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Recently described rhizolutin and collinolactone isolated from Streptomyces Gç 40/10 share the same novel carbon scaffold. Analyses by NMR and X-Ray crystallography verify the structure of collinolactone and propose a revision of rhizolutins stereochemistry. Isotope-labeled precursor feeding shows that collinolactone is biosynthesized via type I polyketide synthase with Baeyer–Villiger oxidation. CRISPR-based genetic strategies led to the identification of the biosynthetic gene cluster and a high-production strain. Chemical semisyntheses yielded collinolactone analogues with inhibitory effects on L929 cell line. Fluorescence microscopy revealed that only particular analogues induce monopolar spindles impairing cell division in mitosis. Inspired by the Alzheimerprotective activity of rhizolutin, we investigated the neuroprotective effects of collinolactone and its analogues on glutamate-sensitive cells (HT22) and indeed, natural collinolactone displays distinct neuroprotection from intracellular oxidative stress.
In recent years, the demand for accurate and efficient 3D body scanning technologies has increased, driven by the growing interest in personalised textile development and health care. This position paper presents the implementation of a novel 3D body scanner that integrates multiple RGB cameras and image stitching techniques to generate detailed point clouds and 3D mesh models. Our system significantly enhances the scanning process, achieving higher resolution and fidelity while reducing the cost, time and effort required for data acquisition and processing. Furthermore, we evaluate the potential use cases and applications of our 3D body scanner, focusing on the textile technology and health sectors. In textile development, the 3D scanner contributes to bespoke clothing production, allowing designers to construct made-to-measure garments, thus minimising waste and enhancing customer satisfaction through fitting clothing. In mental health care, the 3D body scanner can be employed as a tool for body image analysis, providing valuable insights into the psychological and emotional aspects of self-perception. By exploring the synergy between the 3D body scanner and these fields, we aim to foster interdisciplinary collaborations that drive advancements in personalisation, sustainability, and well-being.