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Purpose: The purpose of this paper is to describe and discuss the current state of fashion business academic education worldwide. This is motivated by the wish to develop recommendations for the fashion business bachelor program of Reutlingen Uni versity.
Design/methodology/approach: This paper is based on a systematic review of relevant fashion business academic programs. A qualitative comparison is conducted through a categorization of the programs’ content and a score system evaluating the programs’ concepts.
Findings: Key findings were that several factors ensure successful fashion business education: Industry connections, international networks, project-based work, personalized career services and innovative approaches in teaching that include all steps along the fashion value chain.
Research limitations/implications: The research was primarily limited due to the limited number of schools assessed. As a result of the restricted time frame, those schools that were presented could only be analyzed regarding a few aspects. Future research should focus on a more in-depth analysis and further-reaching comparisons, e.g. comparisons with teaching concepts outside the fashion business area or with requirements by fashion companies.
Die Arbeit stellt die Vision des Internet of Things (IoT) vor und betrachtet sowohl Möglichkeiten der Nutzung als auch Gefahrenpotentiale für die Sicherheit der Nutzer. Insbesondere wird hierbei der Anwendungsfall Smart Home näher betrachtet und am Beispiel ZigBee gravierende Schwächen dieser Geräte aufgezeigt.
Durch Industrie 4.0 kann die individuelle Fertigung von kleineren Stückzahlen zu geringen Kosten ermöglicht werden. Dafür müssen alle Anlagen miteinander vernetzt werden, um Daten austauschen und kommunizieren zu können. Durch die Vernetzung können neue Risiken und Gefahren entstehen. In dieser Arbeit wird die ITSicherheit in der Industrie 4.0 anhand möglichen Bedrohungsszenarien, Herausforderungen und Gegenmaßnahmen evaluiert. Dabei wird untersucht, welche Möglichkeiten Industrieunternehmen haben, um Hackerangriffen vorzubeugen und ob bereits etablierte Sicherheitskonzepte für industrielle Anlagen einfach übernommen werden können.
Das Ziel dieser Arbeit ist, die Infrastruktur einer modernen Fahrzeug-zu Fahrzeug-Kommunikation auf ihre Sicherheit zu prüfen. Dazu werden die Sicherheitsstandards für die Funkkommunikation genauer beschrieben und anschließend mit möglichen Angriffsmodellen geprüft. Mit dem erläuterten Wissen der VANET Architektur werden verschiedene Angriffe verständlicher. Dadurch werden die Schwachstellen offengelegt und Gegenmaßnahmen an passenden Punkten in der Architektur verdeutlicht.
Diese Arbeit beschäftigt sich mit dem neuen elektronischen Personalausweis. Zum einen werden in diesem Paper die Sicherheitsziele des Personalausweises und die technische Umsetzung der Architektur und Protokolle erklärt. Es wird der Ablauf einer Online-Identifizierung für einen Nutzer mithilfe des Ausweises aufgezeigt. Risiken und Schwachstellen der Technologie im Software- und Hardwarebereich werden diskutiert und die bereits erfolgten Hack-Angriffe aufgezeigt. Die Arbeit legt Möglichkeiten dar, wie sich der Nutzer vor Angriffen schützen kann. Es werden die Gründe genannt, warum der neue Personalausweis online nur schwar Anklang findet und warum die Aufklärung über die zur Verfügung stehenden Anwendungen, eine Preisreduzierung der Lesegeräte sowie die vom Europa-Parlament und Europarat erlassene eIDAS-Verordnung nicht helfen werden, um die Nutzung voranzutreiben. Ergebnisse hierfür liefert eine Nutzerstudie. Zum anderen werden Ideen genannt, wie die Nutzung der elektronischen Funktionen des Ausweises stattdessen zu fördern ist.
Im Rahmen der wissenschaftlichen Vertiefung soll auf Basis der vorhandenen Ansätze das IT-Risikomanagement evaluiert werden. Hierbei soll die Frage, inwiefern das IT-Risikomanagement dem Unternehmen eine Hilfestellung bieten kann, geklärt und anschließend anhand von zwei Fallbeispielen dargestellt werden.
Mittlerweile ist der Einsatz von technischen Hilfsmitteln zu Analysezwecken im Sport fester Bestandteil im Trainingsalltag von Trainern und Athleten. In nahezu jeder Sportart werden Videoaufzeichnungen genutzt, um die Bewegungsausführung zu dokumentieren und zu analysieren. Allerdings reichen Aufnahmen von einem statischen Standort oftmals nicht mehr aus. An dieser Stelle kann Virtual Reality (VR) eine Lösung dieses Problems bieten. Durch VR kann der aufgezeichneten Szene eine weitere Ebene hinzugefügt und die Bewegungsabläufe neu und detaillierter bewertet werden. Um Bewegungen in einer virtuellen Umgebung abzubilden, müssen diese mittels Motion Capturing (MoCap) aufgezeichnet werden. Ziel dieser Arbeit ist es, herauszufinden, ob das MoCap System Perception Neuron in der Lage ist, Bewegungen in hoher Geschwindigkeit zu erfassen.
In den letzten Jahren beschäftigten sich Forscher und Automobilhersteller mit den Voraussetzungen für die Einführung von autonomem Fahren. Für Innovationen und Geschäftsmodelle im Bereich der intelligenten Mobilität, aber auch innerhalb der digitalen Wertschöpfungskette, spielen generell Zuverlässigkeit und Qualität der digitalen Datenübertragung eine entscheidende Rolle. Bevor das autonome Fahren vollständig eingeführt wird, muss man feststellen, welche Anforderungen an die digitale Infrastruktur beachtet werden müssen, gleichzeitig muss die Bedrohungslandschaft für autonomes Fahren analysiert werden.
Die folgende Arbeit beschäftigt sich damit, die Anforderungen und Gefahren zu analysieren und allgemeine Handlungsempfehlungen vorzuschlagen.
Ein stark erforschtes Gebiet der Computer Vision ist die Detektion von markanten Punkten des Gesichtszuges (englisch: facial feature detection), wie der Mundwinkel oder des Kinns. Daher lassen sich eine Vielzahl von veröffentlichten Verfahren finden, die sich jedoch teils deutlich hinsichtlich der Detektionsgenauigkeit, Robustheit und Geschwindigkeit unterscheiden. So sind viele Verfahren nur bedingt echtzeitfähig oder liefern nur mit hochaufgelösten Bildquellen ein zufriedenstellendes Ergebnis. In den letzten Jahren wurden daher Verfahren entwickelt, die versuchen, diese Problematiken zu lösen. In dieser Arbeit erfolgt eine Betrachtung dreier dieser State-of-the-Art Verfahren: Constrained Local Neural Fields (CLNF), Discriminative Response Map Fitting (DRMF) und Structured Output SVM (SO SVM), sowie deren Implementierungen. Dazu erfolgt ein empirischer Vergleich hinsichtlich der Detektionsgenauigkeit.
Background. The application of lean management is standard in many companies all over the world. It is used to continuously optimise existing production processes and to reduce the complexity of administrative processes. Unfortunately, in higher education, the awareness of lean management as a highly effective methodology is quite low.
Research aims. The research aim is to show how the lean strategy can be applied in university environments. Finally, this paper addresses the question why it is so difficult to implement lean in a university environment and how an institution of higher education can move forward towards becoming a lean university.
Methodology. Based on a literature review, five key lean principles are presented and examples of their implementation are discussed using short case studies from our own institution. We also compare our findings with those in the literature.
Key findings. Lean offers the chance to improve the management of higher education institutions. This requires a commitment on the part of the university top management aiming at convincing all stakeholders that a culture of lean helps the institution to be able to adapt to the rapidly changing environment of higher education.
Der folgende Artikel befasst sich mit Wearables für Pferde. Ziel ist es, die Sicherheit der Tiere bei einem Ausbruch von einer Weide zu erhöhen und damit Personen- und Sachschäden zu minimieren. Hierzu wird der Stand der Technik zur Standortbestimmung im Freien zusammengetragen und durch eine Klassifizierung der unterschiedlichen Ansätze ermittelt, welche Standortbestimmung pferdegerecht erscheint. Zudem soll ein Fragebogen konzipiert werden, um Charakteristiken und Funktionalitäten für einen Prototypen festzustellen.
In der Medizin existieren verschiedene Reifegradmodelle, die die Digitalisierung von Krankenhäusern unterstützen können. Die Anforderungen an ein Reifegradmodell für diesen Zweck umfassen Aspekte aus allgemeinen und spezifischen Bereichen des Krankenhauses. Die Analyse der Reifegradmodelle HIN, CCMM, EMRAM und O-EMRAM zeigt große Lücken im Bereich des OP sowie fehlende Aspekte in der Notaufnahme auf. Ein umfassendes Reifegradmodell wurde nicht gefunden. Durch eine Kombination aus HIN und CCMM könnten fast alle Bereiche ausreichend abgedeckt werden. Zusätzliche Ergänzungen durch spezialisierte Reifegradmodelle oder sogar die Entwicklung eines umfassenden Reifegradmodells wären sinnvoll.
Die Arbeit stellt die Möglichkeiten von 3D-Controllern für den Einsatz in der interventionellen Radiologie und insbesondere für die Steuerung der Echtzeit-Magnetresonanztomographie (MRT) dar. Dies ist interessant in Bezug auf die kontrollierte Navigation in ein Zielgewebe. Dabei kann der Interventionalist durch Echtzeit- Bildgebung den Verlauf des Eingriffs verfolgen, allerdings kann er bisher das MRT während der Durchführung des Eingriffs nicht selbst steuern, da dies durch den Assistenten im Nebenraum erfolgt. Die Kommunikation ist bei dem hohen Geräuschpegel aber sehr schwer. Diese Arbeit setzt an dieser Stelle an und analysiert 3D-Controller auf die Eignung für die Echtzeit-Steuerung eines MRTs. Dabei wurden trackingbasierte und trackinglose Geräte betrachtet. Als Ergebnis ließ sich festhalten, dass trackingbasierte Verfahren weniger geeignet sind, aufgrund der nicht ausreichenden Interpretation der Eingaben. Die trackinglosen Geräte hingegen sind aufgrund der korrekten Interpretation aller Eingaben und der intuitiven Bedienung geeignet.
Die digitale Zukunft zu definieren und zu gestalten ist in aller Munde - in der Industrie, der Lehre und so auch im Fokus der diesjährigen Informatics Inside Konferenz. Dazu gehören einerseits die Möglichkeiten, die die Digitalisierung mit sich bringt, z.B. beschrieben im Umfeld Krankenhaus oder in der Pferdezucht, andererseits die Schnittstelle zwischen realer und virtueller Welt, ausgeführt an Beispielen der Gesichts- und Bewegungserkennung. Auffällig ist, dass auch die Studierenden sich immer stärker auf die Sicherheit und Privatsphäre persönlicher Daten in einer digitalen Welt fokussieren. Dazu gehören fundamentale Sicherheitsuntersuchungen für ausgewählte Domänen, z.B. Industrie 4.0 oder Smart Home, wie auch die Betrachtung konkreter Einsatzszenarien, wie das autonome Fahren, die Kommunikation zwischen Fahrzeugen und dem neuen Personalausweis. Darüber hinaus stellen die Studierenden ihre Master-Projekte in Kurzbeiträgen vor.
Die Teilnehmer erfüllen nicht nur den Anspruch, die Ergebnisse ihrer Arbeit in schriftlicher Form anschaulich auszuarbeiten, sondern auch interaktiv vor ihrem Publikum zu verteidigen und zu diskutieren. Die Informatics Inside bietet somit ein Forum für Studierende, um während des Studiums zum einen die Ergebnisse ihrer Arbeit professionell einem interessierten Publikum zugänglich zu machen und zum anderen Anregungen anderer Vertiefungsgebiete aufzunehmen, aber auch die Arbeiten anderer kritisch zu hinterfragen.
Reconstructing 3D face shape from a single 2D photograph as well as from video is an inherently ill-posed problem with many ambiguities. One way to solve some of the ambiguities is using a 3D face model to aid the task. 3D morphable face models (3DMMs) are amongst the state of the art methods for 3D face reconstruction, or so called 3D model fitting. However, current existing methods have severe limitations, and most of them have not been trialled on in-the-wild data. Current analysis-by- synthesis methods form complex non linear optimisation processes, and optimisers often get stuck in local optima. Further, most existing methods are slow, requiring in the order of minutes to process one photograph.
This thesis presents an algorithm to reconstruct 3D face shape from a single image as well as from sets of images or video frames in real-time. We introduce a solution for linear fitting of a PCA shape identity model and expression blendshapes to 2D facial landmarks. To improve the accuracy of the shape, a fast face contour fitting algorithm is introduced. These different components of the algorithm are run in iteration, resulting in a fast, linear shape-to- landmarks fitting algorithm. The algorithm, specifically designed to fit to landmarks obtained from in-the-wild images, by tackling imaging conditions that occur in in-the-wild images like facial expressions and the mismatch of 2D–3D contour correspondences, achieves the shape reconstruction accuracy of much more complex, nonlinear state of the art methods, while being multiple orders of magnitudes faster.
Second, we address the problem of fitting to sets of multiple images of the same person, as well as monocular video sequences. We extend the proposed shape-to-landmarks fitting to multiple frames by using the knowledge that all images are from the same identity. To recover facial texture, the approach uses texture from the original images, instead of employing the often-used PCA albedo model of a 3DMM. We employ an algorithm that merges texture from multiple frames in real-time based on a weighting of each triangle of the reconstructed shape mesh.
Last, we make the proposed real-time 3D morphable face model fitting algorithm available as open-source software. In contrast to ubiquitous available 2D-based face models and code, there is a general lack of software for 3D morphable face model fitting, hindering a widespread adoption. The library thus constitutes a significant contribution to the community.
Thematic issue on human-centred ambient intelligence: cognitive approaches, reasoning and learning
(2017)
This editorial presents advances on human-centred Ambient Intelligence applications which take into account cognitive issues when modelling users (i.e. stress, attention disorders), and learn users’ activities/preferences and adapt to them (i.e. at home, driving a car). These papers also show AmI applications in health and education, which make them even more valuable for the general society.
The main challenge when driving heat pumps by PV-electricity is balancing differing electrical and thermal demands. In this article, a heuristic method for optimal operation of a heat pump driven by a maximum share of PV-electricity is presented. For this purpose, the (DHW) are activated in order shift the operation of the heat pump to times of PV-generation. The system under consideration refers to thermal and electrical demands of a single family house. It consists of a heat pump, a thermal energy storage for DHW and of grid connected heating and generation of domestic hot water, the heat pump runs with two different supply temperatures and thereby achieving a maximum overall COP. Within the algorithm for optimization a set of heuristic rules is developed in a way that the operational characteristics of the heat pump in terms of minimum running and stopping times are met as well as the limiting constraints of upper and lower limits of room temperature and energy content of electricity generated, a varying number of heat pump schedules fulfilling the bundary conditions are created. Finally, the schedule offering the maximum on-site utilization of PV-electricity with a minimum number of starts of the heat pump, which serves as secondary condition, is selected. Yearly simulations of this combination have been carried out. Initial results of this method indicate a significant rise in on-site consumption of the PV-electricity and heating demand fulfilment by renewable electricity with no need for a massive TES for the heating system in terms of a big water tank.
Painting galleries typically provide a wealth of data composed of several data types. Those multivariate data are too complex for laymen like museum visitors to first, get an overview about all paintings and to look for specific categories. Finally, the goal is to guide the visitor to a specific painting that he wishes to have a more closer look on. In this paper we describe an interactive visualization tool that first provides such an overview and lets people experiment with the more than 41,000 paintings collected in the web gallery of art. To generate such an interactive tool, our technique is composed of different steps like data handling, algorithmic transformations, visualizations, interactions, and the human user working with the tool with the goal to detect insights in the provided data. We illustrate the usefulness of the visualization tool by applying it to such characteristic data and show how one can get from an overview about all paintings to specific paintings.
How to protect the skin from getting sun burnt? The sun can damage your skin e.g. skin cancer. But the sun has a positive effect to the human. The time in sun and the intensity are key values between enjoy the sunbath and having a negative effect to the skin. A smart device like a UV flower could help you to enjoy the sunbath. It measures the UV index around you and gives this information to a smartphone app. The development steps of such a device are described in this paper. The UV flower is made of textile fabrics.
Medical applications are becoming increasingly important in the current development of health care and therefore a crucial part of the medical industry. An essential component is the development of user interfaces for mobile medical applications. The conceptual process is crucial for the further development of the main development process. Inconsistency or errors in the conceptual phase, have a serious impact on all areas and could prevent the certification for market approval.
This paper presents a guide to support developer with this process. It was developed based on a requirement analysis of the legal requirements to publish a medical device.
A sleep study is a test used to diagnose sleep disorders and is usually done in sleep laboratories. The golden standard for evaluation of sleep is overnight polysomnography (PSG). Unfortunately, in-lab sleep studies are expensive and complex procedures. Furthermore, with a minimum of 22 wire attachments to the patient for sleep recording, this medical procedure is invasive and unfamiliar for the subjects. To solve this problem, low-cost home diagnostic systems, based on noninvasive recording methods requires further researches.
For this intention it is important to find suitable bio vital parameters for classifying sleep phases WAKE, REM, light sleep and deep sleep without any physical impairment at the same time. We decided to analyse body movement (BM), respiration rate (RR) and heart rate variability (HRV) from existing sleep recordings to develop an algorithm which is able to classify the sleep phases automatically. The preliminary results of this project show that BM, RR and HRV are suitable to identify WAKE, REM and NREM stage.
To analyze the humans’ sleep it is necessary as to identify the sleep stages, occurring during the sleep, their durations and sleep cycles. The gold standard procedure for this approach is polysomnography (PSG), which classify the sleep stages based on Rechtschaffen and Kales (R-K) method. This method aside the advantages as high accuracy has however some disadvantages, among others time-consuming and uncomfortable for the patient procedure. Therefore, the development of further methods for the sleep classification in addition to PSG is a promising topic for the investigation and this work has as its aim the presentation of possible ways and goals for this development.
Asymmetric read/write storage technologies such as Flash are becoming
a dominant trend in modern database systems. They introduce
hardware characteristics and properties which are fundamentally
different from those of traditional storage technologies such
as HDDs.
Multi-Versioning Database Management Systems (MV-DBMSs)
and Log-based Storage Managers (LbSMs) are concepts that can
effectively address the properties of these storage technologies but
are designed for the characteristics of legacy hardware. A critical
component of MV-DBMSs is the invalidation model: commonly,
transactional timestamps are assigned to the old and the new version,
resulting in two independent (physical) update operations.
Those entail multiple random writes as well as in-place updates,
sub-optimal for new storage technologies both in terms of performance
and endurance. Traditional page-append LbSM approaches
alleviate random writes and immediate in-place updates, hence reducing
the negative impact of Flash read/write asymmetry. Nevertheless,
they entail significant mapping overhead, leading to write
amplification.
In this work we present an approach called Snapshot Isolation
Append Storage Chains (SIAS-Chains) that employs a combination
of multi-versioning, append storage management in tuple granularity
and novel singly-linked (chain-like) version organization.
SIAS-Chains features: simplified buffer management, multi-version
indexing and introduces read/write optimizations to data placement
on modern storage media. SIAS-Chains algorithmically avoids
small in-place updates, caused by in-place invalidation and converts
them into appends. Every modification operation is executed
as an append and recently inserted tuple versions are co-located.
IT Governance (ITG) is crucial due to its significant impact on enabling innovation and enhancing firm performance. Hence, in the last decade ITG has become important in both academic and in practical research. Although several studies have investigated individual aspects of ITG success and its impact on single determinants, the causal relationship of how ITG promotes firm performance remains unclear. Thus, a more comprehensive understanding about the link between ITG and firm performance is needed. To address this gap, this research aims at understanding how ITG and firm performance are related. Therefore, we conducted a systematic literature review (1) to create an overview on how current research structures the link between ITG mechanisms and firm performance, (2) to uncover key constructs as potential mediators or moderators on the general link between ITG and performance, and (3) to set the basis for future studies on the ITG-firm performance relationship.
We were able to identify a set of specific capabilities corporations need to develop in order to enhance brand love. Furthermore, the effects of most dynamic capabilities on brand love have a strong correlation to the degree of customer orientation. Other results are relevant concerning the proposed moderation and mediation hypotheses. Firstly, the impact of customer orientation on brand love is varied under specific market conditions, supporting our central moderation hypothesis (β = .259, p = .001). To be precise, the impact of customer orientation is strongest in markets that have low competitive differentiation in products and services. Other control variables like age, gender, or market form (B2B versus B2C) lead to no significant heterogeneity in the data set. Finally, mediation analyses show no significant “direct effect” of the existing DC constructs on brand love, supporting the mediating role of customer orientation.
Entwicklung eines nicht vergilbenden, faserbasierten BH's mittels innovativer FIM-Technologie
(2017)
Royal Philip's goal was to use innovation to improve the lives of three billion people a year by 2025. To reach that goal, the company was shifting from selling medical products in a transactional manner to providing integrated healthcare solutions based on digital health technology ("HealthTech").
This shift required a dual transformation. On one hand, the company needed to transform how healthcare was conducted. Healthcare professionals would have to change the way they worked and reimbursement schemes needed to change to incentivize payers, providers, and patients in vastly different ways. On the other hand, Philips needed to redesign how it worked internally. The company componentized its business, introduced digital platforms, and co-created solutions with the various stakeholders of the healthcare industry.
In other words: Royal Philips was transforming itself in order to reinvent healthcare in the digital age.
Es wird gezeigt, wie bei Fernspeisung die Vorhersage der Erwärmung mit entsprechender Modellierung verbessert werden kann und wie der Einfluss von Material und Form des Kabelkanals die Erwärmung und das das Temperaturprofil des Bündels beeinflusst. Es wird auch vorgestellt, dass die erhöhte Erwärmung von Metallkabelkanälen auf die geringere Emissivität zurückzuführen ist und wie das verbessert werden kann.
In 2016, German car manufacturer the Audi Group (AUDI AG) was working on an expanding array of digital innovations. The goals of these innovations varied, and included strengthening customer- and employee-facing processes, digitally enhancing existing products, and developing new, potentially disruptive business models. Audi’s IT unit was critical to each of these efforts. Based on personal interviews with 11 IT- and non-IT executives at Audi, this case examines the different ways in which digitization can help to enhance and transform an organization’s processes, products, and business models. The case also highlights the challenges that arise as large companies “digitize.”
Recent digital technologies like the Internet of Things and Augmented Reality have brought IT into companies’ core products. What were previously purely physical products are becoming hybrid or digitized. Despite receiving a lot of recent attention, digitized products have only seen a slow uptake in businesses so far. In this paper, we study the challenges that keep companies from realizing the desired impacts of digitized products and the practices they employ to address these challenges. To do so, we looked at companies from a set of industries that are highly affected by digital transformation, but at the same time hesitant to move to a more digitized world: the creative industries. Based on a literature review and twelve interviews in creative industries, we developed a conceptual model that can serve as a basis for formulating testable hypotheses for further research in this area.
Electronic word-of-mouth (eWoM) communication has received a lot of attention from the academic community. As multiple research papers focus on specific facets of eWoM, there is a need to integrate current research results systematically. Thus, this paper presents a scientific literature analysis in order to determine the current state-of-the-art in the field of eWoM.
This paper examines the efficacy of social media systems in customer complaint handling. The emergence of social media, as a useful complement and (possibly) a viable alternative to the traditional channels of service delivery, motivates this research. The theoretical framework, developed from literature on social media and complaint handling, is tested against data collected from two different channels (hotline and social media) of a German telecommunication services provider, in order to gain insights into channel efficacy in complaint handling. We contribute to the understanding of firm’s technology usage for complaint handling in two ways:
(a) by conceptualizing and evaluating complaint handling quality across traditional and social media channels and (b) by comparing the impact of complaint handling quality on key performance outcomes such as customer loyalty, positive word-of-mouth, and crosspurchase intentions across traditional and social media channels.
Pokémon Go was the first mobile augmented reality (AR) game to reach the top of the download charts of mobile applications. However, little is known about this new generation of mobile online AR games. Existing theories provide limited applicability for user understanding. Against this background, this research provides a comprehensive framework based on uses and gratification theory, technology risk research, and flow theory. The proposed framework aims to explain the drivers of attitudinal and intentional reactions, such as continuance in gaming or willingness to invest money in in-app purchases. A survey among 642 Pokémon Go players provides insights into the psychological drivers of mobile AR games. The results show that hedonic, emotional, and social benefits and social norms drive consumer reactions while physical risks (but not data privacy risks) hinder consumer reactions. However, the importance of these drivers differs depending on the form of user behavior.
How to separate the wheat from the chaff: improved variable selection for new customer acquisition
(2017)
Steady customer losses create pressure for firms to acquire new accounts, a task that is both costly and risky. Lacking knowledge about their prospects, firms often use a large array of predictors obtained from list vendors, which in turn rapidly creates massive high-dimensional data problems. Selecting the appropriate variables and their functional relationships with acquisition probabilities is therefore a substantial challenge. This study proposes a Bayesian variable selection approach to optimally select targets for new customer acquisition. Data from an insurance company reveal that this approach outperforms nonselection methods and selection methods based on expert judgment as well as benchmarks based on principal component analysis and bootstrap aggregation of classification trees. Notably, the optimal results show that the Bayesian approach selects panel-based metrics as predictors, detects several nonlinear relationships, selects very large numbers of addresses, and generates profits. In a series of post hoc analyses, the authors consider prospects’ response behaviors and cross selling potential and systematically vary the number of predictors and the estimated profit per response. The results reveal that more predictors and higher response rates do not necessarily lead to higher profits.
Characterisation of porous knitted titanium for replacement of intervertebral disc nucleus pulposus
(2017)
Effective restoration of human intervertebral disc degeneration is challenged by numerous limitations of the currently available spinal fusion and arthroplasty treatment strategies. Consequently, use of artificial biomaterial implant is gaining attention as a potential therapeutic strategy. Our study is aimed at investigating and characterizing a novel knitted titanium (Ti6Al4V) implant for the replacement of nucleus pulposus to treat early stages of chronic intervertebral disc degeneration. Specific knitted geometry of the scaffold with a porosity of 67.67 ± 0.824% was used to overcome tissue integration failures. Furthermore, to improve the wear resistance without impairing original mechanical strength, electro-polishing step was employed. Electro-polishing treatment changed a surface roughness from 15.22 ± 3.28 to 4.35 ± 0.87 μm without affecting its wettability which remained at 81.03 ± 8.5°. Subsequently, cellular responses of human mesenchymal stem cells (SCP1 cell line) and human primary chondrocytes were investigated which showed positive responses in terms of adherence and viability. Surface wettability was further enhanced to super hydrophilic nature by oxygen plasma treatment, which eventually caused substantial increase in the proliferation of SCP1 cells and primary chondrocytes. Our study implies that owing to scaffolds physicochemical and biocompatible properties, it could improve the clinical performance of nucleus pulposus replacement.
A wide variety of cell types exhibit substrate topography-based behavior, also known as contact guidance. However, the precise cellular mechanisms underlying this process are still unknown. In this study, we investigated contact guidance by studying the reaction of human endothelial cells (ECs) to well-defined microgroove topographies, both during and after initial cell spreading. As the cytoskeleton plays a major role in cellular adaptation to topographical features, two methods were used to perturb cytoskeletal structures. Inhibition of actomyosin contractility with the chemical inhibitor blebbistatatin demonstrated that initial contact guidance events are independent of traction force generation. However, cell alignment to the grooved substrate was altered at later time points, suggesting an initial ‘passive’ phase of contact guidance, followed by a contractility-dependent ‘active’ phase that relies on mechanosensitive feedback. The actin cytoskeleton was also perturbed in an indirect manner by culturing cells upside down, resulting in decreased levels of contact guidance and suggesting that a possible loss of contact between the actin cytoskeleton and the substrate could lead to cytoskeleton impairment. The process of contact guidance at the microscale was found to be primarily lamellipodia driven, as no bias in filopodia extension was observed on micron-scale grooves.
Intermediate filament reorganization dynamically influences cancer cell alignment and migration
(2017)
The interactions between a cancer cell and its extracellular matrix (ECM) have been the focus of an increasing amount of investigation. The role of the intermediate filament keratin in cancer has also been coming into focus of late, but more research is needed to understand how this piece fits in the puzzle of cytoskeleton-mediated invasion and metastasis. In Panc-1 invasive pancreatic cancer cells, keratin phosphorylation in conjunction with actin inhibition was found to be sufficient to reduce cell area below either treatment alone. We then analyzed intersecting keratin and actin fibers in the cytoskeleton of cyclically stretched cells and found no directional correlation. The role of keratin organization in Panc-1 cellular morphological adaptation and directed migration was then analyzed by culturing cells on cyclically stretched polydimethylsiloxane (PDMS) substrates, nanoscale grates, and rigid pillars. In general, the reorganization of the keratin cytoskeleton allows the cell to become more ‘mobile’- exhibiting faster and more directed migration and orientation in response to external stimuli. By combining keratin network perturbation with a variety of physical ECM signals, we demonstrate the interconnected nature of the architecture inside the cell and the scaffolding outside of it, and highlight the key elements facilitating cancer cell-ECM interactions.
AUDI AG has historically focused on producing and selling premium vehicles but has begun to experiment with providing mobility services, built around car sharing. Its response to the so-called sharing economy addressed strategic and transformational challenges. Strategically, the company pursued additional sources of revenue from targeted, premium mobility services, rather than the less segmented services provided by competitors such as BMW and Zipcar. AUDI AG also transformed its organizational structure, processes and architecture to balance autonomy for innovation and integration for competitiveness.
Cell-cell and cell-extracellular matrix (ECM) adhesion regulates fundamental cellular functions and is crucial for cell-material contact. Adhesion is influenced by many factors like affinity and specificity of the receptor-ligand interaction or overall ligand concentration and density. To investigate molecular details of cell ECM and cadherins (cell-cell) interaction in vascular cells functional nanostructured surfaces were used Ligand-functionalized gold nanoparticles (AuNPs) with 6-8 nm diameter, are precisely immobilized on a surface and separated by non-adhesive regions so that individual integrins or cadherins can specifically interact with the ligands on the AuNPs. Using 40 nm and 90 nm distances between the AuNPs and functionalized either with peptide motifs of the extracellular matrix (RGD or REDV) or vascular endothelial cadherins (VEC), the influence of distance and ligand specificity on spreading and adhesion of endothelial cells (ECs) and smooth muscle cells (SMCs) was investigated. We demonstrate that RGD-dependent adhesion of vascular cells is similar to other cell types and that the distance dependence for integrin binding to ECM-peptides is also valid for the REDV motif. VEC-ligands decrease adhesion significantly on the tested ligand distances. These results may be helpful for future improvements in vascular tissue engineering and for development of implant surfaces.
This work presents a fully integrated GaN gate driver in a 180nm HV BCD technology that utilizes high-voltage energy storing (HVES) in an on-chip resonant LC tank, without the need of any external capacitor. It delivers up to 11nC gate charge at a 5V GaN gate, which exceeds prior art by a factor of 45-83, supporting a broad range of GaN transistor types. The stacked LC tank covers an area of only 1.44mm², which corresponds to a superior value of 7.6nC/mm².
In recent years, significant progress was made on switched-capacitor DCDC converters as they enable fully integrated on chip power management. New converter topologies overcame the fixed input-to-output voltage limitation and achieved high efficiency at high power densities. SC converters are attractive to not only mobile handheld devices with small input and output voltages, but also for power conversion in IoTs, industrial and automotive applications, etc. Such applications need to be capable of handling high input voltages of more than 10V. This talk highlights the challenges of the required supporting circuits and high voltage techniques, which arise for high Vin SC converters. It includes level shifters, charge pumps and back-to-back switches. High Vin conversion is demonstrated in a 4:1 SC DCDC converter with an input voltage as high as 17V with a peak efficiency of 45 %, and a buckboost SC converter with an input voltage range starting from 2 up to 13V, which utilizes a total of 17 ratios and achieves a peak efficiency of 81.5 %. Furthermore a highly integrated micro power supply approach is introduced, which is connected directly to the 120/230 Vrms mains, with an output power of 3mW, resulting in a power density >390μW/mm², which exceeds prior art by a factor of 11.
Managing decentralized corporate energy systems is a challenging task for enterprises. However, the integration of energy objectives into business strategy creates difficulties resulting in inefficient decisions. To improve this, practice-proven methods such as the balanced scorecard and enterprise architecture management are transferred to the energy domain. The methods are evaluated based on a case study. Managing multi-dimensionality and high complexity are the main drivers for an effective and efficient energy management system. Both methods show a positive impact on managing decentralized corporate energy systems and are adaptable to the energy domain.
This paper presents a control strategy for optimal utilization of photovoltaic (PV) generated power in conjunction with an Energy Storage System (ESS). The ESS is specifically designed to be retrofitted into existing PV systems in an end-user application. It can be attached in parallel to the PV system and connects to existing DC/AC inverters. In particular, the study covers the impact such a modification has on the output power of existing PV panels. A distinct degradation of PV output power was found due to the different power characteristics of PV panel and ESS. To overcome such degradation a novel feedback system is proposed. The feedback system continuously modifies the power characteristic of the ESS to match the PV panel and thus achieves optimal power utilization. Impact on PV and power point tracking performance is analyzed. Simulation of the proposed system is performed in MATLAB/Simulink. The results are found to be satisfactory.
A novel configuration of the dual active bridge (DAB) DC/DC converter is presented, enabling more efficient wide voltage range conversion at light loads. A third phase leg as well as a center tapped transformer are introduced to one side of the converter. This concept provides two different turn ratios, thus extending the zero voltage switching operation resulting in higher efficiency. A laboratory prototype was built converting an input voltage of 40V to an output voltage in the range of 350V to 650V. Measurements show a significant increase up to 20% in the efficiency for light-load operation.
Multilevel-cell (MLC) flash is commonly deployed in today’s high density NAND memories, but low latency and high reliability requirements make it barely used in automotive embedded flash applications. This paper presents a time domain voltage sensing scheme that applies a dynamic voltage ramp at the cells’ control gate (CG) in order to achieve fast and reliable sensing suitable for automotive applications.
This publication gives a short introduction and overview of the European project SCOUT and introduces a methodology for a holistic approach to record the state of the art in technical (vehicle and connectivity, human factors regarding physiologic and ergonomic level) and non-technical enablers (societal, economic, legal, regulatory and policy level) of connected and automated driving in Europe. The paper addresses beside the technical topics of environmental perception, E/E architecture, actuators and security, the state of the art of the legal framework in the context of connected and automated driving.
In any autonomous driving system, the map for localization plays a vital part that is often underestimated. The map describes the world around the vehicle outside of the sensor view and is a main input into the decision making process in highly complicated scenarios. Thus there are strict requirements towards the accuracy and timeliness of the map. We present a robust and reliable approach towards crowd based mapping using a GraphSLAM framework based on radar sensors. We show on a parking lot that even in dynamically changing environments, the localization results are very accurate and reliable even in unexplored terrain without any map data. This can be achieved by collaborative map updates from multiple vehicles. To show these claims experimentally, the Joint Graph Optimization is compared to the ground truth on an industrial parking space. Mapping performance is evaluated using a dense map from a total station as reference and localization results are compared with a deeply coupled DGPS/INS system.
The European Economic and Monetary Union (EMU) has been in turmoil for more than six years. The present governance rules do not seem to solve the problems neither permanently nor effectively. There is no vision about the future of Europe in the 21st century. This article describes a realignment of the economic governance, which does not necessarily lead to a transfer or political union. However, it solves the current and future challenges. In fact, the redesign of present rules is the most likely as well as legally and economically option today. The key ideais the detachment from the compulsive idea of an ever closer union. However, this vision requires boldness towards greater flexibility together with an exit clause or a state insolvency procedure for incompliant member states.
This paper models the political budget cycle with stochastic differential equations. The paper highlights the development of future volatility of the budget cycle. In fact, I confirm the proposition of a less volatile budget cycle in future. Moreover, I show that this trend is even amplified due to higher transparency. These findings are new evidence in the literature on electoral cycles. I calibrate a rigorous stochastic model on public deficit-to-GDP data for several countries from 1970 to 2012.
Database management systems (DBMS) are critical performance components in large scale applications under modern update intensive workloads. Additional access paths accelerate look-up performance in DBMS for frequently queried attributes, but the required maintenance slows down update performance. The ubiquitous B+ tree is a commonly used key-indexed access path that is able to support many required functionalities with logarithmic access time to requested records. Modern processing and storage technologies and their characteristics require reconsideration of matured indexing approaches for today's workloads. Partitioned B-trees (PBT) leverage characteristics of modern hardware technologies and complex memory hierarchies as well as high update rates and changes in workloads by maintaining partitions within one single B+-Tree. This paper includes an experimental evaluation of PBTs optimized write pattern and performance improvements. With PBT transactional throughput under TPC-C increases 30%; PBT results in beneficial sequential write patterns even in presence of updates and maintenance operations.