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There are several intra-operative use cases which require the surgeon to interact with medical devices. I used the Leap Motion Controller as input device for three use-cases: 2D-interaction (e.g. advancing EPR data), selection of a value (e.g. room illumination brightness) and an application point and click scenario. I evaluated the Palm Mouse as the most suitable gesture solution to coordinate the mouse and advise to use the implementation using all fingers to perform a click. This small case study introduces the implementations and methods that result those recommendations.