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A fast way to test business ideas and to explore customer problems and needs is to talk to them. Customer interviews help to understand what solutions customers will pay for before investing valuable resources to develop solutions. Customer interviews are a good way to gain qualitative insights. However, conducting interviews can be a difficult procedure and requires specific skills. The current ways of teaching interview skills have significant deficiencies. They especially lack guidance and opportunities to practice. Objective: The goal of this work is to develop and validate a workshop format to teach interview skills for conducting good customer interviews in a practical manner. Method: The research method is based on design science research which serves as a framework. A game-based workshop format was designed to teach interview skills. The approach consists of a half-day, hands-on workshop and is based on an analysis of necessary interview skills. The approach has been validated in several workshops and improved based on learnings from those workshops. Results: Results of the validation show that participants could significantly improve their interview skills while enjoying the game-based exercises. The game-based learning approach supports learning and practicing customer interview skills with playful and interactive elements that encourage greater motivation among participants to conduct interviews.
This book examines the implementation of the Belt and Road Initiative (BRI) in East Africa. The BRI is considered China's central geopolitical and geo-economic project in the era of President Xi Jinping. Through this work, the author aims to contribute to filling some research gaps, such as the lack of depth in studies of individual BRI projects and the underconsideration of processing narratives in participating countries. The guiding question is the extent to which the BRI is a political or hegemonic project of the CCP-directed state-civil society complex in East Africa. To answer these questions, databases of international organizations and policy documents are analyzed. In addition, the author conducts a qualitative content analysis of newspaper articles from local media houses in the countries of Ethiopia, Kenya, and Tanzania to examine three infrastructure projects. The work illustrates that the BRI contributes to increasing connectivity in East Africa. At the same time, the compression of economic relations and the implementation of infrastructure projects in East Africa lead to numerous consequences and contour a hegemonic project.
Automatic classification of rotating machinery defects using Machine Learning (ML) algorithms
(2020)
Electric machines and motors have been the subject of enormous development. New concepts in design and control allow expanding their applications in different fields. The vast amount of data have been collected almost in any domain of interest. They can be static; that is to say, they represent real-world processes at a fixed point of time. Vibration analysis and vibration monitoring, including how to detect and monitor anomalies in vibration data are widely used techniques for predictive maintenance in high-speed rotating machines. However, accurately identifying the presence of a bearing fault can be challenging in practice, especially when the failure is still at its incipient stage, and the signal-to-noise ratio of the monitored signal is small. The main objective of this work is to design a system that will analyze the vibration signals of a rotating machine, based on recorded data from sensors, in the time/frequency domain. As a consequence of such substantial interest, there has been a dramatic increase of interest in applying Machine Learning (ML) algorithms to this task. An ML system will be used to classify and detect abnormal behavior and recognize the different levels of machine operation modes. The proposed solution can be deployed as predictive maintenance for Industry 4.0.
The current advancement of Artificial Intelligence (AI) combined with other digitalization efforts significantly impacts service ecosystems. Artificial intelligence has a substantial impact on new opportunities for the co-creation of value and the development of intelligent service ecosystems. Motivated by experiences and observations from digitalization projects, this paper presents new methodological perspectives and experiences from academia and practice on architecting intelligent service ecosystems and explores the impact of artificial intelligence through real cases supporting an ongoing validation. Digital enterprise architecture models serve as an integral representation of business, information, and technological perspectives of intelligent service-based enterprise systems to support management and development. This paper focuses on architectural models for intelligent service ecosystems, showing the fundamental business mechanism of AI-based value co-creation, the corresponding digital architecture, and management models. The focus of this paper presents the key architectural model perspectives for the development of intelligent service ecosystems.
Our paper gives first answers on a fundamental question: how can the design of architectures of intelligent digital systems and services be accomplished methodologically? Intelligent systems and services are the goals of many current digitalization efforts today and part of massive digital transformation efforts based on digital technologies. Digital systems and services are the foundation of digital platforms and ecosystems. Digtalization disrupts existing businesses, technologies, and economies and promotes the architecture of open environments. This has a strong impact on new value-added opportunities and the development of intelligent digital systems and services. Digital technologies such as artificial intelligence, the Internet of Things, services computing, cloud computing, big data with analytics, mobile systems, and social enterprise networks systems are important enablers of digitalization. The current publication presents our research on the architecture of intelligent digital ecosystems and products and services influenced by the service-dominant logic. We present original methodological extensions and a new reference model for digital architectures with an integral service and value perspective to model intelligent systems and services that effectively align digital strategies and architectures with artificial intelligence as main elements to support intelligent digitalization.
Platforms and their surrounding ecosystems are becoming increasingly important components of many companies' strategies. Artificial Intelligence, in particular, has created new opportunities to create and develop ecosystems around the platform. However, there is not yet a methodology to systematically develop these new opportunities for enterprise development strategy. Therefore, this paper aims to lay a foundation for the conceptualization of Artificial Intelligence-based service ecosystems exploiting a Service-Dominant Logic. The basis for conceptualization is the study of value creation and particularly effective network effects. This research investigates the fundamental idea of extending specific digital concepts considering the influence of Artificial Intelligence on the design of intelligent services, along with their architecture of digital platforms and ecosystems, to enable a smooth evolutionary path and adaptability for human-centric collaborative systems and services. The paper explores an extended digital enterprise conceptual model through a combined, iterative, and permanent task of co-creating value between humans and intelligent systems as part of a new idea of cognitively adapted intelligent services.
Enterprises are currently transforming their strategy, processes, and their information systems to extend their degree of digitalization. The potential of the Internet and related digital technologies, like Internet of Things, services computing, cloud computing, artificial intelligence, big data with analytics, mobile systems, collaboration networks, and cyber physical systems both drives and enables new business designs. Digitalization deeply disrupts existing businesses, technologies and economies and fosters the architecture of digital environments with many rather small and distributed structures. This has a strong impact for new value producing opportunities and architecting digital services and products guiding their design through exploiting a Service-Dominant Logic. The main result of the book chapter extends methods for integral digital strategies with value-oriented models for digital products and services which are defined in the framework of a multi-perspective digital enterprise architecture reference model.
Unternehmen sind derzeit dabei, ihre Strategie, ihre Prozesse und ihre Informationssysteme zu verändern, um ihren Digitalisierungsgrad zu erhöhen. Das Potenzial des Internets und verwandter digitaler Technologien wie Internet der Dinge, Services Computing, Cloud Computing, künstliche Intelligenz, Big Data mit Analysen, mobile Systeme, Kollaborationsnetzwerke und cyber-physikalische Systeme treibt neue Geschäftsmodelle an und ermöglicht sie. Die Digitalisierung führt zu einer tiefgreifenden Umwälzung bestehender Unternehmen, Technologien und Volkswirtschaften und fördert die Architektur digitaler Umgebungen mit vielen eher kleinen und verteilten Strukturen. Dies hat starke Auswirkungen auf neue Wertschöpfungsmöglichkeiten und die Gestaltung digitaler Dienste und Produkte, die durch die Nutzung einer service-dominanten Logik gesteuert werden. Das Hauptergebnis des Buchkapitels erweitert Methoden für integrale digitale Strategien um wertorientierte Modelle für digitale Produkte und Dienstleistungen, die im Rahmen eines multiperspektivischen digitalen Unternehmensarchitektur-Referenzmodells definiert werden.
Enterprises are presently transforming their strategy, culture, processes, and their information systems to become more digital. The digital transformation deeply disrupts existing enterprises and economies. Digitization fosters the development of IT systems with many rather small and distributed structures, like Internet of Things or mobile systems. Since years a lot of new business opportunities appeared using the potential of the Internet and related digital technologies, like Internet of Things, services computing, cloud computing, big data with analytics, mobile systems, collaboration networks, and cyber physical systems. This has a strong impact for architecting digital services and products. The change from a closed-world modeling perspective to more flexible open-world composition and evolution of system architectures defines the moving context for adaptable systems, which are essential to enable the digital transformation. In this paper, we are focusing on a decision-oriented architectural composition approach to support the transformation for digital services and products.
Presently, many companies are transforming their strategy and product base, as well as their culture, processes and information systems to become more digital or to approach for a digital leadership. In the last years new business opportunities appeared using the potential of the Internet and related digital technologies, like Internet of Things, services computing, cloud computing, edge and fog computing, social networks, big data with analytics, mobile systems, collaboration networks, and cyber physical systems. Digitization fosters the development of IT environments with many rather small and distributed structures, like the Internet of Things, Microservices, or other micro-granular elements. This has a strong impact for architecting digital services and products. The change from a closed-world modeling perspective to more flexible open-world composition and evolution of micro-granular system architectures defines the moving context for adaptable systems. We are focusing on a continuous bottom-up integration of micro-granular architectures for a huge amount of dynamically growing systems and services, as part of a new digital enterprise architecture for service dominant digital products.
Digitization of societies changes the way we live, work, learn, communicate, and collaborate. In the age of digital transformation IT environments with a large number of rather small structures like Internet of Things (IoT), microservices, or mobility systems are emerging to support flexible and agile digitized products and services. Adaptable ecosystems with service oriented enterprise architectures are the foundation for self-optimizing, resilient run-time environments and distributed information systems. The resulting business disruptions affect almost all new information processes and systems in the context of digitization. Our aim are more flexible and agile transformations of both business and information technology domains with more flexible enterprise information systems through adaptation and evolution of digital enterprise architectures. The present research paper investigates mechanisms for decision-controlled digitization architectures for Internet of Things and microservices by evolving enterprise architecture reference models and state of the art elements for architectural engineering for micro-granular systems.
Social networks, smart portable devices, Internet of Things (IoT) on base of technologies like analytics for big data and cloud services are emerging to support flexible connected products and agile services as the new wave of digital transformation. Biological metaphors of living and adaptable ecosystems with service-oriented enterprise architectures provide the foundation for self-optimizing and resilient run-time environments for intelligent business services and related distributed information systems. We are extending Enterprise Architecture (EA) with mechanisms for flexible adaptation and evolution of information systems having distributed IoT and other micro-granular digital architecture to support next digitization products, services, and processes. Our aim is to support flexibility and agile transformation for both IT and business capabilities through adaptive digital enterprise architectures. The present research paper investigates additionally decision mechanisms in the context of multi-perspective explorations of enterprise services and Internet of Things architectures by extending original enterprise architecture reference models with state of art elements for architectural engineering and digitization.
The digital transformation of our society changes the way we live, work, learn, communicate, and collaborate. The digitization of software-intensive products and services is enabled basically by four megatrends: Cloud computing, big data mobile systems, and social technologies. This disruptive change interacts with all information processes and systems that are important business enablers for the current digital transformation. The internet of things, social collaboration systems for adaptive case management, mobility systems and services for big data in cloud services environments are emerging to support intelligent user-centered and social community systems. Modern enterprises see themselves confronted with an ever growing design space to engineer business models of the future as well as their IT support, respectively. The decision analytics in this field becomes increasingly complex and decision support, particularly for the development and evolution of sustainable enterprise architectures (EA), is duly needed. With the advent of intelligent user-centered and social community systems, the challenging decision processes can be supported in more flexible and intuitive ways. Tapping into these systems and techniques, the engineers and managers of the enterprise architecture become part of a viable enterprise, i.e. a resilient and continuously evolving system that develops innovative business models.
The Internet of Things (IoT), enterprise social networks, adaptive case management, mobility systems, analytics for big data, and cloud services environments are emerging to support smart connected products and services and the digital transformation. Biological metaphors of living and adaptable ecosystems with service oriented enterprise architectures provide the foundation for self-optimizing and resilient run-time environments for intelligent business services and related distributed information systems. We are investigating mechanisms for flexible adaptation and evolution for the next digital enterprise architecture systems in the context of the digital transformation. Our aim is to support flexibility and agile transformation for both business and related enterprise systems through adaptation and dynamical evolution of digital enterprise architectures. The present research paper investigates mechanisms for decision case management in the context of multi-perspective explorations of enterprise services and Internet of Things architectures by extending original enterprise architecture reference models with state of art elements for architectural engineering for the digitization and architectural decision support.
Intelligent systems and services are the strategic targets of many current digitalization efforts and part of massive digital transformations based on digital technologies with artificial intelligence. Digital platform architectures and ecosystems provide an essential base for intelligent digital systems. The paper raises an important question: Which development paths are induced by current innovations in the field of artificial intelligence and digitalization for enterprise architectures? Digitalization disrupts existing enterprises, technologies, and economies and promotes the architecture of cognitive and open intelligent environments. This has a strong impact on new opportunities for value creation and the development of intelligent digital systems and services. Digital technologies such as artificial intelligence, the Internet of Things, service computing, cloud computing, blockchains, big data with analysis, mobile systems, and social business network systems are essential drivers of digitalization. We investigate the development of intelligent digital systems supported by a suitable digital enterprise architecture. We present methodological advances and an evolutionary path for architectures with an integral service and value perspective to enable intelligent systems and services that effectively combine digital strategies and digital architectures with artificial intelligence.
The Internet of Things, enterprise social networks, adaptive case management, mobility systems, analytics for big data, and cloud services environments are emerging to support smart connected products and services and the digital transformation. Biological metaphors of living and adaptable ecosystems provide the logical foundation for self-optimizing and resilient run-time environments for intelligent business services and related distributed information systems with service-oriented enterprise architectures. We are investigating mechanisms for flexible adaptation and evolution for the next digital enterprise architecture systems in the context of the digital transformation. Our aim is to support flexibility and agile transformation for both business and related enterprise systems through adaptation and dynamical evolution of digital enterprise architectures. The present research paper investigates digital transformations of business and IT and integrates fundamental mappings between adaptable digital enterprise architectures and service-oriented information systems. We are putting a spotlight with the example domain – Internet of Things.
This chapter presents an introduction to the emerging trends for architecting the digital transformation having a strong focus on digital products, intelligent services, and related systems together with methods, models and architectures. The primary aim of this book is to highlight some of the most recent research results in the field. We are providing a focused set of brief descriptions of the chapters included in the book.
In diesem Kapitel wird eine Einführung in die sich abzeichnenden Trends bei der Gestaltung der digitalen Transformation gegeben, wobei der Schwerpunkt auf digitalen Produkten, intelligenten Diensten und damit verbundenen Systemen sowie auf Methoden, Modellen und Architekturen liegt. Das primäre Ziel dieses Buches ist es, einige der neuesten Forschungsergebnisse auf diesem Gebiet hervorzuheben. Wir stellen eine Reihe von Kurzbeschreibungen der im Buch enthaltenen Kapitel zur Verfügung.
Current advances in Artificial Intelligence (AI) combined with other digitalization efforts are changing the role of technology in service ecosystems. Human-centered intelligent systems and services are the target of many current digitalization efforts and part of a massive digital transformation based on digital technologies. Artificial intelligence, in particular, is having a powerful impact on new opportunities for shared value creation and the development of smart service ecosystems. Motivated by experiences and observations from digitalization projects, this paper presents new methodological experiences from academia and practice on a joint view of digital strategy and architecture of intelligent service ecosystems and explores the impact of digitalization based on real case study results. Digital enterprise architecture models serve as an integral representation of business, information, and technology perspectives of intelligent service-based enterprise systems to support management and development. This paper focuses on the novel aspect of closely aligned digital strategy and architecture models for intelligent service ecosystems and highlights the fundamental business mechanism of AI-based value creation, the corresponding digital architecture, and management models. We present key strategy-oriented architecture model perspectives for intelligent systems.
Today, many companies are adapting their strategy, business models, products, services as well as business processes and information systems in order to expand their digitalization level through intelligent systems and services. The paper raises an important question: What are cognitive co-creation mechanisms for extending digital services and architectures to readjust the usage value of smart services? Typically, extensions of digital services and products and their architectures are manual design tasks that are complex and require specialized, rare experts. The current publication explores the basic idea of extending specific digital artifacts, such as intelligent service architectures, through mechanisms of cognitive co-creation to enable a rapid evolutionary path and better integration of humans and intelligent systems. We explore the development of intelligent service architectures through a combined, iterative, and permanent task of co-creation between humans and intelligent systems as part of a new concept of cognitively adapted smart services. In this paper, we present components of a new platform for the joint co-creation of cognitive services for an ecosystem of intelligent services that enables the adaptation of digital services and architectures.
A hybrid deep registration of MR scans to interventional ultrasound for neurosurgical guidance
(2021)
Despite the recent advances in image-guided neurosurgery, reliable and accurate estimation of the brain shift still remains one of the key challenges. In this paper, we propose an automated multimodal deformable registration method using hybrid learning-based and classical approaches to improve neurosurgical procedures. Initially, the moving and fixed images are aligned using classical affine transformation (MINC toolkit), and then the result is provided to the convolutional neural network, which predicts the deformation field using backpropagation. Subsequently, the moving image is transformed using the resultant deformation into a moved image. Our model was evaluated on two publicly available datasets: the retrospective evaluation of cerebral tumors (RESECT) and brain images of tumors for evaluation (BITE). The mean target registration errors have been reduced from 5.35 ± 4.29 to 0.99 ± 0.22 mm in the RESECT and from 4.18 ± 1.91 to 1.68 ± 0.65 mm in the BITE. Experimental results showed that our method improved the state-of-the-art in terms of both accuracy and runtime speed (170 ms on average). Hence, the proposed method provides a fast runtime for 3D MRI to intra-operative US pair in a GPU-based implementation, which shows a promise for its applicability in assisting the neurosurgical procedures compensating for brain shift.
Glioblastomas are the most aggressive fast-growing primary brain cancer which originate in the glial cells of the brain. Accurate identification of the malignant brain tumor and its sub-regions is still one of the most challenging problems in medical image segmentation. The Brain Tumor Segmentation Challenge (BraTS) has been a popular benchmark for automatic brain glioblastomas segmentation algorithms since its initiation. In this year, BraTS 2021 challenge provides the largest multi-parametric (mpMRI) dataset of 2,000 pre-operative patients. In this paper, we propose a new aggregation of two deep learning frameworksnamely, DeepSeg and nnU-Net for automatic glioblastoma recognition in pre-operative mpMRI. Our ensemble method obtains Dice similarity scores of 92.00, 87.33, and 84.10 and Hausdorff Distances of 3.81, 8.91, and 16.02 for the enhancing tumor, tumor core, and whole tumor regions, respectively, on the BraTS 2021 validation set, ranking us among the top ten teams. These experimental findings provide evidence that it can be readily applied clinically and thereby aiding in the brain cancer prognosis, therapy planning, and therapy response monitoring. A docker image for reproducing our segmentation results is available online at (https://hub.docker.com/r/razeineldin/deepseg21).
Purpose: Gliomas are the most common and aggressive type of brain tumors due to their infiltrative nature and rapid progression. The process of distinguishing tumor boundaries from healthy cells is still a challenging task in the clinical routine. Fluid attenuated inversion recovery (FLAIR) MRI modality can provide the physician with information about tumor infiltration. Therefore, this paper proposes a new generic deep learning architecture, namely DeepSeg, for fully automated detection and segmentation of the brain lesion using FLAIR MRI data.
Methods: The developed DeepSeg is a modular decoupling framework. It consists of two connected core parts based on an encoding and decoding relationship. The encoder part is a convolutional neural network (CNN) responsible for spatial information extraction. The resulting semantic map is inserted into the decoder part to get the full-resolution probability map. Based on modified U-Net architecture, different CNN models such as residual neural network (ResNet), dense convolutional network (DenseNet), and NASNet have been utilized in this study.
Results: The proposed deep learning architectures have been successfully tested and evaluated on-line based on MRI datasets of brain tumor segmentation (BraTS 2019) challenge, including s336 cases as training data and 125 cases for validation data. The dice and Hausdorff distance scores of obtained segmentation results are about 0.81 to 0.84 and 9.8 to 19.7 correspondingly.
Conclusion: This study showed successful feasibility and comparative performance of applying different deep learning models in a new DeepSeg framework for automated brain tumor segmentation in FLAIR MR images. The proposed DeepSeg is open source and freely available at https://github.com/razeineldin/DeepSeg/.
Purpose
Artificial intelligence (AI), in particular deep neural networks, has achieved remarkable results for medical image analysis in several applications. Yet the lack of explainability of deep neural models is considered the principal restriction before applying these methods in clinical practice.
Methods
In this study, we propose a NeuroXAI framework for explainable AI of deep learning networks to increase the trust of medical experts. NeuroXAI implements seven state-of-the-art explanation methods providing visualization maps to help make deep learning models transparent.
Results
NeuroXAI has been applied to two applications of the most widely investigated problems in brain imaging analysis, i.e., image classification and segmentation using magnetic resonance (MR) modality. Visual attention maps of multiple XAI methods have been generated and compared for both applications. Another experiment demonstrated that NeuroXAI can provide information flow visualization on internal layers of a segmentation CNN.
Conclusion
Due to its open architecture, ease of implementation, and scalability to new XAI methods, NeuroXAI could be utilized to assist radiologists and medical professionals in the detection and diagnosis of brain tumors in the clinical routine of cancer patients. The code of NeuroXAI is publicly accessible at https://github.com/razeineldin/NeuroXAI.
Automatic segmentation is essential for the brain tumor diagnosis, disease prognosis, and follow-up therapy of patients with gliomas. Still, accurate detection of gliomas and their sub-regions in multimodal MRI is very challenging due to the variety of scanners and imaging protocols. Over the last years, the BraTS Challenge has provided a large number of multi-institutional MRI scans as a benchmark for glioma segmentation algorithms. This paper describes our contribution to the BraTS 2022 Continuous Evaluation challenge. We propose a new ensemble of multiple deep learning frameworks namely, DeepSeg, nnU-Net, and DeepSCAN for automatic glioma boundaries detection in pre-operative MRI. It is worth noting that our ensemble models took first place in the final evaluation on the BraTS testing dataset with Dice scores of 0.9294, 0.8788, and 0.8803, and Hausdorf distance of 5.23, 13.54, and 12.05, for the whole tumor, tumor core, and enhancing tumor, respectively. Furthermore, the proposed ensemble method ranked first in the final ranking on another unseen test dataset, namely Sub-Saharan Africa dataset, achieving mean Dice scores of 0.9737, 0.9593, and 0.9022, and HD95 of 2.66, 1.72, 3.32 for the whole tumor, tumor core, and enhancing tumor, respectively.
In the last decades, several driving systems were developed to improve the driving behaviour in energy efficiency or safety. However, these driving systems cover either the area of energy-efficiency or safety. Furthermore, they do not consider the stress level of the driver when showing a recommendation, although stress can lead to an unsafe or inefficient driving behaviour. In this paper, an approach is presented to consider the driver stress level in a driving system for safe and energy-efficient driving behaviour. The driving system tries to suppress a recommendation when the driver is in stress in order not to stress the driver additionally with recommendations in a stressful driving situation. This can lead to an increase in the road safety and in the user acceptance of the driving system, as the driver is not getting bothered or stressed by the driving system.
The evaluation of the approach showed, that the driving system
is able to show recommendations to the driver, while also reacting
to a high stress level by suppressing recommendations in
order not to stress the driver additionally.
Besides the optimisation of the car, energy-efficiency and safety can also be increased by optimising the driving behaviour. Based on this fact, a driving system is in development whose goal is to educate the driver in energy efficient and safe driving. It monitors the driver, the car and the environment and gives energy-efficiency and safety relevant recommendations. However, the driving system tries not to distract or bother the driver by giving recommendations for example during stressful driving situations or when the driver is not interested in that recommendation. Therefore, the driving system monitors the stress level of the driver as well as the reaction of the driver to a given recommendation and decideswhether to give a recommendation or not. This allows to suppress recommendations when needed and, thus, to increase the road safety and the user acceptance of
the driving system.
Context: Companies need capabilities to evaluate the customer value of software intensive products and services. One way of systematically acquiring data on customer value is running continuous experiments as part of the overall development process. Objective: This paper investigates the first steps of transitioning towards continuous experimentation in a large company, including the challenges faced. Method: We conduct a single-case study using participant observation, interviews, and qualitative analysis of the collected data. Results: Results show that continuous experimentation was well received by the practitioners and practising experimentation helped them to enhance understanding of their product value and user needs. Although the complexities of a large multi-stakeholder business to-business (B2B) environment presented several challenges such as inaccessible users, it was possible to address impediments and integrate an experiment in an ongoing development project. Conclusion: Developing the capability for continuous experimentation in large organisations is a learning process which can be supported by a systematic introduction approach with the guidance of experts. We gained experience by introducing the approach on a small scale in a large organisation, and one of the major steps for future work is to understand how this can be scaled up to the whole development organisation.
Purpose: Human breath analysis is proposed with increasing frequency as a useful tool in clinical application. We performed this study to find the characteristic volatile organic compounds (VOCs) in the exhaled breath of patients with idiopathic pulmonary fibrosis (IPF) for discrimination from healthy subjects. Methods: VOCs in the exhaled breath of 40 IPF patients and 55 healthy controls were measured using a multi-capillary column and ion mobility spectrometer. The patients were examined by pulmonary function tests, blood gas analysis, and serum biomarkers of interstitial pneumonia. Results: We detected 85 VOC peaks in the exhaled breath of IPF patients and controls. IPF patients showed 5 significant VOC peaks; p-cymene, acetoin, isoprene, ethylbenzene, and an unknown compound. The VOC peak of p-cymene was significantly lower (p < 0.001), while the VOC peaks of acetoin, isoprene, ethylbenzene, and the unknown compound were significantly higher (p < 0.001 for all) compared with the peaks of controls. Comparing VOC peaks with clinical parameters, negative correlations with VC (r =−0.393, p = 0.013), %VC (r =−0.569, p < 0.001), FVC (r = −0.440, p = 0.004), %FVC (r =−0.539, p < 0.001), DLco (r =−0.394, p = 0.018), and %DLco (r =−0.413, p = 0.008) and a positive correlation with KL-6 (r = 0.432, p = 0.005) were found for p-cymene. Conclusion: We found characteristic 5 VOCs in the exhaled breath of IPF patients. Among them, the VOC peaks of p-cymene were related to the clinical parameters of IPF. These VOCs may be useful biomarkers of IPF.
The evolution of Services Oriented Architectures (SOA) presents many challenges due to their complex, dynamic and heterogeneous nature. We describe how SOA design principles can facilitate SOA evolvability and examine several approaches to support SOA evolution. SOA evolution approaches can be classified based on the level of granularity they address, namely, service code level, service interaction level and model level. We also discuss emerging trends, such as microservices and knowledge-based support, which can enhance the evolution of future SOA systems.
Software Process Improvement (SPI) programs have been implemented, inter alia, to improve quality and speed of software development. SPI addresses many aspects ranging from individual developer skills to entire organizations. It comprises, for instance, the optimization of specific activities in the software lifecycle as well as the creation of organizational awareness and project culture. In the course of conducting a systematic mapping study on the state-of-the-art in SPI from a general perspective, we observed Software Quality Management (SQM) being of certain relevance in SPI programs. In this paper, we provide a detailed investigation of those papers from the overall systematic mapping study that were classified as addressing SPI in the context of SQM (including testing). From the main study’s result set, 92 papers were selected for an in-depth systematic review to study the contributions and to develop an initial picture of how these topics are addressed in SPI. Our findings show a fairly pragmatic contribution set in which different solutions are proposed, discussed, and evaluated. Among others, our findings indicate a certain reluctance towards standard quality or (test) maturity models and a strong focus on custom review, testing, and documentation techniques, whereas a set of five selected improvement measures is almost equally addressed.
This article covers the design of highly integrated gate drivers and level shifters for high-speed, high power efficiency and dv/dt robustness with focus on automotive applications. With the introduction of the 48 V board net in addition to the conventional 12 V battery, there is an increasing need for fast switching integrated gate drivers in the voltage range of 50 V and above. State-of-the-art drivers are able to switch 50 V in less than 5 ns. The high-voltage electrical drive train demands for galvanic isolated and highly integrated gate drivers. A gate driver with bidirectional signal transmission with a 1 MBit/s amplitude modulation, 10/20 MHz frequency modulation and power transfer over one single transformer will be discussed. The concept of high-voltage charge storing enables an area-efficient fully integrated bootstrapping supply with 70 % less area consumption. EMC is a major concern in automotive. Gate drivers with slope control optimize EMC while maintaining good switching efficiency. A current mode gate driver, which can change its drive current within 10 ns, results in 20 dBuV lower emissions between 7 and 60 MHz and 52 % lower switching loss compared to a conventional constant current gate driver.
Exogenous factors of influence on exhaled breath analysis by ion-mobility spectrometry (MCC/IMS)
(2019)
The interpretation of exhaled breath analysis needs to address to the influence of exogenous factors, especially to a transfer of confounding analytes by the test persons. A test person who was exposed to a disinfectant had exhaled breath analysis by MCC/IMS (Bioscout®) after different time intervals. Additionally, a new sampling method with inhalation of synthetic air before breath analysis was tested. After exposure to the disinfectant, 3-Pentanone monomer, 3-Pentanone dimer, Hexanal, 3-Pentanone trimer, 2-Propanamine, 1-Propanol, Benzene, Nonanal showed significantly higher intensities, in exhaled breath and air of the examination room, compared to the corresponding baseline measurements. Only one ingredient of the disinfectant (1-Propanol) was identical to the 8 analytes. Prolonging the time intervals between exposure and breath analysis showed a decrease of their intensities. However, the half-time of the decrease was different. The inhalation of synthetic air - more than consequently airing the examination room with fresh air - reduced the exogenous and also relevant endogenous analytes, leading to a reduction and even changing polarity of the alveolar gradient. The interpretation of exhaled breath needs further knowledge about the former residence of the proband and the likelihood and relevance of the inhalation of local, site-specific and confounding exogenous analytes by him. Their inhalation facilitates a transfer to the examination room and a detection of high concentrations in room air and exhaled breath, but also the exhalation of new analytes. This may lead to a misinterpretation of these analytes as endogenous resp. disease-specific ones.
Standardisation of breath sampling is important for application of breath analysis in clinical settings. By studying the effect of room airing on indoor and breath analytes and by generating time series of room air with different sampling intervals we sought to get further insights into room air metabolism, to detect the relevance of exogenous VOCs and to make conclusions about their consideration for the interpretation of exhaled breath. Room air and exhaled breath of a healthy subject were analysed before and after room airing. Furthermore a time series of room air with doors and windows closed was taken over 84 h by an automatic sampling every 180 min. A second times series studied room air analytes over 70 h with samples taken every 16.5 min. For breath and room air measurements an IMS coupled to a multi-capillary column (IMS/MCC) [Bio-Scout® - B&S Analytik GmbH, Dortmund, Germany] was used. The peaks were characterized using the Software Visual Now (B&S Analytik, Dortmund Germany) and identified using the software package MIMA (version 1.1, provided by the Max Planck Institute for Informatics, Saarbrücken, Germany) and the database 20160426_SubstanzDbNIST_122 (B & S Analytik GmbH, Dortmund, Germany). In the morning 4 analytes (Decamethylcylopentasiloxane [541-02-6]; Pentan-2-one [107-87-9] – Dimer; Hexan-1-al [66-25-1]; Pentan-2-one [107-87-9]) – Monomer showed high intensities in the room air and exhaled breath. They were significantly but not equally reduced by room airing. The time series about 84 h showed a time dependent decrease of analytes (limonen-monomer and -dimer; Decamethylcylopentasiloxane, Butan-1-ol, Butan-1-ol) as well as increase (Pentan-2-one [107-87-9] – Dimer). Shorter sampling intervals exhibited circadian variations of analyte concentrations for many analytes. Breath sampling in the morning needs room airing before starting. Then the variation of the intensity of indoor analytes can be kept small. The time series of indoor analytes show, that their intensities have a different behaviour, with time dependent declines, constant increases and circadian variations, dependent on room airing. This has implications on the breath sampling procedure and the intrepretation of exhaled breath.
Efficient and robust 3D object reconstruction based on monocular SLAM and CNN semantic segmentation
(2019)
Various applications implement slam technology, especially in the field of robot navigation. We show the advantage of slam technology for independent 3d object reconstruction. To receive a point cloud of every object of interest void of its environment, we leverage deep learning. We utilize recent cnn deep learning research for accurate semantic segmentation of objects. In this work, we propose two fusion methods for cnn-based semantic segmentation and slam for the 3d reconstruction of objects of interest in order to obtain a more robustness and efficiency. As a major novelty, we introduce a cnn-based masking to focus slam only on feature points belonging to every single object. Noisy, complex or even non-rigid features in the background are filtered out, improving the estimation of the camera pose and the 3d point cloud of each object. Our experiments are constrained to the reconstruction of industrial objects. We present an analysis of the accuracy and performance of each method and compare the two methods describing their pros and cons.
There have been substantial research efforts for algorithms to improve continuous and automated assessment of various health-related questions in recent years. This paper addresses the deployment gap between those improving algorithms and their usability in care and mobile health applications. In practice, most algorithms require significant and founded technical knowledge to be deployed at home or support healthcare professionals. Therefore, the digital participation of persons in need of health care professionals lacks a usable interface to use the current technological advances. In this paper, we propose applying algorithms taken from research as web-based microservices following the common approach of a RESTful service to bridge the gap and make algorithms accessible to caregivers and patients without technical knowledge and extended hardware capabilities. We address implementation details, interpretation and realization of guidelines, and privacy concerns using our self-implemented example. Also, we address further usability guidelines and our approach to those.
A lot of people need help in their daily life to wash, select and manage their clothing. The goal of this work is to design an assistant system (eKlarA) to support the user by giving recommendations to choose the clothing combinations, to find the clothing and to wash the clothing. The idea behind eKlarA is to generate a system that uses sensors to identify the clothing and their state in the clothing cycle. The clothing cycle consists of the stations: closets, laundry basket and washing machine in one or several places. The system uses the information about the clothing, weather and calendar to support the user in the different steps of the clothing cycle. The first prototype of this system has been developed and tested. The test results are presented in this work.
Being able to monitor the heart activity of patients during their daily life in a reliable, comfortable and affordable way is one main goal of the personalized medicine. Current wearable solutions lack either on the wearing comfort, the quality and type of the data provided or the price of the device. This paper shows the development of a Textile Sensor Platform (TSP) in the form of an electrocardiogram (ECG)-measuring T-shirt that is able to transmit the ECG signal to a smartphone. The development process includes the selection of the materials, the design of the textile electrodes taking into consideration their electrical characteristics and ergonomy, the integration of the electrodes on the garment and their connection with the embedded electronic part. The TSP is able to transmit a real-time streaming of the ECG-signal to an Android smartphone through Bluetooth Low Energy (BLE). Initial results show a good electrical quality in the textile electrodes and promising results in the capture and transmission of the ECG signal. This is still a working- progress and it is the result of an interdisciplinary master project between the School of Informatics and the School of Textiles & Design of the Reutlingen University.
Turning students into Industry 4.0 entrepreneurs: design and evaluation of a tailored study program
(2022)
Startups in the field of Industry 4.0 could be a huge driver of innovation for many industry sectors such as manufacturing. However, there is a lack of education programs to ensure a sufficient number of well-trained founders and thus a supply of such startups. Therefore, this study presents the design, implementation, and evaluation of a university course tailored to the characteristics of Industry 4.0 entrepreneurship. Educational design-based research was applied with a focus on content and teaching concept. The study program was first implemented in 2021 at a German university of applied sciences with 25 students, of which 22 participated in the evaluation. The evaluation of the study program was conducted with a pretest–posttest-design targeting three areas: (1) knowledge about the application domain, (2) entrepreneurial intention and (3) psychological characteristics. The entrepreneurial intention was measured based on the theory of planned behavior. For measuring psychological characteristics, personality traits associated with entrepreneurship were used. Considering the study context and the limited external validity of the study, the following can be identified in particular: The results show that a university course can improve participants' knowledge of this particular area. In addition, perceived behavioral control of starting an Industry 4.0 startup was enhanced. However, the results showed no significant effects on psychological characteristics.
Background
Personalized medicine requires the integration and analysis of vast amounts of patient data to realize individualized care. With Surgomics, we aim to facilitate personalized therapy recommendations in surgery by integration of intraoperative surgical data and their analysis with machine learning methods to leverage the potential of this data in analogy to Radiomics and Genomics.
Methods
We defined Surgomics as the entirety of surgomic features that are process characteristics of a surgical procedure automatically derived from multimodal intraoperative data to quantify processes in the operating room. In a multidisciplinary team we discussed potential data sources like endoscopic videos, vital sign monitoring, medical devices and instruments and respective surgomic features. Subsequently, an online questionnaire was sent to experts from surgery and (computer) science at multiple centers for rating the features’ clinical relevance and technical feasibility.
Results
In total, 52 surgomic features were identified and assigned to eight feature categories. Based on the expert survey (n = 66 participants) the feature category with the highest clinical relevance as rated by surgeons was “surgical skill and quality of performance” for morbidity and mortality (9.0 ± 1.3 on a numerical rating scale from 1 to 10) as well as for long-term (oncological) outcome (8.2 ± 1.8). The feature category with the highest feasibility to be automatically extracted as rated by (computer) scientists was “Instrument” (8.5 ± 1.7). Among the surgomic features ranked as most relevant in their respective category were “intraoperative adverse events”, “action performed with instruments”, “vital sign monitoring”, and “difficulty of surgery”.
Conclusion
Surgomics is a promising concept for the analysis of intraoperative data. Surgomics may be used together with preoperative features from clinical data and Radiomics to predict postoperative morbidity, mortality and long-term outcome, as well as to provide tailored feedback for surgeons.
This book presents an empirical investigation of the efforts that multinational pharmaceutical companies take in order to find a business model that allows for a profitable access to the Bottom of the Pyramid (BoP) markets. The Bottom of the Pyramid in Africa is frequently mentioned as an attractive market due to its sheer size. Yet most companies struggle to access it because of the low price level, difficult physical market access and challenges when it comes to payment.
More specifically, the book investigates the following business model-related questions: Do pharmaceutical companies provide products that meet the needs of the BoP? What characterizes the value generation of the company? What revenue model leads to a profitable business, and what role does a network of partners play in the business model?
Findings reveal that there is no ‘one-size-fits-all’ answer to these questions. Providing continuous availability, affordability at a good quality of goods and services, creating health awareness, as well as localizing business to achieve a level of inclusivenessare essential prerequisites for success. In the last chapter this book provides a business model prototype that accounts for these key success factors for business at the Bottom of the Pyramid and points to further research topics.
Unternehmertum spielt sowohl für die Entwicklung afrikanischer Länder eine Rolle, als auch für ausländische Unternehmen mit Markteintrittsplänen. Die infrastrukturellen und institutionellen Rahmenbedingungen für Unternehmertum sind nach wie vor schwierig, wobei aber die fortschreitende Digitalisierung zu einer zunehmend aktiven Start-Up Szene in vielen afrikanischen Ländern führt. Nach wie vor existiert ein Mismatch zwischen den Bereichen in denen Start-Ups entstehen und den Bereichen, wo ausländische Unternehmen Partner für den Markteintritt suchen. Somit bleibt es trotz positiver Entwicklung beim Unternehmertum in absehbarer Zeit schwierig adäquate Partner zu finden.
Entrepreneurship plays a role both for the development of African countries and for foreign companies with market entry plans. The infrastructural and institutional conditions for entrepreneurship are still difficult, but the advancing digitization leads to an increasingly active start-up scene in many African countries. There is still a mismatch between the areas where start-ups are created and the areas where foreign companies are looking for partners for market entry. Thus, despite positive developments in entrepreneurship, it remains difficult to find suitable partners in the foreseeable future.
The amount of image data has been rising exponentially over the last decades due to numerous trends like social networks, smartphones, automotive, biology, medicine and robotics. Traditionally, file systems are used as storage. Although they are easy to use and can handle large data volumes, they are suboptimal for efficient sequential image processing due to the limitation of data organisation on single images. Database systems and especially column-stores support more stuctured storage and access methods on the raw data level for entiere series.
In this paper we propose definitions of various layouts for an efficient storage of raw image data and metadata in a column store. These schemes are designed to improve the runtime behaviour of image processing operations. We present a tool called column-store Image Processing Toolbox (cIPT) allowing to easily combine the data layouts and operations for different image processing scenarios.
The experimental evaluation of a classification task on a real world image dataset indicates a performance increase of up to 15x on a column store compared to a traditional row-store (PostgreSQL) while the space consumption is reduced 7x. With these results cIPT provides the basis for a future mature database feature.
Data analytics tasks on large datasets are computationally intensive and often demand the compute power of cluster environments. Yet, data cleansing, preparation, dataset characterization and statistics or metrics computation steps are frequent. These are mostly performed ad hoc, in an explorative manner and mandate low response times. But, such steps are I/O intensive and typically very slow due to low data locality, inadequate interfaces and abstractions along the stack. These typically result in prohibitively expensive scans of the full dataset and transformations on interface boundaries.
In this paper, we examine R as analytical tool, managing large persistent datasets in Ceph, a wide-spread cluster file-system. We propose nativeNDP – a framework for Near Data Processing that pushes down primitive R tasks and executes them in-situ, directly within the storage device of a cluster-node. Across a range of data sizes, we show that nativeNDP is more than an order of magnitude faster than other pushdown alternatives.
Since the beginning of the energy sector liberalization, the design of energy markets has become a prominent field of research. Markets nowadays facilitate efficient resource allocation in many fields of energy system operation, such as plant dispatch, control reserve provisioning, delimitation of related carbon emissions, grid congestion management, and, more recently, smart grid concepts and local energy trading. Therefore, good market designs play an important role in enabling the energy transition toward a more sustainable energy supply for all. In this chapter, we retrace how market engineering shaped the development of energy markets and how the research focus shifted from national wholesale markets to more decentralized and location-sensitive concepts.
Lehre und Lernen unterliegt einem stetigen Wandel, wobei Interaktion als ein zentrales Element der Motivationssteigerung im Lernkontext angesehen wird. Der vorliegende Beitrag zeigt verschiedene Ansätze zur Gestaltung von interaktivem und kollaborativem Lehren und Lernen in einem virtuellen Klassenzimmer auf und stellt ein Beispiel für die Umsetzung und den Einsatz eines solchen Systems vor. Die Mehrwerte und Erfolgsfaktoren, die sich beim Einsatz virtueller Klassenzimmer und deren Gestaltung in Form einer interaktiven blended-learning Umgebung ergeben, werden dargestellt und diskutiert. Mit dem System Accelerator wird eine CSILT (Computer Supported Interactive Learning and Teaching)-Umgebung vorgestellt, in der diese Faktoren zum Einsatz kommen.
In the era of digital transformation, the notion of software quality transcends its traditional boundaries, necessitating an expansion to encompass the realms of value creation for customers and the business. Merely optimizing technical aspects of software quality can result in diminishing returns. Product discovery techniques can be seen as a powerful mechanism for crafting products that align with an expanded concept of quality - one that incorporates value creation. Previous research has shown that companies struggle to determine appropriate product discovery techniques for generating, validating, and prioritizing ideas for new products or features to ensure they meet the needs and desires of the customers and the business. For this reason, we conducted a grey literature review to identify various techniques for product discovery. First, the article provides an overview of different techniques and assesses how frequently they are mentioned in the literature review. Second, we mapped these techniques to an existing product discovery process from previous research to provide concrete guidelines for establishing product discovery in their organizations. The analysis shows, among other things, the increasing importance of techniques to structure the problem exploration process and the product strategy process. The results are interpreted regarding the importance of the techniques to practical applications and recognizable trends.
Context: Many companies are facing an increasingly dynamic and uncertain market environment, making traditional product roadmapping practices no longer sufficiently applicable. As a result, many companies need to adapt their product roadmapping practices for continuing to operate successfully in today’s dynamic market environment. However, transforming product roadmapping practices is a difficult process for organizations. Existing literature offers little help on how to accomplish such a process.
Objective: The objective of this paper is to present a product roadmap transformation approach for organizations to help them identify appropriate improvement actions for their roadmapping practices using an analysis of their current practices.
Method: Based on an existing assessment procedure for evaluating product roadmapping practices, the first version of a product roadmap transformation approach was developed in workshops with company experts. The approach was then given to eleven practitioners and their perceptions of the approach were gathered through interviews.
Results: The result of the study is a transformation approach consisting of a process describing what steps are necessary to adapt the currently applied product roadmapping practice to a dynamic and uncertain market environment. It also includes recommendations on how to select areas for improvement and two empirically based mapping tables. The interviews with the practitioners revealed that the product roadmap transformation approach was perceived as comprehensible, useful, and applicable. Nevertheless, we identified potential for improvements, such as a clearer presentation of some processes and the need for more improvement options in the mapping tables. In addition, minor usability issues were identified.