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Die Arbeit stellt die Möglichkeiten von 3D-Controllern für den Einsatz in der interventionellen Radiologie und insbesondere für die Steuerung der Echtzeit-Magnetresonanztomographie (MRT) dar. Dies ist interessant in Bezug auf die kontrollierte Navigation in ein Zielgewebe. Dabei kann der Interventionalist durch Echtzeit- Bildgebung den Verlauf des Eingriffs verfolgen, allerdings kann er bisher das MRT während der Durchführung des Eingriffs nicht selbst steuern, da dies durch den Assistenten im Nebenraum erfolgt. Die Kommunikation ist bei dem hohen Geräuschpegel aber sehr schwer. Diese Arbeit setzt an dieser Stelle an und analysiert 3D-Controller auf die Eignung für die Echtzeit-Steuerung eines MRTs. Dabei wurden trackingbasierte und trackinglose Geräte betrachtet. Als Ergebnis ließ sich festhalten, dass trackingbasierte Verfahren weniger geeignet sind, aufgrund der nicht ausreichenden Interpretation der Eingaben. Die trackinglosen Geräte hingegen sind aufgrund der korrekten Interpretation aller Eingaben und der intuitiven Bedienung geeignet.
Social networks, smart portable devices, Internet of Things (IoT) on base of technologies like analytics for big data and cloud services are emerging to support flexible connected products and agile services as the new wave of digital transformation. Biological metaphors of living and adaptable ecosystems with service-oriented enterprise architectures provide the foundation for self-optimizing and resilient run-time environments for intelligent business services and related distributed information systems. We are extending Enterprise Architecture (EA) with mechanisms for flexible adaptation and evolution of information systems having distributed IoT and other micro-granular digital architecture to support next digitization products, services, and processes. Our aim is to support flexibility and agile transformation for both IT and business capabilities through adaptive digital enterprise architectures. The present research paper investigates additionally decision mechanisms in the context of multi-perspective explorations of enterprise services and Internet of Things architectures by extending original enterprise architecture reference models with state of art elements for architectural engineering and digitization.
The digital transformation of our society changes the way we live, work, learn, communicate, and collaborate. This disruptive change drive current and next information processes and systems that are important business enablers for the context of digitization since years. Our aim is to support flexibility and agile transformations for both business domains and related information technology with more flexible enterprise information systems through adaptation and evolution of digital architectures. The present research paper investigates the continuous bottom-up integration of micro-granular architectures for a huge amount of dynamically growing systems and services, like microservices and the Internet of Things, as part of a new composed digital architecture. To integrate micro-granular architecture models into living architectural model versions we are extending enterprise architecture reference models by state of art elements for agile architectural engineering to support digital products, services, and processes.
Digitization fosters the development of IT environments with many rather small structures, like Internet of Things (IoT), microservices, or mobility systems. They are needed to support flexible and agile digitized products and services. The goal is to create service-oriented enterprise architectures (EA) that are self optimizing and resilient. The present research paper investigates methods for decision-making concerning digitization architectures for Internet of Things and microservices. They are based on evolving enterprise architecture reference models and state of the art elements for architectural engineering for microgranular systems. Decision analytics in this field becomes increasingly complex and decision support, particularly for the development and evolution of sustainable enterprise architectures, is sorely needed. The challenging of the decision processes can be supported with in a more flexible and intuitive way by an architecture management cockpit.
Saving energy and road safety became important in the last decades, hence several driving assistant systems were developed that help to improve the driving behaviour. However, these driving systems cover the area of either energy-efficiency or safety. Furthermore, they do not consider the reaction of the driver to a shown recommendation and the driver stress level. In this paper, the decision process of showing a recommendation to the driver in an energy-efficient and safety relevant driving system is presented. The decision process considers the driver's reaction to a shown recommendation and the driver stress in order to increase the user acceptance and the road safety. The results of the evaluation showed that the driving system was able to show recommendations when needed, while suppressing recommendations when the driver ignored a recommendation repeatedly or when the driver was in stress.
Introducing continuous experimentation in large software-intensive product and service organisations
(2017)
Software development in highly dynamic environments imposes high risks to development organizations. One such risk is that the developed software may be of only little or no value to customers, wasting the invested development efforts.Continuous experiment ation, as an experiment-driven development approach, may reduce such development risks by iteratively testing product and service assumptions that are critical to the success of the software. Although several experiment-driven development approaches are available, there is little guidance available on how to introduce continuous experimentation into an organization. This article presents a multiple-case study that aims at better understanding the process of introducing continuous experimentation into an organization with an already established development process. The results from the study show that companies are open to adopting such an approach and learning throughout the introduction process. Several benefits were obtained, such as reduced development efforts, deeper customer insights, and better support for development decisions. Challenges included complex stakeholder structures, difficulties in defining success criteria, and building experimen- tation skills. Our findings indicate that organizational factors may limit the benefits of experimentation. Moreover, introducing continuous experimentation requires fundamental changes in how companies operate, and a systematic introduction process can increase the chances of a successful start.
Purpose: Human breath analysis is proposed with increasing frequency as a useful tool in clinical application. We performed this study to find the characteristic volatile organic compounds (VOCs) in the exhaled breath of patients with idiopathic pulmonary fibrosis (IPF) for discrimination from healthy subjects. Methods: VOCs in the exhaled breath of 40 IPF patients and 55 healthy controls were measured using a multi-capillary column and ion mobility spectrometer. The patients were examined by pulmonary function tests, blood gas analysis, and serum biomarkers of interstitial pneumonia. Results: We detected 85 VOC peaks in the exhaled breath of IPF patients and controls. IPF patients showed 5 significant VOC peaks; p-cymene, acetoin, isoprene, ethylbenzene, and an unknown compound. The VOC peak of p-cymene was significantly lower (p < 0.001), while the VOC peaks of acetoin, isoprene, ethylbenzene, and the unknown compound were significantly higher (p < 0.001 for all) compared with the peaks of controls. Comparing VOC peaks with clinical parameters, negative correlations with VC (r =−0.393, p = 0.013), %VC (r =−0.569, p < 0.001), FVC (r = −0.440, p = 0.004), %FVC (r =−0.539, p < 0.001), DLco (r =−0.394, p = 0.018), and %DLco (r =−0.413, p = 0.008) and a positive correlation with KL-6 (r = 0.432, p = 0.005) were found for p-cymene. Conclusion: We found characteristic 5 VOCs in the exhaled breath of IPF patients. Among them, the VOC peaks of p-cymene were related to the clinical parameters of IPF. These VOCs may be useful biomarkers of IPF.
Within the scope of the present cumulative doctoral thesis six scientific papers were published which illustrates that modern reaction model-free (=isoconversional) kinetic analysis (ICKA) methods represents a universal and effective tool for the controlled processing of thermosetting materials. In order to demonstrate the universal applicability of ICKA methods, the thermal cure of different thermosetting materials having a very broad range of chemical composition (melamine-formaldehyde resins, epoxy resins, polyester-epoxy resins, and acrylate/epoxy resins) were analyzed and mathematically modelled. Some of the materials were based on renewable resources (an epoxy resin was made from hempseed oil; linseed oil was modified into an acrylate/epoxy resin). With the aid of ICKA methods not only single-step but also complex multi-step reactions were modelled precisely. The analyzed thermosetting materials were combined with wood, wood-based products, paper, and plant fibers which are processed to various final products. Some of the thermosetting materials were applied as coating (in form of impregnated décor papers or powder and wet coatings respectively) on wood substrates and the epoxy resin from hempseed oil was mixed with plant fibers and processed into bio-based composites for lightweight applications. From the final products mechanical, thermal, and surface properties were determined. The activation energy as function of cure conversion derived from ICKA methods was utilized to predict accurately the thermal curing over the course of time for arbitrary cure conditions. Furthermore the cure models were used to establish correlations between the cross-linking during processing into products and the properties of the final products. Therewith it was possible to derive the process time and temperature that guarantee optimal cross-linking as well as optimal product properties
The presented wide-Vin step-down converter introduces a parallel-resonant converter (PRC), comprising an integrated 5-bit capacitor array and a 300 nH resonant coil, placed in parallel to a conventional buck converter. Unlike conventional resonant concepts, the implemented soft-switching control eliminates input voltage dependent losses over a wide operating range. This ensures high efficiency across a wide range of Vin= 12-48V, 100-500mA load and 5V output at up to 15MHz switching frequency. The peak efficiency of the converter is 76.3 %. Thanks to the low output current ripple, the output capacitor can be as small as 50 nF, while the inductor tolerates a larger ESR, resulting in small component size. The proposed PRC architecture is also suitable for future power electronics applications using fast-switching GaN devices.
This publication gives a short introduction and overview of the European project SCOUT and introduces a methodology for a holistic approach to record the state of the art in technical (vehicle and connectivity, human factors regarding physiologic and ergonomic level) and non-technical enablers (societal, economic, legal, regulatory and policy level) of connected and automated driving in Europe. The paper addresses beside the technical topics of environmental perception, E/E architecture, actuators and security, the state of the art of the legal framework in the context of connected and automated driving.
Diese Arbeit liefert einen Konzeptentwurf, der die Integration verschiedener Systeme mit prozessrelevanten klinischen Diensten gewährleistet. Chirurgische Abläufe werden in Form von Prozessen modelliert. Die Wahl der Notation und die Art der Modellierung dieser Prozesse spielt in der heutigen Forschung in diesem Gebiet eine zentrale Rolle. Sind diese Prozesse modelliert, besteht die Möglichkeit, diese in einer Workflow-Engine automatisiert auszuführen. Im Rahmen der Entwicklung eines Workflow-Managment-Systems stellt sich die Frage, wie die Anbindung dieser Workflow-Engine mit anderen Systemen erfolgen soll. In der Arbeit werden Schnittstellen abstrakt in der Web Services Description Language (WSDL) definiert. Darum werden automatisiert Artefakte erzeugt. Auf der Grundlage dieser Artefakte erfolgt die Integration der Systeme. Die Workflow-Engine kommunizieren über SOAP-Nachrichten (Simple Object Access Protocol) mit den entsprechenden Systemen. Dieser Ansatz wurde mithilfe eines Prototyps validiert und umgesetzt.
Purpose: Medical processes can be modeled using different methods and notations.Currently used modeling systems like Business Process Model and Notation (BPMN) are not capable of describing the highly flexible and variable medical processes in sufficient detail.
Methods: We combined two modeling systems, Business Process Management (BPM) and Adaptive Case Management (ACM), to be able to model non-deterministic medical processes. We used the new Standards Case Management Model and Notation (CMMN) and Decision Management Notation (DMN).
Results: First, we explain how CMMN, DMN and BPMN could be used to model non-deterministic medical processes. We applied this methodology to model 79 cataract operations provided by University Hospital Leipzig, Germany, and four cataract operations provided by University Eye Hospital Tuebingen, Germany. Our model consists of 85 tasks and about 20 decisions in BPMN. We were able to expand the system with more complex situations that might appear during an intervention.
Conclusion: An effective modeling of the cataract intervention is possible using the combination of BPM and ACM. The combination gives the possibility to depict complex processes with complex decisions. This combination allows a significant advantage for modeling perioperative processes.
Nowadays CHP units are discussed for the production of electricity on demand rather than for generation of heat providing electricity as a by-product. By this means, CHP units are capable of satisfying a higher share of the electricity demand on-site and in this new role, CHP units are able to reduce the load on the power grid and to compensate for high fluctuations of solar and wind power.
Evidently, a novel control strategy for CHP units is required in order to shift the operation oriented at the heat demand to an operation led by the electricity demand. Nevertheless, the heat generated by the CHP unit needs to be utilized completely in any case, for maintaining energy as well as economic efficiency. Such a strategy has been developed at Reutlingen University, and it will be presented in the paper. Part of the strategy is an intelligent management for the thermal energy storage (TES) ensuring that the storage is at low level in terms of its heat content just before an electricity demand is calling the CHP unit into operation. Moreover, a proper forecast of both, heat and electricity demand, is incorporated and the requirements of the CHP unit in terms of maintenance and lifetime are considered by limiting the number of starts and stops per unit time and by maintaining a certain minimum length of the operation intervals.
All aspects of this novel control strategy are revealed in the paper, which has been implemented on a controller for further testing at two sites in the field. Results from these tests are given as well as results from a simulation model, which is able to evaluate the performance of the control strategy for an entire year.
This article covers the design of highly integrated gate drivers and level shifters for high-speed, high power efficiency and dv/dt robustness with focus on automotive applications. With the introduction of the 48 V board net in addition to the conventional 12 V battery, there is an increasing need for fast switching integrated gate drivers in the voltage range of 50 V and above. State-of-the-art drivers are able to switch 50 V in less than 5 ns. The high-voltage electrical drive train demands for galvanic isolated and highly integrated gate drivers. A gate driver with bidirectional signal transmission with a 1 MBit/s amplitude modulation, 10/20 MHz frequency modulation and power transfer over one single transformer will be discussed. The concept of high-voltage charge storing enables an area-efficient fully integrated bootstrapping supply with 70 % less area consumption. EMC is a major concern in automotive. Gate drivers with slope control optimize EMC while maintaining good switching efficiency. A current mode gate driver, which can change its drive current within 10 ns, results in 20 dBuV lower emissions between 7 and 60 MHz and 52 % lower switching loss compared to a conventional constant current gate driver.
Though bioprinting is a forward-looking approach in bone tissue engineering, the development of bioinks which are on the one hand processable with the chosen printing technique, and on the other hand possess the relevant mechanical as well as osteoconductive features remains a challenge. In the present study, polymer solutions based on methacrylated gelatin and methacrylated hyaluronic acid modified with hydroxyapatite (HAp) particles (5 wt%) were prepared. Encapsulation of primary human adipose derived stem cells in the HAp-containing gels and culture for 28 d resulted in a storage moduli significantly increased to 126% ± 9.6% compared to the value on day 1 by the sole influence of the HAp. Additional use of osteogenic media components resulted in an increase of storage module up to 199% ± 27.8%. Similarly, the loss moduli was increased to 370% ± 122.1% under the influence of osteogenic media components and HAp. Those changes in rheological material characteristics indicate a distinct change in elastic and viscous hydrogel properties, and are attributed to extensive matrix production in the hydrogels by the encapsulated cells, what could also be proven by staining of bone matrix components like collagen I, fibronectin, alkaline phosphatase and osteopontin. When using the cell-laden polymer solutions as bioinks to build up relevant geometries, the ink showed excellent printability and the printed grid structure's integrity remained intact over a culture time of 28 d. Again, an intense matrix formation as well as upregulation of osteogenic markers by the encapsulated cells could be shown. In conclusion, we demonstrated that our HAp-containing bioinks and hydrogels on basis of methacrylated gelatin and hyaluronic acid are on the one hand highly suitable for the build up of relevant three-dimensional geometries with microextrusion bioprinting, and on the other hand exhibit a significant positive effect on bone matrix development and remodeling in the hydrogels, as indicated by rheological measurements and staining of bone components. This makes the developed composite hydrogels an excellent material for bone bioprinting approaches.
Sesam öffne Dich
(2017)
Aus ähnlichen Beweggründen, die Ferdinand von Steinbeis im Großen verfolgte, ist es den Bemühungen des Textilfachlehrers Reichelt und dem damaligen Prof. Stängle zu verdanken, dass gegen Ende des 19. Jahrhunderts an der in der Zwischenzeit zum Technikum für Textilindustrie avancierten Reutlinger Textilanstalt eine reichhaltige Sammlung von Modellen und Gewebemustern eingerichtet und aufgebaut wurde. Den Schwerpunkt der aus über 500000 Mustern und Gewebefragmenten bestehenden Kollektion bilden europäische Jacquard-Gewebe und engliche Anzugsstoffe aus dem 19. Jahrhundert. Das Glanzstück der Reutlinger Gewebesammlung bilden ... etwa 900 altjapanische Gewebefragmente aus der Zeit von 1530 bis 1880 ...
A novel configuration of the dual active bridge (DAB) DC/DC converter is presented, enabling more efficient wide voltage range conversion at light loads. A third phase leg as well as a center tapped transformer are introduced to one side of the converter. This concept provides two different turn ratios, thus extending the zero voltage switching operation resulting in higher efficiency. A laboratory prototype was built converting an input voltage of 40V to an output voltage in the range of 350V to 650V. Measurements show a significant increase up to 20% in the efficiency for light-load operation.
This paper presents a control strategy for optimal utilization of photovoltaic (PV) generated power in conjunction with an Energy Storage System (ESS). The ESS is specifically designed to be retrofitted into existing PV systems in an end-user application. It can be attached in parallel to the PV system and connects to existing DC/AC inverters. In particular, the study covers the impact such a modification has on the output power of existing PV panels. A distinct degradation of PV output power was found due to the different power characteristics of PV panel and ESS. To overcome such degradation a novel feedback system is proposed. The feedback system continuously modifies the power characteristic of the ESS to match the PV panel and thus achieves optimal power utilization. Impact on PV and power point tracking performance is analyzed. Simulation of the proposed system is performed in MATLAB/Simulink. The results are found to be satisfactory.
How to protect the skin from getting sun burnt? The sun can damage your skin e.g. skin cancer. But the sun has a positive effect to the human. The time in sun and the intensity are key values between enjoy the sunbath and having a negative effect to the skin. A smart device like a UV flower could help you to enjoy the sunbath. It measures the UV index around you and gives this information to a smartphone app. The development steps of such a device are described in this paper. The UV flower is made of textile fabrics.
Trotz der oft schwierigen Rahmenbedingungen auf den Märkten Subsahara Afrikas ist es möglich, ein erfolgreiches Geschäft aufzubauen, sofern man die adäquate Markteintrittsform wählt und darüber hinaus bereit ist, das eigene Geschäftsmodell an die lokalen Gegebenheiten anzupassen. Eine Herausforderung ist die politische, wirtschaftliche und kulturelle Heterogenität in Subsahara Afrika, die es unmöglich macht, den Kontinent als einen Markt zu bearbeiten. Allerdings gibt es seit Jahrzehnten regionale Integrationsabkommen, die jedoch erst in den letzten Jahren wiederbelebt und vorangetrieben wurden, wie z. B. die ECOWAS (Economic Community of West African States), die EAC (East African Community) und die SADC (South African Development Corporation). Inzwischen funktionieren diese Initiativen soweit, dass einige ausländische Unternehmen beginnen, Teile des Geschäftes regional und nicht mehr national zu organisieren, also die Länder als gemeinsamen Markt zu bearbeiten. In der Regel sind die kulturellen Unterschiede in Nachbarländern nicht so groß. Aus diesen Gründen besteht Wachstumspotential für geschäftlich interessante Märkte in Subsahara Afrika.