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Bone homeostasis is maintained by osteoblasts (bone formation) and osteoclasts (bone resorption). While there have been numerous studies investigating mesenchymal stem cells and their potential to differentiate into osteoblasts as well as their interaction with different bone substitute materials, there is only limited knowledge concerning in vitro generated osteoclasts. Due to the increasing development of degradable bone-grafting materials and the need of sophisticated in vitro test methods, it is essential to gain deeper insight into the process of osteoclastogenesis and the resorption functionality of human osteoclasts. Therefore, we focused on the comparison of osteoclastogenesis and resorption activity on tissue culture polystyrene (TCPS) and bovine extracellular bone matrices (BMs). Cortical bone slices were used as two-dimensional (2D) substrates, whereas a thermally treated cancellous bone matrix was used for three-dimensional (3D) experiments. We isolated primary human monocytes and induced osteoclastogenesis by medium supplementation. Subsequently, the expression of the vitronectin receptor (αVβ3) and cathepsin K as well as the characteristic actin formation on TCPS and the two BMs were examined. The cell area of human osteoclasts was analyzed on TCPS and on BMs, whereas significantly larger osteoclasts could be detected on BMs. Additionally, we compared the diameter of the sealing zones with the measured diameter of the resorption pits on the BMs and revealed similar diameters of the sealing zones and the resorption pits. We conclude that using TCPS as culture substrate does not affect the expression of osteoclast-specific markers. The analysis of resorption activity can successfully be conducted on cortical as well as on cancellous bone matrices. For new in vitro test systems concerning bone resorption, we suggest the establishment of a 2D assay for high throughput screening of new degradable bone substitute materials with osteoclasts.
In thermopervaporation the same economically favorable driving force as in membrane distillation, i.e., a temperature difference between feed and permeate for the transport, is used but with non-porous thin-film composite membranes. Membrane pores cannot be wetted and long-term operational stability can be achieved with the appropriate coating layer, but normally with a decrease of the flux compared to membrane distillation with porous hydrophobic membranes.
Porous asymmetric PVDF membranes were made to achieve low permeation resistance and pores which could be overcoated with polyelectrolyte polymers. This coating prohibits pore wetting and strongly reduces adsorption of organic substances.
Those membranes showed a high permeation rate for water due to a structure of phase-separated hydrophilic and hydrophobic three-dimensional domains. The permeation rates of these composite membranes for water is between 6 and 12 l/(h m²) at a feed temperature of 60 °C and permeate at a temperature of 40 °C of a 2% saline solution feed depending on the operational parameters. This is only a slight reduction of 10–15% in permeation rate compared to membrane distillation with porous hydrophobic membranes.
In whey dewatering experiment this membrane showed a constant performance over 4 days in intermittent operation mode and stability in cleaning with strong alkaline solution.
Comparison of sleep characteristics measurements: a case study with a population aged 65 and above
(2020)
Good sleep is crucial for a healthy life of every person. Unfortunately, its quality often decreases with aging. A common approach to measuring the sleep characteristics is based on interviews with the subjects or letting them fill in a daily questionnaire and afterward evaluating the obtained data. However, this method has time and personal costs for the interviewer and evaluator of responses. Therefore, it would be important to execute the collection and evaluation of sleep characteristics automatically. To do that, it is necessary to investigate the level of agreement between measurements performed in a traditional way using questionnaires and measurements obtained using electronic monitoring devices. The study presented in this manuscript performs this investigation, comparing such sleep characteristics as "time going to bed", "total time in bed", "total sleep time" and "sleep efficiency". A total number of 106 night records of elderly persons (aged 65+) were analyzed. The results achieved so far reveal the fact that the degree of agreement between the two measurement methods varies substantially for different characteristics, from 31 minutes of mean difference for "time going to bed" to 77 minutes for "total sleep time". For this reason, a direct exchange of objective and subjective measuring methods is currently not possible.
Shorter product life cycles and emerging technologies in the field of industrial equipment are changing the prerequisites and circumstances under which the design of assembly and logistics systems take place. Planners have to adapt the production in accordance with the underlying product at a higher pace, oversee a more complex system and - most importantly - find the ideal solution for functional as well as social interaction between humans and machines in a cyber-physical system. Such collaborative work systems consider the individual capabilities and potentials of humans and machines to combine them in a manner that assists the operator during his daily work routine towards more productive, less burdening work. To be able to design work systems which act on that maxim, specific competences such as the ability of integrated process and product planning as well as systems and interface competence are required. The ESB Logistics Learning Factory trains students as well as professionals to gain such qualification by providing a close-to-reality learning environment based on a didactical concept which covers all relevant methods for ergonomic work system design and a state-of-the-art infrastructure composed of a manual assembly system, service robots, visual assistance systems, sensor-based work load monitoring and logistical resources. Group-based, activity oriented scenarios enable the participants to put the learnings into practice within their professional environments. By this, learning factories have an indirect impact on the transfer of proven best practices to the industry and thereby on the diffusion of the idea of human-centric working environment.
Background aims: In vitro engineered adipose tissue is in great demand to treat lost or damaged soft tissue or to screen for new drugs, among other applications.However, today most attempts depend on the use of animal-derived sera. To pave the way for the application of adipose tissue-engineered
products in clinical trials or as reliable and robust in vitro test systems, sera should be completely excluded from the production process. In this study, we aimed to develop an in vitro adipose tissue model in the absence of sera and maintain its function long-term.
Methods: Human adipose tissue-derived stem cells were expanded and characterized in a xeno- and serum-free environment. Adipogenic differentiation was induced using a completely defined medium. Developed adipocytes were maintained in a completely defined maturation medium for additional 28 days. In addition to cell-viability and adherence, adipocyte-specific markers such as perilipin A expression of leptin release were evaluated.
Results: The defined differentiation medium enhanced cell adherence and lipid
accumulation at a significant level compared with the corresponding negative control. The defined maturation medium also significantly supported cell adherence and functional adipocyte maturation during the long-term culture period.
Conclusions: The process described here enables functional adipocyte generation and maintenance without the addition fo unknown or unimal-derived constituents, achieving an important milestone in the introduction of adipose tissue engineered products into clinical trials or in vitro screening.
Healthy sleep is one of the prerequisites for a good human body and brain condition, including general well-being. Unfortunately, there are several sleep disorders that can negatively affect this. One of the most common is sleep apnoea, in which breathing is impaired. Studies have shown that this disorder often remains undiagnosed. To avoid this, developing a system that can be widely used in a home environment to detect apnoea and monitor the changes once therapy has been initiated is essential. The conceptualisation of such a system is the main aim of this research. After a thorough analysis of the available literature and state of the art in this area of knowledge, a concept of the system was created, which includes the following main components: data acquisition (including two parts), storage of the data, apnoea detection algorithm, user and device management, data visualisation. The modules are interchangeable, and interfaces have been defined for data transfer, most of which operate using the MQTT protocol. System diagrams and detailed component descriptions, including signal requirements and visualisation mockups, have also been developed. The system's design includes the necessary concepts for the implementation and can be realised in a prototype in the next phase.
The functionality of existing cyber-physical production systems generally focuses on mapping technologic specifications derived from production requirements. Consequently, such systems base their conception on a structurally mechanistic paradigm. Insofar as these approaches have considered humans, their conception likewise is based on the structurally identical paradigm. Due to the fundamental reorientation towards explicitly human-centered approaches, the fact that essential aspects of the dimension "human" remain unconsidered by the previous paradigm becomes more and more apparent. To overcome such limitations, mapping the "social" dimension requires a structurally different approach. In this paper, an anthropocentric approach is developed based on possible conceptions of the human being, enabling a structural integration of the human being in an extended dimension. Through the model, extending concepts for better integration of the human being in the sense of human-centered approaches, as envisioned in the Industrie 5.0 conception, is possible.
The troubles began when Tom, the business analyst, asked the customer what he wants. The customer came up with good ideas for software features. Tom created a brilliant roadmap and defined the requirements for a new software product. Mary, the development team leader, was already eager to start developing and happy when she got the requirements. She and her team went ahead and created the software right away. Afterwards, Paul tested the software against the requirements. As soon as the software fulfilled the requirements, Linda, the product manager, deployed it to the customer. The customer did not like the software and ignored it. Ringo, the head of software development, was fired. How come? Nowadays, we have tremendous capabilities for creating nearly all kinds of software to fulfill the needs of customers. We can apply agile practices for reacting flexibly to changing requirements, we can use distributed development, open source, or other means for creating software at low cost, we can use cloud technologies for deploying software rapidly, and we can get enormous amounts of data showing us how customers actually use software products. However, the sad reality is that around 90% of products fail, and more than 60% of the features of a typical software product are rarely or never used. But there is a silver lining – an insight regarding successful features: Around 60% of the successes stem from a significant change of an initial idea. This gives us a hint on how to build the right software for users and customers.
The incudo-malleal joint (IMJ) in the human middle ear is a true diarthrodial joint and it has been known that the flexibility of this joint does not contribute to better middle-ear sound transmission. Previous studies have proposed that a gliding motion between the malleus and the incus at this joint prevents the transmission of large displacements of the malleus to the incus and stapes and thus contributes to the protection of the inner ear as an immediate response against large static pressure changes. However, dynamic behavior of this joint under static pressure changes has not been fully revealed. In this study, effects of the flexibility of the IMJ on middle-ear sound transmission under static pressure difference between the middle-ear cavity and the environment were investigated. Experiments were performed in human cadaveric temporal bones with static pressures in the range of +/- 2 kPa being applied to the ear canal (relative to middle-ear cavity). Vibrational motions of the umbo and the stapes footplate center in response to acoustic stimulation (0.2-8 kHz) were measured using a 3D-Laser Doppler vibrometer for (1) the natural IMJ and (2) the IMJ with experimentally-reduced flexibility. With the natural condition of the IMJ, vibrations of the umbo and the stapes footplate center under static pressure loads were attenuated at low frequencies below the middle-ear resonance frequency as observed in previous studies. After the flexibility of the IMJ was reduced, additional attenuations of vibrational motion were observed for the umbo under positive static pressures in the ear canal (EC) and the stapes footplate center under both positive and negative static EC pressures. The additional attenuation of vibration reached 4~7 dB for the umbo under positive static EC pressures and the stapes footplate center under negative EC pressures, and 7~11 dB for the stapes footplate center under positive EC pressures. The results of this study indicate an adaptive mechanism of the flexible IMJ in the human middle ear to changes of static EC pressure by reducing the attenuation of the middle-ear sound transmission. Such results are expected to be used for diagnosis of the IMJ stiffening and to be applied to design of middle-ear prostheses.
Learning factories can complement each other by training different competencies in the field of digitalisation and Industry 4.0. They depict diverse sections of the product development process and focus on various technologies. Within the framework of the International Association of Learning Factories (IALF), the operating organisations of learning factories exchange information on research, training and education. One of the aims is to develop joint projects. The article presents different concepts of cooperation between learning factories while focusing on the improvement of the development of learners competencies e.g. with a broader range of topics. A concept of a joint course between the learning factories in Bochum, Reutlingen and Darmstadt is explained in detail. The three learning factories will be examined with regard to their similarities and differences. The joint course focuses on the target group of students and the topic of digitalisation in the development and production of products. The course and its contents are explained in detail. The new learning approach is evaluated on the basis of feedback from the participants. Finally, challenges resulting from the cooperation between learning factories at different locations and with different operating models will be discussed.
COVID-19 and educational inequality: How school closures affect low- and high-achieving students
(2021)
In spring 2020, governments around the globe shut down schools to mitigate the spread of the novel coronavirus. We argue that low-achieving students may be particularly affected by the lack of educator support during school closures. We collect detailed time-use information on students before and during the school closures in a survey of 1099 parents in Germany. We find that while students on average reduced their daily learning time of 7.4 h by about half, the reduction was significantly larger for low-achievers (4.1 h) than for high-achievers (3.7 h). Low-achievers disproportionately replaced learning time with detrimental activities such as TV or computer games rather than with activities more conducive to child development. The learning gap was not compensated by parents or schools who provided less support for low-achieving students.
Cross-linked thermoplastics
(2022)
Cross-linked thermoplastics represent an important class of materials for numerous applications such as heat-shrinkable tubing, rotational molded parts, and polyolefin foams. By cross-linking olefins, their mechanical performance can be significantly enhanced. This chapter covers the three main methods for the cross-linking of thermoplastics: radiation cross-linking, chemical cross-linking with organic peroxides, and cross-linking using silane-grafting agents. It also considers the major effects of the cross-linking procedure on the performance of the thermoplastic materials discussed.
Crosslinked thermoplastics
(2014)
Cross-linked thermoplastics represent an important class of materials for numerous applications such as heat-shrinkable tubing, rotational molded parts, and polyolefin foams. By cross-linking olefins, their mechanical performance can be significantly enhanced. This chapter covers the three main methods for the cross-linking of thermoplastics: radiation cross-linking, chemical cross-linking with organic peroxides, and cross-linking using silane-grafting agents. It also considers the major effects of the cross-linking procedure on the performance of the thermoplastic materials discussed.
For the widespread establishment of a circular economy, the acceptance of used products among consumers is a prerequisite. This paper investigates the customer experience of product service systems related to used products (PSSuP), such as renting, remanufacturing, and second-hand models, and aims to point out the offering characteristics that effect customer response and customer engagement. This study was conducted by means of a content analysis-based literature review of 69 empirical PSSuP studies. A frequency analysis of the categories that determine customer experience creation was conducted, as well as a contingency analysis to reveal the interrelationship between these categories. On this basis, the different PSSuP types were compared, and four strategic orientations of customer experience creation in PSSuP are pointed out: price, confidence, convenience, and delight orientation. For each of these strategic orientations, supportive PSSuP offering characteristics are specified. Building on the findings of this study, theoretical and managerial implications for product–service systems marketing are pointed out, and the need for research on the role of information and communication technology as an enabler of customer experience creation in PSSuP is highlighted.
The generous feed-in tariffs (FiTs) introduced in Germany—which resulted in major growth in decentralized solar photovoltaic (PV) systems—will phase out in the coming years, making many of the existing distributed generation assets stranded. This challenge creates an opportunity for community-focused energy utilities, such as Elektrizitätswerke Schönau eG (EWS) based in Schönau, Germany, to try a new approach to assist its customers, makes the transition to a more sustainable future. This chapter describes how EWS is developing products and offering community-based solutions including peer-to-peer trading using automated platforms. Such innovative offering may lead to successful differentiation in a competitive and highly decentralized future.
Cyanate ester resins
(2022)
Cyanate ester resins are an important class of thermosetting compounds that experience an ever-increasing interest as matrix systems for advanced polymer composite materials, which among other application fields are especially suitable for highly demanding applications in the aerospace or microelectronics industries. Other names for cyanate ester resins are cyanate resins, cyanic esters, or triazine resins. The various types of cyanate ester monomers share the –OCN functional group that trimerizes in the course of resin formation to yield a highly branched heterocyclic polymeric network based on the substituted triazine core structure.
Cyanate esters
(2014)
Cyanate ester resins are an important class of thermosetting compounds that have experienced an ever-increasing interest as matrix systems for advanced polymer composite materials, which among other applications, are especially suitable for highly demanding functions in the aerospace or microelectronics industries. Other names for cyanate ester resins are cyanate resins, cyanic esters, or triazine resins. The various types of cyanate ester monomers share the aOCN functional group that trimerizes in the course of resin formation to yield a highly branched heterocyclic polymeric network based on the substituted triazine core structure. The basic reaction sequence leading to the typical cyanate ester polymer molecule is depicted in Figure 11.1. The curing reaction may take place with or without catalyst.
The data present in this article affords insides in the characterization of a newly described bi-functional furan-melamine monomer, which is used for the production of monodisperse, furan-functionalized melamine formaldehyde particles. In the related research article Urdl et al., 2019 data interpretations can be found. The furan functionalization of particles is necessary to perform reversible Diels-Alder reactions with maleimide (BMI) crosslinker to form thermoreversible network systems. To understand the reaction conditions of Diels Alder (DA) reaction with a Fu-Mel monomer and a maleimide crosslinker, model DA reaction were performed and evaluated using dynamic FT-IR measurements. During retro Diels-Alder (rDA) reactions of the monomer system, it was found out that some side reaction occurred at elevated temperatures. The data of evaluating the side reaction is described in one part of this manuscript. Additional high resolution SEM images of Fu Mel particles are shown and thermoreversible particle networks with BMI2 are shown. The data of different Fu-Mel particle networks with maleimide crosslinker are presented. Therefore, the used maleimide crosslinker with different spacer lengths were synthesized and the resulting networks were analyzed by ATR-FT-IR, SEM and DSC.
This article contains data on the synthesis and mechanical characterization of polysiloxane-based urea-elastomers (PSUs) and is related to the research article entitled “Influence of PDMS molecular weight on transparency and mechanical properties of soft polysiloxane-urea-elastomers for intraocular lens application” (Riehle et al., 2018) [1]. These elastomers were prepared by a two-step polyaddition using the aliphatic diisocyanate 4,4′-Methylenbis(cyclohexylisocyanate) (H12MDI), a siloxane-based chain extender 1,3-Bis(3-aminopropyl)-1,1,3,3-tetramethyldisiloxane (APTMDS) and amino-terminated polydimethylsiloxanes (PDMS) or polydimethyl-methyl-phenyl-siloxane-copolymers (PDMS-Me,Ph), respectively. (More details about the synthesis procedure and the reaction scheme can be found in the related research article (Riehle et al., 2018) [1]).
Amino-terminated polydimethylsiloxanes with varying molecular weights and PDMS-Me,Ph-copolymers were prepared prior by a base-catalyzed ring-chain equilibration of a cyclic siloxane and the endblocker APTMDS. This DiB article contains a procedure for the synthesis of the base catalyst tetramethylammonium-3-aminopropyl-dimethylsilanolate and a generic synthesis procedure for the preparation of a PDMS having a targeted number average molecular weight of 3000 g mol−1. Molecular weights and the amount of methyl-phenyl-siloxane within the polysiloxane-copolymers were determined by 1H NMR and 29Si NMR spectroscopy. The corresponding NMR spectra and data are described in this article.
Additionally, this DiB article contains processed data on in line and off line FTIR-ATR spectroscopy, which was used to follow the reaction progress of the polyaddition by showing the conversion of the diisocyanate. All relevant IR band assignments of a polydimethylsiloxane-urea spectrum are described in this article.
Finally, data on the tensile properties and the mechanical hysteresis-behaviour at 100% elongation of PDMS-based polyurea-elastomers are shown in dependence to the PDMS molecular weight.
The increasing emergence of cyber-physical systems (CPS) and a global crosslinking of these CPS to cyber-physical production systems (CPPS) are leading to fundamental changes of future work and logistic systems requiring innovative methods to plan, control and monitor changeable production systems and new forms of human-machine-collaboration. Particularly logistic systems have to obey the versatility of CPPS and will be transferred to so-called cyber physical logistic systems, since the logistical networks will underlie the requirements of constant changes initiated by changeable production systems. This development is driven and enhanced by increasingly volatile and globalized market and manufacturing environments combined with a high demand for individualized products and services. Also nowadays mainly used centralized control systems are pushed to their limits regarding their abilities to deal with the arising complexity to plan, control and monitor changeable work and logistic systems. Decentralized control systems bear the potential to cope with these challenges by distributing the required operations on various nodes of the resulting decentralized control system.
Learning factories, like the ESB Logistics Learning Factory at ESB Business School (Reutlingen University), provide a wide range of possibilities to develop new methods and innovative technical solutions in a risk-free and close-to-reality factory environment and to transfer knowledge as well as specific competences into the training of students and professionals. To intensify the research and training activities in the field of future work and logistics systems, ESB Business School is transferring its existing production system into a CPPS involving decentralized planning, control and monitoring methods and systems, human-machine-collaboration as well as technical assistance systems for changeable work and logistics systems.
In the context of Industry 4.0, intralogistics faces an increasingly complex and dynamic environment driven by a high level of product customisation and complex manufacturing processes. One approach to deal with these changing conditions is the decentralised and intelligent connectivity of intralogistics systems. However, wireless connectivity presents a major challenge in the industry due to strict requirements such as safety and real-time data transmission. In this context, the fifth generation of mobile communications (5G) is a promising technology to meet the requirements of safety-critical applications. Particularly, since 5G offers the possibility of establishing private 5G networks, also referred to as standalone non-public networks. Through their isolation from public networks, private 5G networks provide exclusive coverage for private organisations offering them high intrinsic network control and data security. However, 5G is still under development and is being gradually introduced in a continuous release process. This process lacks transparency regarding the performance of 5G in individual releases, complicating the successful adoption of 5G as an industrial communication. Additionally, the evaluation of 5G against the specified target performance is insufficient due to the impact of the environment and external interfering factors on 5G in the industrial environment. Therefore, this paper aims to develop a technical decision-support framework that takes a holistic approach to evaluate the practicality of 5G for intralogistics use cases by considering two fundamental stages. The first of these analyses technical parameters and characteristics of the use case to evaluate the theoretical feasibility of 5G. The second stage investigates the application's environment, which substantially impacts the practicality of 5G, for instance, the influence of surrounding materials. Finally, a case study validates the proposed framework by means of an autonomous mobile robot. As a result, the validation proves the proposed framework's applicability and shows the practicality of the autonomous mobile robot, when integrating it into a private 5G network testbed.
Driven by digital transformation, manufacturing systems are heading towards autonomy. The implementation of autonomous elements in manufacturing systems is still a big challenge. Especially small and medium sized enterprises (SME) often lack experience to assess the degree of Autonomous Production. Therefore, a description model for the assessment of stages for Autonomous Production has been identified as a core element to support such a transformation process. In contrast to existing models, the developed SME-tailored model comprises different levels within a manufacturing system, from single manufacturing cells to the factory level. Furthermore, the model has been validated in several case studies.
This paper presents a description model for smart, connected devices used in a manufacturing context. Similar to the wide spread adoption of smart products for personal and private usage, recent developments lead to a plethora of devices offering a variety of features and capabilities. Manufacturing companies undergoing digital transformation demand guidance with respect to the systematic introduction of smart, connected devices. The introduction of smart connected devices constitutes a strategic decision cost due to the high future committed cost after introduction and maintaining a smart device fleet by a vendor. This paper aims to support the introduction efforts by classifying the devices and thus helping companies identify their specific requirements for smart, connected devices before initiating widespread procurement. By mapping the features of these devices based on various attributes, allows the clustering of smart, connected devices including a requirement list for their implementation on the shopfloor. Four individual commercially available smart connected devices were analyzed using the description model.
Normal breathing during sleep is essential for people’s health and well-being. Therefore, it is crucial to diagnose apnoea events at an early stage and apply appropriate therapy. Detection of sleep apnoea is a central goal of the system design described in this article. To develop a correctly functioning system, it is first necessary to define the requirements outlined in this manuscript clearly. Furthermore, the selection of appropriate technology for the measurement of respiration is of great importance. Therefore, after performing initial literature research, we have analysed in detail three different methods and made a selection of a proper one according to determined requirements. After considering all the advantages and disadvantages of the three approaches, we decided to use the impedance measurement-based one. As a next step, an initial conceptual design of the algorithm for detecting apnoea events was created. As a result, we developed an activity diagram on which the main system components and data flows are visually represented.
Detecting the adherence of driving rules in an energy-efficient, safe and adaptive driving system
(2016)
An adaptive and rule-based driving system is being developed that tries to improve the driving behavior in terms of the energy-efficiency and safety by giving recommendations. Therefore, the driving system has to monitor the adherence of driving rules by matching the rules to the driving behavior. However, existing rule matching algorithms are not sufficient, as the data within a driving system is changing frequently. In this paper a rule matching algorithm is introduced that is able to handle frequently changing data within the context of the driving system. 15 journeys were used to evaluate the performance of the rule matching algorithms. The results showed that the introduced algorithm outperforms existing algorithms in the context of the driving system. Thus, the introduced algorithm is suited for matching frequently changing data against rules with a higher performance, why it will be used in the driving system for the detection of broken energy-efficiency of safety-relevant driving rules.
Rapidly changing market conditions and global competition are leading to an increasing complexity of logistics systems and require innovative approaches with respect to the organisation and control of these systems. In scientific research, concepts of autonomously controlled logistics systems show a promising approach to meet the increasing requirements for flexible and efficient order processing. In this context, this work aims to introduce a system that is able to adjust order processing dynamically, and optimise intralogistics transportation regarding various generic intralogistics target criteria. The logistics system under consideration consists of various means of transport for autonomous decision-making and fulfilment of transport orders with defined source-sink relationships. The context of this work is set by introducing the Learning Factory Werk 150 with its existing hardware and software infrastructure and its defined target figures to measure the performance of the system. Specifically, the important target figures cost and performance are considered for the transportation system. The core idea of the system’s logic is to solve the problem of order allocation to specific means of transport by linking a Genetic Algorithm with a Multi-Agent System. The implementation of the developed system is described in an application scenario at the learning factory.
The approach of self-organized and autonomous controlled systems offers great potential to meet new requirements for the economical production of customized products with small batch sizes based on a distributed, flexible management of dynamics and complexity within the production and intralogistics system. To support the practical application of self-organization for intralogistics systems, a catalogue of criteria for the evaluation of the self-organization of flexible logistics systems has been developed and validated, which enables the classification of logistics systems as well as the identification and evaluation of corresponding potentials that can be achieved by increasing the degree of self-organization.
Future intralogistics systems need to adapt flexibly to changing material flow requirements in line with future versatile factory environments, producing personalized products under the performance and cost conditions of today's mass production. Small batch sized down to a batch size of "1" lead to a high complexity in the design and economical manufacturing of these customized products. Intralogistics systems are integrated into higher-level areas (segment level) as well as into upsteam and downstream performance units (system-wide areas). This includes the logistic activities relevant for the system (organized according to storage, picking, transport) such as transportation or storage tasks of tools, semi-finished products, components, assemblies and containers, and waste. Today's centralized material flow control systems, which work based on predefined processes, are not capable and more specifically not suitable to deal with the arising complexity of changeable intralogistics systems. Autononomous, decentralized material flow control systems distribute the required decision-making and control processes on intelligent logistic entities. A major step for the development of an autonomous control method for hybrid intralogistics systems (manual, semi-automated and automated) is the development of a generic archetype for intralogistics systems regarding the system boundaries, elements and relations resulting in a descriptive model taking into account amongst others the time of demand, availability of resources, economic efficiency and technical performance parameters. The ESB Logistics Learning Factory at ESB Business School (Reutlingen University) serves for this as a close-to-reality development and validation environment.
The Industry 4.0 paradigm requires concepts for integrating intelligent/ smart IoT Solutions into manufacturing. Such intelligent solutions are envisioned to increase flexibility and adaptability in smart factories. Especially autonomous cobots capable of adapting to changing conditions are a key enabler for changeable factory concepts. However, identifying the requirements and solution scenarios incorporating intelligent products challenges the manufacturing industry, especially in the SME sector. In pick and place scenarios, changing coordinate systems of workpiece carriers cause placing process errors. Using the IPIDS framework, this paper describes the development of a tool-center-point positioning method to improve the process stability of a collaborative robot in a changeable assembly workstation. Applying the framework identifies the requirement for an intelligent workpiece carrier as a part of the solution. Implementing and evaluating the solution within a changeable factory validates the IPIDS framework.
The Circular Economy aims to reintroduce the value of products back into the economic cycle at the same value chain level. While the activities of the Circular Economy are already well-defined, there exists a gap in how returned products are treated by the industry. This study aims to examine how a process should be designed to handle returned products in the context of the Circular Economy. To achieve this, a machine learning-based algorithm is used to classify data and extract relevant information throughout the product life cycle. The focus of this research is limited to land transportation systems within the Sharing Economy sector.
Due to constantly changing conditions, demand, and technologies, companies increasingly seek flexibility. Productivity results from automation, improved working conditions and the focus of people in production in interaction with machines. Unfortunately, the human factor is often not considered to increase flexibility and productivity with new concepts. This work aims to develop a hybrid assistance system that allows a dynamic configuration of cyber-physical production systems considering the current order situation and available resources utilizing simulation. The system also considers human factors in addition to economic factors, which contributes to the extended economic appraisal.
Development of an easy teaching and simulation solution for an autonomous mobile robot system
(2019)
With mass customized production becoming the mainstream, industries are shifting from large-scale manufacturing to flexible and customized production of small batch sizes. Agile manufacturing strategies adopted by SMEs are driving the usage of collaborative robots in today's factories. Major challenges in the adoption of cobots in the industry are the lack of a highly trained workforce to program the robot to perform complex tasks and integration of robot systems to other smart devices in the factory. In addition, the teaching and simulation by non-robotics experts of many industrial collaborative robot systems like the KUKA LBR iiwa is a major challenge, since these systems are designed to be programmed by robot experts and not by shop floor workers or other non-experts. This paper describes the research and development activities done for reducing the barriers in operation and ensure holistic integration of LBR iiwa cobot in the assembly on the example of the ESB Logistics Learning Factory. These include a visual programming solution for the easy teaching of various tasks. Robotic tasts are classified based on common robotics applications and application-specific blocks abstracting specific actions are implemented. A factory worker with no programming competency cour create robot programs by combining these blocks using a Graphical User Interface. In addition, a simulation solution was developed to visualized, analyse, and optimize robotic workflow before deployment. an autonomous mobile robot is integrated with the LBR iiw to improve reconfigurability and thus also the productivity. The system as a whole is controlled using an event-driven distributed control system. Finally, the capabilities of the system are analysed based on the design principles of Industrie 4.0 and potential future research ideas are discussed to further improve the system.
Development of an expert system to overpass citizens technological barriers on smart home and living
(2023)
Adopting new technologies can be overwhelming, even for people with experience in the field. For the general public, learning about new implementations, releases, brands, and enhancements can cause them to lose interest. There is a clear need to create point sources and platforms that provide helpful information about the novel and smart technologies, assisting users, technicians, and providers with products and technologies. The purpose of these platforms is twofold, as they can gather and share information on interests common to manufacturers and vendors. This paper presents the ”Finde-Dein-SmartHome” tool. Developed in association with the Smart Home & Living competence center [5] to help users learn about, understand, and purchase available technologies that meet their home automation needs. This tool aims to lower the usability barrier and guide potential customers to clear their doubts about privacy and pricing. Communities can use the information provided by this tool to identify market trends that could eventually lower costs for providers and incentivize access to innovative home technologies and devices supporting long-term care.
The self-healing effect of melamine-based surfaces, triggered by temperature, was investigated. The temperature triggered reversible healing chemistry, on which the self-healing effect is based, was the Diels-Alder (DA) reaction between furan and malemeide groups. Melamine-furan containing building blocks were connected by multi-functional maleimide crosslinker via a Diels-Alder (DA) reaction to giva a DA adduct. The DA adduct was then reacted with formaldehyde to form a network by conventional condensation reaction of melamine amino groups with formaldehyde. The obtained resin was characterised and used for the impregnation of paper. Impregnated papers and neat resin werde used to perform scratch-healing tests and mechanical analysis of the novel coating system.
Technologies for mapping the “digital twin“ have been under development for approximately 20 years. Nowadays increasingly intelligent, individualized products encourages companies to respond innovatively to customer requirements and to handle the rising product variations quickly.
An integrated engineering network, spanning across the entire value chain, is operated to intelligently connect various company divisions, and to generate a business ecosystem for products, services and communities. The conditions for the digital twin are thereby determined in which the digital world can be fed into the real, and the real world back into the digital to deal such intelligent products with rising variations.
The term digital twin can be described as a digital copy of a real factory, machine, worker etc., that is created and can be independently expanded, automatically updated as well as being globally available in real time. Every real product and production site is permanently accompanied by a digital twin. First prototypes of such digital twins already exist in the ESB Logistics Learning Factory on a cloud- and app based software that builds on a dynamic, multidimensional data and information model. A standardized language of the robot control systems via software agents and positioning systems has to be integrated. The aspect of the continuity of the real factory in the digital factory as an economical means of ensuring continuous actuality of digital models looks as the basis of changeability.
For the indoor localization sensor combinations that in addition to the hardware already contain the software required for the sensor data fusion should be used. Processing systems, scenario-live-simulations and digital shop floor management results in a mandatory procedural combination. Essential to the digital twin is the ability to consistently provide all subsystems with the latest state of all required information, methods and algorithms.
Mystery shopping (MS) is a widely used tool to monitor the quality of service and personal selling. In consultative retail settings, assessments of mystery shoppers are supposed to capture the most relevant aspects of sales people’s service and sales behavior. Given the important conclusions drawn by managers from MS results, the standard assumption seems to be that assessments of mystery shoppers are strongly related to customer satisfaction and sales performance. However, surprisingly scant empirical evidence supports this assumption. We test the relationship between MS assessments and customer evaluations and sales performance with large-scale data from three service retail chains. Surprisingly, we do not find asubstantial correlation. The results show that mystery shoppers are not good proxies for real customers. While MS assessments are not related to sales, our findings confirm the established correlation between customer satisfaction measurements and sales results.
The paradigmatic shift of production systems towards Cyber-Physical Production Systems (CPPSs) requires the development of flexible and decentralized approaches. In this way, such systems enable manufacturers to respond quickly and accurately to changing requirements. However, domain-specific applications require the use of suitable conceptualizations. The issue at hand, when using various conceptualizations is the interoperability of different ontologies. To achieve flexibility and adaptability in CPPSs though requires overcoming interoperability issues within CPPSs. This paper presents an approach to increase flexibility and adaptability in CPPSs while addressing the interoperability issue. In this work, OWL ontologies conceptualize domain knowledge. The Intelligent Manufacturing Knowledge Ontology Repository (IMKOR) connects the domain knowledge in different ontologies. Testing if adaptions in one ontology within the IMKOR provide knowledge to the whole IMKOR. The tests showed, positive results and the repository makes the knowledge available to the whole CPPS. Furthermore, an increase in flexibility and adaptability was noticed.
Fatigue and drowsiness are responsible for a significant percentage of road traffic accidents. There are several approaches to monitor the driver's drowsiness, ranging from the driver's steering behavior to the analysis of the driver, e.g. eye tracking, blinking, yawning, or electrocardiogram (ECG). This paper describes the development of a low-cost ECG sensor to derive heart rate variability (HRV) data for drowsiness detection. The work includes hardware and software design. The hardware was implemented on a printed circuit board (PCB) designed so that the board can be used as an extension shield for an Arduino. The PCB contains a double, inverted ECG channel including low-pass filtering and provides two analog outputs to the Arduino, which combines them and performs the analog-to-digital conversion. The digital ECG signal is transferred to an NVidia embedded PC where the processing takes place, including QRS-complex, heart rate, and HRV detection as well as visualization features. The resulting compact sensor provides good results in the extraction of the main ECG parameters. The sensor is being used in a larger frame, where facial-recognition-based drowsiness detection is combined with ECG-based detection to improve the recognition rate under unfavorable light or occlusion conditions.
Palladium-doped silica materials with SiCH3 groups were fabricated by sol-gel method under various calcination atmospheres and membranes were made thereof by coating process. The results showed that air atmosphere can lead to the partial oxidation of metallic Pd0 to PdO while N2 and H2 atmospheres can effectively prevent metallic Pd0 from being oxidized. H2 atmosphere is proved to be a more prominent way to slow down the decomposition of organic SiCH3 group than N2 and air atmospheres. The surface area, micropore volume and porosity of palladium-doped silica membrane material calcined in H2 atmosphere are much higher than those calcined in N2 atmosphere. Compared with N2 atmosphere, the palladium-doped silica membranes calcined in H2 atmosphere showed higher H2 permeability and H2/CO2 selectivity before and after the steam exposure. The apparent activation energy of H2 permeation through the palladium-doped silica membrane calcined under H2 atmosphere (2.51 ± 0.05 kJ/mol) was slightly lower than that calcined under N2 atmosphere (2.84 ± 0.04 kJ/mol). Calcination atmosphere plays some role in membrane performance, which has greater influence on the permeance than on the gas permselectivity. Calcination under H2 atmosphere is well conducive to improve the gas permeance and H2 permselectivity of palladium-doped silica membrane.
Here, we report the continuous peroxide-initiated grafting of vinyltrimethoxysilane (VTMS) onto a standard polyolefin by means of reactive extrusion to produce a functionalized liquid ethylene propylene copolymer (EPM). The effects of the process parameters governing the grafting reaction and their synergistic interactions are identified, quantified and used in a mathematical model of the extrusion process. As process variables the VTMS and peroxide concentrations and the extruder temperature setting were systematically studied for their influence on the grafting and the relative grafting degree using a face-centered central composite design (FCD). The grafting degree was quantified by 1H NMR spectroscopy. Response surface methodology (RSM) was used to calculate the most efficient grafting process in terms of chemical usage and graft yield. With the defined processing window, it was possible to make precise predictions about the grafting degree with at the same time highest possible relative degree of grafting.
In vitro composed vascularized adipose tissue is and will continue to be in great demand e.g. for the treatment of extensive high-graded burns or the replacement of tissue after tumor removal. Up to date, the lack of adequate culture conditions, mainly a culture medium, decelerates further achievements. In our study, we evaluated the influence of epidermal growth factor (EGF) and hydrocortisone (HC), often supplemented in endothelial cell (EC) specific media, on the co-culture of adipogenic differentiated adipose derived stem cells (ASCs) and microvascular endothelial cells (mvECs). In ASCs, EGF and HC are thought to inhibit adipogenic differentiation and have lipolytic activities. Our results showed that in indirect co-culture for 14 days, adipogenic differentiated ASCs further incorporated lipids and partly gained an univacuolar morphology when kept in media with low levels of EGF and HC. In media with high EGF and HC levels, cells did not incorporate further lipids, on the contrary, cells without lipid droplets appeared. Glycerol release, to measure lipolysis, also increased with elevated amounts of EGF and HC in the culture medium. Adipogenic differentiated ASCs were able to release leptin in all setups. MvECs were functional and expressed the cell specific markers, CD31 and von Willebrand factor (vWF), independent of the EGF and HC content as long as further EC specific factors were present. Taken together, our study demonstrates that adipogenic differentiated ASCs can be successfully co-cultured with mvECs in a culture medium containing low or no amounts of EGF and HC, as long as further endothelial cell and adipocyte specific factors are available.
Several ionic liquids are excellent solvents for cellulose. Starting from that finishing of PET fabrics with cellulose dissolved in ionic liquids like 1-ethyl 3-methyl imidazolium acetate, diethylphosphate and chloride, or the chloride of butyl-methyl imidazolium has been investigated. Finishing has been carried out from solutions of different concentrations, using microcrystalline cellulose or cotton and by employing different cross-linkers. Viscosity of solutions has been investigated for different ionic liquids,concentrations, cellulose sources, linkers and temperatures. Since ionic liquids exhibit no vapor pressure,simple pad-dry-cure processes are excluded. Before drying the ionic liquid has to be removed by a rinsing step. Accordingly rinsing with fresh ionic liquid followed by water or the direct rinsing with waterhave been tested. The amount of cellulose deposited has been investigated by gravimetry, zinc chlorideiodine test as well as reactive dyeing. Results concerning wettability, water up-take, surface resistance,wear-resistance or washing stability are presented.
Nowadays CHP units are discussed for the production of electricity on demand rather than for generation of heat providing electricity as a by-product. By this means, CHP units are capable of satisfying a higher share of the electricity demand on-site and in this new role, CHP units are able to reduce the load on the power grid and to compensate for high fluctuations of solar and wind power.
Evidently, a novel control strategy for CHP units is required in order to shift the operation oriented at the heat demand to an operation led by the electricity demand. Nevertheless, the heat generated by the CHP unit needs to be utilized completely in any case, for maintaining energy as well as economic efficiency. Such a strategy has been developed at Reutlingen University, and it will be presented in the paper. Part of the strategy is an intelligent management for the thermal energy storage (TES) ensuring that the storage is at low level in terms of its heat content just before an electricity demand is calling the CHP unit into operation. Moreover, a proper forecast of both, heat and electricity demand, is incorporated and the requirements of the CHP unit in terms of maintenance and lifetime are considered by limiting the number of starts and stops per unit time and by maintaining a certain minimum length of the operation intervals.
All aspects of this novel control strategy are revealed in the paper, which has been implemented on a controller for further testing at two sites in the field. Results from these tests are given as well as results from a simulation model, which is able to evaluate the performance of the control strategy for an entire year.
Modern power DMOS transistors greatly benefit from the continuous advances of the technology, which yield devices with very low area-specific RDS,on figures of merit and therefore allow for significantly reduced active areas. However, in many applications, where the devices must dissipate high amounts of energy and thus are subjected to significant self-heating, the active area is not dictated by RDS,on requirements, but by the energy constraints. In this paper, a simple method of improving the energy capability and reliability of power DMOS transistors operating in pulsed conditions is proposed and experimentally verified. The method consists in redistributing the power density from the hotter to the cooler device regions, hence achieving a more homogeneous temperature distribution and a reduced peak temperature. To demonstrate the principle, a simple gate offset circuit is used to redistribute the current density to the cooler DMOS parts. No technology changes are needed for the implementation, only minor changes to the driver circuit are necessary, with a minimal impact on the additional required active area. Improvements in the energy capability from 9.2% up to 39% have been measured. Furthermore, measurements have shown that the method remains effective also if the operating conditions change significantly. The simplicity and the effectiveness of the implementation makes the proposed method suitable to be used in a wide range of applications.
In an effort to make the cultural and institutional aspects of energy efficiency in industrial organizations more visible, this article introduces a theoretical framework of decision-making processes. Taking a sociological perspective and viewing organizations as cultural systems embedded in wider social contexts, I have developed a multilevel framework addressing institutional, organizational, and individual dimensions shaping decisions on energy efficiency. The framework's development is based on qualitative empirical fieldwork and integrates insights into organizational theory; neo-institutional theory, the attention-based view of the firm, and organizational culture theories. I conclude that decisions on energy efficiency are results of problematization and theorization processes. These processes emerge between the institutional issue-field, the organization, and its members. The model explains decisions shaped by environment (external and material), organizational processes (energy-efficiency practices, climate and culture) and individuals’ characteristics. The framework serves several purposes: introducing a meta-theory of decision making, providing a concept for empirical analysis, and enabling connectivity to the research on barriers.
Traditional communication of research on climate change fails to encourage individual, corporate, and political leaders to take appropriate action. We argue that this problem is based on an overly simplistic unidirectional model of science communication. Conversely, theory shows that active learning processes are better suited to initiate and mobilize engagement among all stakeholders. Here, we integrate theoretical insights on active learning with empirical evidence from serious gaming: communication should be understood as an integral design feature that relates active learning on climate change to tangible action.
Hypothesis
The origin of negative surface charge at water/air interface is still not clear. The most probable origin is specific adsorption of OH− ions. From diffuse layer potential, we can evaluate the surface density of ions in the Stern layer which can be a measure for the specific adsorption of ions and determines whether the surface charge is solely due to the specific adsorption of OH− ions.
Experiments
Equilibrium thickness of foam films of pure water and aqueous solutions of NaCl, HCl, and NaOH was measured as a function of disjoining pressure for water and as a function of concentration for the aqueous solutions at 298.15 K. Quartz-glass cells thoroughly cleaned and immersed in pure water before use were used for the measurement.
Findings
Application of a modified Poisson-Boltzmann equation to the equilibrium film thickness gave the diffuse layer potential and the surface density of ions in the Stern layer. From the concentration dependence of the surface density, it was concluded that not only OH− ions but also Cl− ions and HCO3− and/or CO32− ions adsorb specifically at the water/air interface.
Nowadays, the importance of early active patient mobilization in the recovery and rehabilitation phase has increased significantly. One way to involve patients in the treatment is a gamification-like approach, which is one of the methods of motivation in various life processes. This article shows a system prototype for patients who require physical activity because of active early mobilization after medical interventions or during illness. Bedridden patients and people with a sedentary lifestyle (predominantly lying in bed) are also potential users. The main idea for the concept was non-contact system implementation for the patients making them feel effortless during its usage. The system consists of three related parts: hardware, software, and game application. To test the relevance and coherence of the system, it was used by 35 people. The participants were asked to play a video game requiring them to make body movements while lying down. Then they were asked to take part in a small survey to evaluate the system's usability. As a result, we offer a prototype consisting of hardware and software parts that can increase and diversify physical activity during active early mobilization of patients and prevent the occurrence of possible health problems due to predominantly low activity. The proposed design can be possibly implemented in hospitals, rehabilitation centers, and even at home.
Today, many industrial tasks are not automated and still require human intervention. One of these tasks is the unloading of oversea containers. After the end of transportation to the sorting center, the containers must be unloaded manually for further sending the parcels to the recipients. A robot-based automatic unloading of containers was therefore researched. However, the promising results of the system developed in these projects could not be commercialized due to problems with its reliability. Mechanical, algorithmic or other limitations are possible causes of the observed errors. To analyze errors, it is necessary to evaluate the results of the robot’s work without complicating the existing system by adding new sensors to it. This paper presents a reference system based on machine learning to evaluate the robotics grasps of parcels. It analyzes two states of the container: before and after picking up one box. The states are represented as a point cloud received from a laser scanner. The proposed system evaluates the success of transferring a box from an overseas container to the sorting line by supervised learning using convolutional neural networks (CNN) and manual labeling of the data. The process of obtaining a working model using a hyperband model search with a maximum classification error of 3.9 % is also described.
Since November 2011 the standard DIN 4709 stipulates performance tests for Micro-CHP units in Germany. In contrast to steady state measurements of the CHP unit itself, the test according to DIN 4709 includes the thermal storage tank as well as the internal control unit, and it is based on a 24 h test cycle following a specified thermal load profile. Hence, heat losses from the storage tank are as well taken into account as transient losses of the CHP unit. In addition, the control strategy for loading and unloading the storage tank affects the test results.
The DIN 4709 test cycle has been applied at the test stand for Micro-CHP units at Reutlingen University, and results for the Micro-CHP unit WhisperGen and the EC Power units XRGI 15® and XRGI 20® are available. During the analysis a method has been developed to evaluate the results in case the test cycle does not end in a time slot between 24 and 24.5 h after the starting as demanded by DIN 4709. Since this method has been successfully applied to the test of various CHP units of different size and technology so far, it is suggested to incorporate it to DIN 4709 during the next revision of the standard.
The performance numbers obtained reveal the differences in efficiencies measured at steady-state on the one hand and following the DIN 4709 test cycle on the other hand. While the deviations in electrical efficiencies are small, thermal efficiencies according to DIN 4709 fall below steady state data by 3–6 percentage points. This is attributed to transient thermal losses and heat losses from the storage tank, which are not included in steady state and separate testing of the CHP unit, only.