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Umsetzung der DIN EN ISO 9001:2015. - Band 2. Agile Organisation, Risiko- und Change Management
(2017)
Mit der neuen DIN EN ISO 9001:2015 haben sich die Anforderungen an die Unternehmensorganisation und Unternehmensprozesse weiterentwickelt. Die Umstellung fällt Unternehmen teilweise schwer, da viele Themen, die früher nur kurz in der Norm genannt und wenig vertieft umgesetzt wurden, jetzt im zentralen Fokus stehen, wie z.B. das Risikomanagement. Das Buch in zwei Bänden gibt einen Überblick über die wichtigsten Themenschwerpunkte, die bei einer Umsetzung der DIN EN ISO 9001:2015 bearbeitet werden müssen. Es werden Vorgehensweisen, Methoden und Werkzeuge dargestellt, die in einem Einführungsprojekt in einem Unternehmen entwickelt und umgesetzt wurden. Themenschwerpunkte des Bands 2 sind: Einführung eines Risikomanagements nach DIN EN ISO 9001:2015, Change Management zur Implementierung der DIN EN ISO 9001:2015, Schaffung agiler Organisationsstrukturen im Kontext der DIN EN ISO 9001:2015.
Rapid Prototyping Plattformen reduzieren die Entwicklungszeit, indem das Überprüfen einer Idee in Form eines Prototyps schnell umzusetzen ist und mehr Zeit für die eigentliche Anwendungsentwicklung mit Benutzerschnittstellen zur Verfügung steht. Dieser Ansatz wird schon lange bei technischen Plattformen, wie bspw. dem Arduino, verfolgt. Um diese Form von Prototyping auf Wearables zu übertragen, wird in diesem Paper WearIT vorgestellt. WearIT besteht als Wearable Prototyping Plattform aus vier Komponenten: Einer Weste, Sensor- und Aktorshieldss, einer eigenen bibliothek sowie einem Mainboard bestehend aus Arduino, Raspberry Pi, einer Steckplatine und einem GPS-Modul. Als Ergebnis kann ein Wearable Prototyp schnell, durch das Anbringen von Sensor- und Aktorshields an der WearIT Weste, entwickelt werden. Diese Sensor- und Aktorshields können anschließend durch die WearIT-Bibliothek programmiert werden. Dafür kann über Virtual Network Computing (VNC) mit einem entfernten Rechner auf die Bildschirminhalte des Rasperry Pis zugegriffen und der Arduino programmiert werden.
Im Rahmen der wissenschaftlichen Vertieung werden unterschiedliche empirische Forschungsmethoden erörtert.
Im ersten Schritt werden die Grundlagen der empirischen Forschungsmethoden ermittelt und klassifiziert. Nach der Klassifikation der Forschungsmethoden werden zwei Forschunsmethoden angewandt. Die Auswahl der Methoden fällt auf die quantitative und qualitative Forschungsmethode.
Diese Forschungsmethoden werden während der Analysephase eingesetzt, um den weltweiten Ist-Zustand der Tochtergesellschaften zu ermitteln. Hierbei geht es um die Analyse des Import- und Export-Prozesses bei den Tochtergesellschaften der HUGO BOSS AG. Ziel ist es, die Ergebnisse für die Master Thesis einzusetzen. Anhand der Ergebnisse können Gemeinsamkeiten oder auch Abweichungen im Zollabwicklungsprozess aufgezeigt werden, die später in der Konzeption berücksichtigt werden.
Hierzu wird die qualitative Methode eingesetzt, welche die Basis für die Konzeptionierung der Umfrage liefert. Abschließend wurde für die Verifikation der Ergebnisse die qualitative Methode für die Interviews eingesetzt.
Automatisierte Analyse von Review-Daten beschäftigt sich mit den Möglichkeiten, freien Text zu analysieren und relevante Informationen daraus zu extrahieren. Die Arbeit setzt sich dabei mit Methoden des unüberwachten Lernens auseinander. Hierbei steht die Methode der Topic Modellierung im Mittelpunkt. Es werden Verfahren betrachtet, die im Bereich der textbasierten Informationsgewinnung bekannt sind. Latent Semantic Indexing LSI, (probabilistic) pLSI und Latent Dirichlet Allocation (LDA) werden erläutert und verglichen. Die Arbeit zeigt, wie LDA genutzt wurde, um einen nhaltlichen Überblick über einen Datenkorpus von 1 Mio. Reviews zu bekommen und diesen auf einen feineren Detailgrad zu betrachten. Die Topic-basierte Analyse wird genutzt, um Erkentnisse für ein Opinion Mining System zu generieren, welches eine tiefergehende Analyse vornehmen wird. Der gesamte Prozess ist als vollständig automatisiert und maschinell unüberwacht konzeptioniert.
Im Rahmen dieser Arbeit wurde ein urbaner Mixed-Reality Fahrsimulator umgesetzt. Die reale Umgebung wird hierbei in einer Greenscreen-Kammer mit Hilfe von Kamerabildern aus Nutzersicht und einem Chroma Key Shader innerhalb der virtuellen Umgebung sichtbar gemacht. Dies soll die Immersion und die Interaktivität innerhalb der virtuellen Umgebung durch die Darstellung und Verwendung von realen Elementen erhöhen.
Als virtuelle Umgebung wurde eine zufallsgenerierte Stadt geschaffen, in der KI-Fahrzeuge fahren. Die Ergebnisse der Entwicklung dieses Fahrsimulators werden in dieser Arbeit erläutert.
Der Fahrsimulator soll der Entwicklung von menschzentrierten Human-Machine-Interfaces und Motion-Capture-Komponenten dienen.
Das Knie ist das am häufigsten von Verletzungen betroffene Gelenk beim Skifahren. Durch die Messung bestimmter Einflussfaktoren, wie Kniewinkel und Muskelaktivität, kann eine Aussage über die Wahrscheinlichkeit einer drohenden Verletzung getroffen werden. Diese Daten können als Basis genutzt werden, um eine entsprechende Reaktion des Bindungssystems des Skis hervorzurufen. Durch die automatische Auslösung der Skibindung bei der Überschreitung der Grenzwerte wird das Knie entlastet, um möglichen Verletzungen vorzubeugen. Im Rahmen eines Forschungsprojekts der TU München wurde von einem Team der TU München und der Hochschule Reutlingen eine Skiunterhose entwickelt, mit der in Echtzeit der Kniewinkel erfasst und drahtlos an eine Auswerteeinheit gesendet werden kann.
Zukünftige Montagearbeitsplätze müssen veränderten Herausforderungen, wie z. B. der zunehmenden Anzahl von Mensch Roboter-Kollaborationen, gerecht werden. Die Virtual Reality (VR)-Technik bietet im Rahmen der Arbeitsplatzgestaltung neue Möglichkeiten, diesen veränderten Planungsherausforderungen gerecht zu werden. Die Ausarbeitung stellt eine Methode zur Bewertung des sinnvollen Einsatzes der VR-Technik für einen spezifischen Arbeitsplatz vor. Außerdem wird aufgezeigt, wie die VR-Technik in den Prozess der Arbeitsplatzgestaltung integriert werden kann.
This paper presents a novel multi-modal CNN architecture that exploits complementary input cues in addition to sole color information. The joint model implements a mid-level fusion that allows the network to exploit cross modal interdependencies already on a medium feature-level. The benefit of the presented architecture is shown for the RGB-D image understanding task. So far, state-of-the-art RGB-D CNNs have used network weights trained on color data. In contrast, a superior initialization scheme is proposed to pre-train the depth branch of the multi-modal CNN independently. In an end-to-end training the network parameters are optimized jointly using the challenging Cityscapes dataset. In thorough experiments, the effectiveness of the proposed model is shown. Both, the RGB GoogLeNet and further RGB-D baselines are outperformed with a significant margin on two different tasks: semantic segmentation and object detection. For the latter, this paper shows how to extract object level groundtruth from the instance level annotations in Cityscapes in order to train a powerful object detector.
Technologies for mapping the “digital twin“ have been under development for approximately 20 years. Nowadays increasingly intelligent, individualized products encourages companies to respond innovatively to customer requirements and to handle the rising product variations quickly.
An integrated engineering network, spanning across the entire value chain, is operated to intelligently connect various company divisions, and to generate a business ecosystem for products, services and communities. The conditions for the digital twin are thereby determined in which the digital world can be fed into the real, and the real world back into the digital to deal such intelligent products with rising variations.
The term digital twin can be described as a digital copy of a real factory, machine, worker etc., that is created and can be independently expanded, automatically updated as well as being globally available in real time. Every real product and production site is permanently accompanied by a digital twin. First prototypes of such digital twins already exist in the ESB Logistics Learning Factory on a cloud- and app based software that builds on a dynamic, multidimensional data and information model. A standardized language of the robot control systems via software agents and positioning systems has to be integrated. The aspect of the continuity of the real factory in the digital factory as an economical means of ensuring continuous actuality of digital models looks as the basis of changeability.
For the indoor localization sensor combinations that in addition to the hardware already contain the software required for the sensor data fusion should be used. Processing systems, scenario-live-simulations and digital shop floor management results in a mandatory procedural combination. Essential to the digital twin is the ability to consistently provide all subsystems with the latest state of all required information, methods and algorithms.
Close and safe interaction of humans and robots in joint production environments is technically feasible, however should not be implemented as an end in itself but to deliver improvement in any of a production system’s target dimensions. Firstly, this paper shows that an essential challenge for system integrators during the design of HRC applications is to identify a suitable distribution of available tasks between a robotic and a human resource. Secondly, it proposes an approach to determine task allocation by considering the actual capabilities of both human and robot in order to improve work quality. It matches those capabilities with given requirements of a certain task in order to identify the maximum congruence as the basis for the allocation decision. The approach is based on a study and subsequent generic description of human and robotic capabilities as well as a heuristic procedure that facilities the decision making process.
The presented wide-Vin step-down converter introduces a parallel-resonant converter (PRC), comprising an integrated 5-bit capacitor array and a 300 nH resonant coil, placed in parallel to a conventional buck converter. Unlike conventional resonant concepts, the implemented soft-switching control eliminates input voltage dependent losses over a wide operating range. This ensures high efficiency across a wide range of Vin= 12-48V, 100-500mA load and 5V output at up to 15MHz switching frequency. The peak efficiency of the converter is 76.3 %. Thanks to the low output current ripple, the output capacitor can be as small as 50 nF, while the inductor tolerates a larger ESR, resulting in small component size. The proposed PRC architecture is also suitable for future power electronics applications using fast-switching GaN devices.
Despite the significant potential offered by the powder coating process for finishing wood-based materials, until now it has been used almost exclusively for coating Medium Density Fiber Board (MDF). A research project aims to develop processes and substrate materials that will allow lightweight boards to be powder coated.
Modern power semiconductor devices have low capacitances and can therefore achieve very fast switching transients under hard-switching conditions. However, these transients are often limited by parasitic elements, especially by the source inductance and the parasitic capacitances of the power semiconductor. These limitations cannot be compensated by conventional gate drivers. To overcome this, a novel gate driver approach for power semiconductors was developed. It uses a transformer which accelerates the switching by transferring energy from the source path to the gate path.
Experimental results of the novel gate driver approach show a turn-on energy reduction of 78% (from 80 μJ down to 17 μJ) with a drain-source voltage of 500V and a drain current of 60 A. Furthermore, the efficiency improvement is demonstrated for a hard-switching boost converter. For a switching frequency of 750 kHz with an input voltage of 230V and an output voltage of 400V, it was possible to extend the output power range by 35%(from 2.3kW to 3.1 kW), due to the reduction of the turn-on losses, therefore lowering the junction temperature of the GaN-HEMT.
A device including a first and second monitoring unit, the first monitoring unit detecting a first voltage potential and the second monitoring unit detecting a second voltage potential, the monitoring units comparing the first voltage potential and the second voltage potential to the value of the supply voltage and activate a control unit as a function of the comparisons, the control unit determining a switching point in time of a second power transistor, and an arrangement being present which generates current when the second power transistor is being switched on, the current changing the first voltage potential, and the control unit activates a first power transistor when the first voltage potential has the same value as the supply voltage, so that the first power transistor is de-energized.
Reconstructing 3D face shape from a single 2D photograph as well as from video is an inherently ill-posed problem with many ambiguities. One way to solve some of the ambiguities is using a 3D face model to aid the task. 3D morphable face models (3DMMs) are amongst the state of the art methods for 3D face reconstruction, or so called 3D model fitting. However, current existing methods have severe limitations, and most of them have not been trialled on in-the-wild data. Current analysis-by- synthesis methods form complex non linear optimisation processes, and optimisers often get stuck in local optima. Further, most existing methods are slow, requiring in the order of minutes to process one photograph.
This thesis presents an algorithm to reconstruct 3D face shape from a single image as well as from sets of images or video frames in real-time. We introduce a solution for linear fitting of a PCA shape identity model and expression blendshapes to 2D facial landmarks. To improve the accuracy of the shape, a fast face contour fitting algorithm is introduced. These different components of the algorithm are run in iteration, resulting in a fast, linear shape-to- landmarks fitting algorithm. The algorithm, specifically designed to fit to landmarks obtained from in-the-wild images, by tackling imaging conditions that occur in in-the-wild images like facial expressions and the mismatch of 2D–3D contour correspondences, achieves the shape reconstruction accuracy of much more complex, nonlinear state of the art methods, while being multiple orders of magnitudes faster.
Second, we address the problem of fitting to sets of multiple images of the same person, as well as monocular video sequences. We extend the proposed shape-to-landmarks fitting to multiple frames by using the knowledge that all images are from the same identity. To recover facial texture, the approach uses texture from the original images, instead of employing the often-used PCA albedo model of a 3DMM. We employ an algorithm that merges texture from multiple frames in real-time based on a weighting of each triangle of the reconstructed shape mesh.
Last, we make the proposed real-time 3D morphable face model fitting algorithm available as open-source software. In contrast to ubiquitous available 2D-based face models and code, there is a general lack of software for 3D morphable face model fitting, hindering a widespread adoption. The library thus constitutes a significant contribution to the community.
Die Erfindung betrifft einen Rollstuhl mit einem Gestell mit Rädern, einem Sitz sowie zwei gegenüber dem Sitz verlagerbaren Fußplatten und ein Trainingsgerät zur Bewegungstherapie der unteren Extremitäten einer in dem Rollstuhl sitzenden Person. Um das Trainingsgerät vereinfacht auszubilden, enthält das Trainingsgerät unabhängig von einer Fahrbewegung des Rollstuhls betreibbar eine an dem Gestell befestigbare, von einer Steuereinheit gesteuerte Elektromaschine, welche zur wechselweise erzwungenen Verlagerung der beiden Fußplatten mit den Fußplatten mechanisch gekoppelt ist.
Entwicklung eines nicht vergilbenden, faserbasierten BH's mittels innovativer FIM-Technologie
(2017)
Asymmetric read/write storage technologies such as Flash are becoming
a dominant trend in modern database systems. They introduce
hardware characteristics and properties which are fundamentally
different from those of traditional storage technologies such
as HDDs.
Multi-Versioning Database Management Systems (MV-DBMSs)
and Log-based Storage Managers (LbSMs) are concepts that can
effectively address the properties of these storage technologies but
are designed for the characteristics of legacy hardware. A critical
component of MV-DBMSs is the invalidation model: commonly,
transactional timestamps are assigned to the old and the new version,
resulting in two independent (physical) update operations.
Those entail multiple random writes as well as in-place updates,
sub-optimal for new storage technologies both in terms of performance
and endurance. Traditional page-append LbSM approaches
alleviate random writes and immediate in-place updates, hence reducing
the negative impact of Flash read/write asymmetry. Nevertheless,
they entail significant mapping overhead, leading to write
amplification.
In this work we present an approach called Snapshot Isolation
Append Storage Chains (SIAS-Chains) that employs a combination
of multi-versioning, append storage management in tuple granularity
and novel singly-linked (chain-like) version organization.
SIAS-Chains features: simplified buffer management, multi-version
indexing and introduces read/write optimizations to data placement
on modern storage media. SIAS-Chains algorithmically avoids
small in-place updates, caused by in-place invalidation and converts
them into appends. Every modification operation is executed
as an append and recently inserted tuple versions are co-located.
To analyze the humans’ sleep it is necessary as to identify the sleep stages, occurring during the sleep, their durations and sleep cycles. The gold standard procedure for this approach is polysomnography (PSG), which classify the sleep stages based on Rechtschaffen and Kales (R-K) method. This method aside the advantages as high accuracy has however some disadvantages, among others time-consuming and uncomfortable for the patient procedure. Therefore, the development of further methods for the sleep classification in addition to PSG is a promising topic for the investigation and this work has as its aim the presentation of possible ways and goals for this development.
A sleep study is a test used to diagnose sleep disorders and is usually done in sleep laboratories. The golden standard for evaluation of sleep is overnight polysomnography (PSG). Unfortunately, in-lab sleep studies are expensive and complex procedures. Furthermore, with a minimum of 22 wire attachments to the patient for sleep recording, this medical procedure is invasive and unfamiliar for the subjects. To solve this problem, low-cost home diagnostic systems, based on noninvasive recording methods requires further researches.
For this intention it is important to find suitable bio vital parameters for classifying sleep phases WAKE, REM, light sleep and deep sleep without any physical impairment at the same time. We decided to analyse body movement (BM), respiration rate (RR) and heart rate variability (HRV) from existing sleep recordings to develop an algorithm which is able to classify the sleep phases automatically. The preliminary results of this project show that BM, RR and HRV are suitable to identify WAKE, REM and NREM stage.
Medical applications are becoming increasingly important in the current development of health care and therefore a crucial part of the medical industry. An essential component is the development of user interfaces for mobile medical applications. The conceptual process is crucial for the further development of the main development process. Inconsistency or errors in the conceptual phase, have a serious impact on all areas and could prevent the certification for market approval.
This paper presents a guide to support developer with this process. It was developed based on a requirement analysis of the legal requirements to publish a medical device.
How to protect the skin from getting sun burnt? The sun can damage your skin e.g. skin cancer. But the sun has a positive effect to the human. The time in sun and the intensity are key values between enjoy the sunbath and having a negative effect to the skin. A smart device like a UV flower could help you to enjoy the sunbath. It measures the UV index around you and gives this information to a smartphone app. The development steps of such a device are described in this paper. The UV flower is made of textile fabrics.
Electronic word-of-mouth (eWoM) communication has received a lot of attention from the academic community. As multiple research papers focus on specific facets of eWoM, there is a need to integrate current research results systematically. Thus, this paper presents a scientific literature analysis in order to determine the current state-of-the-art in the field of eWoM.
We were able to identify a set of specific capabilities corporations need to develop in order to enhance brand love. Furthermore, the effects of most dynamic capabilities on brand love have a strong correlation to the degree of customer orientation. Other results are relevant concerning the proposed moderation and mediation hypotheses. Firstly, the impact of customer orientation on brand love is varied under specific market conditions, supporting our central moderation hypothesis (β = .259, p = .001). To be precise, the impact of customer orientation is strongest in markets that have low competitive differentiation in products and services. Other control variables like age, gender, or market form (B2B versus B2C) lead to no significant heterogeneity in the data set. Finally, mediation analyses show no significant “direct effect” of the existing DC constructs on brand love, supporting the mediating role of customer orientation.
Characterisation of porous knitted titanium for replacement of intervertebral disc nucleus pulposus
(2017)
Effective restoration of human intervertebral disc degeneration is challenged by numerous limitations of the currently available spinal fusion and arthroplasty treatment strategies. Consequently, use of artificial biomaterial implant is gaining attention as a potential therapeutic strategy. Our study is aimed at investigating and characterizing a novel knitted titanium (Ti6Al4V) implant for the replacement of nucleus pulposus to treat early stages of chronic intervertebral disc degeneration. Specific knitted geometry of the scaffold with a porosity of 67.67 ± 0.824% was used to overcome tissue integration failures. Furthermore, to improve the wear resistance without impairing original mechanical strength, electro-polishing step was employed. Electro-polishing treatment changed a surface roughness from 15.22 ± 3.28 to 4.35 ± 0.87 μm without affecting its wettability which remained at 81.03 ± 8.5°. Subsequently, cellular responses of human mesenchymal stem cells (SCP1 cell line) and human primary chondrocytes were investigated which showed positive responses in terms of adherence and viability. Surface wettability was further enhanced to super hydrophilic nature by oxygen plasma treatment, which eventually caused substantial increase in the proliferation of SCP1 cells and primary chondrocytes. Our study implies that owing to scaffolds physicochemical and biocompatible properties, it could improve the clinical performance of nucleus pulposus replacement.
How to separate the wheat from the chaff: improved variable selection for new customer acquisition
(2017)
Steady customer losses create pressure for firms to acquire new accounts, a task that is both costly and risky. Lacking knowledge about their prospects, firms often use a large array of predictors obtained from list vendors, which in turn rapidly creates massive high-dimensional data problems. Selecting the appropriate variables and their functional relationships with acquisition probabilities is therefore a substantial challenge. This study proposes a Bayesian variable selection approach to optimally select targets for new customer acquisition. Data from an insurance company reveal that this approach outperforms nonselection methods and selection methods based on expert judgment as well as benchmarks based on principal component analysis and bootstrap aggregation of classification trees. Notably, the optimal results show that the Bayesian approach selects panel-based metrics as predictors, detects several nonlinear relationships, selects very large numbers of addresses, and generates profits. In a series of post hoc analyses, the authors consider prospects’ response behaviors and cross selling potential and systematically vary the number of predictors and the estimated profit per response. The results reveal that more predictors and higher response rates do not necessarily lead to higher profits.
Seit über 50 Jahren dominiert die neoklassische Kapitalmarkttheorie unser Verständnis für die Abläufe an Finanzmärkten. Sie hat eine Vielzahl von Theorien und Konzepten (z.B. Portfoliotheorie, Capital Asset Pricing Model oder Value-at-Risk) hervorgebracht und basiert auf der Annahme eines streng rationalen Homo Oeconomicus.
Das vorliegende Buch möchte Praktikern die Türe öffnen zu einer neu entstehenden, verhaltenswissenschaftlichen Sicht auf die Finanzmärkte, in der ein realitätsnäherer Homo Oeconomicus Humanus an den Märkten agiert. Er setzt bei der Entscheidungsfindung begrenzt rationale Heuristiken ein und lässt sich von emotionalen Einflüssen lenken.
Die Autoren schlagen zunächst den Bogen von der neoklassischen Sicht der Finanzmärkte zur Behavioral Finance. Anschließend werden spekulative Blasen, von der Tulpenmanie bis zur Subprime Hypothekenblase, als Anzeichen für begrenzte Rationalität an Finanzmärkten ausführlich vorgestellt. Danach stehen die Heuristiken bei Anlageentscheidungen an Wertpapiermärkten im Vordergrund. Die dadurch ausgelösten Verzerrungen werden ntsprechend ihrer Risiko-/Renditeschädlichkeit im Rahmen des RRS-Index® eingeordnet. Abschließend werden Beispiele für die Anwendung der Behavioral-Finance-Erkenntnisse im Wealth Management und Corporate Governance diskutiert und es wird ein Blick auf aktuelle Entwicklungen der Neuro-Finance und Emotional Finance geworfen.
In dieser Auflage neu hinzugekommen ist Financial Nudging, eine besonders vielversprechende Anwendung von Behavioral Finance-Erkenntnissen.
Dieses Buch beschreibt detailliert die Voraussetzungen und den Prozessablauf von Business Cases. Diese stellen in der Praxis das wichtigste Instrument dar, um unternehmerische Entscheidungen auf ihre Vorteilhaftigkeit zu analysieren. Um einen adäquaten Business Case zu erstellen, reicht allerdings die reine Beherrschung der relevanten Methoden der Investitionsrechnung nicht aus. Andreas Taschner gibt hilfreiche Anleitungen und Tipps zur Methodenwahl und Ergebnisdarstellung und erläutert weitergehende Fragen, wie die Berücksichtigung von Unsicherheit oder die Einbeziehung nicht-monetärer Faktoren. Die Orientierung am idealtypischen Prozess hilft beim Erarbeiten eigener Business Cases und liefert einen Leitfaden für die ersten selbstständigen Arbeiten. Anwendungsbezogene Fragen und Antworten vertiefen die Thematik. „Business Cases“ wendet sich an Unternehmenspraktiker in den Bereichen Investition, Controlling, Planung und Unternehmensführung. Studierende der Wirtschaftswissenschaften an Fachhochschulen und Universitäten, insbesondere mit den Schwerpunkten Controlling und Unternehmensführung, profitieren von der kompakten Wissensvermittlung.
Pokémon Go was the first mobile augmented reality (AR) game to reach the top of the download charts of mobile applications. However, little is known about this new generation of mobile online AR games. Existing theories provide limited applicability for user understanding. Against this background, this research provides a comprehensive framework based on uses and gratification theory, technology risk research, and flow theory. The proposed framework aims to explain the drivers of attitudinal and intentional reactions, such as continuance in gaming or willingness to invest money in in-app purchases. A survey among 642 Pokémon Go players provides insights into the psychological drivers of mobile AR games. The results show that hedonic, emotional, and social benefits and social norms drive consumer reactions while physical risks (but not data privacy risks) hinder consumer reactions. However, the importance of these drivers differs depending on the form of user behavior.
Die Europäische Währungs- und Wirtschaftsunion (EWWU) bedarf einer weiteren Stabilisierung, da die institutionellen Regelungen langfristig keine hinreichende Bindekraft auf die Mitgliedsländer entfalten. Die Herausforderung ist die Rückgewinnung der verlorengegangenen Glaubwürdigkeit in das Regelwerk im Zuge der europäischen Staatsverschuldungskrise seit dem Jahr 2010. Um die Währungsunion zu erhalten, muss einerseits im Primärrecht das "No Bailout" in Art. 125 AEUV glaubwürdig angewandt werden können und andererseits die Regelungen im Sekundärrecht, u.a. der Stabilitäts- und Wachstumspakt, der Fiskalpakt oder das europäische Semester, unabhängiger und schneller rechtsverbindlich vollzogen werden. Der hier vorgeschlagene und klug in den europäischen Rahmen eingepasste "staatliche Insolvenzmechanismus", verbunden mit einer im Ultima Ratio rechtsverbindlichen "Austrittsklausel" wäre ein Lösungsansatz. Ein Scheitern der EWWU ist abwendbar, aber der fehlende Reformwille könnte dem Zerfall der Währungsunion Vorschub leisten.
Understanding the factors that influence the accuracy of visual SLAM algorithms is very important for the future development of these algorithms. So far very few studies have done this. In this paper, a simulation model is presented and used to investigate the effect of the number of scene points tracked, the effect of the baseline length in triangulation and the influence of image point location uncertainty. It is shown that the latter is very critical, while the other all play important roles. Experiments with a well known semi-dense visual SLAM approach are also presented, when used in a monocular visual odometry mode. The experiments show that not including sensor bias and scale factor uncertainty is very detrimental to the accuracy of the simulation results.
Though bioprinting is a forward-looking approach in bone tissue engineering, the development of bioinks which are on the one hand processable with the chosen printing technique, and on the other hand possess the relevant mechanical as well as osteoconductive features remains a challenge. In the present study, polymer solutions based on methacrylated gelatin and methacrylated hyaluronic acid modified with hydroxyapatite (HAp) particles (5 wt%) were prepared. Encapsulation of primary human adipose derived stem cells in the HAp-containing gels and culture for 28 d resulted in a storage moduli significantly increased to 126% ± 9.6% compared to the value on day 1 by the sole influence of the HAp. Additional use of osteogenic media components resulted in an increase of storage module up to 199% ± 27.8%. Similarly, the loss moduli was increased to 370% ± 122.1% under the influence of osteogenic media components and HAp. Those changes in rheological material characteristics indicate a distinct change in elastic and viscous hydrogel properties, and are attributed to extensive matrix production in the hydrogels by the encapsulated cells, what could also be proven by staining of bone matrix components like collagen I, fibronectin, alkaline phosphatase and osteopontin. When using the cell-laden polymer solutions as bioinks to build up relevant geometries, the ink showed excellent printability and the printed grid structure's integrity remained intact over a culture time of 28 d. Again, an intense matrix formation as well as upregulation of osteogenic markers by the encapsulated cells could be shown. In conclusion, we demonstrated that our HAp-containing bioinks and hydrogels on basis of methacrylated gelatin and hyaluronic acid are on the one hand highly suitable for the build up of relevant three-dimensional geometries with microextrusion bioprinting, and on the other hand exhibit a significant positive effect on bone matrix development and remodeling in the hydrogels, as indicated by rheological measurements and staining of bone components. This makes the developed composite hydrogels an excellent material for bone bioprinting approaches.
Es wird gezeigt, wie bei Fernspeisung die Vorhersage der Erwärmung mit entsprechender Modellierung verbessert werden kann und wie der Einfluss von Material und Form des Kabelkanals die Erwärmung und das das Temperaturprofil des Bündels beeinflusst. Es wird auch vorgestellt, dass die erhöhte Erwärmung von Metallkabelkanälen auf die geringere Emissivität zurückzuführen ist und wie das verbessert werden kann.
Royal Philip's goal was to use innovation to improve the lives of three billion people a year by 2025. To reach that goal, the company was shifting from selling medical products in a transactional manner to providing integrated healthcare solutions based on digital health technology ("HealthTech").
This shift required a dual transformation. On one hand, the company needed to transform how healthcare was conducted. Healthcare professionals would have to change the way they worked and reimbursement schemes needed to change to incentivize payers, providers, and patients in vastly different ways. On the other hand, Philips needed to redesign how it worked internally. The company componentized its business, introduced digital platforms, and co-created solutions with the various stakeholders of the healthcare industry.
In other words: Royal Philips was transforming itself in order to reinvent healthcare in the digital age.
Painting galleries typically provide a wealth of data composed of several data types. Those multivariate data are too complex for laymen like museum visitors to first, get an overview about all paintings and to look for specific categories. Finally, the goal is to guide the visitor to a specific painting that he wishes to have a more closer look on. In this paper we describe an interactive visualization tool that first provides such an overview and lets people experiment with the more than 41,000 paintings collected in the web gallery of art. To generate such an interactive tool, our technique is composed of different steps like data handling, algorithmic transformations, visualizations, interactions, and the human user working with the tool with the goal to detect insights in the provided data. We illustrate the usefulness of the visualization tool by applying it to such characteristic data and show how one can get from an overview about all paintings to specific paintings.
Ziel eines aktuellen Forschungsprojektes an der Hochschule Reutlingen, das gemeinsam mit dem Ingenieurbüro Ganssloser und der Universität Tübingen durchgeführt wird, ist es, Flexibilitäten in Unternehmen, die im Verbund als virtuelles Kraftwerk am Strommarkt agieren, zu erkennen und nutzbar zu machen. Zu diesem Zweck soll eine Steuerbox für Industrie- und Gewerbebetriebe entwickelt werden, die einerseits mit der zentralen Leitwarte des virtuellen Kraftwerks kommuniziert und andererseits die Anlagen des Unternehmens so steuert, dass die zur Verfügung stehenden Flexibilitäten möglichst optimal genutzt werden. Die Hochschule Reutlingen beschäftigt sich innterhalb des Projekts mit der Erkennung und Beschreibung von Flexibilitäten in Unternehmen.
Characteristics of modern computing and storage technologies fundamentally differ from traditional hardware. There is a need to optimally leverage their performance, endurance and energy consumption characteristics. Therefore, existing architectures and algorithms in modern high performance database management systems have to be redesigned and advanced. Multi Version Concurrency Control (MVCC) approaches in data-base management systems maintain multiple physically independent tuple versions. Snapshot isolation approaches enable high parallelism and concurrency in workloads with almost serializable consistency level. Modern hardware technologies benefit from multi-version approaches. Indexing multi-version data on modern hardware is still an open research area. In this paper, we provide a survey of popular multi-version indexing approaches and an extended scope of high performance single-version approaches. An optimal multi-version index structure brings look-up efficiency of tuple versions, which are visible to transactions, and effort on index maintenance in balance for different workloads on modern hardware technologies.
Database management systems (DBMS) are critical performance components in large scale applications under modern update intensive workloads. Additional access paths accelerate look-up performance in DBMS for frequently queried attributes, but the required maintenance slows down update performance. The ubiquitous B+ tree is a commonly used key-indexed access path that is able to support many required functionalities with logarithmic access time to requested records. Modern processing and storage technologies and their characteristics require reconsideration of matured indexing approaches for today's workloads. Partitioned B-trees (PBT) leverage characteristics of modern hardware technologies and complex memory hierarchies as well as high update rates and changes in workloads by maintaining partitions within one single B+-Tree. This paper includes an experimental evaluation of PBTs optimized write pattern and performance improvements. With PBT transactional throughput under TPC-C increases 30%; PBT results in beneficial sequential write patterns even in presence of updates and maintenance operations.
In any autonomous driving system, the map for localization plays a vital part that is often underestimated. The map describes the world around the vehicle outside of the sensor view and is a main input into the decision making process in highly complicated scenarios. Thus there are strict requirements towards the accuracy and timeliness of the map. We present a robust and reliable approach towards crowd based mapping using a GraphSLAM framework based on radar sensors. We show on a parking lot that even in dynamically changing environments, the localization results are very accurate and reliable even in unexplored terrain without any map data. This can be achieved by collaborative map updates from multiple vehicles. To show these claims experimentally, the Joint Graph Optimization is compared to the ground truth on an industrial parking space. Mapping performance is evaluated using a dense map from a total station as reference and localization results are compared with a deeply coupled DGPS/INS system.
A gate driver approach is presented for the reduction of turn-on losses in hard switching applications. A significant turn-on loss reduction of up to 55% has been observed for SiCMOSFETs. The gate driver approach uses a transformer which couples energy from the power path back into the gate path during switching events, providing increased gate driver current and thereby faster switching speed.
The gate driver approach was tested on a boost converter running at a switching frequency up to 300 kHz. With an input voltage of 300V and an output voltage of 600V, it was possible to reduce the converter losses by 8% at full load. Moreover, the output power range could be extended by 23% (from 2.75kW to 3.4 kW) due to the reduction of the turn-on losses.
In this work we investigate the behavior of MIS- and Schottky-gate AlGaN/GaN HEMTs under high-power pulsestress. A special setup capable of applying pulses of constant power is used to evaluate the electro-thermal response in different operating points. For both types of devices, the time to failure was found to decrease with increasing drain-source voltage. Overall, the Schottky-gate device displays a higher pulse robustness. The pulse withstand time of the MIS-gate device is limited by the occurrence of a thermal instability at approximately 240°C while the Schottky-gate device displays a rapid increase of the gate leakage current prior to failure. The mechanism responsible for this gate current is further investigated by static and transient temperature measurements and yielded activation energies of 0.6 eV and 0.84 eV.
46 Prozent der Arbeitsplätze in der Automobilindustrie sind bis 2030 durch Automatisierung und Digitalisierung bedroht – die Tätigkeiten werden dann nicht mehr von Menschen, sondern von intelligenten Robotern und Systemen erledigt. Das ist das zentrale Ergebnis unserer Studie „Digitale Transformation – Der Einfluss der Digitalisierung auf die Workforce in der Automobilindustrie“, die wir gemeinsam mit dem Herman Hollerith Lehr- und Forschungszentrum an der Hochschule Reutlingen erstellt haben.
Erfindungsgemäß wird ein Verfahren zur Optimierung des Betriebs eines in einem Regelkreis für einen Aufwärtswandler vorgesehenen digitalen Reglers (30) zur Verfügung gestellt. Das Verfahren umfasst die folgenden Verfahrensschritte: Auswerten (S1) mindestens einer Ausgangsgröße des digitalen Reglers im Betrieb des Aufwärtswandlers. Schätzen (S2) des instantanen Lastwiderstandswertes (RL) in der Strecke des Regelkreises anhand der mindestens einen ausgewerteten Ausgangsgröße. Einstellen (S3) mindestens eines Reglerkoeffizienten des digitalen Reglers anhand des geschätzten instantanen Lastwiderstandswertes (RL) im Betrieb des Aufwärtswandlers. Erfindungsgemäß bedingt eine Veränderung in der Einstellung des mindestens einen Reglerkoeffizienten eine Veränderung der Transitfrequenz im Regelkreis. Ferner wird ein Regelkreis für einen Aufwärtswandler mit einem digitalen Regler zur Verfügung gestellt, welcher eingerichtet ist, um die Schritte des erfindungsgemäßen Verfahrens durchzuführen. Des Weiteren wird ein Computerprogrammprodukt mit computerausführbarem Programmcode zur Durchführung des erfindungsgemäßen Verfahrens zur Verfügung gestellt.
Cell-cell and cell-extracellular matrix (ECM) adhesion regulates fundamental cellular functions and is crucial for cell-material contact. Adhesion is influenced by many factors like affinity and specificity of the receptor-ligand interaction or overall ligand concentration and density. To investigate molecular details of cell ECM and cadherins (cell-cell) interaction in vascular cells functional nanostructured surfaces were used Ligand-functionalized gold nanoparticles (AuNPs) with 6-8 nm diameter, are precisely immobilized on a surface and separated by non-adhesive regions so that individual integrins or cadherins can specifically interact with the ligands on the AuNPs. Using 40 nm and 90 nm distances between the AuNPs and functionalized either with peptide motifs of the extracellular matrix (RGD or REDV) or vascular endothelial cadherins (VEC), the influence of distance and ligand specificity on spreading and adhesion of endothelial cells (ECs) and smooth muscle cells (SMCs) was investigated. We demonstrate that RGD-dependent adhesion of vascular cells is similar to other cell types and that the distance dependence for integrin binding to ECM-peptides is also valid for the REDV motif. VEC-ligands decrease adhesion significantly on the tested ligand distances. These results may be helpful for future improvements in vascular tissue engineering and for development of implant surfaces.
Intermediate filament reorganization dynamically influences cancer cell alignment and migration
(2017)
The interactions between a cancer cell and its extracellular matrix (ECM) have been the focus of an increasing amount of investigation. The role of the intermediate filament keratin in cancer has also been coming into focus of late, but more research is needed to understand how this piece fits in the puzzle of cytoskeleton-mediated invasion and metastasis. In Panc-1 invasive pancreatic cancer cells, keratin phosphorylation in conjunction with actin inhibition was found to be sufficient to reduce cell area below either treatment alone. We then analyzed intersecting keratin and actin fibers in the cytoskeleton of cyclically stretched cells and found no directional correlation. The role of keratin organization in Panc-1 cellular morphological adaptation and directed migration was then analyzed by culturing cells on cyclically stretched polydimethylsiloxane (PDMS) substrates, nanoscale grates, and rigid pillars. In general, the reorganization of the keratin cytoskeleton allows the cell to become more ‘mobile’- exhibiting faster and more directed migration and orientation in response to external stimuli. By combining keratin network perturbation with a variety of physical ECM signals, we demonstrate the interconnected nature of the architecture inside the cell and the scaffolding outside of it, and highlight the key elements facilitating cancer cell-ECM interactions.
A wide variety of cell types exhibit substrate topography-based behavior, also known as contact guidance. However, the precise cellular mechanisms underlying this process are still unknown. In this study, we investigated contact guidance by studying the reaction of human endothelial cells (ECs) to well-defined microgroove topographies, both during and after initial cell spreading. As the cytoskeleton plays a major role in cellular adaptation to topographical features, two methods were used to perturb cytoskeletal structures. Inhibition of actomyosin contractility with the chemical inhibitor blebbistatatin demonstrated that initial contact guidance events are independent of traction force generation. However, cell alignment to the grooved substrate was altered at later time points, suggesting an initial ‘passive’ phase of contact guidance, followed by a contractility-dependent ‘active’ phase that relies on mechanosensitive feedback. The actin cytoskeleton was also perturbed in an indirect manner by culturing cells upside down, resulting in decreased levels of contact guidance and suggesting that a possible loss of contact between the actin cytoskeleton and the substrate could lead to cytoskeleton impairment. The process of contact guidance at the microscale was found to be primarily lamellipodia driven, as no bias in filopodia extension was observed on micron-scale grooves.
Saving energy and road safety became important in the last decades, hence several driving assistant systems were developed that help to improve the driving behaviour. However, these driving systems cover the area of either energy-efficiency or safety. Furthermore, they do not consider the reaction of the driver to a shown recommendation and the driver stress level. In this paper, the decision process of showing a recommendation to the driver in an energy-efficient and safety relevant driving system is presented. The decision process considers the driver's reaction to a shown recommendation and the driver stress in order to increase the user acceptance and the road safety. The results of the evaluation showed that the driving system was able to show recommendations when needed, while suppressing recommendations when the driver ignored a recommendation repeatedly or when the driver was in stress.