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A fast way to test business ideas and to explore customer problems and needs is to talk to them. Customer interviews help to understand what solutions customers will pay for before investing valuable resources to develop solutions. Customer interviews are a good way to gain qualitative insights. However, conducting interviews can be a difficult procedure and requires specific skills. The current ways of teaching interview skills have significant deficiencies. They especially lack guidance and opportunities to practice. Objective: The goal of this work is to develop and validate a workshop format to teach interview skills for conducting good customer interviews in a practical manner. Method: The research method is based on design science research which serves as a framework. A game-based workshop format was designed to teach interview skills. The approach consists of a half-day, hands-on workshop and is based on an analysis of necessary interview skills. The approach has been validated in several workshops and improved based on learnings from those workshops. Results: Results of the validation show that participants could significantly improve their interview skills while enjoying the game-based exercises. The game-based learning approach supports learning and practicing customer interview skills with playful and interactive elements that encourage greater motivation among participants to conduct interviews.
The current advancement of Artificial Intelligence (AI) combined with other digitalization efforts significantly impacts service ecosystems. Artificial intelligence has a substantial impact on new opportunities for the co-creation of value and the development of intelligent service ecosystems. Motivated by experiences and observations from digitalization projects, this paper presents new methodological perspectives and experiences from academia and practice on architecting intelligent service ecosystems and explores the impact of artificial intelligence through real cases supporting an ongoing validation. Digital enterprise architecture models serve as an integral representation of business, information, and technological perspectives of intelligent service-based enterprise systems to support management and development. This paper focuses on architectural models for intelligent service ecosystems, showing the fundamental business mechanism of AI-based value co-creation, the corresponding digital architecture, and management models. The focus of this paper presents the key architectural model perspectives for the development of intelligent service ecosystems.
Platforms and their surrounding ecosystems are becoming increasingly important components of many companies' strategies. Artificial Intelligence, in particular, has created new opportunities to create and develop ecosystems around the platform. However, there is not yet a methodology to systematically develop these new opportunities for enterprise development strategy. Therefore, this paper aims to lay a foundation for the conceptualization of Artificial Intelligence-based service ecosystems exploiting a Service-Dominant Logic. The basis for conceptualization is the study of value creation and particularly effective network effects. This research investigates the fundamental idea of extending specific digital concepts considering the influence of Artificial Intelligence on the design of intelligent services, along with their architecture of digital platforms and ecosystems, to enable a smooth evolutionary path and adaptability for human-centric collaborative systems and services. The paper explores an extended digital enterprise conceptual model through a combined, iterative, and permanent task of co-creating value between humans and intelligent systems as part of a new idea of cognitively adapted intelligent services.
Unternehmen sind derzeit dabei, ihre Strategie, ihre Prozesse und ihre Informationssysteme zu verändern, um ihren Digitalisierungsgrad zu erhöhen. Das Potenzial des Internets und verwandter digitaler Technologien wie Internet der Dinge, Services Computing, Cloud Computing, künstliche Intelligenz, Big Data mit Analysen, mobile Systeme, Kollaborationsnetzwerke und cyber-physikalische Systeme treibt neue Geschäftsmodelle an und ermöglicht sie. Die Digitalisierung führt zu einer tiefgreifenden Umwälzung bestehender Unternehmen, Technologien und Volkswirtschaften und fördert die Architektur digitaler Umgebungen mit vielen eher kleinen und verteilten Strukturen. Dies hat starke Auswirkungen auf neue Wertschöpfungsmöglichkeiten und die Gestaltung digitaler Dienste und Produkte, die durch die Nutzung einer service-dominanten Logik gesteuert werden. Das Hauptergebnis des Buchkapitels erweitert Methoden für integrale digitale Strategien um wertorientierte Modelle für digitale Produkte und Dienstleistungen, die im Rahmen eines multiperspektivischen digitalen Unternehmensarchitektur-Referenzmodells definiert werden.
Presently, many companies are transforming their strategy and product base, as well as their culture, processes and information systems to become more digital or to approach for a digital leadership. In the last years new business opportunities appeared using the potential of the Internet and related digital technologies, like Internet of Things, services computing, cloud computing, edge and fog computing, social networks, big data with analytics, mobile systems, collaboration networks, and cyber physical systems. Digitization fosters the development of IT environments with many rather small and distributed structures, like the Internet of Things, Microservices, or other micro-granular elements. This has a strong impact for architecting digital services and products. The change from a closed-world modeling perspective to more flexible open-world composition and evolution of micro-granular system architectures defines the moving context for adaptable systems. We are focusing on a continuous bottom-up integration of micro-granular architectures for a huge amount of dynamically growing systems and services, as part of a new digital enterprise architecture for service dominant digital products.
Digitization of societies changes the way we live, work, learn, communicate, and collaborate. In the age of digital transformation IT environments with a large number of rather small structures like Internet of Things (IoT), microservices, or mobility systems are emerging to support flexible and agile digitized products and services. Adaptable ecosystems with service oriented enterprise architectures are the foundation for self-optimizing, resilient run-time environments and distributed information systems. The resulting business disruptions affect almost all new information processes and systems in the context of digitization. Our aim are more flexible and agile transformations of both business and information technology domains with more flexible enterprise information systems through adaptation and evolution of digital enterprise architectures. The present research paper investigates mechanisms for decision-controlled digitization architectures for Internet of Things and microservices by evolving enterprise architecture reference models and state of the art elements for architectural engineering for micro-granular systems.
Social networks, smart portable devices, Internet of Things (IoT) on base of technologies like analytics for big data and cloud services are emerging to support flexible connected products and agile services as the new wave of digital transformation. Biological metaphors of living and adaptable ecosystems with service-oriented enterprise architectures provide the foundation for self-optimizing and resilient run-time environments for intelligent business services and related distributed information systems. We are extending Enterprise Architecture (EA) with mechanisms for flexible adaptation and evolution of information systems having distributed IoT and other micro-granular digital architecture to support next digitization products, services, and processes. Our aim is to support flexibility and agile transformation for both IT and business capabilities through adaptive digital enterprise architectures. The present research paper investigates additionally decision mechanisms in the context of multi-perspective explorations of enterprise services and Internet of Things architectures by extending original enterprise architecture reference models with state of art elements for architectural engineering and digitization.
The digital transformation of our society changes the way we live, work, learn, communicate, and collaborate. The digitization of software-intensive products and services is enabled basically by four megatrends: Cloud computing, big data mobile systems, and social technologies. This disruptive change interacts with all information processes and systems that are important business enablers for the current digital transformation. The internet of things, social collaboration systems for adaptive case management, mobility systems and services for big data in cloud services environments are emerging to support intelligent user-centered and social community systems. Modern enterprises see themselves confronted with an ever growing design space to engineer business models of the future as well as their IT support, respectively. The decision analytics in this field becomes increasingly complex and decision support, particularly for the development and evolution of sustainable enterprise architectures (EA), is duly needed. With the advent of intelligent user-centered and social community systems, the challenging decision processes can be supported in more flexible and intuitive ways. Tapping into these systems and techniques, the engineers and managers of the enterprise architecture become part of a viable enterprise, i.e. a resilient and continuously evolving system that develops innovative business models.
The Internet of Things (IoT), enterprise social networks, adaptive case management, mobility systems, analytics for big data, and cloud services environments are emerging to support smart connected products and services and the digital transformation. Biological metaphors of living and adaptable ecosystems with service oriented enterprise architectures provide the foundation for self-optimizing and resilient run-time environments for intelligent business services and related distributed information systems. We are investigating mechanisms for flexible adaptation and evolution for the next digital enterprise architecture systems in the context of the digital transformation. Our aim is to support flexibility and agile transformation for both business and related enterprise systems through adaptation and dynamical evolution of digital enterprise architectures. The present research paper investigates mechanisms for decision case management in the context of multi-perspective explorations of enterprise services and Internet of Things architectures by extending original enterprise architecture reference models with state of art elements for architectural engineering for the digitization and architectural decision support.
Intelligent systems and services are the strategic targets of many current digitalization efforts and part of massive digital transformations based on digital technologies with artificial intelligence. Digital platform architectures and ecosystems provide an essential base for intelligent digital systems. The paper raises an important question: Which development paths are induced by current innovations in the field of artificial intelligence and digitalization for enterprise architectures? Digitalization disrupts existing enterprises, technologies, and economies and promotes the architecture of cognitive and open intelligent environments. This has a strong impact on new opportunities for value creation and the development of intelligent digital systems and services. Digital technologies such as artificial intelligence, the Internet of Things, service computing, cloud computing, blockchains, big data with analysis, mobile systems, and social business network systems are essential drivers of digitalization. We investigate the development of intelligent digital systems supported by a suitable digital enterprise architecture. We present methodological advances and an evolutionary path for architectures with an integral service and value perspective to enable intelligent systems and services that effectively combine digital strategies and digital architectures with artificial intelligence.
The Internet of Things, enterprise social networks, adaptive case management, mobility systems, analytics for big data, and cloud services environments are emerging to support smart connected products and services and the digital transformation. Biological metaphors of living and adaptable ecosystems provide the logical foundation for self-optimizing and resilient run-time environments for intelligent business services and related distributed information systems with service-oriented enterprise architectures. We are investigating mechanisms for flexible adaptation and evolution for the next digital enterprise architecture systems in the context of the digital transformation. Our aim is to support flexibility and agile transformation for both business and related enterprise systems through adaptation and dynamical evolution of digital enterprise architectures. The present research paper investigates digital transformations of business and IT and integrates fundamental mappings between adaptable digital enterprise architectures and service-oriented information systems. We are putting a spotlight with the example domain – Internet of Things.
In diesem Kapitel wird eine Einführung in die sich abzeichnenden Trends bei der Gestaltung der digitalen Transformation gegeben, wobei der Schwerpunkt auf digitalen Produkten, intelligenten Diensten und damit verbundenen Systemen sowie auf Methoden, Modellen und Architekturen liegt. Das primäre Ziel dieses Buches ist es, einige der neuesten Forschungsergebnisse auf diesem Gebiet hervorzuheben. Wir stellen eine Reihe von Kurzbeschreibungen der im Buch enthaltenen Kapitel zur Verfügung.
Today, many companies are adapting their strategy, business models, products, services as well as business processes and information systems in order to expand their digitalization level through intelligent systems and services. The paper raises an important question: What are cognitive co-creation mechanisms for extending digital services and architectures to readjust the usage value of smart services? Typically, extensions of digital services and products and their architectures are manual design tasks that are complex and require specialized, rare experts. The current publication explores the basic idea of extending specific digital artifacts, such as intelligent service architectures, through mechanisms of cognitive co-creation to enable a rapid evolutionary path and better integration of humans and intelligent systems. We explore the development of intelligent service architectures through a combined, iterative, and permanent task of co-creation between humans and intelligent systems as part of a new concept of cognitively adapted smart services. In this paper, we present components of a new platform for the joint co-creation of cognitive services for an ecosystem of intelligent services that enables the adaptation of digital services and architectures.
A hybrid deep registration of MR scans to interventional ultrasound for neurosurgical guidance
(2021)
Despite the recent advances in image-guided neurosurgery, reliable and accurate estimation of the brain shift still remains one of the key challenges. In this paper, we propose an automated multimodal deformable registration method using hybrid learning-based and classical approaches to improve neurosurgical procedures. Initially, the moving and fixed images are aligned using classical affine transformation (MINC toolkit), and then the result is provided to the convolutional neural network, which predicts the deformation field using backpropagation. Subsequently, the moving image is transformed using the resultant deformation into a moved image. Our model was evaluated on two publicly available datasets: the retrospective evaluation of cerebral tumors (RESECT) and brain images of tumors for evaluation (BITE). The mean target registration errors have been reduced from 5.35 ± 4.29 to 0.99 ± 0.22 mm in the RESECT and from 4.18 ± 1.91 to 1.68 ± 0.65 mm in the BITE. Experimental results showed that our method improved the state-of-the-art in terms of both accuracy and runtime speed (170 ms on average). Hence, the proposed method provides a fast runtime for 3D MRI to intra-operative US pair in a GPU-based implementation, which shows a promise for its applicability in assisting the neurosurgical procedures compensating for brain shift.
Glioblastomas are the most aggressive fast-growing primary brain cancer which originate in the glial cells of the brain. Accurate identification of the malignant brain tumor and its sub-regions is still one of the most challenging problems in medical image segmentation. The Brain Tumor Segmentation Challenge (BraTS) has been a popular benchmark for automatic brain glioblastomas segmentation algorithms since its initiation. In this year, BraTS 2021 challenge provides the largest multi-parametric (mpMRI) dataset of 2,000 pre-operative patients. In this paper, we propose a new aggregation of two deep learning frameworksnamely, DeepSeg and nnU-Net for automatic glioblastoma recognition in pre-operative mpMRI. Our ensemble method obtains Dice similarity scores of 92.00, 87.33, and 84.10 and Hausdorff Distances of 3.81, 8.91, and 16.02 for the enhancing tumor, tumor core, and whole tumor regions, respectively, on the BraTS 2021 validation set, ranking us among the top ten teams. These experimental findings provide evidence that it can be readily applied clinically and thereby aiding in the brain cancer prognosis, therapy planning, and therapy response monitoring. A docker image for reproducing our segmentation results is available online at (https://hub.docker.com/r/razeineldin/deepseg21).
Purpose: Gliomas are the most common and aggressive type of brain tumors due to their infiltrative nature and rapid progression. The process of distinguishing tumor boundaries from healthy cells is still a challenging task in the clinical routine. Fluid attenuated inversion recovery (FLAIR) MRI modality can provide the physician with information about tumor infiltration. Therefore, this paper proposes a new generic deep learning architecture, namely DeepSeg, for fully automated detection and segmentation of the brain lesion using FLAIR MRI data.
Methods: The developed DeepSeg is a modular decoupling framework. It consists of two connected core parts based on an encoding and decoding relationship. The encoder part is a convolutional neural network (CNN) responsible for spatial information extraction. The resulting semantic map is inserted into the decoder part to get the full-resolution probability map. Based on modified U-Net architecture, different CNN models such as residual neural network (ResNet), dense convolutional network (DenseNet), and NASNet have been utilized in this study.
Results: The proposed deep learning architectures have been successfully tested and evaluated on-line based on MRI datasets of brain tumor segmentation (BraTS 2019) challenge, including s336 cases as training data and 125 cases for validation data. The dice and Hausdorff distance scores of obtained segmentation results are about 0.81 to 0.84 and 9.8 to 19.7 correspondingly.
Conclusion: This study showed successful feasibility and comparative performance of applying different deep learning models in a new DeepSeg framework for automated brain tumor segmentation in FLAIR MR images. The proposed DeepSeg is open source and freely available at https://github.com/razeineldin/DeepSeg/.
Purpose
Artificial intelligence (AI), in particular deep neural networks, has achieved remarkable results for medical image analysis in several applications. Yet the lack of explainability of deep neural models is considered the principal restriction before applying these methods in clinical practice.
Methods
In this study, we propose a NeuroXAI framework for explainable AI of deep learning networks to increase the trust of medical experts. NeuroXAI implements seven state-of-the-art explanation methods providing visualization maps to help make deep learning models transparent.
Results
NeuroXAI has been applied to two applications of the most widely investigated problems in brain imaging analysis, i.e., image classification and segmentation using magnetic resonance (MR) modality. Visual attention maps of multiple XAI methods have been generated and compared for both applications. Another experiment demonstrated that NeuroXAI can provide information flow visualization on internal layers of a segmentation CNN.
Conclusion
Due to its open architecture, ease of implementation, and scalability to new XAI methods, NeuroXAI could be utilized to assist radiologists and medical professionals in the detection and diagnosis of brain tumors in the clinical routine of cancer patients. The code of NeuroXAI is publicly accessible at https://github.com/razeineldin/NeuroXAI.
Automatic segmentation is essential for the brain tumor diagnosis, disease prognosis, and follow-up therapy of patients with gliomas. Still, accurate detection of gliomas and their sub-regions in multimodal MRI is very challenging due to the variety of scanners and imaging protocols. Over the last years, the BraTS Challenge has provided a large number of multi-institutional MRI scans as a benchmark for glioma segmentation algorithms. This paper describes our contribution to the BraTS 2022 Continuous Evaluation challenge. We propose a new ensemble of multiple deep learning frameworks namely, DeepSeg, nnU-Net, and DeepSCAN for automatic glioma boundaries detection in pre-operative MRI. It is worth noting that our ensemble models took first place in the final evaluation on the BraTS testing dataset with Dice scores of 0.9294, 0.8788, and 0.8803, and Hausdorf distance of 5.23, 13.54, and 12.05, for the whole tumor, tumor core, and enhancing tumor, respectively. Furthermore, the proposed ensemble method ranked first in the final ranking on another unseen test dataset, namely Sub-Saharan Africa dataset, achieving mean Dice scores of 0.9737, 0.9593, and 0.9022, and HD95 of 2.66, 1.72, 3.32 for the whole tumor, tumor core, and enhancing tumor, respectively.
In the last decades, several driving systems were developed to improve the driving behaviour in energy efficiency or safety. However, these driving systems cover either the area of energy-efficiency or safety. Furthermore, they do not consider the stress level of the driver when showing a recommendation, although stress can lead to an unsafe or inefficient driving behaviour. In this paper, an approach is presented to consider the driver stress level in a driving system for safe and energy-efficient driving behaviour. The driving system tries to suppress a recommendation when the driver is in stress in order not to stress the driver additionally with recommendations in a stressful driving situation. This can lead to an increase in the road safety and in the user acceptance of the driving system, as the driver is not getting bothered or stressed by the driving system.
The evaluation of the approach showed, that the driving system
is able to show recommendations to the driver, while also reacting
to a high stress level by suppressing recommendations in
order not to stress the driver additionally.
Besides the optimisation of the car, energy-efficiency and safety can also be increased by optimising the driving behaviour. Based on this fact, a driving system is in development whose goal is to educate the driver in energy efficient and safe driving. It monitors the driver, the car and the environment and gives energy-efficiency and safety relevant recommendations. However, the driving system tries not to distract or bother the driver by giving recommendations for example during stressful driving situations or when the driver is not interested in that recommendation. Therefore, the driving system monitors the stress level of the driver as well as the reaction of the driver to a given recommendation and decideswhether to give a recommendation or not. This allows to suppress recommendations when needed and, thus, to increase the road safety and the user acceptance of
the driving system.