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Characterisation of porous knitted titanium for replacement of intervertebral disc nucleus pulposus
(2017)
Effective restoration of human intervertebral disc degeneration is challenged by numerous limitations of the currently available spinal fusion and arthroplasty treatment strategies. Consequently, use of artificial biomaterial implant is gaining attention as a potential therapeutic strategy. Our study is aimed at investigating and characterizing a novel knitted titanium (Ti6Al4V) implant for the replacement of nucleus pulposus to treat early stages of chronic intervertebral disc degeneration. Specific knitted geometry of the scaffold with a porosity of 67.67 ± 0.824% was used to overcome tissue integration failures. Furthermore, to improve the wear resistance without impairing original mechanical strength, electro-polishing step was employed. Electro-polishing treatment changed a surface roughness from 15.22 ± 3.28 to 4.35 ± 0.87 μm without affecting its wettability which remained at 81.03 ± 8.5°. Subsequently, cellular responses of human mesenchymal stem cells (SCP1 cell line) and human primary chondrocytes were investigated which showed positive responses in terms of adherence and viability. Surface wettability was further enhanced to super hydrophilic nature by oxygen plasma treatment, which eventually caused substantial increase in the proliferation of SCP1 cells and primary chondrocytes. Our study implies that owing to scaffolds physicochemical and biocompatible properties, it could improve the clinical performance of nucleus pulposus replacement.
Dieses Buch beschreibt detailliert die Voraussetzungen und den Prozessablauf von Business Cases. Diese stellen in der Praxis das wichtigste Instrument dar, um unternehmerische Entscheidungen auf ihre Vorteilhaftigkeit zu analysieren. Um einen adäquaten Business Case zu erstellen, reicht allerdings die reine Beherrschung der relevanten Methoden der Investitionsrechnung nicht aus. Andreas Taschner gibt hilfreiche Anleitungen und Tipps zur Methodenwahl und Ergebnisdarstellung und erläutert weitergehende Fragen, wie die Berücksichtigung von Unsicherheit oder die Einbeziehung nicht-monetärer Faktoren. Die Orientierung am idealtypischen Prozess hilft beim Erarbeiten eigener Business Cases und liefert einen Leitfaden für die ersten selbstständigen Arbeiten. Anwendungsbezogene Fragen und Antworten vertiefen die Thematik. „Business Cases“ wendet sich an Unternehmenspraktiker in den Bereichen Investition, Controlling, Planung und Unternehmensführung. Studierende der Wirtschaftswissenschaften an Fachhochschulen und Universitäten, insbesondere mit den Schwerpunkten Controlling und Unternehmensführung, profitieren von der kompakten Wissensvermittlung.
Afrika ist aufgrund überdurchschnittlicher Wirtschaftswachstumsraten und als die weltweit letzten unbearbeiteten Märkte seit einigen Jahren ein populäres Thema der Wirtschaft. Deutsche Unternehmen sind allerdings mit ihrem Engagement auf den afrikanischen Märkten sehr zurückhaltend. So schwankt der Anteil der deutschen Exporte nach Afrika an den deutschen Gesamtexporten seit zehn Jahren um die zwei Prozent; betrachtet man nur Subsahara‐Afrika, so waren es sogar nur 0,5 % in 2014 (Allafi und Koch 2015, S. 3). Bezüglich der Direktinvestitionen (nur Beteiligungskapital, ohne Direktinvestitionskredite) spielt Afrika eine noch geringere Rolle mit nur 1,5 % aller deutschen Investitionen in 2014, wobei hiervon so gut wie alle nach Nordafrika und Südafrika geflossen sind (Deutsche Bundesbank 2015, S. 12 f.). Neben den Standardgründen wie beispielsweise politischen Risiken, schlechter Infrastruktur, schwacher institutioneller Rahmenbedingungen und Governance‐Problemen (vgl. zum Beispiel World Bank 2016a), ist ein gängiges Markteintrittsproblem die fehlende Verfügbarkeit von lokalen Partnern in den Bereichen Vertrieb, Logistik und teilweise auch Produktion (vgl. zum Beispiel Carlowitz und Röndigs 2016). Aktuell ist ein Markteintritt in Afrika ohne lokalen Partner aufgrund der völlig anderen und schwierigen Rahmenbedingungen fast unmöglich.
Medical applications are becoming increasingly important in the current development of health care and therefore a crucial part of the medical industry. The work focuses on the analysis of requirements and the challenges arisen from designing mobile medical applications in relation to the user interface. The paper describes the current status in the development of mobile medical apps and illustrates the development of e-health market. The author will explain the requirements and will illustrate the hurdles and problems. He refers to the German market which is similar to the European and compares that with the market in the USA.
Sleep quality and in general, behavior in bed can be detected using a sleep state analysis. These results can help a subject to regulate sleep and recognize different sleeping disorders. In this work, a sensor grid for pressure and movement detection supporting sleep phase analysis is proposed. In comparison to the leading standard measuring system, which is Polysomnography (PSG), the system proposed in this project is a non invasive sleep monitoring device. For continuous analysis or home use, the PSG or wearable actigraphy devices tends to be uncomfortable. Besides this fact, they are also very expensive. The system represented in this work classifies respiration and body movement with only one type of sensor and also in a non invasive way. The sensor used is a pressure sensor. This sensor is low cost and can be used for commercial proposes. The system was tested by carrying out an experiment that recorded the sleep process of a subject. These recordings showed the potential for classification of breathing rate and body movements. Although previous researches show the use of pressure sensors in recognizing posture and breathing, they have been mostly used by positioning the sensors between the mattress and bedsheet. This project however, shows an innovative way to position the sensors under the mattress.
To evaluate the quality of sleep, it is important to determine how much time was spent in each sleep stage during the night. The gold standard in this domain is an overnight polysomnography (PSG). But the recording of the necessary electrophysiological signals is extensive and complex and the environment of the sleep laboratory, which is unfamiliar to the patient, might lead to distorted results. In this paper, a sleep stage detection algorithm is proposed that uses only the heart rate signal, derived from electrocardiogram (ECG), as a discriminator. This would make it possible for sleep analysis to be performed at home, saving a lot of effort and money. From the heart rate, using the fast Fourier transformation (FFT), three parameters were calculated in order to distinguish between the different sleep stages. ECG data along with a hypnogram scored by professionals was used from Physionet database, making it easy to compare the results. With an agreement rate of 41.3%, this approach is a good foundation for future research.
Die weiterhin hohen Schulden in einigen Staaten der Europäischen Wirtschafts- und Währungsunion lassen nach wie vor staatliche Insolvenzen befürchten. Um die entstandenen Probleme zu bewältigen, aber auch damit eine solche Situation erst gar nicht eintritt, hält der Autor eine staatliche Insovenzordnung – mit Bail-out durch die anderen Mitgliedstaaten nur in Notfällen – für erforderlich. Er schlägt einen staatlichen Abwicklungsmechanismus für überschuldete Euro-Länder vor, der auf einem Konzept des Sachverständigenrates für Wirtschaft von 2016 beruht.
This paper studies whether a monetary union can be managed solely by a rule based approach. The Five Presidents’ Report of the European Union rejects this idea. It suggests a centralisation of powers. We analyse the philosophy of policy rules from the vantage point of the German economic school of thought. There is evidence that a monetary union consisting of sovereign states is well organised by rules, together with the principle of subsidiarity. The root cause of the euro crisis is rather the weak enforcement of rules, compounded by structural problems. Therefore, we suggest a genuine rule-based paradigm for a stable future of the Economic and Monetary Union.
Digitization transforms business process models and processes in many enterprises. However, many of them need guidance, how digitization is impacting the design of their information systems. Therefore, this paper investigates the influence of digitization on information system design. We apply a two-phase research method applying a literature review and an exploratory case study. The case study took place in the IT service provider of a large insurance enterprise. The study’s results suggest that a number of areas of information system design are affected, such as architecture, processes, data and services.
This article provides a general overview of the most promising candidates of bio based materials and deals with the most important issues when it comes to their incorporation into PF resins. Due to their abundance on Earth, much knowledge of lignin-based materials has already been gained and uses of lignin in PF resins have been studied for many decades. Other natural polyphenols that are less frequently considered for impregnation are covered as well, as they do also possess some potential for PF substitution.
High quality decorative laminate panels typically consist of two major types of components: the surface layers comprising décor and overlay papers that are impregnated with melamine-based resins, and the core which is made of stacks of kraft papers impregnated with phenolic (PF) resin. The PF-impregnated layers impart superior hydrolytic stability, mechanical strength and fire-resistance to the composite. The manufacturing involves the complex interplay between resin, paper and impregnation/drying processes. Changes in the input variables cause significant alterations in the process characteristics and adaptations of the used materials and specific process conditions may, in turn, be required. This review summarizes the main variables influencing both processability and technological properties of phenolic resin impregnated papers and laminates produced therefrom. It is aimed at presenting the main influences from the involved components (resin and paper), how these may be controlled during the respective process steps (resin preparation and paper production), how they influence the impregnation and lamination conditions, how they affect specific aspects of paper and laminate performance, and how they interact with each other
(synergies).
This paper presents a novel multi-modal CNN architecture that exploits complementary input cues in addition to sole color information. The joint model implements a mid-level fusion that allows the network to exploit cross modal interdependencies already on a medium feature-level. The benefit of the presented architecture is shown for the RGB-D image understanding task. So far, state-of-the-art RGB-D CNNs have used network weights trained on color data. In contrast, a superior initialization scheme is proposed to pre-train the depth branch of the multi-modal CNN independently. In an end-to-end training the network parameters are optimized jointly using the challenging Cityscapes dataset. In thorough experiments, the effectiveness of the proposed model is shown. Both, the RGB GoogLeNet and further RGB-D baselines are outperformed with a significant margin on two different tasks: semantic segmentation and object detection. For the latter, this paper shows how to extract object level groundtruth from the instance level annotations in Cityscapes in order to train a powerful object detector.
Despite the significant potential offered by the powder coating process for finishing wood-based materials, until now it has been used almost exclusively for coating Medium Density Fiber Board (MDF). A research project aims to develop processes and substrate materials that will allow lightweight boards to be powder coated.
In this paper a method for the generation of gSPM with ontology-based generalization was presented. The resulting gSPM was modeled with BPMN/BPMNsix in an efficient way and could be executed with BPMN workflow engines. In the next step the implementation of resource concepts, anatomical structures, and transition probabilities for workflow execution will be realized.
Software and system development is complex and diverse, and a multitude of development approaches is used and combined with each other to address the manifold challenges companies face today. To study the current state of the practice and to build a sound understanding about the utility of different development approaches and their application to modern software system development, in 2016, we launched the HELENA initiative. This paper introduces the 2nd HELENA workshop and provides an overview of the current project state. In the workshop, six teams present initial findings from their regions, impulse talk are given, and further steps of the HELENA roadmap are discussed.
Software startups often make assumptions about the problems and customers they are addressing as well as the market and the solutions they are developing. Testing the right assumptions early is a means to mitigate risks. Approaches such as Lean Startup foster this kind of testing by applying experimentation as part of a constant build-measure-learn feedback loop. The existing research on how software startups approach experimentation is very limited. In this study, we focus on understanding how software startups approach experimentation and identify challenges and advantages with respect to conducting experiments. To achieve this, we conducted a qualitative interview study. The initial results show that startups often spent a disproportionate amount of time focusing on creating solutions without testing critical assumptions. Main reasons are the lack of awareness, that these assumptions can be tested early and a lack of knowledge and support on how to identify, prioritize and test these assumptions. However, startups understand the need for testing risky assumptions and are open to conducting experiments.
Context: The current situation and future scenarios of the automotive domain require a new strategy to develop high quality software in a fast pace. In the automotive domain, it is assumed that a combination of agile development practices and software product lines is beneficial, in order to be capable to handle high frequency of improvements. This assumption is based on the understanding that agile methods introduce more flexibility in short development intervals. Software product lines help to manage the high amount of variants and to improve quality by reuse of software for long term development.
Goal: This study derives a better understanding of the expected benefits for a combination. Furthermore, it identifies the automotive specific challenges that prevent the adoption of agile methods within the software product line.
Method: Survey based on 16 semi structured interviews from the automotive domain, an internal workshop with 40 participants and a discussion round on ESE congress 2016. The results are analyzed by means of thematic coding.