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Artificial intelligence (AI) technologies, such as machine learning or deep learning, have been predicted to highly impact future organizations and radically change the way how projects are managed. The Project Management Institute (PMI), the network of around 1.1 million certified project managers, ranked AI as one of the top three disruptors of their profession. In an own study on the effect of AI, 37% of the project management processes can be executed by machine learning and other AI technologies. In addition, Gartner recently postulated that 80% of the work of today's project managers may be eliminated by AI in 2030.
This editorial aims to outline today's project and portfolio management in context of pharmaceutical research and development (R&D), followed by an AI-vision and a more tangible mission, and illustrate what the consequences of an AI-enabled project and portfolio management could be for pharmaceutical R&D.
The digital transformation is today’s dominant business transformation having a strong influence on how digital services and products are designed in a service-dominant way. A popular underlying theory of value creation and economic exchange that is known as the service-dominant (S-D) logic can be connected to many successful digital business models. However, S-D logic by itself is abstract. Companies cannot directly use it as an instrument for business model innovation and design in an easy way. To address this a comprehensive ideation method based on S-D logic is proposed, called service-dominant design (SDD). SDD is aimed at supporting firms in the transition to a service- and value-oriented perspective. The method provides a simplified way to structure the ideation process based on four model components. Each component consists of practical implications, auxiliary questions and visualization techniques that were derived from a literature review, a use case evaluation of digital mobility and a focus group discussion. SDD represents a first step of having a toolset that can support established companies in the process of service- and value-orientation as part of their digital transformation efforts.
Enterprises are currently transforming their strategy, processes, and their information systems to extend their degree of digitalization. The potential of the Internet and related digital technologies, like Internet of Things, services computing, cloud computing, artificial intelligence, big data with analytics, mobile systems, collaboration networks, and cyber physical systems both drives and enables new business designs. Digitalization deeply disrupts existing businesses, technologies and economies and fosters the architecture of digital environments with many rather small and distributed structures. This has a strong impact for new value producing opportunities and architecting digital services and products guiding their design through exploiting a Service-Dominant Logic. The main result of the book chapter extends methods for integral digital strategies with value-oriented models for digital products and services which are defined in the framework of a multi-perspective digital enterprise architecture reference model.
Due to digitalization, constant technological progress and ever shorter product life cycles, enterprises are currently facing major challenges. In order to succeed in the market, business models have to be adapted more often and more quickly to changing market conditions than they used to be. Fast adaptability, also called agility, is a decisive competitive factor in today’s world. Because of the ever-growing IT part of products and the fact that they are manufactured using IT, changing the business model has a major impact on the enterprise architecture (EA). However, developing EAs is a very complex task, because many stakeholders with conflicting interests are involved in the decision-making process. Therefore, a lot of collaboration is required. To support organizations in developing their EA, this article introduces a novel integrative method that systematically integrates stakeholder interests into decision-making activities. By using the method, collaboration between stakeholders involved is improved by identifying points of contact between them. Furthermore, standardized activities make decision-making more transparent and comparable without limiting creativity.
This research-oriented book presents key contributions on architecting the digital transformation. It includes the following main sections covering 20 chapters: · Digital Transformation · Digital Business · Digital Architecture · Decision Support · Digital Applications Focusing on digital architectures for smart digital products and services, it is a valuable resource for researchers, doctoral students, postgraduates, graduates, undergraduates, academics and practitioners interested in digital transformation.
This chapter presents an introduction to the emerging trends for architecting the digital transformation having a strong focus on digital products, intelligent services, and related systems together with methods, models and architectures. The primary aim of this book is to highlight some of the most recent research results in the field. We are providing a focused set of brief descriptions of the chapters included in the book.
Gelatin is one of the most prominent biopolymers in biomedical material research and development. It is frequently used in hybrid hydrogels, which combine the advantageous properties of bio‐based and synthetic polymers. To prevent the biological component from leaching out of the hydrogel, the biomolecules can be equipped with azides. Those groups can be used to immobilize gelatin covalently in hydrogels by the highly selective and specific azide–alkyne cycloaddition. In this contribution, we functionalized gelatin with azides at its lysine residues by diazo transfer, which offers the great advantage of only minimal side‐chain extension. Approximately 84–90% of the amino groups are modified as shown by 1H‐NMR spectroscopy, 2,4,6‐trinitrobenzenesulfonic acid assay as well as Fourier‐transform infrared spectroscopy, rheology, and the determination of the isoelectric point. Furthermore, the azido‐functional gelatin is incorporated into hydrogels based on poly(ethylene glycol) diacrylate (PEG‐DA) at different concentrations (0.6, 3.0, and 5.5%). All hydrogels were classified as noncyctotoxic with significantly enhanced cell adhesion of human fibroblasts on their surfaces compared to pure PEG‐DA hydrogels. Thus, the new gelatin derivative is found to be a very promising building block for tailoring the bioactivity of materials.
This book is about the challenges that emerge for organizations from an ever faster changing world. While useful at their time, several management tools, including classic strategic planning processes, will no longer suffice to address these challenges in a timely and comprehensive fashion. While individual management tools are still valid to solve specific problems, they need to be employed based on a clear understanding of what the greater challenge is and how they need to be combined and prioritized with other approaches. In order to do so, companies can apply the clarity of thinking from the military with regard to which leadership level is responsible for what and how these levels need to interact in order to produce a single aligned response to an outside opportunity or threat. Finally, the tool of business wargaming, while known for some time, proves to be an ideal approach to quickly and effectively bring all leadership levels together, align them around a common objective and lay the groundwork for effective implementation of targeted responses that will keep the organization competitive and in the game for the long run. The book offers a comprehensive introduction to business wargaming, including a historical account, a classification of different types of games and a number of specific real-world examples. This book is targeted at practicing managers dealing with the aforementioned challenges, as well as for students of business and strategy at every level.
Uncontrolled movements of laparoscopic instruments can lead to inadvertent injury of adjacent structures. The risk becomes evident when the dissecting instrument is located outside the field of view of the laparoscopic camera. Technical solutions to ensure patient safety are appreciated. The present work evaluated the feasibility of an automated binary classification of laparoscopic image data using Convolutional Neural Networks (CNN) to determine whether the dissecting instrument is located within the laparoscopic image section. A unique record of images was generated from six laparoscopic cholecystectomies in a surgical training environment to configure and train The CNN. By using a temporary version of the neural network, the annotation of the training image files could be automated and accelerated. A combination of oversampling and selective data augmentation was used to enlarge the fully labelled image data set and prevent loss of accuracy due to imbalanced class volumes. Subsequently the same approach was applied to the comprehensive, fully annotated Cholec80 database. The described process led to the generation of extensive and balanced training image data sets. The performance of the CNN-based binary classifiers was evaluated on separate test records from both databases. On our recorded data, an accuracy of 0.88 with regard to the safety-relevant classification was achieved. The subsequent evaluation on the Cholec80 data set yielded an accuracy of 0.84. The presented results demonstrate the feasibility of a binary classification of laparoscopic image data for the detection of adverse events in a surgical training environment using a specifically configured CNN architecture.
Context: Nowadays, companies are challenged by increasing market dynamics, rapid changes and disruptive participants entering the market. To survive in such an environment, companies must be able to quickly discover product ideas that meet the needs of both customers and the company and deliver these products to customers. Dual-track agile is a new type of agile development that combines product discovery and delivery activities in parallel, iterative, and cyclical ways. At present, many companies have difficulties in finding and establishing suitable approaches for implementing dual-track agile in their business context.
Objective: In order to gain a better understanding of how product discovery and product delivery can interact with each other and how this interaction can be implemented in practice, this paper aims to identify suitable approaches to dual-track agile.
Method: We conducted a grey literature review (GLR) according to the guidelines to Garousi et al.
Results: Several approaches that support the integration of product discovery with product delivery were identified. This paper presents a selection of these approaches, i.e., the Discovery-Delivery Cycle model, Now-Next-Later Product Roadmaps, Lean Sprints, Product Kata, and Dual-Track Scrum. The approaches differ in their granularity but are similar in their underlying rationales. All approaches aim to ensure that only validated ideas turn into products and thus promise to lead to products that are better received by their users.
Selecting a suitable development method for a specific project context is one of the most challenging activities in process design. To extend the so far statistical construction of hybrid development methods, we analyze 829 data points to investigate which context factors influence the choice of methods or practices. Using exploratory factor analysis, we derive five base clusters consisting of up to 10 methods. Logistic regression analysis then reveals which context factors have an influence on the integration of methods from these clusters in the development process. Our results indicate that only a few context factors including project/product size and target application domain significantly influence the choice. This summary refers to the paper “Determining Context Factors for Hybrid Development Methods with Trained Models”. This paper was published in the proceedings of the International Conference on Software and System Process in 2020.
Context: Currently, most companies apply approaches for product roadmapping that are based on the assumption that the future is highly predicable. However, nowadays companies are facing the challenge of increasing market dynamics, rapidly evolving technologies, and shifting user expectations. Together with the adaption of lean and agile practices it makes it increasingly difficult to plan and predict upfront which products, services or features will satisfy the needs of the customers. Therefore, they are struggling with their ability to provide product roadmaps that fit into dynamic and uncertain market environments and that can be used together with lean and agile software development practices.
Objective: To gain a better understanding of modern product roadmapping processes, this paper aims to identify suitable processes for the creation and evolution of product roadmaps in dynamic and uncertain market environments.
Method: We performed a Grey Literature Review (GLR) according to the guidelines from Garousi et al.
Results: 32 approaches to product roadmapping were identified. Typical characteristics of these processes are the strong connection between the product roadmap and the product vision, an emphasis on stakeholder alignment, the definition of business and customer goals as part of the roadmapping process, a high degree of flexibility with respect to reaching these goals, and the inclusion of validation activities in the roadmapping process. An overall goal of nearly all approaches is to avoid waste by early reducing development and business risks. From the list of the 32 approaches found, four representative roadmapping processes are described in detail.
A systematic study using a central composite design of experiments (DoE) was performed on the oxygen plasma surface modifications of two different polymers—Pellethane 2363-55DE, which is a polyurethane, and vinyltrimethoxysilane-grafted ethylene-propylene (EPR-g-VTMS), a cross-linked ethylene-propylene rubber. The impacts of four parameters—gas pressure, generator power, treatment duration, and process temperature—were assessed, with static contact angles and calculated surface free energies (SFEs) as the main responses in the DoE. The plasma effects on the surface roughness and chemistry were determined using scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). Through the sufficiently accurate DoE model evaluation, oxygen gas pressure was established as the most impactful factor, with the surface energy and polarity rising with falling oxygen pressure. Both polymers, though different in composition, exhibited similar modification trends in surface energy rise in the studied system. The SEM images showed a rougher surface topography after low pressure plasma treatments. XPS and subsequent multivariate data analysis of the spectra established that higher oxidized species were formed with plasma treatments at low oxygen pressures of 0.2 mbar.
Der Masterstudiengang Human-Centered Computing der Hochschule Reutlingen ist geprägt durch die Zusammenarbeit von Mensch und Computer. Eine wichtige Rolle an der Schnittstelle spielt die Sensorik, die der diesjährigen Konferenz Informatics Inside das Motto „perceive(it)“ verleiht. Dabei hebt das Wortspiel „it“ für die Informationstechnologie und die englische Übersetzung des Personalpronomens „es“ die Dualität der Wahrnehmung der Informationstechnologie durch den Menschen und der Realität durch den Computer hervor. Das Spannungsfeld zwischen künstlichen Sinneserweiterungen und der intelligenten Verarbeitung von Sensordaten ermöglicht unzählige Anwendungen für digitale Medien, virtuelle Welten, realitätsnahe Simulationen, computergestützte Arbeitsprozesse sowie intelligente Assistenzsysteme in der Produktion, im Haushalt, in der Medizin und in der Mobilität. Meine Aufmerksamkeit gilt hierbei der praxisnahen Forschung als Motor für diesen technischen Fortschritt.
Mit diesem Strategiepapier formulieren die Universitäts-, Landes- und Hochschulbibliotheken des Landes Baden-Württemberg die aus ihrer Sicht zentralen Entwicklungsfelder und Herausforderungen der kommenden Jahre. Die Bibliotheken und das Bibliotheksservice-Zentrum Baden-Württemberg (BSZ) sorgen als Wissenschafts- und Kultureinrichtungen gemeinsam für die akademische Informationsinfrastruktur. Sie nehmen die Herausforderungen der Digitalisierung an und gestalten den Wandel im Dialog mit Forschenden, Lehrenden und Studierenden aktiv mit.
Unternehmen wenden insbesondere bei IT-nahen Projekten seit einigen Jahren auch im Controlling verstärkt ein agiles Vorgehen an. Erfahrungen zeigen jedoch, dass dies nicht bei allen Projekten in jedem Unternehmen funktioniert. Hybride Ansätze, die agile mit klassischen Projekt-Management-Methoden verbinden, bieten eine Lösung.
Direct observation of structural heterogeneity and tautomerization of single hypericin molecules
(2021)
Tautomerization is a fundamental chemical reaction which involves the relocation of a proton in the reactants. Studying the optical properties of tautomeric species is challenging because of ensemble averaging. Many molecules, such as porphines, porphycenes, or phenanthroperylene quinones, exhibit a reorientation of the transition dipole moment (TDM) during tautomerization, which can be directly observed in single-molecule experiments. Here, we study single hypericin molecules, which is a prominent phenanthroperylene quinone showing antiviral, antidepressive, and photodynamical properties. Observing abrupt flipping of the image pattern combined with time-dependent density functional theory calculations allows drawing conclusions about the coexistence of four tautomers and their conversion path. This approach allows the unambiguous assignment of a TDM orientation to a specific tautomer and enables the determination of the chemical structure in situ. Our approach can be applied to other molecules showing TDM reorientation during tautomerization, helping to gain a deeper understanding of this important process.
Im IGF-Projekt Nr. 19617 N wurden stickstoff- und phosphorsubstituierte Alkoxysilane hergestellt und ihre flammhemmenden Eigenschaften für Textilien untersucht. Die Synthesen erfolgten nach unterschiedlichen Strategien wie der Klick-Chemie und der nukleophilen Substitution kommerziell erhältlicher Organophosphorverbindungen mit aminobasierten Trialkoxysilanen und/oder Cyanurchlorid. Diese neuartigen, halogen- und aldehydfreien Flammschutzmittel wurden auf Stoffe aus Baumwolle (BW), Polyethylenterephthalat (PET), Polyamid (PA), sowie Mischgeweben daraus mit der industriell etablierten Pad-Dry-Cure-Technik und mittels Sol-Gel-Verfahren aufgetragen. Die flammhemmenden Eigenschaften wurden mit den Prüfverfahren nach EN ISO 15025 (Schutzkleidung – Schutz gegen Hitze und Flammprüfverfahren für begrenzte Flammenausbreitung= bewertet. Eine gute Schwerentflammbarkeit der hybriden organisch-anorganischen Materialien wurde bei einer geringen Menge von 3-5 Gew.% auf Baumwollgeweben erreicht. Darüber hinaus konnten die Wasserlöslichkeit und die Waschbeständigkeit durch die an das Phosphoratom gebundenen funktionellen Gruppen und durch die Optimierung der Härtungstemperatur kontrolliert werden. Insgesamt zeigte das Forschungsprojekt, dass N-P-Silane sehr gute permanente Flammschutzmittel für Textilien sind.
Warum haben wir ausgerechnet einen Roboter für unseren Titel ausgesucht, der starke Ähnlichkeit hat mit Robbi aus „Robbi, Tobbi und das Fliewatüüt“. Ein Roboter aus den 80ern als Sinnbild für die Zukunft der Arbeit? Nicht ganz. Er steht vielmehr für die Anfänge der Automatisierung, mit der das Ende der Arbeit prophezeit wurde. Heute schaut sein moderner, agiler Nachfolger keck ums Eck. Der „Robbi“ von heute ist hervorgegangen aus einer ständigen technologischen Entwicklung, die unsere Arbeitswelt in erheblichem Maße verändert hat und noch verändern wird. Wie Sie sehen werden, war „Robbi“ sehr wandlungsfähig. Doch was bedeutet das für uns? Wie könnte sie aussehen, die Zukunft der Arbeit? Und was verändert sich dadurch für jeden Einzelnen von uns? Diese Fragen haben wir Professorinnen und Professoren aller Fakultäten gestellt. Sie beschäftigen sich in ihrer Forschung mit digitalen Arbeitsmodellen und zukunftsfähigen Bildungskonzepten, mit Krankenhäusern der Zukunft und Künstlicher Intelligenz. Vieles unterscheidet sich, doch vieles ist auch gleich: Es geht um Vertrauen. Was bedeutet die zunehmende Digitalisierung für unsere Arbeitskultur? Es geht um Verantwortung, uns selbst und anderen gegenüber. Es geht um Vielfalt. Wer sind sie, die Arbeitskräfte von morgen? Es geht um Vernetzung, denn die ist in einer digitalen Welt allgegenwärtig. Für uns als Hochschule ist die „Zukunft der Arbeit“ ein besonders wichtiges Thema, denn unsere Studierenden heute werden sich morgen in dieser neuen Arbeitswelt bewegen und sie gestalten. Welche Kompetenzen müssen wir Ihnen vermitteln? Das ist eine Frage, die wir uns immer wieder neu stellen.