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The effect of Hofmeister anions on the surface properties of polyelectrolyte multilayers built from hyaluronan and chitosan by layer-by-layer deposition is studied by ellipsometry and atomic force microscopy. The thickness, roughness and morphology of the resulting coatings were found to depend on the type of the anion. Relationship between the surface properties and the biological response of the polyelectrolyte multilayers is established by assessing the degree of protein (albumin) adsorption.
This paper is concerned with the study, optimization and control of the moisture sorption kinetics of agricultural products at temperatures typically found in processing and storage. A nonlinear autoregressive with exogenous inputs (NARX) neural network was developed to predict moisture sorption kinetics and consequently equilibrium moisture contents of shiitake mushrooms (Lentinula edodes (Berk.) Pegler) over a wide range of relative humidity and different temperatures. Sorption kinetic data of mushroom caps was separately generated using a continuous, gravimetric dynamic vapour sorption analyser at emperatures of 25-40 °C over a stepwise variation of relative humidity ranging from 0 to 85%. The predictive power of the neural network was based on physical data, namely relative humidity and temperature. The model was fed with a total of 4500 data points by dividing them into three subsets, namely, 70% of the data was used for training, 15% of the data for testing and 15% of the data for validation, randomly selected from the whole dataset. The NARX neural network was capable of precisely simulating equilibrium moisture contents of mushrooms derived from the dynamic vapour sorption kinetic data throughout the entire range of relative humidity.
Knee osteoarthritis is a common complication and can lead to total loss of joint function in patients. Treatment by either partial or total knee replacement with appropriate UHMWPE based implantsis highly invasive, may cause complications and may show unsatisfying results. Alternatively, treatment may be done by insertion of an elastic interpositional knee spacer with optimized material characteristics.
We report the development of high performance polyurethane-based polymers modified with bioactive molecules for fabrication of such knee spacers. In order to tailor mechanical and tribological properties and to improve resist to enzymatic degradation we propose a core-shell model for the spacer with specifically adapted properties.
Organisationen sind immer mehr gefragt, auch digitale Arbeitsumgebungen bewusst zu formen. Neue Technologien und digitale Arbeitspraktiken verlagern den Ort, an dem eine gemeinsame Identität gebildet wird, zunehmend in virtuelle Räume. Bislang fokussieren sich Führungskräfte und Change Manager jedoch zu sehr auf Dinge, die sie anfassen und plastisch gestalten können. Die Autoren erörtern daher, wie Unternehmen auch in virtuellen Arbeitswelten die organisationale Identität gestalten und aufrechterhalten können, um auf diese Weise das Change Management zu unterstützen.
Analog-/Mixed-Signal (AMS) design verification is one of the most challenging and time consuming tasks of todays complex system on chip (SoC) designs. In contrast to digital system design, AMS designers have to deal with a continuous state space of conservative quantities, highly nonlinear relationships, non-functional influences, etc. enlarging the number of possibly critical scenarios to infinity. In this special session we demonstrate the verification of functional properties using simulative and formal methods. We combine different approaches including automated abstraction and refinement of mixed-level models, state-space discretization as well as affine arithmetic. To reach sufficient verification coverage with reasonable time and effort, we use enhanced simulation schemes to avoid conventional simulation drawbacks.
An integrated synchronous buck converter with a high resolution dead time control for input voltages up to 48V and 10MHz switching frequency is presented. The benefit of an enhanced dead time control at light loads to enable zero voltage switching at both the high-side and low-side switch at low output load is studied. This way, compact multi-MHz DCDC converters can be implemented at high efficiency over a wide load current range. The concept also eliminates body diode forward conduction losses and minimizes reverse recovery losses. A dead time resolution of 125 ps is realized by an 8-bit differential delay chain. A further efficiency enhancement by soft switching at the high-side switch at light load is achieved with a voltage boost of the switching node by dead time control in forced continuous conduction mode. The monolithic converter is implemented in an 180nm high-voltage BiCMOS technology. At V IN = 48V, V OUT = 5V, 50mA load, 10MHz switching frequency and 500 nH output inductance, the efficiency is measured to be increased by 14.4% compared to a conventional predictive dead time control. A peak efficiency of 80.9% is achieved at 12V input.
Different sensor types using chemical and biochemical principles are described. The former are mainly gas sensors, the latter are applied especially to liquids. Those label-free direct detection methods are compared with applications where assays take advantage of labeled receptors.
Furthermore, selected applications in the area of gas sensors are discussed, and sensors for process control, point-of-care diagnostics, environmental analytics, and food analytics are reviewed. In addition, multiplexing approaches used in microplates and microarrays are described.
On account of the huge number of sensor types and the wide range of possible applications, only the most important ones are selected here.
In thermopervaporation the same economically favorable driving force as in membrane distillation, i.e., a temperature difference between feed and permeate for the transport, is used but with non-porous thin-film composite membranes. Membrane pores cannot be wetted and long-term operational stability can be achieved with the appropriate coating layer, but normally with a decrease of the flux compared to membrane distillation with porous hydrophobic membranes.
Porous asymmetric PVDF membranes were made to achieve low permeation resistance and pores which could be overcoated with polyelectrolyte polymers. This coating prohibits pore wetting and strongly reduces adsorption of organic substances.
Those membranes showed a high permeation rate for water due to a structure of phase-separated hydrophilic and hydrophobic three-dimensional domains. The permeation rates of these composite membranes for water is between 6 and 12 l/(h m²) at a feed temperature of 60 °C and permeate at a temperature of 40 °C of a 2% saline solution feed depending on the operational parameters. This is only a slight reduction of 10–15% in permeation rate compared to membrane distillation with porous hydrophobic membranes.
In whey dewatering experiment this membrane showed a constant performance over 4 days in intermittent operation mode and stability in cleaning with strong alkaline solution.
The Internet of Things (IoT) refers to the interconnectedness of physical objects, and works by equipping the latter with sensors and actuators as a means to connect to the internet. The number of connected things has increased threefold over the past five years. Consequently, firms expect the IoT to become a source of new business models driven by technology. However, only a few early adopters have started to install and use IoT appliances on a frequent basis. So it is still unclear which factors drive technological acceptance of IoT appliances. Confronting this gap in current research, the present paper explores how IoT appliances are conceptually defined, which factors drive technological acceptance of IoT appliances, and how firms can use results in order to improve value propositions in corresponding business models. lt is discovered that IoT appliance vendors need to support a broad focus as the potential buyers expose a large variety. As conclusions from this insight, the paper illustrates some flexible marketing strategies.
Kennzahlen zur Liquidität
(2016)
Wer mit Argumenten Veränderungen bewirken will, muss seine Ansprechpartner für seine Lösungsansätze gewinnen. Ob dies gelingt, ist heutzutage keine Frage von rhetorischem Talent und Charisma mehr. Denn Techniken des Storylinings und Storytellings machen eine Professionalisierung betriebswirtschaftlicher Argumentation und Gedankenführung für jedermann möglich.
This article reviews the literature on Christmas economics. First, we present an overall picture of the debate on the potential welfare loss of gift-giving and we show strategies that reduce the potential welfare loss and might increase the number of presents received. Second, we discuss the effect of Christmas on prices and the business cycle. We provide evidence that at Christmas stock prices and airfares increase, while food prices decrease.
Business process management and IT supported processes are an actual topic. The procedure of finding a business process system that implements your processes the best way is not easy and takes a lot of time. In this article you will find a recommendation for an open source system. Four selected open source workflow management systems are tested and analyzed. Mean criteria for the evaluation are listed in a criteria catalogue and rated by experts by their importance. Finally, the systems are evaluated by the criteria and the best evaluated system can be recommended.
IT environments that consist of a very large number of rather small structures like microservices, Internet of Things (IoT) components, or mobility systems are emerging to support flexible and agile products and services in the age of digital transformation. Biological metaphors of living and adaptable ecosystems with service-oriented enterprise architectures provide the foundation for self-optimizing, resilient run-time environments and distributed information systems. We are extending Enterprise Architecture (EA) methodologies and models that cover a high degree of heterogeneity and distribution to support the digital transformation and related information systems with micro-granular architectures. Our aim is to support flexibility and agile transformation for both IT and business capabilities within adaptable digital enterprise architectures. The present research paper investigates mechanisms for integrating Microservice Architectures (MSA) by extending original enterprise architecture reference models with elements for more flexible architectural metamodels and EA-mini-descriptions.
The fast moving process of digitization1 demands flexibility in order to adapt to rapidly changing business requirements and newly emerging business opportunities. New features have to be developed and deployed to the production environment a lot faster. To be able to cope with this increased velocity and pressure, a lot of software developing companies have switched to a Microservice Architecture (MSA) approach. Applications built this way consist of several fine-grained and heterogeneous services that are independently scalable and deployable. However, the technological and business architectural impacts of microservices based applications directly affect their integration into the digital enterprise architecture. As a consequence, traditional Enterprise Architecture Management (EAM) approaches are not able to handle the extreme distribution, diversity, and volatility of micro-granular systems and services. We are therefore researching mechanisms for dynamically integrating large amounts of microservices into an adaptable digital enterprise architecture.
The paper focuses on a recently introduced paradigm for the logistic process of picking, with respect to the man-to-goods and goods-to-man concept: the robot to-goods. First the task and system architecture of the fast deployable autonomous commissioning system are described, then the economic efficiency of the system is analysed in a real business case scenario using a simplified method, which is explained and discussed. The clearly positive net present value of the investment and the short payback period obtained in the business case prove how the robot-to-goods paradigm for the commissioning process, implemented through the automation of the forklift platform, is economically attractive for small and medium size enterprises.
Methods for increasing the energy efficiency of induction motors by an appropriate control strategy have been a subject of research during the last years. Several methods for loss minimization have been developed for induction motors operated in a steady state. In recent years, some solutions for the dynamic case have been given as well either using an online or offline optimization approach, implying a certain computational burden, which is undesired in practice. This paper shows that the appropriate application of steady state techniques during transients due to a changing motor torque is a suboptimal strategy with an acceptable performance for efficiency optimization given an induction machine where saturation effects of the main inductance must be considered. The optimization problem is simplified such that a simple suboptimal solution is possible and the quality of the suboptimal solution is investigated by simulations and measurements. The proposed solution is simple, easy to implement, and does not require an online optimization. In addition, the influence of magnetizing induction saturation is considered.
Converting users into customers : the role of user profile information and customer journey analysis
(2016)
Due to the digital transformation, the importance of web analysis and user profiling for enterprises is increasing rapidly as customers focus on digital channels to obtain information about products and brands. While there exists a lot research on these topics, only a minority of firms use them to their advantage. This study aims to tighten the link between research and business such that experimental methods can be used for the improvement of communication strategies in practice. Therefore, a systematic literature analysis is conducted, workshops are observed and documented and an empirical study is used to integrate single steps into a framework for the
practical usage of user profiling and customer journey analysis.
Reliable and accurate car driver head pose estimation is an important function for the next generation of advanced driver assistance systems that need to consider the driver state in their analysis. For optimal performance, head pose estimation needs to be non-invasive, calibration-free and accurate for varying driving and illumination conditions. In this pilot study we investigate a 3D head pose estimation system that automatically fits a statistical 3D face model to measurements of a driver’s face, acquired with a low-cost depth sensor on challenging real-world data. We evaluate the results of our sensor-independent, driver-adaptive approach to those of a state-of-the-art camera-based 2D face tracking system as well as a non-adaptive 3D model relative to own ground-truth data, and compare to other 3D benchmarks. We find large accuracy benefits of the adaptive 3D approach.
A seamless convergence of the digital and physical factory aiming in personalized Product Emergence Process (PPEP) for smart products within ESB Logistics Learning Factory at Reutlingen University.
A completely new business model with reference to Industrie4.0 and facilitated by 3D experience software in today's networked society in which customers expect immediate responses, delightful experience and simple solutions is one of the mission scenarios in the ESB Logistics Learning Factory at ESB Business School (Reutlingen University).
The business experience platform provides software solutions for every organization in the company respectively in the factory. An interface with dashboards, project management apps, 3D - design and construction apps with high end visualization, manufacturing and simulation apps as well as intelligence and social network apps in a collaborative interactive environment help the user to learn the creation of a value end to end process for a personalized virtual and later real produced product.
Instead of traditional ways of working and a conventional operating factory real workers and robots work semi-intuitive together. Centerpiece in the self-planned interim factory is the smart personalized product, uniquely identifiable and locatable at all times during the production process – a scooter with an individual colored mobile phone – holder for any smart phone produced with a 3D printer in lot size one. Smart products have in the future solutions incorporated internet based services – designed and manufactured - at the costs of mass products. Additionally the scooter is equipped with a retrievable declarative product memory. Monitoring and control is handled by sensor tags and a raspberry positioned on the product. The engineering design and implementation of a changeable production system is guided by a self-execution system that independently find amongst others esplanade workplaces.
The imparted competences to students and professionals are project management method SCRUM, customization of workflows by Industrie4.0 principles, the enhancements of products with new personalized intelligent parts, electrical and electronic selfprogrammed components and the control of access of the product memory information, to plan in a digital engineering environment and set up of the physical factory to produce customer orders. The gained action-orientated experience refers to the chances and requirements for holistic digital and physical systems.
Dieser Beitrag beschreibt das Markenmanagement von Profifußballvereinen durch den Einsatz von Social Media. Um sich ein stückweit vom nichtplanbaren sportlichen Erfolg unabhängig zu machen, sollten sich Fußballvereine als Marke positionieren. Dazu steht ihnen allerdings traditionellerweise ein geringes Marketingbudget zur Verfügung. Social Media bietet Fußballvereinen die Möglichkeit, relativ kostengünstig und effektiv die eigene Marke aufzubauen und zu pflegen. Der Beitrag erläutert diesbezüglich die Notwendigkeit eines systematischen Markenmanagements, geht auf die Besonderheiten der Vermarktung eines Profifußballvereins ein und zeigt anhand von Beispielen, wie Social Media zum Markenaufbau respektive zur Markenpflege genutzt werden kann.
This paper addresses the turn-on switching process of insulated-gate bipolar transistor (IGBT) modules with anti-parallel free-wheeling diodes (FWD) used in inductive load switching power applications. An increase in efficiency, i.e. decrease in switching losses, calls for a fast switching process of the IGBT, but this commonly implies high values of the reverse-recovery current overshoot. To overcome this undesired behaviour, a solution was proposed which achieves an independent control of the collector current slope and peak reverse recovery current by applying a gate current that is briefly turned negative during the turn-on process. The feasibility of this approach has already been shown, however, a sophisticated control method is required for applying it in applications with varying currents, temperature and device parameters. In this paper a solution based on an adaptive, iterative closed-loop ontrol is proposed. Its effectiveness is demonstrated by experimental results from a 1200 V/200A IGBT power module for different load currents and reverse-recovery current overshoots.
Sleep is an important aspect in life of every human being. The average sleep duration for an adult is approximately 7 h per day. Sleep is necessary to regenerate physical and psychological state of a human. A bad sleep quality has a major impact on the health status and can lead to different diseases. In this paper an approach will be presented, which uses a long-term monitoring of vital data gathered by a body sensor during the day and the night supported by mobile application connected to an analyzing system, to estimate sleep quality of its user as well as give recommendations to improve it in real-time. Actimetry and historical data will be used to improve the individual recommendations, based on common techniques used in the area of machine learning and big data analysis.
Stress is becoming an important topic in modern life. The influence of stress results in a higher rate of health disorders such as burnout, heart problems, obesity, asthma, diabetes, depressions and many others. Furthermore individual’s behavior and capabilities could be directly affected leading to altered cognition, inappropriate decision making and problem solving skills. In a dynamic and unpredictable environment, such as automotive, this can result in a higher risk for accidents. Different papers faced the estimation as well as prediction of drivers’ stress level during driving. Another important question is not only the stress level of the driver himself, but also the influence on and of a group of other drivers in the near area. This paper proposes a system, which determines a group of drivers in a near area as clusters and it derives the individual stress level. This information will be analyzed to generate a stress map, which represents a graphical view about road section with a higher stress influence. Aggregated data can be used to generate navigation routes with a lower stress influence to decrease stress influenced driving as well as improve road safety.
The loss contribution of a 2.3kW synchronous GaN-HEMT boost converter for an input voltage of 250V and an output voltage of 500V was analyzed. A simulation model which consists of two parts is introduced. First, a physics-based model is used to determine the switching losses. Then, a system simulation is applied to calculate the losses of the specific elements. This approach allows a fast and accurate system evaluation as required for further system optimization.
In this work, a hard- and a zero-voltage turn-on switching converter are compared. Measurements were performed to verify the simulation model, showing a good agreement. A peak efficiency of 99% was achieved for an output power of 1.4kW. Even with an output power above 400W, it was possible to obtain a system efficiency exceeding 98 %.
This paper presents a compact 3 kW bidirectional GaN-HEMT DC/DC converter for 360V to 400-500 V. A very high efficiency has been reached by applying a zero voltage turn-on in conjunction with a negative gate-source voltage, even though normally-off HEMTs are used. Further improvements were achieved by adapting the switching frequency to the load current and output voltage, as will be explained by means of the loss contribution of the specific elements for a constant and an adaptive switching frequency. Measurements have shown a high converter efficiency exceeding 99% over a wide output power range of up to 3 kW.
Like many others, fashion companies have to deal with a global and very competitive environment. Thus companies rely on accurate sales forecasts - as key success factor of an efficient supply chain management. However, forecasters have to take into account some specificities of the fashion industry. To respond to these constraints, a variety of different forecasting methods exists, including new, computer-based predictive analytics. After the evaluation of different methods, their application to the fashion industry is investigated through semi structured expert interviews. Despite several benefits predictive analytics is not yet frequently used in practice. This research does not only reflect an industry profile, but also gives important insights about the future potential and obstacles of predictive analytics.
In this article an energy harvesting system for measuring the wind speed starting from 2 m/s (about 2 Bft) is presented, which uses the same source for measuring and supplying power (energy autarkic). The use of the same source for measurement and power supply increases the number of potential applications since needed power is present with the measuring signal. For the case of measuring the wind velocity, one might consider applications in tunnels, tubes, pipelines, air conditioning or for controlling clogging of filters. Bluetooth Low Energy (BLE) is chosen as radio technology, since it provides the possibility to realize a unidirectional communication; requiring only a single telegram (advertising telegram) for sending the measured value. A more complex establishment of communication required by WLAN or 6LoWPAN could therefore be avoided to significantly reduce the overall energy consumption. Since the advertisement telegram does not make any provision for security or against hacking in general, a security concept is presented which includes encryption and resilience against replay attacks in a unidirectional communication system.
To facilitate the presented concepts beyond wind sensors, the system is divided into three major modules namely the generator-sensor module, the radio module and the energy management module. Whereas the first two might be changed in different applications the energy management module could be reused in many different applications. It supplies and stores the needed energy and switches power on and off in a deterministic way to ensure the radio module can operate correctly.
Systemic Constellation describes an approach that enables practitioners to examine and address typical issues in diversity management from a different, relational perspective. Systemic Constellation utilizes the human ability to recognize the qualities of relationships between two or more people from their spatial alignment to each other (transverbal language) and the capability to illustrate inner pictures by placing humans or objects in a room as representatives (representative perception). Systemic Constellation originated in the field of family therapy and counseling, but through research, guidance work, and teaching activities over the last two decades, it has developed into a generic, structural, constellation logic with multiple methods of application. It has been adapted to a variety of topics and issues, and a number of constellation formats. This article serves as a starting point for the transfer of Systemic Constellation into diversity management. It appears that conventional approaches taught in traditional management classes (such as focusing on tools, setting targets, planning measures, and offering incentives) are of limited use when trying to deal with problematic situations in diversity management. Preliminary trials show that new solutions and insights into deeper underlying dynamics can be gained on personal and institutional levels when applying Systemic Constellation. Participants find the application of the model as very beneficial. Systemic Constellation is grounded in personal experience and particularly in a person’s own experience of the consistency of representative perception. This viewpoint can only be conveyed rudimentarily in a scientific article. Readers should feel encouraged to apply Systemic Constellations themselves and use it in their work, experimentally and professionally. To harness the full potential of Systemic Constellations in diversity management, further research needs to be done.
Recent MIT CISR research found that an obsessive focus on innovation is a characteristic of CIOs of top-performing firms. There are now more ways than ever that a firm can be disrupted by and disruptive with digital innovations. Indeed, a growing number of firms and individuals are using increasingly powerful digital technologies and figuring out ways to develop better products and services, better customer and employee experiences, and new business models. The new digital imperative is to compete with more types of digital innovations - and IT units must refine approaches to producing them. Based on an in-depth caste study, this briefing takes a look at how German car manufacturer AUDI AG has expanded its portfolio of digital innovations.
In 2016, German car manufacturer the Audi Group (AUDI AG) was working on an expanding array of digital innovations. The goals of these innovations varied, and included strengthening customer- and employee-facing processes, digitally enhancing existing products, and developing new, potentially disruptive business models. Audi's IT unit was critical to each of these efforts. This case examines the different ways in which digitization can help to enhance and transform an organization's processes, products, and business models. The case also highlights the challenges that may arise as organizations attempt to expand and diversify their portfolio of digital innovations.
Diese Ausarbeitung befasst sich mit der Fragestellung, inwiefern interaktive Systeme innerhalb eines historischen Ausstellungskontextes herangezogen werden können, um die methodische Vermittlung von Informationen zu fördern und zu unterstützen. Als Anwendungsfall wird hierbei auf das Schloss Aulendorf zurückgegriffen.
Reality mining refers to an application of data mining, using sensor data to drive behavioral patterns in the real world. However, research in this field started a decade ago when technology was far behind today's state of the art. This paper discusses which requirements are now posed to applications in the context of reality mining. A survey has shown which sensors are available in state-of-the-art smartphones and usable to gather data for reality mining. As another contribution of this paper, a reality mining application architecture is proposed to facilitate the implementation of such applications. A proof of concept verifies the assumptions made on reality mining and the presented architecture.
The acquisition of data for reality mining applications is a critical factor, since many mobile devices, e.g. smartphones, must be capable of capturing the required data. Otherwise, only a small target group would be able to use the reality mining application. In the course of a survey, we have identified smartphone features which might be relevant for various reality mining applications. The survey classifies these features and shows how the support of each feature has changed over the years by analyzing 143 smartphones released between 2004 and 2015. All analyzed devices can be ranked by their number of provided features. Furthermore, this paper deals with quality issues which have occurred during carrying out the survey.
Broad acceptance of finite-element-based analysis of structural problems and the increased availability of CAD-systems for structural tasks, which help to generate meshes of non-trivial geometries, have been setting a standard for the evaluation of designs in mechanical engineering in the last few decades. The development of automated or semi-automated optimizers, integrated into the Computer-Aided Engineering (CAE)-packages or working as outer loop machines, requiring the solver to do the analysis of the specific designs, has been accepted by most advanced users of the simulation community as well. The availability and inexpensive processing power of computers is increasing without any limitations foreseen in the coming years. There is little doubt that virtual product development will continue using the tools that have proved to be so successful and so easy to handle.
Recycling of poly(ethylene terephthalate) (PET) is of crucial importance, since worldwide amounts of PETwaste increase rapidly due to its widespread applications. Hence, several methods have been developed, like energetic, material, thermo-mechanical and chemical recycling of PET. Most frequently, PET-waste is incinerated for energy recovery, used as additive in concrete composites or glycolysed to yield mixtures of monomers and undefined oligomers. While energetic and thermo-mechanical recycling entail downcycling of the material, chemical recycling requires considerable amounts of chemicals and demanding processing steps entailing toxic and ecological issues. This review provides a thorough survey of PET-recycling including energetic, material, thermo-mechanical and chemical methods. It focuses on chemical methods describing important reaction parameters and yields of obtained reaction products. While most methods yield monomers, only a few yield undefined low molecular weight oligomers for impaired applications (dispersants or plasticizers). Further, the present work presents an alternative chemical recycling method of PET in comparison to existing chemical methods.
Adapting characteristics of biomaterials specifically for in vitro and in vivo applications is becoming increasingly important in order to control interactions between material and biological systems. These complex interactions are influenced by surface properties like chemical composition, charge, mechanical and topographic attributes. In many cases it is not useful or even not possible to alter the base material but changing surface, to improve biocompatibility or to make surfaces bioactive, may be achieved by thin coatings. An already established method is the coating with polyelectrolyte multilayers (PEM). To adjust adhesion, proliferation and improve vitality of certain cell types, we modified the roughness of PEM coatings. We included different types nanoparticles (NP’s) in different concentrations into PEM coatings for controlling surface roughness. Surface properties were characterized and the reaction of 3 different cell types on these coatings was tested.
Virtual prototyping of integrated mixed-signal smart sensor systems requires high-performance co-simulation of analog frontend circuitry with complex digital controller hardware and embedded real-time software. We use SystemC/TLM 2.0 in conjunction with a cycle-count accurate temporal decoupling approach (TD) to simulate digital components and firmware code execution at high speed while preserving clock-cycle accuracy and, thus, real-time behavior at time quantum boundaries. Optimal time quanta ensuring real-time capability can be calculated and set automatically during simulation if the simulation engine has access to exact timing information about upcoming inter-process communication events. These methods fail in the case of non-deterministic, asynchronous events, resulting in potentially invalid simulation results. In this paper, we propose an extension to the case of asynchronous events generated by blackbox sources from which a priori event timing information is not available, such as coupled analog simulators or hardware in the loop. Additional event processing latency or rollback effort caused by temporal decoupling is minimized by calculating optimal time quanta dynamically in a SystemC model using a linear prediction scheme. We analyze the theoretical performance of the presented predictive temporal decoupling approach (PTD) by deriving a cost model that expresses the expected simulation effort in terms of key parameters such as time quantum size and CPU time per simulation cycle. For an exemplary smart-sensor system model, we show that quasi-periodic events that trigger activities in TD processes are handled accurately after the predictor has settled.
Optimization-based design automation for analog ICs still remains behind the demands. A promising alternative is given by procedural approaches such as parameterized generators, also known as PCells. We are working on a complete analog design flow based on parameterized generators for entire circuits and corresponding layout modules. Because the conventional programming of such enhanced generators is far too complicated and costly, new methods are needed to ease their development. This paper presents gPCDS (graphical PCDS), a novel tool for a designer-oriented development of schematic module generators, integrated into a common schematic entry environment. The tool is based on PCDS (Parameterized Circuit Description Scheme), a meta-language for the creation of parametrized analog circuits. Schematic module generators are a very desirable complement to layout module generators in order to achieve a seamless schematic- driven layout design flow on module level. By facilitating a way of generator development that matches a design expert’s mentality, gPCDS contributes to close this gap in the analog design flow.
The extracellular environment of vascular cells in vivo is complex in its chemical composition, physical properties, and architecture. Consequently, it has been a great challenge to study vascular cell responses in vitro, either to understand their interaction with their native environment or to investigate their interaction with artificial structures such as implant surfaces. New procedures and techniques from materials science to fabricate bio-scaffolds and surfaces have enabled novel studies of vascular cell responses under well-defined, controllable culture conditions. These advancements are paving the way for a deeper understanding of vascular cell biology and materials–cell interaction. Here, we review previous work focusing on the interaction of vascular smooth muscle cells (SMCs) and endothelial cells (ECs) with materials having micro- and nanostructured surfaces. We summarize fabrication techniques for surface topographies, materials, geometries, biochemical functionalization, and mechanical properties of such materials. Furthermore, various studies on vascular cell behavior and their biological responses to micro- and nanostructured surfaces are reviewed. Emphasis is given to studies of cell morphology and motility, cell proliferation, the cytoskeleton and cell-matrix adhesions, and signal transduction pathways of vascular cells. We finalize with a short outlook on potential interesting future studies.
Based on well-established robotic concepts of autonomous localization and navigation we present a system prototype to assist camera-based indoor navigation for human utilization implemented in the Robot Operating System (ROS). Our prototype takes advantage of state-of-the-art computer vision and robotic methods. Our system is designed for assistive indoor guidance. We employ a vibro tactile belt to serve as a guiding device to render derived motion suggestions to the user via vibration patterns. We evaluated the effectiveness of a variety of vibro-tactile feedback patterns for guidance of blindfolded users. Our prototype demonstrates that a vision-based system can support human navigation, and may also assist the visually impaired in a human-centered way.
Polyethylene glycol (PEG) is a widely used modification for drug delivery systems. It reduces undesired interaction with biological components, aggregation of complexes and serves as a hydrophilic linker of ligands for targeted drug delivery. However, PEGylation can also lead to undesired changes in physicochemical characteristics of chitosan/siRNA nanoplexes and hamper gene silencing.
To address this conflicting issue, PEG-chitosan copolymers were synthesized with stepwise increasing degrees of PEG substitution (1.5% to 8.0%). Subsequently formed PEG-chitosan/siRNA nanoplexes were characterized physicochemically and biologically. The results showed that small ratios of chitosan PEGylation did not affect nanoplex stability and density. However, higher PEGylation ratios reduced nanoplex size and charge, as well as cell uptake and final siRNA knockdown efficiency.
Therefore, we recommend fine-tuning of PEGylation ratios to generate PEG-chitosan/siRNA delivery systems with maximum bioactivity. The degree of PEGylation for chitosan/siRNA nanoplexes should be kept low in order to maintain optimal nanoplex efficiency.
Willingness-to-pay for alternative fuel vehicle characteristics : a stated choice study for Germany
(2016)
In the light of European energy efficiency and clean air regulations, as well as an ambitious electric mobility goal of the German government, we examine consumer preferences for alternative fuel vehicles (AFVs) based on a Germany-wide discrete choice experiment among 711 potential car buyers. We estimate consumers’ willingness to-pay and compensating variation (CV) for improvements in vehicle attributes, also taking taste differences in the population into account by applying a latent class model with 6 distinct consumer segments. Our results indicate that about 1/3 of the consumers are oriented towards at least one AFV option, with almost half of them being AFV-affine, showing a high probability of choosing AFVs despite their current shortcomings. Our results suggest that German car buyers’ willingness-to-pay for improvements of the various vehicle attributes varies considerably across consumer groups and that the vehicle features have to meet some minimum requirements for considering AFVs. The CV values show that decision-makers in the administration and industry should focus on the most promising consumer group of ‘AFV aficionados’ and their needs. It also shows that some vehicle attribute improvements could increase the demand for AFVs cost-effectively, and that consumers would accept surcharges for some vehicle attributes at a level which could enable their private provision and economic operation (e.g. fast-charging infrastructure). Improvement of other attributes will need governmental subsidies to compensate for insufficient consumer valuation (e.g. battery capacity).
The increasing slew rate of modern power switches can increase the efficiency and reduce the size of power electronic applications. This requires a fast and robust signal transmission to the gate driver of the high-side switch. This work proposes a galvanically isolated capacitive signal transmission circuit to increase common mode transient immunity (CMTI). An additional signal path is introduced to significantly improve the transmission robustness for small duty cycles to assure a safe turn-off of the power switch. To limit the input voltage range at the comparator on the secondary side during fast high-side transitions, a clamping structure is implemented. A comparison between a conventional and the proposed signal transmission is performed using transistor level simulations. A propagation delay of about 2 ns over a wide range of voltage transients of up to 300V/ns at input voltages up to 600V is achieved.
In contrast to IC design, MEMS design still lacks sophisticated component libraries. Therefore, the physical design of MEMS sensors is mostly done by simply drawing polygons. Hence, the sensor structure is only given as plain graphic data which hinders the identification and investigation of topology elements such as spring, anchor, mass and electrodes. In order to solve this problem, we present a rule-based recognition algorithm which identifies the architecture and the topology elements of a MEMS sensor. In addition to graphic data, the algorithm makes use of only a few marking layers, as well as net and technology information. Our approach enables RC-extraction with commercial field solvers and a subsequent synthesis of the sensor circuit. The mapping of the extracted RC-values to the topology elements of the sensor enables a detailed analysis and optimization of actual MEMS sensors.
In this paper we present our work in progress on revisiting traditional DBMS mechanisms to manage space on native Flash and how it is administered by the DBA. Our observations and initial results show that: the standard logical database structures can be used for physical organization of data on native Flash; at the same time higher DBMS performance is achieved without incurring extra DBA overhead. Initial experimental evaluation indicates a 20% increase in transactional throughput under TPC-C, by performing intelligent data placement on Flash, less erase operations and thus better Flash longevity.
In times of e-commerce and digitalization, new markets are opening, young companies have the possibility to grow and new perspectives arise in terms of customer relationship. Customers require more possibilities of personalization. In the same time, companies have access to new and especially more information about the customer. Seems like it was a correlation that could evolve greatly if there weren't privacy issues. Vast amount of data about consumers are collected in Big Data warehouses. These shall be analyzed via predictive analytics and customers shall be classified by algorithms like clustering models, propensity models or collaborative filtering. All these subjects are growing in importance, as they are shaping the global marketing landscape. Marketers develop together with IT scientists new ways of analyzing customer databases and benefit from more accurate segmentation methods as that have been used until now. The following paper shall provide a literature review on new methods of consumer segmentation regarding the high inflow of new information via e-commerce. It will introduce readers in the subject of predictive analytics and will discuss several predictive models. The writing of the paper is not based on own empirical researches, but shall serve as a reference text for further researches. A conclusion will complete the paper.