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Human bestrophin-1 (hBest1) is a transmembrane Ca2+- dependent anion channel, associated with the transport of Cl−, HCO3- ions, γ-aminobutiric acid (GABA), glutamate (Glu), and regulation of retinal homeostasis. Its mutant forms cause retinal degenerative diseases, defined as Bestrophinopathies. Using both physicochemical - surface pressure/mean molecular area (π/A) isotherms, hysteresis, compressibility moduli of hBest1/sphingomyelin (SM) monolayers, Brewster angle microscopy (BAM) studies, and biological approaches - detergent membrane fractionation, Laurdan (6-dodecanoyl-N,N-dimethyl-2-naphthylamine) and immunofluorescence staining of stably transfected MDCK-hBest1 and MDCK II cells, we report:
1) Ca2+, Glu and GABA interact with binary hBest1/SM monolayers at 35 °C, resulting in changes in hBest1 surface conformation, structure, self-organization and surface dynamics. The process of mixing in hBest1/SM monolayers is spontaneous and the effect of protein on binary films was defined as “fluidizing”, hindering the phase-transition of monolayer from liquid-expanded to intermediate (LE-M) state;
2) in stably transfected MDCK-hBest1 cells, bestrophin-1 was distributed between detergent resistant (DRM) and detergent-soluble membranes (DSM) - up to 30 % and 70 %, respectively; in alive cells, hBest1 was visualized in both liquid-ordered (Lo) and liquid-disordered (Ld) fractions, quantifying protein association up to 35 % and 65 % with Lo and Ld. Our results indicate that the spontaneous miscibility of hBest1 and SM is a prerequisite to diverse protein interactions with membrane domains, different structural conformations and biological functions.
The Twelfth International Conference on Advances in Databases, Knowledge, and Data Applications (DBKDA 2020) continued a series of events covering a large spectrum of topics related to advances in fundamentals on databases, evolution of relation between databases and other domains, data base technologies and content processing, as well as specifics in applications domains databases. Advances in different technologies and domains related to databases triggered substantial improvements for content processing, information indexing, and data, process and knowledge mining. The push came from Web services, artificial intelligence, and agent technologies, as well as from the generalization of the XML adoption. High-speed communications and computations, large storage capacities, and load-balancing for distributed databases access allow new approaches for content processing with incomplete patterns, advanced ranking algorithms and advanced indexing methods. Evolution on e-business, ehealth and telemedicine, bioinformatics, finance and marketing, geographical positioning systems put pressure on database communities to push the ‘de facto’ methods to support new requirements in terms of scalability, privacy, performance, indexing, and heterogeneity of both content and technology.
Steady state efficiency optimization techniques for induction motors are state of the art and various methods have already been developed. This paper provides new insights in the efficiency optimized operation in dynamic regime. The paper proposes an anticipative flux modification in order to decrease losses during torque and speed transients. These trajectories are analyzed based on a numerical study for different motors. Measurement results for one motor are given as well.
The shift of populations to cities is creating challenges in many respects, thus leading to increasing demand for smart solutions of urbanization problems. Smart city applications range from technical and social to economic and ecological. The main focus of this work is to provide a systematic literature review of smart city research to answer two main questions: (1) How is current research on smart cities structured? and (2) What directions are relevant for future research on smart cities? To answer these research questions, a text-mining approach is applied to a large number of publications. This provides an overview and gives insights into relevant dimensions of smart city research. Although the main dimensions of research are already described in the literature, an evaluation of the relevance of such dimensions is missing. Findings suggest that the dimensions of environment and governance are popular, while the dimension of economy has received only limited attention.
Purpose: Despite growing interest in the intersection of supply chain management (SCM) and management accounting (MA) in the academic debate, there is a lack of understanding regarding both the content and the delimitation of this topic. As of today, no common conceptualization of supply chain management accounting (SCMA) exists. The purpose of this study is to provide an overview of the research foci of SCMA in the scholarly debate of the past two decades. Additionally, it analyzes whether and to what extent the academic discourse of MA in SCs has already found its way into both SCM and MA higher education, respectively.
Design/methodology/approach: A content analysis is conducted including 114 higher education textbooks written in English or in German language.
Findings: The study finds that SC-specific concepts of MA are seldom covered in current textbooks of both disciplines. The authors conclude that although there is an extensive body of scholarly research about SCMA concepts, there is a significant discrepancy with what is taught in higher education textbooks.
Practical implications: There is a large discrepancy between the extensive knowledge available in scholarly research and what we teach in both disciplines. This implies that graduates of both disciplines lack important knowledge and skills in controlling and accounting for SCs. To bring about the necessary change, MA and SCM in higher education must be more integrative.
Originality/value: To the best of the authors knowledge, this study is first of its kind comprising a large textbook sample in both English and German languages. It is the first substantiated assessment of the current state of integration between SCM and MA in higher education.
Driven by digital transformation, manufacturing systems are heading towards autonomy. The implementation of autonomous elements in manufacturing systems is still a big challenge. Especially small and medium sized enterprises (SME) often lack experience to assess the degree of Autonomous Production. Therefore, a description model for the assessment of stages for Autonomous Production has been identified as a core element to support such a transformation process. In contrast to existing models, the developed SME-tailored model comprises different levels within a manufacturing system, from single manufacturing cells to the factory level. Furthermore, the model has been validated in several case studies.
Process quality has reached a high level on mass production, utilizing well known methods like the DoE. The drawback of the unterlying statistical methods is the need for tests under real production conditions, which cause high costs due to the lost output. Research over the last decade let to methods for correcting a process by using in-situ data to correct the process parameters, but still a lot of pre-production is necessary to get this working. This paper presents a new approach in improving the product quality in process chains by using context data - which in part are gathered by using Industry 4.0 devices - to reduce the necessary pre-production.
In recent years, machine learning algorithms have made a huge development in performance and applicability in industry and especially maintenance. Their application enables predictive maintenance and thus offers efficiency increases. However, a successful implementation of such solutions still requires high effort in data preparation to obtain the right information, interdisciplinarity in teams as well as a good communication to employees. Here, small and medium sized enterprises (SME) often lack in experience, competence and capacity. This paper presents a systematic and practice-oriented method for an implementation of machine learning solutions for predictive maintenance in SME, which has already been validated.
The chemical synthesis of polysiloxanes from monomeric starting materials involves a series of hydrolysis, condensation and modification reactions with complex monomeric and oligomeric reaction mixtures. Real-time monitoring and precise process control of the synthesis process is of great importance to ensure reproducible intermediates and products and can readily be performed by optical spectroscopy. In chemical reactions involving rapid and simultaneous functional group transformations and complex reaction mixtures, however, the spectroscopic signals are often ambiguous due to overlapping bands, shifting peaks and changing baselines. The univariate analysis of individual absorbance signals is hence often only of limited use. In contrast, batch modelling based on the multivariate analysis of the time course of principal components (PCs) derived from the reaction spectra provides a more efficient tool for real time monitoring. In batch modelling, not only single absorbance bands are used but information over a broad range of wavelengths is extracted from the evolving spectral fingerprints and used for analysis. Thereby, process control can be based on numerous chemical and morphological changes taking place during synthesis. “Bad” (or abnormal) batches can quickly be distinguished from “normal” ones by comparing the respective reaction trajectories in real time. In this work, FTIR spectroscopy was combined with multivariate data analysis for the in-line process characterization and batch modelling of polysiloxane formation. The synthesis was conducted under different starting conditions using various reactant concentrations. The complex spectral information was evaluated using chemometrics (principal component analysis, PCA). Specific spectral features at different stages of the reaction were assigned to the corresponding reaction steps. Reaction trajectories were derived based on batch modelling using a wide range of wavelengths. Subsequently, complexity was reduced again to the most relevant absorbance signals in order to derive a concept for a low-cost process spectroscopic set-up which could be used for real-time process monitoring and reaction control.
The automation of work by means of disruptive technologies such as Artificial Intelligence (AI) and Robotic Process Automation (RPA) is currently intensely discussed in business practice and academia. Recent studies indicate that many tasks manually conducted by humans today will not in the future. In a similar vein, it is expected that new roles will emerge. The aim of this study is to analyze prospective employment opportunities in the context of RPA in order to foster our understanding of the pivotal qualifications, expertise and skills necessary to find an occupation in a completely changing world of work. This study is based on an explorative, content analysis of 119 job advertisements related to RPA in Germany. The data was collected from major German online job platforms, qualitatively coded, and subsequently analyzed quantitatively. The research indicates that there indeed are employment opportunities, especially in the consulting sector. The positions require different technological expertise such as specific programming languages and knowledge in statistics. The results of this study provide guidance for organizations and individuals on reskilling requirements for future employment. As many of the positions require profound IT expertise, the generally accepted perspective that existing employees affected by automation can be retrained to work in the emerging positions has to be seen extremely critical. This paper contributes to the body of knowledge by providing a novel perspective on the ongoing discussion of employment opportunities, and reskilling demands of the existing workforce in the context of recent technological developments and automation.
Despite strong political efforts in Europe, industrial small- and medium sized enterprises (SMEs) seem to neglect adopting practices for energy effciency. By taking a cultural perspective, this study investigated what drives the establishment of energy effciency and corresponding practices in SMEs. Based on 10 ethnographic case studies and a quantitative survey among 500 manufacturing SMEs, the results indicate the importance of everyday employee behavior in achieving energy savings. The studied enterprises value behavior related measures as similarly important as technical measures. Raising awareness for energy issues within the organization, therefore, constitutes an essential leadership task that is oftentimes perceived as challenging and frustrating. It was concluded that the embedding of energy efficiency in corporate strategy, the use of a broad spectrum of different practices, and the empowerment and involvement of employees serve as major drivers in establishing energy effciency within SMEs. Moreover, the findings reveal institutional influences on shaping the meanings of energy effciency for the SMEs by raising attention for energy effciency in the enterprises and making energy effciency decisions more likely. The main contribution of the paper is to offer an alternative perspective on energy effciency in SMEs beyond the mere adoption of energy-effcient technology.
In recent years, the development and application of decellularized extracellular matrices (ECMs) for use as biomaterials have grown rapidly. These cell-derived matrices (CDMs) represent highly bioactive and biocompatible materials consisting of a complex assembly of biomolecules. Even though CDMs mimic the natural microenvironment of cells in vivo very closely, they still lack specifically addressable functional groups, which are often required to tailor a biomaterial functionality by bioconjugation. To overcome this limitation, metabolic glycoengineering has emerged as a powerful tool to equip CDMs with chemical groups such as azides. These small chemical handles are known for their ability to undergo bioorthogonal click reactions, which represent a desirable reaction type for bioconjugation. However, ECM insolubility makes its processing very challenging. In this contribution, we isolated both the unmodified ECM and azide-modified clickECM by osmotic lysis. In a first step, these matrices were concentrated to remove excessive water from the decellularization step. Next, the hydrogel-like ECM and clickECM films were mechanically fragmentized, resulting in easy to pipette suspensions with fragment sizes ranging from 7.62 to 31.29 μm (as indicated by the mean d90 and d10 values). The biomolecular composition was not impaired as proven by immunohistochemistry. The suspensions were used for the reproducible generation of surface coatings, which proved to be homogeneous in terms of ECM fragment sizes and coating thicknesses (the mean coating thickness was found to be 33.2 ± 7.3 μm). Furthermore, they were stable against fluid-mechanical abrasion in a laminar flow cell. When primary human fibroblasts were cultured on the coated substrates, an increased bioactivity was observed. By conjugating the azides within the clickECM coatings with alkyne-coupled biotin molecules, a bioconjugation platform was obtained, where the biotin–streptavidin interaction could be used. Its applicability was demonstrated by equipping the bioactive clickECM coatings with horseradish peroxidase as a model enzyme.
The extracellular matrix (ECM) naturally surrounds cells in humans, and therefore represents the ideal biomaterial for tissue engineering. ECM from different tissues exhibit different composition and physical characteristics. Thus, ECM provides not only physical support but also contains crucial biochemical signals that influence cell adhesion, morphology, proliferation and differentiation. Next to native ECM from mature tissue, ECM can also be obtained from the in vitro culture of cells. In this study, we aimed to highlight the supporting effect of cell-derived- ECM (cdECM) on adipogenic differentiation. ASCs were seeded on top of cdECM from ASCs (scdECM) or pre-adipocytes (acdECM). The impact of ECM on cellular activity was determined by LDH assay, WST I assay and BrdU assay. A supporting effect of cdECM substrates on adipogenic differentiation was determined by oil red O staining and subsequent quantification. Results revealed no effect of cdECM substrates on cellular activity. Regarding adipogenic differentiation a supporting effect of cdECM substrates was obtained compared to control. With these results, we confirm cdECM as a promising biomaterial for adipose tissue engineering.
Bone tissue is highly vascularized. The crosstalk of vascular and osteogenic cells is not only responsible for the formation of the strongly divergent tissue types but also for their physiological maintenance and repair. Extrusion-based bioprinting presents a promising fabrication method for bone replacement. It allows for the production of large-volume constructs, which can be tailored to individual tissue defect geometries. In this study, we used the all-gelatin-based toolbox of methacryl-modified gelatin (GM), non-modified gelatin (G) and acetylated GM (GMA) to tailor both the properties of the bioink towards improved printability, and the properties of the crosslinked hydrogel towards enhanced support of vascular network formation by simple blending. The vasculogenic behavior of human dermal microvascular endothelial cells (HDMECs) and human adipose-derived stem cells (ASCs) was evaluated in the different hydrogel formulations for 14 days. Co-culture constructs including a vascular component and an osteogenic component (i.e. a bone bioink based on GM, hydroxyapatite and ASCs) were fabricated via extrusion-based bioprinting. Bioprinted co-culture constructs exhibited functional tissue-specific cells whose interplay positively affected the formation and maintenance of vascular-like structures. The setup further enabled the deposition of bone matrix associated proteins like collagen type I, fibronectin and alkaline phosphatase within the 30-day culture.
Improvement of a three-layered in vitro skin model for topical application of irritating substances
(2020)
In the field of skin tissue engineering, the development of physiologically relevant in vitro skin models comprising all skin layers, namely epidermis, dermis, and subcutis, is a great challenge. Increasing regulatory requirements and the ban on animal experiments for substance testing demand the development of reliable and in vivo-like test systems, which enable high-throughput screening of substances. However, the reproducibility and applicability of in vitro testing has so far been insufficient due to fibroblast-mediated contraction. To overcome this pitfall, an advanced 3-layered skin model was developed. While the epidermis of standard skin models showed an 80% contraction, the initial epidermal area of our advanced skin models was maintained. The improved barrier function of the advanced models was quantified by an indirect barrier function test and a permeability assay. Histochemical and immunofluorescence staining of the advanced model showed well-defined epidermal layers, a dermal part with distributed human dermal fibroblasts and a subcutis with round-shaped adipocytes. The successful response of these advanced 3-layered models for skin irritation testing demonstrated the suitability as an in vitro model for these clinical tests: only the advanced model classified irritative and non-irritative substances correctly. These results indicate that the advanced set up of the 3-layered in vitro skin model maintains skin barrier function and therefore makes them more suitable for irritation testing.
Different types of raw cotton were investigated by a commercial ultraviolet-visible/near infrared (UV-Vis/NIR) spectrometer (210–2200 nm) as well as on a home-built setup for NIR hyperspectral imaging (NIR-HSI) in the range 1100–2200 nm. UV-Vis/NIR reflection spectroscopy reveals the dominant role proteins, hydrocarbons and hydroxyl groups play in the structure of cotton. NIR-HSI shows a similar result. Experimentally obtained data in combination with principal component analysis (PCA) provides a general differentiation of different cotton types. For UV-Vis/NIR spectroscopy, the first two principal components (PC) represent 82 % and 78 % of the total data variance for the UV-Vis and NIR regions, respectively. Whereas, for NIR-HSI, due to the large amount of data acquired, two methodologies for data processing were applied in low and high lateral resolution. In the first method, the average of the spectra from one sample was calculated and in the second method the spectra of each pixel were used. Both methods are able to explain ≥90 % of total variance by the first two PCs. The results show that it is possible to distinguish between different cotton types based on a few selected wavelength ranges. The combination of HSI and multivariate data analysis has a strong potential in industrial applications due to its short acquisition time and low-cost development. This study opens a novel possibility for a further development of this technique towards real large-scale processes.
This book presents an empirical investigation of the efforts that multinational pharmaceutical companies take in order to find a business model that allows for a profitable access to the Bottom of the Pyramid (BoP) markets. The Bottom of the Pyramid in Africa is frequently mentioned as an attractive market due to its sheer size. Yet most companies struggle to access it because of the low price level, difficult physical market access and challenges when it comes to payment.
More specifically, the book investigates the following business model-related questions: Do pharmaceutical companies provide products that meet the needs of the BoP? What characterizes the value generation of the company? What revenue model leads to a profitable business, and what role does a network of partners play in the business model?
Findings reveal that there is no ‘one-size-fits-all’ answer to these questions. Providing continuous availability, affordability at a good quality of goods and services, creating health awareness, as well as localizing business to achieve a level of inclusivenessare essential prerequisites for success. In the last chapter this book provides a business model prototype that accounts for these key success factors for business at the Bottom of the Pyramid and points to further research topics.
Here, we report the mechanical and water sorption properties of a green composite based on Typha latifolia fibres. The composite was prepared either completely binder-less or bonded with 10% (w/w) of a bio-based resin which was a mixture of an epoxidized linseed oil and a tall-oil based polyamide. The flexural modulus of elasticity, the flexural strength and the water absorption of hot pressed Typha panels were measured and the influence of pressing time and panel density on these properties was investigated. The cure kinetics of the biobased resin was analyzed by differential scanning calorimetry (DSC) in combination with the iso-conversional kinetic analysis method of Vyazovkin to derive the curing conditions required for achieving completely cured resin. For the binderless Typha panels the best technological properties were achieved for panels with high density. By adding 10% of the binder resin the flexural strength and especially the water absorption were improved significantly.
Here, we report the continuous peroxide-initiated grafting of vinyltrimethoxysilane (VTMS) onto a standard polyolefin by means of reactive extrusion to produce a functionalized liquid ethylene propylene copolymer (EPM). The effects of the process parameters governing the grafting reaction and their synergistic interactions are identified, quantified and used in a mathematical model of the extrusion process. As process variables the VTMS and peroxide concentrations and the extruder temperature setting were systematically studied for their influence on the grafting and the relative grafting degree using a face-centered central composite design (FCD). The grafting degree was quantified by 1H NMR spectroscopy. Response surface methodology (RSM) was used to calculate the most efficient grafting process in terms of chemical usage and graft yield. With the defined processing window, it was possible to make precise predictions about the grafting degree with at the same time highest possible relative degree of grafting.
nKV in action: accelerating KVstores on native computational storage with NearData processing
(2020)
Massive data transfers in modern data intensive systems resulting from low data-locality and data-to-code system design hurt their performance and scalability. Near-data processing (NDP) designs represent a feasible solution, which although not new, has yet to see widespread use.
In this paper we demonstrate various NDP alternatives in nKV, which is a key/value store utilizing native computational storage and near-data processing. We showcase the execution of classical operations (GET, SCAN) and complex graph-processing algorithms (Betweenness Centrality) in-situ, with 1.4x-2.7x better performance due to NDP. nKV runs on real hardware - the COSMOS+ platform.
Massive data transfers in modern key/value stores resulting from low data-locality and data-to-code system design hurt their performance and scalability. Near-data processing (NDP) designs represent a feasible solution, which although not new, have yet to see widespread use.
In this paper we introduce nKV, which is a key/value store utilizing native computational storage and near-data processing. On the one hand, nKV can directly control the data and computation placement on the underlying storage hardware. On the other hand, nKV propagates the data formats and layouts to the storage device where, software and hardware parsers and accessors are implemented. Both allow NDP operations to execute in host-intervention-free manner, directly on physical addresses and thus better utilize the underlying hardware. Our performance evaluation is based on executing traditional KV operations (GET, SCAN) and on complex graph-processing algorithms (Betweenness Centrality) in-situ, with 1.4×-2.7× better performance on real hardware – the COSMOS+ platform.
Massive data transfers in modern data intensive systems resulting from low data-locality and data-to-code system design hurt their performance and scalability. Near-data processing (NDP) and a shift to code-to-data designs may represent a viable solution as packaging combinations of storage and compute elements on the same device has become viable.
The shift towards NDP system architectures calls for revision of established principles. Abstractions such as data formats and layouts typically spread multiple layers in traditional DBMS, the way they are processed is encapsulated within these layers of abstraction. The NDP-style processing requires an explicit definition of cross-layer data formats and accessors to ensure in-situ executions optimally utilizing the properties of the underlying NDP storage and compute elements. In this paper, we make the case for such data format definitions and investigate the performance benefits under NoFTL-KV and the COSMOS hardware platform.
The tale of 1000 cores: an evaluation of concurrency control on real(ly) large multi-socket hardware
(2020)
In this paper, we set out the goal to revisit the results of “Starring into the Abyss [...] of Concurrency Control with [1000] Cores” and analyse in-memory DBMSs on today’s large hardware. Despite the original assumption of the authors, today we do not see single-socket CPUs with 1000 cores. Instead multi-socket hardware made its way into production data centres. Hence, we follow up on this prior work with an evaluation of the characteristics of concurrency control schemes on real production multi-socket hardware with 1568 cores. To our surprise, we made several interesting findings which we report on in this paper.
In this paper, we present a new approach for achieving robust performance of data structures making it easier to reuse the same design for different hardware generations but also for different workloads. To achieve robust performance, the main idea is to strictly separate the data structure design from the actual strategies to execute access operations and adjust the actual execution strategies by means of so-called configurations instead of hard-wiring the execution strategy into the data structure. In our evaluation we demonstrate the benefits of this configuration approach for individual data structures as well as complex OLTP workloads.
Modern mixed (HTAP)workloads execute fast update-transactions and long running analytical queries on the same dataset and system. In multi-version (MVCC) systems, such workloads result in many short-lived versions and long version-chains as well as in increased and frequent maintenance overhead.
Consequently, the index pressure increases significantly. Firstly, the frequent modifications cause frequent creation of new versions, yielding a surge in index maintenance overhead. Secondly and more importantly, index-scans incur extra I/O overhead to determine, which of the resulting tuple versions are visible to the executing transaction (visibility-check) as current designs only store version/timestamp information in the base table – not in the index. Such index-only visibility-check is critical for HTAP workloads on large datasets.
In this paper we propose the Multi Version Partitioned B-Tree (MV-PBT) as a version-aware index structure, supporting index-only visibility checks and flash-friendly I/O patterns. The experimental evaluation indicates a 2x improvement for analytical queries and 15% higher transactional throughput under HTAP workloads. MV-PBT offers 40% higher tx. throughput compared to WiredTiger’s LSM-Tree implementation under YCSB.
Customer orientation should be the core engine of every organisation while IT can be considered as the enabler to generate competitive advantages along customer processes in marketing, sales and service. Research shows that customer relationship management (CRM) enables organisations to perform better and experience indicates that organisations that focus on customer orientation are more successful. With marketplace organisations such as Amazon, Alibaba or Conrad shaping the future of customer centricity and information technology, German B2B organisations need to shift their value contribution from product-centric to customer-centric. While these organisations are currently attempting to implement CRM software and putting their customers more into focus, the question remains how organisations are approaching the implementation of CRM and whether these attempts are paying off in terms of business performance.
Here, we study resin cure and network formation of solid melamine formaldehyde pre-polymer over a large temperature range viadynamic temperature curing profiles. Real-time infrared spectroscopy is used to analyze the chemical changes during network formation and network hardening. By applying chemometrics (multivariate curve resolution,MCR), the essential chemical functionalities that constitute the network at a given stage of curing are mathematically extracted and tracked over time. The three spectral components identified by MCR were methylol-rich, ether linkages-rich and methylene linkages-rich resin entities. Based on dynamic changes of their characteristic spectral patterns in dependence of temperature, curing is divided into five phases: (I) stationary phase with free methylols as main chemical feature, (II) formation of flexible network cross-linked by ether linkages, (III) formation of rigid, ether-cross-linked network, (IV) further hardening via transformation of methylols and ethers into methylene-cross-linkages, and (V) network consolidation via transformation of ether into methylene bridges. The presented spectroscopic/chemometric approach can be used as methodological basis for the functionality design of MF-based surface films at the stage of laminate pressing, i.e., for tailoring the technological property profile of cured MF films using a causal understanding of the underlying chemistry based on molecular markers and spectroscopic fingerprints.
The article studies a novel approach of inflation modeling in economics. We utilize a stochastic differential equation (SDE) of the form dXt=aXtdt+bXtdBtH, where dBtH is a fractional Brownian motion in order to model inflationary dynamics. Standard economic models do not capture the stochastic nature of inflation in the Eurozone. Thus, we develop a new stochastic approach and take into consideration fractional Brownian motions as well as Lévy processes. The benefits of those stochastic processes are the modeling of interdependence and jumps, which is equally confirmed by empirical inflation data. The article defines and introduces the rules for stochastic and fractional processes and elucidates the stochastic simulation output.
Since the global financial crisis of 2008/2009, there has been no challenge to the financial and banking system comparable to that during the Corona crisis.
Weak profitability, unresolved regulatory challenges and increasing competition in the digital sector pose further challenges for banks.
The stability of the financial system and access to financial markets was not at risk during the pandemic. Through joint efforts and better bank capitalisation, the financial system is now more resilient than during the financial crisis.
Provided that grants and loans in the “next generation EU” fund are well targeted for structural reforms and investments in the future, this should boost confi-dence and growth.
However, further improvements in financial stability, such as increased capital requirements, regulation of shadow banks or reforms in financial supervision, are needed.
The livestock sector is growing steadily and is responsible for around 18% of global greenhouse‐gas‐emissions, which is more than the global transport sec-tor (Steinfeld et al. 2006). This paper examines the potential of social marketing to reduce meat consumption. The aim is to understand consumers’ motivation in diet choices and to learn what opportunities social marketing can provide to counteract negative environmental and health trends. The authors believe that research to answer this question should start in metropolitan areas, be-cause measures should be especially effective there. Based on the Theory of Planned Behaviour (TPB, Ajzen 1991) and the Technology‐Acceptance‐Model by Huijts et al. (2012), an online‐study with participants from the metropolitan region (n = 708) was conducted in which central socio‐psychological constructs for a meat consumption reduction were examined. It was shown that attitude, personal norm and habit have a critical influence on the intention to reduce meat consumption. A segmentation of consumers based on these factors led to three consumer clusters: vegetarians/flexitarians, potential flexitarians and convinced meat eaters. Potential flexitarians are an especially relevant target group for the development of social‐marketing‐measures to reduce meat consumption. In co‐creation‐workshops with potential flexitarians from the metropolitan region, barriers and benefits of reducing meat consumption were identified. The factors of environmental protection, animal welfare and desire for variety turn out to be the most relevant motivational factors. Based on these factors, consumers proposed a variety of social marketing measures, such as applications and labels to inform about the environmental impact of meat products.
In Germany, mobility is currently in a state of flux. Since June 2019, electric kick scooters (e-scooters) have been permitted on the roads, and this market is booming. This study employs a user survey to generate new data, supplemented by expert interviews to determine whether such e-scooters are a climate-friendly means of transport. The environmental impacts are quantified using a life cycle assessment. This results in a very accurate picture of e-scooters in Germany. The global warming potential of an e-scooter calculated in this study is 165 g CO2-eq./km, mostly due to material and production (that together account for 73% of the impact). By switching to e-scooters where the battery is swapped, the global warming potential can be reduced by 12%. The lowest value of 46 g CO2-eq./km is reached if all possibilities are exploited and the life span of e-scooters is increased to 15 months. Comparing these emissions with those of the replaced modal split, e-scooters are at best 8% above the modal split value of 39 g CO2-eq./km.
Our paper investigates the response of acquiring firms’ stock returns around the announcement date in cross-border mergers and acquisitions (M&A) between listed Chinese acquirers and German targets. We apply an event study methodology to examine the shareholder value effect based on a sample of M&A deals over the most recent period of 2012-2018. We apply a market model event study based on the argumentation of Brown and Warner (1985) and use short-term observation periods according to Andrade, Mitchell, and Stafford (2001) as well as Hackbarth and Morellec (2008). The results indicate that the announcement of M&A involving German targets results in a positive cumulative abnormal return of on average 2.18% for Chinese acquirers’ shareholders in a five-day symmetric event window. Furthermore, we found slight indications of possible information leakage prior to the formal announcement. Although it shows that the size of acquiring firms is not necessarily correlated with the positive abnormal returns in the short run, this study suggests that Chinese acquirers’ shareholders gain higher abnormal returns when the German targets are non-listed companies.
Businesses need to cope with myriad challenges including increasingly competitive markets and rapid developments in digital technology. The overall aim of the research described in this paper is to generate fresh insights into the impacts of digitalisation on the design and management of global supply chains. It focuses on understanding the current adoption rate of new technologies in global supply chains, identifying perceived opportunities and challenges and clarifying the critical factors driving (and inhibiting) their deployment. The authors administered an online survey with a global sample of respondents from various supply chain functions, resulting in a sample of 142 responses. Significant differences emerged in adoption patterns between companies of different sizes. Moreover, the study pointed to a widening gap (or a ‘digital divide’) between leaders and laggards in terms of technology adoption. Perceived benefits and challenges also differ notably between companies of varying sizes. Adoption patterns are very diverse across specific technologies. The results further suggest that there is a significant correlation between adoption of digital technologies and different dimensions of company performance.
This paper studies the impact of financial liquidity on the macro-economy. We extend a classic macroeconomic modeland compute numerical simulations. The model confirms that persistently low inflation can occur despite a high degreeof financial liquidity due to a reallocation of cash, normal and risk-free bonds. In that regard, our model uncovers anexplanation of a flat Phillips curve. Overall, our approach contributes to a rather disregarded matter in macroeconomictheory.
Energy efficient electric control of drives is more and more important for electric mobility and manufacturing industries. Online dynamic optimization of induction machines is challenging due to the computational complexity involved and the variable power losses during dynamic operation of induction machines. This paper proposes a simple technique for sub-optimal online loss optimization using rotor flux linkage templates for energy efficient dynamic operation of induction machines. Such a rotor flux linkage template is given by a rotor flux linkage trajectory which is optimal for a specific scenario. This template is calculated in an offline optimization process. For a specific scenario during real time operation the rotor flux linkage is calculated by appropriately scaling the given template.
In this work, a brushless, harmonic-excited wound-rotor synchronous machine is investigated which utilizes special stator and rotor windings. The windings magnetically decouple the fundamental torque-producing field from the harmonic field required for the inductive power transfer to the field coil. In contrast to conventional harmonic-excited synchronous machines, the whole winding is utilized for both torque production and harmonic excitation such that no additional copper for auxiliary windings is needed. Different rotor topologies using rotating power electronic components are investigated and their efficiencies have been compared based on Finite-Element calculation and circuit analysis.
Companies are becoming aware of the potential risks arising from sustainability aspects in supply chains. These risks can affect ecological, economic or social aspects. One important element in managing those risks is improved transparency in supply chains by means of digital transformation. Innovative technologies like blockchain technology can be used to enforce transparency. In this paper, we present a smart contract-based Supply Chain Control Solution to reduce risks. Technological capabilities of the solution will be compared to a similar technology approach and evaluated regarding their benefits and challenges within the framework of supply chain models. As a result, the proposed solution is suitable for the dynamic administration of complex supply chains.
Globalisation, shorter product life cycles, and increasing product varieties have led to complex supply chains. At the same time, there is a growing interest of customers and governments in having a greater transparency of brands, manufacturers, and producers throughout the supply chain. Due to the complex structure of collaborative manufacturing networks, the increase of supply chain transparency is a challenge for manufacturing companies. The blockchain technology offers an innovative solution to increase the transparency, security, authenticity, and auditability of products. However, there are still uncertainties when applying the blockchain technology to manufacturing scenarios and thus enable all stakeholders to trace back each component of an assembled product. This paper proposes a framework design to increase the transparency and auditability of products in collaborative manufacturing networks by adopting the blockchain technology. In this context, each component of a product is marked with a unique identification number generated by blockchain-based smart contracts. In this way, a transparent auditability of assembled products and their components can be achieved for all stakeholders, including the custome.
The key aim of Open Strategy is to open up the process of strategy development to larger groups within and even outside an organization. Furthermore, Open Strategy aims to include broad groups of stakeholders in the various steps of the strategy process. The question at hand is how can Open Strategy be achieved? What approaches can be used? Scenario planning and business wargaming are approaches perceived as relevant tools in the field of strategy and strategic foresight and in the context of Open Strategy because of their participative nature. The aim of this article is to assess to what degree scenario planning and business wargaming can be used in the context of Open Strategy. While these approaches are suitable, their current application limits the number of potential participants. Further research and experimentation in practice with larger groups and/or online approaches, or a combination of both, are needed to explore the potential of scenario planning and business wargaming as tools for Open Strategy.
This study investigates how integrated reporting (IR) creates value for investors. It examines how providers of financial capital benefit from an improved firm information environment provided by IR. Specifically, this study investigates the effect of voluntary IR disclosure on analyst earnings forecast accuracy as well as on firm value. To do so, we use an international sample of 167 listed companies that voluntarily publish an integrated report. Our analysis shows no significant effect of a voluntary IR publication on analyst earnings forecast accuracy and no significant effect on firm value. We thus do not find evidence for the fulfillment of IR's promises regarding improved information environment and value creation of voluntary adopters. We conclude that such companies might already have a relatively high level of transparency leading to an absent additional effect of IR disclosure. Positive effects of IR appear to be more relevant in environments where IR is mandatory.
Customer foresight is a relatively new research field. We introduce the customer foresight territory by discussing it localization between customer research and foresight research. For this purposse, we look at a variety of methods that help to understand customers and future realities. On this basis we provide an overwiew of customer foresight methods and outline an ideal-typical research journey.
Machine learning (ML) techniques are rapidly evolving, both in academia and practice. However, enterprises show different maturity levels in successfully implementing ML techniques. Thus, we review the state of adoption of ML in enterprises. We find that ML technologies are being increasingly adopted in enterprises, but that small and medium-size enterprises (SME) are struggling with the introduction in comparison to larger enterprises. In order to identify enablers and success factors we conduct a qualitative empirical study with 18 companies in different industries. The results show that especially SME fail to apply ML technologies due to insufficient ML knowhow. However, partners and appropriate tools can compensate this lack of resources. We discuss approaches to bridge the gap for SME.
The promise of the EVs is twofold. First, rejuvenating a transport sector that still heavily depends on fossil fuels and second, integrating intermittent renewable energies into the power mix. However, it is still not clear how electricity networks will cope with the predicted increase in EVs and their charging demand, especially in combination with conventional energy demand. This paper proposes a methodology which allows to predict the impact of EV charging behavior on the electricity grid. Moreover, this model simulates the driving and charging behavior of heterogeneous EV drivers which differ in their mobility pattern, decision-making heuristics and charging strategies. The simulations show that uncoordinated charging results in charging load clustering. In contrast, decentralized coordination allows to fill the valleys of the conventional load curve and to integrate EVs without the need of a costly expansion of the electricity grid.
The process for the production of customized bras is really challenging. Although the need is very clear, the lingerie industry is currently facing a lack of data, knowledge and expertise for the realization of an automated process chain. Different studies and surveys have shown, that the majority of women wear the incorrect bra size. In addition to aesthetic problems, health risks such as headaches, back problems or digestive problems of the wearers can result from this. An important prerequisite for improvements is the basic knowledge about the female breast, both in terms of body measurements and different breast shapes. The current size systematic for bras only defines a bra size by the relation between bust girth and underbust girth and standardized cup forms do not justice to the high variability of the human body. As the bra type shapes the female breast, basic knowledge about the relation of measurements and shapes from the clothed and the unclothed breast is missing.
In the present project, studies are conducted to explore the female breast and to derive new breast-specific body measurements, different breast shapes and deformation knowledge using existing bras.
Furthermore, an innovative process is being developed that leads from 3D scanning to individual and interactive pattern construction, which allows an automatic pattern creation based on individual body measurements and the influence of different material parameters.
In the course of the presentation, the current project status will be shown and the future developments and project steps will be introduced.
Today's pattern making methods for industrial purposes are including construction principles, which are based on mathematical formula and sizing charts. As a result, there are two-dimensional flats, which can be converted into a three-dimensional garment. Because of their high linearity, those patterns are incapable of recreating the complexity of the human body, which results in insufficient fit. Subsequent changes of the pattern require a high degree of experience and lead to an inefficient product development process. It is known that draping allows the development of more complex and demanding patterns, which corresponds more to the actual body shape. Therefore, this method is used in custom tailoring and haute couture to achieve perfect garment fit but is also associated with time.
So, there is the act of defiance to improve the fit of garments, to speed up production but maintain a good value for money. Reutlingen University is therefore working on the development of 3D-modelled body shapes for 3D draping, considering different layers of clothing, such as jackets or coats. For this purpose, 3D modelling is used to develop 3D-bodies that correspond to the finished dimensions of the garment. By flattening of the modelled body, it is then possible to obtain an optimal 2D Pattern of the body. The comparison of the conventional method and the developed method is done by 3D simulation.
Finally, the optical fit test is demonstrated by the simulated basic cuts, that a significantly better body wrapping through the newly developed methodology could be achieved. Unlike in the basic cuts, which were achieved by classical design principles have been created, only a few adjustments are necessary to obtain an optimized basic cut. Also, when considering the body distance, it is shown that the newly developed basic patterns provide a more even enclosure of the body.
Some widely used optical measurement systems require a scan in wavelength or in one spatial dimension to measure the topography in all three dimensions. Novel hyperspectral sensors based on an extended Bayer pattern have a high potential to solve this issue as they can measure three dimensions in a single shot. This paper presents a detailed examination of a hyperspectral sensor including a description of the measurement setup. The evaluated sensor (Ximea MQ022HG-IM-SM5X5-NIR) offers 25 channels based on Fabry–Pérot filters. The setup illuminates the sensor with discrete wavelengths under a specified angle of incidence. This allows characterization of the spatial and angular response of every channel of each macropixel of the tested sensor on the illumination. The results of the characterization form the basis for a spectral reconstruction of the signal, which is essential to obtain an accurate spectral image. It turned out that irregularities of the signal response for the individual filters are present across the whole sensor.
A methodology for designing planar spiral antennas with a feeding network embedded within a dielectric is presented. To avoid a purely academic work which may not be manufactured with available standard technologies, the approach takes into account manufacturing process requirements by choice of used materials in the simulation. General design rules are provided. They encompass amongst others, selection criteria for dielectric material, aspects to consider when sketching the radiating element design, as well as those for the implementation of the feeding network. A rule of thumb, which maybe helpful in the determination of the antenna supporting substrate’s height, has been found. The appeal of the method resides in the fact that it eases up the design process and helps to minimize errors, saving time and money. The approach also enables the design of a compact and small-size spiral antenna as antenna-in-package (AiP), and provides the opportunity to assemble the antenna with other RF components/systems on the same layer stack or on the same integration platform.
The generous feed-in tariffs (FiTs) introduced in Germany—which resulted in major growth in decentralized solar photovoltaic (PV) systems—will phase out in the coming years, making many of the existing distributed generation assets stranded. This challenge creates an opportunity for community-focused energy utilities, such as Elektrizitätswerke Schönau eG (EWS) based in Schönau, Germany, to try a new approach to assist its customers, makes the transition to a more sustainable future. This chapter describes how EWS is developing products and offering community-based solutions including peer-to-peer trading using automated platforms. Such innovative offering may lead to successful differentiation in a competitive and highly decentralized future.