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This study is about estimating the reproducibility of finding palpation points of three different anatomical landmarks in the human body (Xiphoid Process and the 2 Hip Crests) to support a navigated ultrasound application. On 6 test subjects with different body mass index the three palpation points were located five times by two examiners. The deviation from the target position was calculated and correlated to the fat thickness above each palpation point. The reproducibility of the measurements had a mean error of ≈13.5 mm +- 4 mm, which seems to be sufficient for the desired application field.
Polyurethane-bases block copolymers (TPCUs) are block-copolymers with systematically varied soft and hard segments. They have been suggested to serve as material for chondral implants in joint regeneration. Such applications may require the adhesion of chondrocytes to the implant surface, facilitating cell growth while keeping their phenotype. Thus, aims of this work were (1) to modify the surface of soft biostable polyurethane-based model implants (TPCU and TSiPCU) with high-molecular weight hyaluronic acid (HA) using an optimized multistep strategy of immobilization, and (2) to evaluate bioactivity of the modified TPCUs in vitro. Our results show no cytotoxic potential of the TPCUs. HAbioactive molecules (Mw =700kDa) were immobilized onto the polyurethane surface via polyethylenimine (PEI) spacers, and modifications were confirmed by several characterization methods. Tests with porcine chondrocytes indicated the potential of the TPCU-HA for inducing enhanced cell proliferation.
Digitalization changes the manufacturing dramatically. In regard of employees’ demands, global trends and the technological vision of future factories, automotive manufacturing faces a huge number of diverse challenges. Currently, research focuses on technological aspects of future factories in terms of digitalization. New ways of work and new organizational models for future factories have not been described yet. There are assumptions on how to develop the organization of work in a future factory but up to now, literature shows deficits in scientifically substantiated answers in this research area. Consequently, the objective of this paper is to present an approach on a work organization design for automotive Industry 4.0 manufacturing. Future requirements were analyzed and deducted to criteria that determine future agile organization design. These criteria were then transformed into functional mechanisms, which define the approach for shopfloor organization design
Die öffentliche Verwaltung und die in ihr lebenden und arbeitenden Menschen sehen sich häufig mit einer institutionalisierten Dilemma-Situation konfrontiert. Die Ursachen hierfür sind darin zu sehen, dass öffentliches Verwaltungshanden mit sehr wenigen Ausnahmen keinem Selbstzweck dient. Stattdessen dient es anderen Funktionssystmen und wird mit deren binären (Funktions-)Codes beobachtet und zwangsnotwendig bewertet. Die Möglichkeiten des Einzelnen, steuernd und gegebenenfalls korrigieren einzugreifen, sind in einer modernen durch extrem hohe Komplexität und (internationale) Verflechtung bestimmten Gesellschaft gering.
The present publication reports the purification effort of two natural bone blocks, that is, an allogeneic bone block (maxgraft®, botiss biomaterials GmbH, Zossen, Germany) and a xenogeneic block (SMARTBONE®, IBI S.A., Mezzovico Vira, Switzerland) in addition to previously published results based on histology. Furthermore, specialized scanning electron microscopy (SEM) and in vitro analyses (XTT, BrdU, LDH) for testing of the cytocompatibility based on ISO 10993-5/-12 have been conducted. The microscopic analyses showed that both bone blocks possess a trabecular structure with a lamellar subarrangement. In the case of the xenogeneic bone block, only minor remnants of collagenous structures were found, while in contrast high amounts of collagen were found associated with the allogeneic bone matrix. Furthermore, only island-like remnants of the polymer coating in case of the xenogeneic bone substitute seemed to be detectable. Finally, no remaining cells or cellular remnants were found in both bone blocks. The in vitro analyses showed that both bone blocks are biocompatible. Altogether, the purification level of both bone blocks seems to be favorable for bone tissue regeneration without the risk for inflammatory responses or graft rejection. Moreover, the analysis of the maxgraft® bone block showed that the underlying purification process allows for preserving not only the calcified bone matrix but also high amounts of the intertrabecular collagen matrix.
Changing requirements and qualification profiles of employees, increasingly complex digital systems up to artificial intelligence, missing standards for the seamless embedding of existing resources and unpredictable return on investments are just a few examples of the challenges of an SME in the age of digitalisation. In most cases there is a lack of suitable tools and methods to support companies in the digital transformation process in the value creation processes, but also of training and learning materials. A European research project (BITTMAS - Business Transformation towards Digitalisation and Smart systems, ERASMUS+, 2016-1 DE02-KA202-003437) with international partners from science, associations and industry has addressed this issue and developed various methods and instruments to support SMEs. Within the scope of a literature search, 16 suitable digitalisation concepts for production and logistics were identified. In the following, a learning platform with a literature database with multivariable sorting options according to branches and keywords of digitalisation, a video gallery with basic and advanced knowledge and a glossary were created in order to provide the user with consolidated and structured specialist knowledge. The 16 identifying concepts for transforming value-added processes in the context of digitalisation were transferred to a learning platform using developed learning paths in coaching and training to online course modules including test questions. A maturity model was developed and implemented in a self assessment tool for the analysis to identify the potential of digitalisation in production and logistics in relation to the current technological digitalisation level of the company. As a result, the user receives one or more of the 16 potential digitalisation concepts suggested or the delta for the necessary, not yet available enabler technologies is presented as a spider diagram. For a successful implementation of the identified suitable digitalisation concepts in production and logistics, a further tool was developed to identify supplementary requirements for all company divisions and stakeholders in relation to the "digital transformation" in the form of a self-evaluation. This paper presents the methods and tools developed, the accompanying learning materials and the learning platform.
The promise of immutable documents to make it easier and less expensive for consumers and producers to collaborate in a verifiable way would represent an enormous progress, especially as companies strive for establish service contracts which are based on the flow of many small transactions using machine-to-machine communication. The blockchain technology logs these data, verifies the authenticity and make them available for service offers. This work deals with an architecture enabling to setup order processing between consumers and produceers using blockchain. In this way, the technical feasibility is shown and the special characteristics of blockchain production networks will be discussed.
Sowohl bei den industriellen als auch wissenschaftlichen Institutionen nimmt die Anwendung der additiven Fertigung stetig zu und ist insbesondere in den Bereichen der Prototypenentwicklung nicht mehr wegzudenken. Die werkzeuglose Herstellung von Teilen ermöglicht eine dynamische Nutzung der Produktionsressourcen bis unmittelbar zum Fertigungsstart. Dies erlaubt, einerseits in den Bereichen der Feinterminierung und Ablaufplanung, agil auf Veränderungen zu reagieren und andererseits Modelle unterschiedlicher Fertigungsaufträge miteinander zu kombinieren, um somit eine hohe Effizienz der Fertigungsanlagen zu erreichen. Bei der Nutzung von multiplen Anlagen in einem Unternehmen oder im Partnerverbund stellt die vorhandene Intransparenz Unternehmen und Unternehmensnetzwerke vor viele Herausforderungen. Die Blockchain Technologie ermöglicht eine gemeinsame Datenbasis zwischen den Teilnehmern. Die Einträge werden protokolliert und die Authentizität der Teilnehmer wird gewährleistet. Dies führt, im Falle der Beziehung zwischen Kunden und Produzenten, zu einer nachprüfbaren Zusammenarbeit, da Unternehmen Dienstleistungsverträge abschließen, die auf dem Fluss vieler kleiner Transaktionen basieren. In diesem Beitrag wird dargestellt, wie verfügbare additive Fertigungsressourcen erkannt werden, sowie, unter der Verwendung der Blockchain-Technologie, in einem dezentralen Produktionsnetzwerk angeboten und von unterschiedlichen Akteuren genutzt werden können.
This paper investigates the possibility to effectively monitor and control the respiratory action using a very simple and non invasive technique based on a single lightweight reduced-size wireless surface electromyography (sEMG) sensor placed below the sternum. The captured sEMG signal, due to the critical sensor position, is characterized by a low energy level and it is affected by motion artifacts and cardiac noise. In this work we present a preliminary study performed on adults for assessing the correlation of the spirometry signal and the sEMG signal after the removal of the superimposed heart signal. This study and the related findings could be useful in respiratory monitoring of preterm infants.