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In der zunehmenden Individualisierung von Produkten zeigt sich, dass Kundennähe und digital vernetzte Zusammenarbeit aller Partner wertvolle Erfolgspotenziale darstellen. Für komplexe Kundenauftragsprozesse gilt es, zu vernetzen und die Prozesse und Systeme in Form eines ganzheitlichen Ansatzes zukunftsfähig zu gestalten. Dabei wird der Herausforderung begegnet, Daten und Dokumente zu digitalisieren und den manuellen Aufwand zu reduzieren. Der Untersuchungsgegenstand ist der Abwicklungsprozess, ausgehend von einer Online-Konfiguration durch den Kunden bis zur Bestellabwicklung. In diesem Beitrag wird ein Vorgehensmodell aufgezeigt, das Unternehmen in die Lage versetzt, ihren Kundenauftragsprozess durch ein digitales Geschäftsmodell zukunftsfähig auszugestalten. Nutzenpotenziale sind eine verstärkte Kundenbindung durch eng verzahnte digitale Kollaboration, verstärkte Wirtschaftlichkeit durch Reduktion der Prozesskosten sowie eine Optimierung der Customer Experience durch effiziente Abläufe.
The data present in this article affords insides in the characterization of a newly described bi-functional furan-melamine monomer, which is used for the production of monodisperse, furan-functionalized melamine formaldehyde particles. In the related research article Urdl et al., 2019 data interpretations can be found. The furan functionalization of particles is necessary to perform reversible Diels-Alder reactions with maleimide (BMI) crosslinker to form thermoreversible network systems. To understand the reaction conditions of Diels Alder (DA) reaction with a Fu-Mel monomer and a maleimide crosslinker, model DA reaction were performed and evaluated using dynamic FT-IR measurements. During retro Diels-Alder (rDA) reactions of the monomer system, it was found out that some side reaction occurred at elevated temperatures. The data of evaluating the side reaction is described in one part of this manuscript. Additional high resolution SEM images of Fu Mel particles are shown and thermoreversible particle networks with BMI2 are shown. The data of different Fu-Mel particle networks with maleimide crosslinker are presented. Therefore, the used maleimide crosslinker with different spacer lengths were synthesized and the resulting networks were analyzed by ATR-FT-IR, SEM and DSC.
A new two-dimensional fluorescence sensor system was developed for in-line monitoring of mammalian cell cultures. Fluorescence spectroscopy allows for the detection and quantification of naturally occurring intra- and extracellular fluorophores in the cell broth. The fluorescence signals correlate the the cells' current redox state and other relevant process parameters. Cell culture pretests with twelve different excitation wavelengths showed that only three wavelengths account for a vast majority of spectral variation. Accordingly, the newly developed device utilizes three high-power LEDs as excitation sources in combination with a back-thinned CCD-spectrometer for fluorescence detection.
Ein Halo-Effekt liegt vor, wenn der Eindruck eines dominanten Merkmals die Beurteilung anderer Eigenschaften eines Objekts beeinflusst. Es handelt sich um eine kognitive Verzerrung, die zu verzerrten Beurteilungen führt. In einem sportbezogenenen Kontext ist der Halo-Effekt bislang kaum erforscht worden, obwohl dies wesentlich dazu beitragen könnte, das Denken und Verhalten von Sportfans zu verstehen. Das Ziel des vorliegenden Beitrags ist es, die Frage zu beantworten, die gleichermaßen für die Theorie und die Praxis des Sportmanagements von Interesse ist: gibt es einen Halo-Effekt im Fußball? Der Beitrag präsentiert die Ergebnisse einer empirischen Untersuchung, in deren Rahmen Fans von Vereinen aus der deutschen Fußball-Bundesliga befragt wurden.
The detection and characterisation of oxide layers on metallic copper samples plays an important role for power electronic modules in the automotive industry. However, since precise identification of oxide layers by visual inspection is difficult and time consuming due to inhomogeneous colour distribution, a reliable and efficient method for estimating their thickness is needed. In this study, hyperspectral imaging in the visible wavelength range (425–725 nm) is proposed as an in-line inspection method for analysing oxide layers in real-time during processing of copper components such as printed circuit boards in the automotive industry. For implementation in the production line a partial least square regression (PLSR) model was developed with a calibration set of n = 12 with about 13,000 spectra per sample to determine the oxide layer thickness on top of the technical copper surfaces. The model shows a good prediction performance in the range of 0–30 nm compared to Auger electron spectroscopy depth profiles as a reference method. The root mean square error (RMSE) is 1.75 nm for calibration and 2.70 nm for full cross validation. Applied to an external dataset of four new samples with about 13,000 spectra per sample the model provides an RMSE of 1.84 nm for prediction and demonstrates the robustness of the model during real-time processing. The results of this study prove the ability and usefulness of the proposed method to estimate the thickness of oxide layers on technical copper. Hence, the application of hyperspectral imaging for the industrial process control of electronic devices is very promising.
Die digitale Transformation verändert branchenübergreifend Geschäftsmodelle und ist damit ein Schlüssel für den langfristigen Unternehmenserfolg. In der Praxis scheitert sie jedoch häufig an der richtigen Umsetzung. Der Digital-Business-Excellence-Ansatz soll Unternehmen helfen, den digitalen Wandel erfolgreich zu gestalten.
In vitro, hydrogel-based ECMs for functionalizing surfaces of various material have played an essential role in mimicking native tissue matrix. Polydimethylsiloxane (PDMS) is widely used to build microfluidic or organ-on-chip devices compatible with cells due to its easy handling in cast replication. Despite such advantages, the limitation of PDMS is its hydrophobic surface property. To improve wettability of PDMS-based devices, alginate, a naturally derived polysaccharide, was covalently bound to the PDMS surface. This alginate then crosslinked further hydrogel onto the PDMS surface in desired layer thickness. Hydrogel-modified PDMS was used for coating a topography chip system and in vitro investigation of cell growth on the surfaces. Moreover, such hydrophilic hydrogel-coated PDMS is utilized in a microfluidic device to prevent unspecific absorption of organic solutions. Hence, in both exemplary studies, PDMS surface properties were modified leading to improved devices.
Indoor localization systems are becoming more and more important with the digitalization of the industrial sector. Sensor data such as the current position of machines, transport vehicles, goods or tools represent an essential component of cyber physical production systems (CCPS). However, due to the high costs of these sensors, they are not widespread and are used mainly in special scenarios. However, especially optical indoor positioning systems (OIPS) based on cameras have certain advantages due to their technological specifications. In this paper, the application scenarios and requirements as well as their characteristics are presented and a classification approach of OIPS is introduced.
Although integrins are responsible for the interaction of cells with their environment, e.g., the extracellular matrix or artificial substrates, there is still a lack of knowledge about their role in cell adhesion and migration on protein-coated substrates with microtopography. Understanding such interactions could lead to new applications in e.g., medical implants as well as shed light on processes such as embryonic development, angiogenesis, wound healing, and tumor progression. In this work, the influence of surface topography and chemistry on αvβ3 and α5β1 integrin-mediated cell adhesion and migration of healthy and malignant human cell types (human coronary artery endothelial cells, human osteosarcoma cells, and human skin fibroblasts cells) was studied, using microgrooved and flat substrates covered by two different extracellular proteins, fibronectin and vitronectin. Although some general behaviors can be observed, cell migration (speed, directionality, and persistence time) and morphological adaptation (cell area, aspect ratio, and circularity) of cells on protein coated microgrooved substrates are mainly dependent on the cell type and its specific integrin expression.