. Therefore, we present different offloading models and focus on an intervention-free execution. By propagating the Shared State with the latest modifications of the database to the computational storage device, it is able to process data with transactional guarantees. Thus, we achieve to extend the design space of HTAP with NDP by providing a solution that optimizes for performance isolation, data freshness, and the reduction of data transfers. In contrast to traditional systems, we experience no significant drop in performance when an OLAP query is invoked but a steady and 30% faster throughput. Lastly, in-situ result-set management and consumption as well as NDP pipelines are proposed to achieve flexibility in processing data on heterogeneous hardware. As those produce final and intermediary results, we continue investigating their management and identified that an on-device materialization comes at a low cost but enables novel consumption modes and reuse semantics. Thereby, we achieve significant performance improvements of up to 400x by reusing once materialized results multiple times.

Enterprises and societies currently face crucial challenges, while Society 5.0 can contribute to a supersmart society, especially for manufacturing and healthcare, and Industry 4.0 becomes important in the global manufacturing industry. Smart energy digital platforms are architected to manage energy supply efficiently. Furthermore, the above digital platforms are expected to collect various kinds of data and analyze Big Data for the trends in the sharing economy in ecosystems. The adaptive integrated digital architecture framework (AIDAF) for Design Thinking Approach with Risk Management is expected to make an alignment with digital IT strategy. In this paper, we propose that various energy management systems and related digital platforms are designed and implemented in an alignment to digital IT strategy for sharing economy toward Society 5.0, with the AIDAF framework for Design Thinking Approach with Risk Management. The vision of AIDAF applications to enable sharing economy and digital platforms is explained and extended in the context of Society 5.0. In addition, challenges and future activities for this area are discussed that cover the directions of smart energy for Society 5.0.

The volume includes papers presented at the International KES Conference on Human Centred Intelligent Systems 2022 (KES HCIS 2022), held in Rhodes, Greece on June 20–22, 2022. This book highlights new trends and challenges in intelligent systems, which play an important part in the digital transformation of many areas of science and practice. It includes papers offering a deeper understanding of the human-centred perspective on artificial intelligence, of intelligent value co-creation, ethics, value-oriented digital models, transparency, and intelligent digital architectures and engineering to support digital services and intelligent systems, the transformation of structures in digital businesses and intelligent systems based on human practices, as well as the study of interaction and the co-adaptation of humans and systems.

Digital assistants like Alexa, Google Assistant or Siri have seen a large adoption over the past years. Using artificial intelligence (AI) technologies, they provide a vocal interface to physical devices as well as to digital services and have spurred an entire new ecosystem. This comprises the big tech companies themselves, but also a strongly growing community of developers that make these functionalities available via digital platforms. At present, only few research is available to understand the structure and the value creation logic of these AI-based assistant platforms and their ecosystem. This research adopts ecosystem intelligence to shed light on their structure and dynamics. It combines existing data collection methods with an automated approach that proves useful in deriving a network-based conceptual model of Amazon’s Alexa assistant platform and ecosystem. It shows that skills are a key unit of modularity in this ecosystem, which is linked to other elements such as service, data, and money flows. It also suggests that the topology of the Alexa ecosystem may be described using the criteria reflexivity, symmetry, variance, strength, and centrality of the skill coactivations. Finally, it identifies three ways to create and capture value on AI-based assistant platforms. Surprisingly only a few skills use a transactional business model by selling services and goods but many skills are complementary and provide information, configuration, and control services for other skill provider products and services. These findings provide new insights into the highly relevant ecosystems of AI-based assistant platforms, which might serve enterprises in developing their strategies in these ecosystems. They might also pave the way to a faster, data-driven approach for ecosystem intelligence.

Glioblastoma WHO IV belongs to a group of brain tumors that are still incurable. A promising treatment approach applies photodynamic therapy (PDT) with hypericin as a photosensitizer. To generate a comprehensive understanding of the photosensitizer-tumor interactions, the first part of our study is focused on investigating the distribution and penetration behavior of hypericin in glioma cell spheroids by fluorescence microscopy. In the second part, fluorescence lifetime imaging microscopy (FLIM) was used to correlate fluorescence lifetime (FLT) changes of hypericin to environmental effects inside the spheroids. In this context, 3D tumor spheroids are an excellent model system since they consider 3D cell–cell interactions and the extracellular matrix is similar to tumors in vivo. Our analytical approach considers hypericin as probe molecule for FLIM and as photosensitizer for PDT at the same time, making it possible to directly draw conclusions of the state and location of the drug in a biological system. The knowledge of both state and location of hypericin makes a fundamental understanding of the impact of hypericin PDT in brain tumors possible. Following different incubation conditions, the hypericin distribution in peripheral and central cryosections of the spheroids were analyzed. Both fluorescence microscopy and FLIM revealed a hypericin gradient towards the spheroid core for short incubation periods or small concentrations. On the other hand, a homogeneous hypericin distribution is observed for long incubation times and high concentrations. Especially, the observed FLT change is crucial for the PDT efficiency, since the triplet yield, and hence the O2 activation, is directly proportional to the FLT. Based on the FLT increase inside spheroids, an incubation time  30 min is required to achieve most suitable conditions for an effective PDT.

Ein Design Thinking-Projekt mit 17 20–50-jährigen kirchenfernen Proband*innen untersuchte die Fragestellung aus einer klaren Bedürfnisorientierung dieser für die Zukunft der Kirche wichtigen Altersgruppe. Mit ihnen wurden konkrete Lösungsvorschläge erarbeitet. Konsens der Proband*innen war, dass Kirche viel Potential hat, das sie aktuell nicht ausschöpft. Um die Kirchenbindung zu stabilisieren bzw. perspektivisch zu erhöhen, müsste Kirche im Lebensraum ihrer Mitglieder sichtbarer werden, und das vor allem digital. Zudem müsste sie ihre Angebote für das Leben der Mitglieder als relevant darstellen und aktiv mit einem offenen Ohr auf die Gemeindeglieder zugehen, statt auf ihr Kommen zu warten

A single-phase fixed-frequency operated power factor correction circuit with reduced switching losses is proposed. The circuit uses the combination of a boost converter with an added clamp-switch, a pulse wave shaping circuit, and a standard control IC to discharge the transistor's output capacitance prior to its turn-on. In this way, a very low-complexity control circuit implementation to reduce switching losses or even achieve complete zero-voltage switching without additional sensors is possible. Moreover, this operation method is achieved at a constant switching frequency, possibly simplifying the design of the EMI filter and the converter's inductor. Experimental test results for a 100 W prototype converter are presented to validate the feasibility of the proposed operating method and corresponding circuit structure.

Since half a decade, there has been an increasing interest in Robotic Process Automation (RPA) by business firms. However, academic literature has been lacking attention to RPA, before adopting the topic to a larger extent. The aim of this study is to review and structure the latest state of scholarly research on RPA. This chapter is based on a systematic literature review that is used as a basis to develop a conceptual framework to structure the field. Our study shows that some areas of RPA have been extensively examined by many authors, e.g. potential benefits of RPA. Other categories, such as empirical studies on adoption of RPA or organisational readiness models, have remained research gaps.

Eine wichtige Informationsgrundlage für strategische Entscheidungen im Sportmarketing bildet das Markenimage, da es die Perspektive der Anspruchsgruppen auf die Marke widerspiegelt. Die Analyse des Markenimages ist jedoch methodisch komplex, weshalb dafür der Einsatz Künstlicher Neuronaler Netze eingehender untersucht wird. Denn dieses Verfahren der Künstlichen Intelligenz ermöglicht die Modellierung vielschichtiger und nichtlinearer Wirkungsbeziehungen. Der konzeptionelle Ansatz wird am empirischen Praxisbeispiel des Sportartikelherstellers adidas veranschaulicht, indem ein mehrschichtiges Künstliches Neuronales Netz zwischen den Bewertungen spezifischer Markenattribute und der Gesamtmarke modelliert wird. Mithilfe einer Analyse der Verbindungsgewichte des Netzes wird der Variableneinfluss verschiedener Markenattribute gemessen, woraus sich konkrete Implikationen für die Sportmarketingpraxis ergeben.

Das regelmäßige Schmieren von Maschinen verhindert Schäden, reduziert Ausfallzeiten und vermeidet Reparaturkosten. Schmiervorgänge werden jedoch oft unzureichend dokumentiert. Für die Überwachung manueller Schmierprozesse an Maschinen wird daher eine Smart-Maintenance-Lösung aufgebaut. Zusätzlich wird eine intelligente Fettpresse als cyber-physisches System entwickelt. Dadurch lassen sich Schmiervorgänge transparent dokumentieren und Fehlschmierungen verhindern.

Die Liebherr Hydraulikbagger GmbH setzt sich aktiv mit der Implementierung von Risikomanagementsystemen auseinander und treibt so das risikoorientierte Prozessmanagement weiter voran. Dabei gilt es vor allem, Prozesse auf Risiko-Anfälligkeiten und ihre Relevanz für den Unternehmenserfolg zu analysieren.

Digitalization has gained a foothold in our everyday lives. However, it remains to be seen what digital tools B2B companies can benefit from. During the last few years, chatbots have been on the rise and have played a more significant role in B2B marketing. Thus, this research follows a literature review to examine the current state of B2B chatbots. With this, the study will discover the buyer’s preferences for chatbots compared to sales agents and the role of chatbots in different stages of the B2B sales funnel.

Durch die Entwicklungen der vergangenen Jahre hin zu technisch komplexeren Maschinen und Anlagen steigt die Bedeutung der Instandhaltung als wesentlichem Schlüssel zur Sicherung der Verfügbarkeit von Maschinen und Anlagen. Wesentliche Ansatzpunkte zur Verbesserung sind hier die Verfügbarkeit von Informationen, voraussagende Instandhaltungsstrategien und eine verbesserte Informationsbereitstellung. Diese können auf technischer Ebene durch spezialisierte Cyberphysische Systeme realisiert werden. In diesem Beitrag wird ein Überblick über die wesentlichen Bausteine, aus smarten Komponenten, smarten Planungssystemen und smarten Benutzerschnittstellen gegeben, die für eine erfolgreiche Umsetzung notwendig sind.

Wide bandgap semiconductors enable high switching frequencies and thus the integration of filters into the inverter. The current paper addresses the design problem for the filter components such that a given dV/dt at the inverter terminals is obtained.

Production systems are becoming increasingly complex, which means that the main task of industrial maintenance, ensuring the technical availability of a production system, is also becoming increasingly difficult. The previous focus of maintenance efforts on individual machines must give way to a holistic view encompassing the whole production system. Against this background, the technical availability of a production system must be redefined. The aim of this publication is to present different definition approaches of production systems’ availability and to demonstrate the effects of random machine failures on the key figures considering the complexity of the production system using a discrete event simulation.

Personality matters! So lässt sich die Forschung zu Persönlichkeit und Berufserfolg des letzten Jahrhunderts zusammenfassen. Beruflicher Erfolg hängt nicht nur von den kognitiven Fähigkeiten ab, wie beispielsweise der allgemeinen Intelligenz, sondern auch von der Persönlichkeit. Das werden Führungskräfte sicher bestätigen können. Was aber macht eine Persönlichkeit aus, die beruflich sehr leistungsfähig ist? Wie wirken sich verschiedene Persönlichkeitsmerkmale darauf aus, wie gut man mit beruflichen Anforderungen zurechtkommt? Und welche Persönlichkeitsprofile eignen sich für welche Tätigkeitsfelder? Mit diesen Fragen beschäftigt sich die Organisations- und Arbeitspsychologie seit vielen Jahren. Gewissenhaftigkeit (Conscientiousness) hat sie als einen besonders wichtigen Faktor für die berufliche Leistungsfähigkeit identifiziert. In einer Metastudie fassen Michael Wilmot und Deniz Ones die Erkenntnisse zur Gewissenhaftigkeit aus 100 Jahren Forschung zusammen – und erfassen dabei 2.500 primäre Studien mit über 1,1 Millionen befragten Personen.

Der vorliegende Beitrag schlägt auf Basis der Erfahrungen in der Augenheilkunde mit der SARS-CoV-2-Pandemie in den Jahren 2020 und 2021 einen Leitfaden für den Umgang mit (zukünftigen) Pandemien vor. Die Kernpunkte: • Das weltweite Epidemie-Geschehen sollte stets beobachtet werden. • Deutet sich eine Pandemie an, sollte im ersten Schritt ein Krisenstab eingerichtet werden, der die Pandemielage bewertet und Maßnahmen koordinieren kann. • Die zu ergreifenden Maßnahmen einer augenheilkundlichen Einrichtung betreffen vor allem die Sicherstellung der Versorgungssituation sowie organisatorische und wirtschaftliche Bereiche, um eine tragfähige Fortführung des Betriebs zu ermöglichen.

The aim of this work is to establish and generalize a relationship between fractional partial differential equations (fPDEs) and stochastic differential equations (SDEs) to a wider class of stochastic processes, including fractional Brownian motions and sub-fractional Brownian motions with Hurst parameter H ∈ (1/2,1). We start by establishing the connection between a fPDE and SDE via the Feynman-Kac Theorem, which provides a stochastic representation of a general Cauchy problem. In hindsight, we extend this connection by assuming SDEs with fractional and sub-fractional Brownian motions and prove the generalized Feynman-Kac formulas under a (sub-)fractional Brownian motion. An application of the theorem demonstrates, as a by-product, the solution of a fractional integral, which has relevance in probability theory.

Management und Führung sind Funktionen, die in Organisationen benötigt werden, um Aktivitäten und Prozesse zu koordinieren und um immer wieder Veränderungen umzusetzen. Der Beitrag stellt die Unterschiede zwischen Management und Führung dar und bettet diese in den Kontext aktueller Entwicklungen ein. Denn durch die Digitalisierung der Arbeitswelt, die Pandemie sowie die New Work-Bewegung verändert sich die Art und Weise, wie wir zusammenarbeiten. Entsprechend viel wird über Führung und Management diskutiert – auch in der Augenheilkunde. Ziel ist es, dass auf Basis der vorliegenden Überlegungen in den Einrichtungen der Augenheilkunde Management und Führung reflektiert und zielorientiert und zukunftsfähig gestaltet werden können.

Surface-enhanced Raman spectroscopy (SERS) provides a strong enhancement to an inherently weak Raman signal, which strongly depends on the material, design, and fabrication of the substrate. Here, we present a facile method of fabricating a non-uniform SERS substrate based on an annealed thin gold (Au) film that offers multiple resonances and gap sizes within the same sample. It is not only chemically stable, but also shows reproducible trends in terms of geometry and plasmonic response. Scanning electron microscopy (SEM) reveals particle-like and island-like morphology with different gap sizes at different lateral positions of the substrate. Extinction spectra show that the plasmonic resonance of the nanoparticles/metal islands can be continuously tuned across the substrate. We observed that for the analytes 1,2-bis(4-pyridyl) ethylene (BPE) and methylene blue (MB), the maximum SERS enhancement is achieved at different lateral positions, and the shape of the extinction spectra allows for the correlation of SERS enhancement with surface morphology. Such non-uniform SERS substrates with multiple nanoparticle sizes, shapes, and interparticle distances can be used for fast screening of analytes due to the lateral variation of the resonances within the same sample.

Perforations of the tympanic membrane (TM) can occur as a result of injury or inflammation of the middle ear. These perforations can lead to conductive hearing loss (HL), where in some cases the magnitude of HL exceeds that attributable to the observed TM perforation alone. We aim with this study to better understand the effects of location and size of TM perforations on the sound transmitting properties of the middle ear. The middle ear transfer function (METF) of six human temporal bones (TB; freshly frozen specimen of body donors) were compared before and after perforation of the TM at different locations (anterior or posterior lower quadrant) and of different sizes (1mm, ¼ of the TM, ½ of the TM, and full ablation). The METF were correlated with a Finite Element (FE) model of the middle ear, in which similar alterations were simulated. The measured and simulated FE model METFs exhibited frequency and perforation size dependent amplitude losses at all locations and severities. In direct comparison, posterior TM perforations affected the transmission properties to a larger degree than perforations of the anterior quadrant. This could possibly be caused by an asymmetry of the TM, where the malleus-incus complex rotates and results in larger deflections in the posterior TM half than in the anterior TM half. The FE model of the TM with a sealed cavity suggest that small perforations result in a decrease of TM rigidity and thus to an increase in oscillation amplitude of the TM, mostly above 1 kHz. The location and size of TM perforations influence the METF in a reproducible way. Correlating our data with the FE model could help to better understand the pathologic mechanisms of middle-ear diseases. If small TM perforations with uncharacteristically significant HL are observed in daily clinical practice, additional middle ear pathologies should be considered. Further investigations on the loss of TM pretension due to perforations may be informative.

Mit den Aufgaben und Fallstudien des Übungsbuchs lassen sich die zentralen Kapitel und Themen des Lehrbuchs gezielt wiederholen und vertiefen. Es bietet zu jedem Werkzeug Aufgaben und Fragestellungen aus der Praxis. Zusätzlich werden komplexe Anwendungsfälle namhafter deutscher und internationaler Unternehmen wie Ernst & Young, HUGO BOSS, Alfred Kärcher und Bayer angeboten.

For optimization of production processes and product quality, often knowledge of the factors influencing the process outcome is compulsory. Thus, process analytical technology (PAT) that allows deeper insight into the process and results in a mathematical description of the process behavior as a simple function based on the most important process factors can help to achieve higher production efficiency and quality. The present study aims at characterizing a well-known industrial process, the transesterification reaction of rapeseed oil with methanol to produce fatty acid methyl esters (FAME) for usage as biodiesel in a continuous micro reactor set-up. To this end, a design of experiment approach is applied, where the effects of two process factors, the molar ratio and the total flow rate of the reactants, are investigated. The optimized process target response is the FAME mass fraction in the purified nonpolar phase of the product as a measure of reaction yield. The quantification is performed using attenuated total reflection infrared spectroscopy in combination with partial least squares regression. The data retrieved during the conduction of the DoE experimental plan were used for statistical analysis. A non-linear model indicating a synergistic interaction between the studied factors describes the reactor behavior with a high coefficient of determination (R²) of 0.9608. Thus, we applied a PAT approach to generate further insight into this established industrial process.

Artificial intelligence (AI) is not yet widely used in small- and medium-sized industrial enterprises (SME). The reasons for this are manifold and range from not understanding use cases, not enough trained employees, to too little data. This article presents a successful design-oriented case study at a medium-sized company, where the described reasons are present. In this study, future demand forecasts are generated based on historical demand data for products at a material number level using a gradient boosting machine (GBM). An improvement of 15% on the status quo (i.e. based on the root mean squared error) could be achieved with rather simple techniques. Hence, the motivation, the method, and the first results are presented. Concluding challenges, from which practical users should derive learning experiences and impulses for their own projects, are addressed.

Public transport causes in rural areas high costs per passenger and kilometer as the frequency of scheduled busses is low and therefore, many people avoid using public transport. With the trend of moving from urban regions to countryside individual traffic will further increase. To tackle issues of emissions, mobility for young and elderly people and provide economically meaningful public transport a new concept was elaborated in Germany. This consists of (partly) autonomous shuttle busses which are remote controlled. For implementation rural districts of Germany have worked together and set up a three-phase plan consisting of a project with public funding, a highly frequent used pilot region and industrial partners with the commitment and possibilities for necessary investments. The concept promises economical value with respect to installation, service and maintaining costs, it leads to lower barriers for public transport of young and elderly people and ultimately reduces emissions and congestions.