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A fast way to test business ideas and to explore customer problems and needs is to talk to them. Customer interviews help to understand what solutions customers will pay for before investing valuable resources to develop solutions. Customer interviews are a good way to gain qualitative insights. However, conducting interviews can be a difficult procedure and requires specific skills. The current ways of teaching interview skills have significant deficiencies. They especially lack guidance and opportunities to practice. Objective: The goal of this work is to develop and validate a workshop format to teach interview skills for conducting good customer interviews in a practical manner. Method: The research method is based on design science research which serves as a framework. A game-based workshop format was designed to teach interview skills. The approach consists of a half-day, hands-on workshop and is based on an analysis of necessary interview skills. The approach has been validated in several workshops and improved based on learnings from those workshops. Results: Results of the validation show that participants could significantly improve their interview skills while enjoying the game-based exercises. The game-based learning approach supports learning and practicing customer interview skills with playful and interactive elements that encourage greater motivation among participants to conduct interviews.
Radiofrequency ablation is an ablation technique to treat tumors with focused heat. Computer tomography, ultrasound and magnetic resonance imaging (MRI) are imaging modalities which can be used for image-guided procedures. MRI offers several advantages in comparison to the other imaging modalities, such as radiation-free fluoroscopic imaging, temperature mapping, a high-soft-tissue contrast and free selection of imaging planes. This work addresses the application of 3Dcontrollers for controlling interventional, fluoroscopic MR sequences at the scenario of MR guided radiofrequency ablation of hepatic malignancies. During this procedure, the interventionalist can monitor the targeting of the tumor with near-real time fluoroscopic sequences. In general, adjustments of the imaging planes are necessary during tumor targeting, which is performed by an assistant in the control room. Therefore, communication between the interventionalist in the scanner room and the assistant in the control room is essential. However, verbal communication is impaired due to the loud scanning noises. Alternatively, non-verbal communication between the two persons is possible, however limited to a few gestures and susceptible to misunderstandings. This work is analyzing different 3D-controllers to enable control of interventional MR sequences during MR-guided procedures directly by the interventionalist. Leap Motion, Wii Remote, SpaceNavigator, Phantom Omni and Foot Switch were selected. For that a simulation was built in C++ with VTK to feign the real scenario for test purposes. Previous results showed that Leap Motion is not suitable for the application while Wii Remote and Foot Switch are possible input devices. Final evaluation showed a generally time reduction with the use of 3D-controllers. Best results were reached with Wii Remote in 34 seconds. Handholding input devices like Wii Remote have further potential to integrate them in real environment to reduce intervention time.
Die Arbeit stellt die Möglichkeiten von 3D-Controllern für den Einsatz in der interventionellen Radiologie und insbesondere für die Steuerung der Echtzeit-Magnetresonanztomographie (MRT) dar. Dies ist interessant in Bezug auf die kontrollierte Navigation in ein Zielgewebe. Dabei kann der Interventionalist durch Echtzeit- Bildgebung den Verlauf des Eingriffs verfolgen, allerdings kann er bisher das MRT während der Durchführung des Eingriffs nicht selbst steuern, da dies durch den Assistenten im Nebenraum erfolgt. Die Kommunikation ist bei dem hohen Geräuschpegel aber sehr schwer. Diese Arbeit setzt an dieser Stelle an und analysiert 3D-Controller auf die Eignung für die Echtzeit-Steuerung eines MRTs. Dabei wurden trackingbasierte und trackinglose Geräte betrachtet. Als Ergebnis ließ sich festhalten, dass trackingbasierte Verfahren weniger geeignet sind, aufgrund der nicht ausreichenden Interpretation der Eingaben. Die trackinglosen Geräte hingegen sind aufgrund der korrekten Interpretation aller Eingaben und der intuitiven Bedienung geeignet.
Excellence in IT is both a driver and a key enabler of the digital transformation. The digital transformation changes the way we live, work, learn, communicate, and collaborate. The Internet of Things (IoT) fundamentally influences today’s digital strategies with disruptive business operating models and fast changing markets. New business information systems are integrating emerging Internet of Things infrastructures and components. With the huge diversity of Internet of Things technologies and products organizations have to leverage and extend previous Enterprise Architecture efforts to enable business value by integrating Internet of Things architectures. Both architecture engineering and management of current information systems and business models are complex and currently integrating beside the Internet of Things synergistic subjects, like Enterprise Architecture in context with services & cloud computing, semantic-based decision support through ontologies and knowledge-based systems, big data management, as well as mobility and collaboration networks. To provide adequate decision support for complex business/IT environments, we have to make transparent the impact of business and IT changes over the integral landscape of affected architectural capabilities, like directly and transitively impacted IoT-objects, business categories, processes, applications, services, platforms and infrastructures. The paper describes a new metamodel-based approach for integrating Internet of Things architectural objects, which are semi-automatically federated into a holistic Digital Enterprise Architecture environment.
The current advancement of Artificial Intelligence (AI) combined with other digitalization efforts significantly impacts service ecosystems. Artificial intelligence has a substantial impact on new opportunities for the co-creation of value and the development of intelligent service ecosystems. Motivated by experiences and observations from digitalization projects, this paper presents new methodological perspectives and experiences from academia and practice on architecting intelligent service ecosystems and explores the impact of artificial intelligence through real cases supporting an ongoing validation. Digital enterprise architecture models serve as an integral representation of business, information, and technological perspectives of intelligent service-based enterprise systems to support management and development. This paper focuses on architectural models for intelligent service ecosystems, showing the fundamental business mechanism of AI-based value co-creation, the corresponding digital architecture, and management models. The focus of this paper presents the key architectural model perspectives for the development of intelligent service ecosystems.
Platforms and their surrounding ecosystems are becoming increasingly important components of many companies' strategies. Artificial Intelligence, in particular, has created new opportunities to create and develop ecosystems around the platform. However, there is not yet a methodology to systematically develop these new opportunities for enterprise development strategy. Therefore, this paper aims to lay a foundation for the conceptualization of Artificial Intelligence-based service ecosystems exploiting a Service-Dominant Logic. The basis for conceptualization is the study of value creation and particularly effective network effects. This research investigates the fundamental idea of extending specific digital concepts considering the influence of Artificial Intelligence on the design of intelligent services, along with their architecture of digital platforms and ecosystems, to enable a smooth evolutionary path and adaptability for human-centric collaborative systems and services. The paper explores an extended digital enterprise conceptual model through a combined, iterative, and permanent task of co-creating value between humans and intelligent systems as part of a new idea of cognitively adapted intelligent services.
Unternehmen sind derzeit dabei, ihre Strategie, ihre Prozesse und ihre Informationssysteme zu verändern, um ihren Digitalisierungsgrad zu erhöhen. Das Potenzial des Internets und verwandter digitaler Technologien wie Internet der Dinge, Services Computing, Cloud Computing, künstliche Intelligenz, Big Data mit Analysen, mobile Systeme, Kollaborationsnetzwerke und cyber-physikalische Systeme treibt neue Geschäftsmodelle an und ermöglicht sie. Die Digitalisierung führt zu einer tiefgreifenden Umwälzung bestehender Unternehmen, Technologien und Volkswirtschaften und fördert die Architektur digitaler Umgebungen mit vielen eher kleinen und verteilten Strukturen. Dies hat starke Auswirkungen auf neue Wertschöpfungsmöglichkeiten und die Gestaltung digitaler Dienste und Produkte, die durch die Nutzung einer service-dominanten Logik gesteuert werden. Das Hauptergebnis des Buchkapitels erweitert Methoden für integrale digitale Strategien um wertorientierte Modelle für digitale Produkte und Dienstleistungen, die im Rahmen eines multiperspektivischen digitalen Unternehmensarchitektur-Referenzmodells definiert werden.
The Internet of Things (IoT) fundamentally influences today’s digital strategies with disruptive business operating models and fast changing markets. New business information systems are integrating emerging Internet of Things infrastructures and components. With the huge diversity of Internet of Things technologies and products organizations have to leverage and extend previous enterprise architecture efforts to enable business value by integrating the Internet of Things into their evolving Enterprise Architecture Management environments. Both architecture engineering and management of current enterprise architectures is complex and has to integrate beside the Internet of Things synergistic disciplines like EAM - Enterprise Architecture and Management with disciplines like: services & cloud computing, semantic-based decision support through ontologies and knowledge-based systems, big data management, as well as mobility and collaboration networks. To provide adequate decision support for complex business/IT environments, it is necessary to identify affected changes of Internet of Things environments and their related fast adapting architecture. We have to make transparent the impact of these changes over the integral landscape of affected EAM-capabilities, like directly and transitively impacted IoT-objects, business categories, processes, applications, services, platforms and infrastructures. The paper describes a new metamodel-based approach for integrating partial Internet of Things objects, which are semi-automatically federated into a holistic Enterprise Architecture Management environment.
Presently, many companies are transforming their strategy and product base, as well as their culture, processes and information systems to become more digital or to approach for a digital leadership. In the last years new business opportunities appeared using the potential of the Internet and related digital technologies, like Internet of Things, services computing, cloud computing, edge and fog computing, social networks, big data with analytics, mobile systems, collaboration networks, and cyber physical systems. Digitization fosters the development of IT environments with many rather small and distributed structures, like the Internet of Things, Microservices, or other micro-granular elements. This has a strong impact for architecting digital services and products. The change from a closed-world modeling perspective to more flexible open-world composition and evolution of micro-granular system architectures defines the moving context for adaptable systems. We are focusing on a continuous bottom-up integration of micro-granular architectures for a huge amount of dynamically growing systems and services, as part of a new digital enterprise architecture for service dominant digital products.
Digitization fosters the development of IT environments with many rather small structures, like Internet of Things (IoT), microservices, or mobility systems. They are needed to support flexible and agile digitized products and services. The goal is to create service-oriented enterprise architectures (EA) that are self optimizing and resilient. The present research paper investigates methods for decision-making concerning digitization architectures for Internet of Things and microservices. They are based on evolving enterprise architecture reference models and state of the art elements for architectural engineering for microgranular systems. Decision analytics in this field becomes increasingly complex and decision support, particularly for the development and evolution of sustainable enterprise architectures, is sorely needed. The challenging of the decision processes can be supported with in a more flexible and intuitive way by an architecture management cockpit.
Digitization of societies changes the way we live, work, learn, communicate, and collaborate. In the age of digital transformation IT environments with a large number of rather small structures like Internet of Things (IoT), microservices, or mobility systems are emerging to support flexible and agile digitized products and services. Adaptable ecosystems with service oriented enterprise architectures are the foundation for self-optimizing, resilient run-time environments and distributed information systems. The resulting business disruptions affect almost all new information processes and systems in the context of digitization. Our aim are more flexible and agile transformations of both business and information technology domains with more flexible enterprise information systems through adaptation and evolution of digital enterprise architectures. The present research paper investigates mechanisms for decision-controlled digitization architectures for Internet of Things and microservices by evolving enterprise architecture reference models and state of the art elements for architectural engineering for micro-granular systems.
The digital transformation of our life changes the way we work, learn, communicate, and collaborate. Enterprises are presently transforming their strategy, culture, processes, and their information systems to become digital. The digital transformation deeply disrupts existing enterprises and economies. Digitization fosters the development of IT systems with many rather small and distributed structures, like Internet of Things, Microservices and mobile services. Since years a lot of new business opportunities appear using the potential of services computing, Internet of Things, mobile systems, big data with analytics, cloud computing, collaboration networks, and decision support. Biological metaphors of living and adaptable ecosystems provide the logical foundation for self optimizing and resilient run-time environments for intelligent business services and adaptable distributed information systems with service oriented enterprise architectures. This has a strong impact for architecting digital services and products following both a value-oriented and a service perspective. The change from a closed world modeling world to a more flexible open-world composition and evolution of enterprise architectures defines the moving context for adaptable and high distributed systems, which are essential to enable the digital transformation. The present research paper investigates the evolution of Enterprise Architecture considering new defined value-oriented mappings between digital strategies, digital business models and an improved digital enterprise architecture.
Social networks, smart portable devices, Internet of Things (IoT) on base of technologies like analytics for big data and cloud services are emerging to support flexible connected products and agile services as the new wave of digital transformation. Biological metaphors of living and adaptable ecosystems with service-oriented enterprise architectures provide the foundation for self-optimizing and resilient run-time environments for intelligent business services and related distributed information systems. We are extending Enterprise Architecture (EA) with mechanisms for flexible adaptation and evolution of information systems having distributed IoT and other micro-granular digital architecture to support next digitization products, services, and processes. Our aim is to support flexibility and agile transformation for both IT and business capabilities through adaptive digital enterprise architectures. The present research paper investigates additionally decision mechanisms in the context of multi-perspective explorations of enterprise services and Internet of Things architectures by extending original enterprise architecture reference models with state of art elements for architectural engineering and digitization.
The digital transformation of our society changes the way we live, work, learn, communicate, and collaborate. This disruptive change drive current and next information processes and systems that are important business enablers for the context of digitization since years. Our aim is to support flexibility and agile transformations for both business domains and related information technology with more flexible enterprise information systems through adaptation and evolution of digital architectures. The present research paper investigates the continuous bottom-up integration of micro-granular architectures for a huge amount of dynamically growing systems and services, like microservices and the Internet of Things, as part of a new composed digital architecture. To integrate micro-granular architecture models into living architectural model versions we are extending enterprise architecture reference models by state of art elements for agile architectural engineering to support digital products, services, and processes.
New business opportunities appeared using the potential of the Internet and related digital technologies, like the Internet of Things, services computing, artificial intelligence, cloud, edge, and fog computing, social networks, big data with analytics, mobile systems, collaboration networks, and cyber-physical systems. Companies are transforming their strategy and product base, as well as their culture, processes and information systems to adopt digital transformation or to approach for digital leadership. Digitalization fosters the development of IT environments with many rather small and distributed structures, like the Internet of Things, Microservices, or other micro-granular elements. Digitalization has a substantial impact for architecting the open and complex world of highly distributed digital servcies and products, as part of a new digital enterprise architecture, which structure and direct service-dominant digital products and services. The present research paper investigates mechanisms for supporting the evolution of digital enterprise architectures with user-friendly methods and instruments of interaction, visualization, and intelligent decision management during the exploration of multiple and interconnected perspectives by an architecture management cockpit.
The digital transformation of our society changes the way we live, work, learn, communicate, and collaborate. The digitization of software-intensive products and services is enabled basically by four megatrends: Cloud computing, big data mobile systems, and social technologies. This disruptive change interacts with all information processes and systems that are important business enablers for the current digital transformation. The internet of things, social collaboration systems for adaptive case management, mobility systems and services for big data in cloud services environments are emerging to support intelligent user-centered and social community systems. Modern enterprises see themselves confronted with an ever growing design space to engineer business models of the future as well as their IT support, respectively. The decision analytics in this field becomes increasingly complex and decision support, particularly for the development and evolution of sustainable enterprise architectures (EA), is duly needed. With the advent of intelligent user-centered and social community systems, the challenging decision processes can be supported in more flexible and intuitive ways. Tapping into these systems and techniques, the engineers and managers of the enterprise architecture become part of a viable enterprise, i.e. a resilient and continuously evolving system that develops innovative business models.
Enterprises are transforming their strategy, culture, processes, and their information systems to enlarge their digitalization efforts or to approach for digital leadership. The digital transformation profoundly disrupts existing enterprises and economies. In current times, a lot of new business opportunities appeared using the potential of the Internet and related digital technologies: The Internet of Things, services computing, cloud computing, artificial intelligence, big data with analytics, mobile systems, collaboration networks, and cyber physical systems. Digitization fosters the development of IT environments with many rather small and distributed structures, like the Internet of Things, microservices, or other micro-granular elements. Architecting micro-granular structures have a substantial impact on architecting digital services and products. The change from a closed-world modeling perspective to more flexible Open World of living software and system architectures defines the context for flexible and evolutionary software approaches, which are essential to enable the digital transformation. In this paper, we are revealing multiple perspectives of digital enterprise architecture and decisions to effectively support value and service oriented software systems for intelligent digital services and products.
Artificial Intelligence-based Assistants AIAs are spreading quickly both in homes and offices. They already have left their original habitats of "intelligent speakers" providing easy access to music collections. The initiated a multitude of new devices and are already populating devices such as TV sets. Characteristic for the intelligent digital assistants is the formation of platforms around their core functionality. Thus, AIS capabilities of the assistants are used to offer new services and create new interfaces for business processes. There are positive network effects between the assistants and the services as well as within the services. Therefore, many companies see the need to get involved in the field of digital assistants but lack a framework to align their initiatives with their corporate strategies. In order to lay the foundation for a comprehensive method, we are therefore investigating intelligent digital assistants. Based on this analysis, we are developing a framework of strategic opportunities and challenges.
Der lokale Bekleidungseinzelhandel steht unter immer stärkerem Konkurrenzdruck durch Versandunternehmen. Zusätzlich bestehen durch gewachsene Architekturen eine Reihe von Wachstumshemmnissen. Daher sollen hier eine Reihe von Ansätzen zur Gestaltung datenzentrierter Unternehmensarchitekturen für den Bekleidungseinzelhandel vorgestellt werden. Sie basieren auf dem Einsatz von RFID zur Gewinnung von Kundenprofilen in den Niederlassungen und dem Einsatz von Big-Data basierten Auswertungs- und Analysemechanismen. Mit den vorgestellten Konzepten ist es Unternehmen des Bekleidungseinzelhandels möglich, ähnlich wie Versandunternehmen, individuelle Ansprachen des Kunden und Angebote zu entwickeln
The Internet of Things (IoT), enterprise social networks, adaptive case management, mobility systems, analytics for big data, and cloud services environments are emerging to support smart connected products and services and the digital transformation. Biological metaphors of living and adaptable ecosystems with service oriented enterprise architectures provide the foundation for self-optimizing and resilient run-time environments for intelligent business services and related distributed information systems. We are investigating mechanisms for flexible adaptation and evolution for the next digital enterprise architecture systems in the context of the digital transformation. Our aim is to support flexibility and agile transformation for both business and related enterprise systems through adaptation and dynamical evolution of digital enterprise architectures. The present research paper investigates mechanisms for decision case management in the context of multi-perspective explorations of enterprise services and Internet of Things architectures by extending original enterprise architecture reference models with state of art elements for architectural engineering for the digitization and architectural decision support.
Intelligent systems and services are the strategic targets of many current digitalization efforts and part of massive digital transformations based on digital technologies with artificial intelligence. Digital platform architectures and ecosystems provide an essential base for intelligent digital systems. The paper raises an important question: Which development paths are induced by current innovations in the field of artificial intelligence and digitalization for enterprise architectures? Digitalization disrupts existing enterprises, technologies, and economies and promotes the architecture of cognitive and open intelligent environments. This has a strong impact on new opportunities for value creation and the development of intelligent digital systems and services. Digital technologies such as artificial intelligence, the Internet of Things, service computing, cloud computing, blockchains, big data with analysis, mobile systems, and social business network systems are essential drivers of digitalization. We investigate the development of intelligent digital systems supported by a suitable digital enterprise architecture. We present methodological advances and an evolutionary path for architectures with an integral service and value perspective to enable intelligent systems and services that effectively combine digital strategies and digital architectures with artificial intelligence.
The Internet of Things, enterprise social networks, adaptive case management, mobility systems, analytics for big data, and cloud services environments are emerging to support smart connected products and services and the digital transformation. Biological metaphors of living and adaptable ecosystems provide the logical foundation for self-optimizing and resilient run-time environments for intelligent business services and related distributed information systems with service-oriented enterprise architectures. We are investigating mechanisms for flexible adaptation and evolution for the next digital enterprise architecture systems in the context of the digital transformation. Our aim is to support flexibility and agile transformation for both business and related enterprise systems through adaptation and dynamical evolution of digital enterprise architectures. The present research paper investigates digital transformations of business and IT and integrates fundamental mappings between adaptable digital enterprise architectures and service-oriented information systems. We are putting a spotlight with the example domain – Internet of Things.
The digital transformation of our society changes the way we live, work, learn, communicate, and collaborate. This disruptive change interacts with all information processes and systems that are important business enablers for the digital transformation since years. The Internet of Things, social collaboration systems for adaptive case management, mobility systems and services for Big Data in cloud services environments are emerging to support intelligent user-centered and social community systems. They will shape future trends of business innovation and the next wave of information and communication technology. Biological metaphors of living and adaptable ecosystems provide the logical foundation for self-optimizing and resilient run-time environments for intelligent business services and related distributed information systems with service-oriented enterprise architectures. The present research investigates mechanisms for flexible adaptation and evolution of digital enterprise architectures in the context of integrated synergistic disciplines like distributed service-oriented architectures and information systems, EAM - Enterprise Architecture and Management, metamodeling, semantic echnologies, web services, cloud computing and Big Data technology. Our aim is to support flexibility and agile transformations for both business domains and related enterprise systems through adaptation and evolution of digital enterprise architectures. The present research paper investigates digital transformations of business and IT and integrates fundamental mappings between adaptable digital enterprise architectures and service-oriented information systems.
In diesem Kapitel wird eine Einführung in die sich abzeichnenden Trends bei der Gestaltung der digitalen Transformation gegeben, wobei der Schwerpunkt auf digitalen Produkten, intelligenten Diensten und damit verbundenen Systemen sowie auf Methoden, Modellen und Architekturen liegt. Das primäre Ziel dieses Buches ist es, einige der neuesten Forschungsergebnisse auf diesem Gebiet hervorzuheben. Wir stellen eine Reihe von Kurzbeschreibungen der im Buch enthaltenen Kapitel zur Verfügung.
In current times, a lot of new business opportunities appeared using the potential of the Internet and related digital technologies, like Internet of Things, services computing, cloud computing, big data with analytics, mobile systems, collaboration networks, and cyber physical systems. Enterprises are presently transforming their strategy, culture, processes, and their information systems to become more digital. The digital transformation deeply disrupts existing enterprises and economies. Digitization fosters the development of IT environments with many rather small and distributed structures, like Internet of Things. This has a strong impact for architecting digital services and products. The change from a closed-world modeling perspective to more flexible open-world and living software and system architectures defines the moving context for adaptable and evolutionary software approaches, which are essential to enable the digital transformation. In this paper, we are putting a spotlight to service oriented software evolution to support the digital transformation with micro granular digital architectures for digital services and products.
Digitization is the use of digital technologies for creating innovative digital business models and transforming existing business models, processes and systems. Digitization creates profound changes in the economy and society. Information is often captured and processed without human intervention using digital means. Digitization impacts nearly all products and services as well as the customer and the value-creation perspective.
Big Data und Cloud Systeme werden zunehmend von mobilen, benutzerzentrierten und agil veränderbaren Informationssystemen im Kontext von digitalen sozialen Netzwerken genutzt. Metaphern aus der Biologie für lebendige und selbstheilende Systeme und Umgebungen liefern die Basis für intelligente adaptive Informationssysteme und für zugehörige serviceorientierte digitale Unternehmensarchitekturen. Wir berichten über unsere Forschungsarbeiten über Strukturen und Mechanismen adaptiver digitaler Unternehmensarchitekturen für die Entwicklung und Evolution von serviceorientierten Ökosystemen und deren Technologien wie Big Data, Services & Cloud Computing, Web Services und Semantikunterstützung. Für unsere aktuellen Forschungsarbeiten nutzen wir praxisrelevante SmartLife Szenarien für die Entwicklung, Wartung und Evolution zukunftsgerechter serviceorientierter Informationssysteme. Diese Systeme nutzen eine stark wachsende Zahl externer und interner Services und fokussieren auf die Besonderheiten der Weiterentwicklung der Informationssysteme für integrierte Big Data und Cloud Kontexte. Unser Forschungsansatz beschäftigt sich mit der systematischen und ganzheitlichen Modellbildung adaptiver digitaler Unternehmensarchitekturen - gemäß standardisierter Referenzmodelle und auf Standards aufsetzenden Referenzarchitekturen, die für besondere Einsatzszenarien auch bei kleineren Anwendungskontexten oder an neue Kontexte einfacher adaptiert werden können. Um Semantik-gestützte Analysen zur Entscheidungsunterstützung von System- und Unternehmensarchitekten zu ermöglichen, erweitern wir unser bisheriges Referenzmodell für ITUnternehmensarchitekturen ESARC – Enterprise Services Architecture Reference Cube – um agile Mechanismen der Adaption und Konsistenzbehandlung sowie die zugehörigen Metamodelle und Ontologien für Digitale Enterprise Architekturen um neue Aspekte wie Big Data und Cloud Kontexte.
Today, many companies are adapting their strategy, business models, products, services as well as business processes and information systems in order to expand their digitalization level through intelligent systems and services. The paper raises an important question: What are cognitive co-creation mechanisms for extending digital services and architectures to readjust the usage value of smart services? Typically, extensions of digital services and products and their architectures are manual design tasks that are complex and require specialized, rare experts. The current publication explores the basic idea of extending specific digital artifacts, such as intelligent service architectures, through mechanisms of cognitive co-creation to enable a rapid evolutionary path and better integration of humans and intelligent systems. We explore the development of intelligent service architectures through a combined, iterative, and permanent task of co-creation between humans and intelligent systems as part of a new concept of cognitively adapted smart services. In this paper, we present components of a new platform for the joint co-creation of cognitive services for an ecosystem of intelligent services that enables the adaptation of digital services and architectures.
Handling complexity in modern software engineering : editorial introduction to issue 32 of CSIMQ
(2022)
The potential of the Internet and related digital technologies, such as the Internet of Things (IoT), cognition and artificial intelligence, data analytics, services computing, cloud computing, mobile systems, collaboration networks, and cyber-physical systems, are both strategic drivers and enablers of modern digital platforms with fast-evolving ecosystems of intelligent services for digital products. This issue of CSIMQ presents three recent articles on modern software engineering. First, we focus on continuous software development and place it in the context of software architectures and digital transformation. The first contribution is followed by the description of the basis of specific security requirements and adequate digital monitoring mechanisms. Finally, we present a practical example of the digital management of livestock farming.
The digitization of our society changes the way we live, work, learn, communicate, and collaborate. This disruptive change interacts with all information processes and systems that are important business enablers for the context of digitization since years. Our aim is to support flexibility and agile transformations for both business domains and related information technology and enterprise systems through adaptation and evolution of digital enterprise architectures. The present research paper investigates collaborative decision mechanisms for adaptive digital enterprise architectures by extending original architecture reference models with state of art elements for agile architectural engineering for the digitization and collaborative architectural decision support.
The digitization of our society changes the way we live, work, learn, communicate, and collaborate. The Internet of Things, enterprise social networks, adaptive case management, mobility systems, analytics for big data, and cloud services environments are emerging to support smart connected products and services and the digital transformation. Biological metaphors of living and adaptable ecosystems provide the logical foundation for self-optimizing and resilient run-time environments for intelligent business services and service-oriented enterprise architectures. Our aim is to support flexibility and agile transformations for both business domains and related information technology. The present research paper investigates mechanisms for decision analytics in the context of multi-perspective explorations of enterprise services and their digital enterprise architectures by extending original architecture reference models with state of art elements for agile architectural engineering for the digitization and collaborative architectural decision support. The paper’s context focuses on digital transformations of business and IT and integrates fundamental mappings between adaptable digital enterprise architectures and service-oriented information systems. We are putting a spotlight on the example domain – Internet of Things.
The internet of things, enterprise social networks, adaptive case management, mobility systems, analytics for big data, and cloud environments are emerging to support smart connected i.e. digital products and services and the digital transformation. Biological metaphors for living and adaptable ecosystems are currently providing the logical foundation for resilient run-time environments with serviceoriented digitization architectures and for self-optimizing intelligent business services and related distributed information systems. We are investigating mechanisms for flexible adaptation and evolution of information systems with digital architecture in the context of the ongoing digital transformation. The goal is to support flexible and agile transformations for both business and related information systems through adaptation and dynamical evolution of their digital architectures. The present research paper investigates mechanisms of decision analytics for digitization architectures, putting a spotlight to internet of things micro-granular architectures, by extending original enterprise architecture reference models with digitization architectures and their multi-perspective architectural decision management.
SmartLife ecosystems are emerging as intelligent user-centered systems that will shape future trends in technology and communication. Biological metaphors of living adaptable ecosystems provide the logical foundation for self-optimizing and self-healing run-time environments for intelligent adaptable business services and related information systems with service-oriented enterprise architectures. The present research in progress work investigates mechanisms for adaptable enterprise architectures for the development of service-oriented ecosystems with integrated technologies like Semantic Technologies, Web Services, Cloud Computing and Big Data Management. With a large and diverse set of ecosystem services with different owners, our scenario of service-based SmartLife ecosystems can pose challenges in their development, and more importantly, for maintenance and software evolution. Our research explores the use of knowledge modeling using ontologies and flexible metamodels for adaptable enterprise architectures to support program comprehension for software engineers during maintenance and evolution tasks of service-based applications. Our previous reference enterprise architecture model ESARC -- Enterprise Services Architecture Reference Cube -- and the Open Group SOA Ontology was extended to support agile semantic analysis, program comprehension and software evolution for a SmartLife applications scenario. The Semantic Browser is a semantic search tool that was developed to provide knowledge-enhanced investigation capabilities for service-oriented applications and their architectures.
The digitization of our society changes the way we live, work, learn, communicate, and collaborate. This disruptive change interacts with all information processes and systems that are important business enablers for the context of digitization since years. Our aim is to support flexibility and agile transformations for both business domains and related information technology with more flexible enterprise information systems through adaptation and evolution of digital enterprise architectures. The present research paper investigates the continuous bottom-up integration of micro-granular architectures for a huge amount of dynamically growing systems and services, like microservices and the Internet of Things, as part of a new digital enterprise architecture. To integrate micro granular architecture models to living architectural model versions we are extending more traditional enterprise architecture reference models with state of art elements for agile architectural engineering to support the digitization of products, services, and processes.
Mit dem Kunstbegriff "Virtuelle Realität" beschreibt man die Darstellung von künstlichen Welten und die Interaktion mit den selbigen. Meist verbindet man damit teure Spiel- und Filmproduktionen. Doch durch derzeitige Entwicklungen können auch kleine Entwicklerstudios und Endanwender auf Bewegungserkennungssysteme zurückgreifen. In dieser Ausarbeitung werden zwei Prototypen vorgestellt, die auf eben diese Systeme zurückgreifen. In den Prototypen soll eine Interaktion mit der Umwelt und ein "Mittendringefühl" im Rahmen von Serious Games ermöglicht werden.
Background
The actual task of electrocardiographic examinations is to increase the reliability of diagnosing the condition of the heart. Within the framework of this task, an important direction is the solution of the inverse problem of electrocardiography, based on the processing of electrocardiographic signals of multichannel cardio leads at known electrode coordinates in these leads (Titomir et al. Noninvasiv electrocardiotopography, 2003), (Macfarlane et al. Comprehensive Electrocardiology, 2nd ed. (Chapter 9), 2011).
Results
In order to obtain more detailed information about the electrical activity of the heart, we carry out a reconstruction of the distribution of equivalent electrical sources on the heart surface. In this area, we hold reconstruction of the equivalent sources during the cardiac cycle at relatively low hardware cost. ECG maps of electrical potentials on the surface of the torso (TSPM) and electrical sources on the surface of the heart (HSSM) were studied for different times of the cardiac cycle. We carried out a visual and quantitative comparison of these maps in the presence of pathological regions of different localization. For this purpose we used the model of the heart electrical activity, based on cellular automata.
Conclusions
The model of cellular automata allows us to consider the processes of heart excitation in the presence of pathological regions of various sizes and localization. It is shown, that changes in the distribution of electrical sources on the surface of the epicardium in the presence of pathological areas with disturbances in the conduction of heart excitation are much more noticeable than changes in ECG maps on the torso surface.
Purpose
Computerized medical imaging processing assists neurosurgeons to localize tumours precisely. It plays a key role in recent image-guided neurosurgery. Hence, we developed a new open-source toolkit, namely Slicer-DeepSeg, for efficient and automatic brain tumour segmentation based on deep learning methodologies for aiding clinical brain research.
Methods
Our developed toolkit consists of three main components. First, Slicer-DeepSeg extends the 3D Slicer application and thus provides support for multiple data input/ output data formats and 3D visualization libraries. Second, Slicer core modules offer powerful image processing and analysis utilities. Third, the Slicer-DeepSeg extension provides a customized GUI for brain tumour segmentation using deep learning-based methods.
Results
The developed Slicer-DeepSeg was validated using a public dataset of high-grade glioma patients. The results showed that our proposed platform’s performance considerably outperforms other 3D Slicer cloud-based approaches.
Conclusions
Developed Slicer-DeepSeg allows the development of novel AI-assisted medical applications in neurosurgery. Moreover, it can enhance the outcomes of computer-aided diagnosis of brain tumours. Open-source Slicer-DeepSeg is available at github.com/razeineldin/Slicer-DeepSeg.
Intraoperative imaging can assist neurosurgeons to define brain tumours and other surrounding brain structures. Interventional ultrasound (iUS) is a convenient modality with fast scan times. However, iUS data may suffer from noise and artefacts which limit their interpretation during brain surgery. In this work, we use two deep learning networks, namely UNet and TransUNet, to make automatic and accurate segmentation of the brain tumour in iUS data. Experiments were conducted on a dataset of 27 iUS volumes. The outcomes show that using a transformer with UNet is advantageous providing an efficient segmentation modelling long-range dependencies between each iUS image. In particular, the enhanced TransUNet was able to predict cavity segmentation in iUS data with an inference rate of more than 125 FPS. These promising results suggest that deep learning networks can be successfully deployed to assist neurosurgeons in the operating room.
A hybrid deep registration of MR scans to interventional ultrasound for neurosurgical guidance
(2021)
Despite the recent advances in image-guided neurosurgery, reliable and accurate estimation of the brain shift still remains one of the key challenges. In this paper, we propose an automated multimodal deformable registration method using hybrid learning-based and classical approaches to improve neurosurgical procedures. Initially, the moving and fixed images are aligned using classical affine transformation (MINC toolkit), and then the result is provided to the convolutional neural network, which predicts the deformation field using backpropagation. Subsequently, the moving image is transformed using the resultant deformation into a moved image. Our model was evaluated on two publicly available datasets: the retrospective evaluation of cerebral tumors (RESECT) and brain images of tumors for evaluation (BITE). The mean target registration errors have been reduced from 5.35 ± 4.29 to 0.99 ± 0.22 mm in the RESECT and from 4.18 ± 1.91 to 1.68 ± 0.65 mm in the BITE. Experimental results showed that our method improved the state-of-the-art in terms of both accuracy and runtime speed (170 ms on average). Hence, the proposed method provides a fast runtime for 3D MRI to intra-operative US pair in a GPU-based implementation, which shows a promise for its applicability in assisting the neurosurgical procedures compensating for brain shift.
Glioblastomas are the most aggressive fast-growing primary brain cancer which originate in the glial cells of the brain. Accurate identification of the malignant brain tumor and its sub-regions is still one of the most challenging problems in medical image segmentation. The Brain Tumor Segmentation Challenge (BraTS) has been a popular benchmark for automatic brain glioblastomas segmentation algorithms since its initiation. In this year, BraTS 2021 challenge provides the largest multi-parametric (mpMRI) dataset of 2,000 pre-operative patients. In this paper, we propose a new aggregation of two deep learning frameworksnamely, DeepSeg and nnU-Net for automatic glioblastoma recognition in pre-operative mpMRI. Our ensemble method obtains Dice similarity scores of 92.00, 87.33, and 84.10 and Hausdorff Distances of 3.81, 8.91, and 16.02 for the enhancing tumor, tumor core, and whole tumor regions, respectively, on the BraTS 2021 validation set, ranking us among the top ten teams. These experimental findings provide evidence that it can be readily applied clinically and thereby aiding in the brain cancer prognosis, therapy planning, and therapy response monitoring. A docker image for reproducing our segmentation results is available online at (https://hub.docker.com/r/razeineldin/deepseg21).
Intraoperative brain deformation, so called brain shift, affects the applicability of preoperative magnetic resonance imaging (MRI) data to assist the procedures of intraoperative ultrasound (iUS) guidance during neurosurgery. This paper proposes a deep learning-based approach for fast and accurate deformable registration of preoperative MRI to iUS images to correct brain shift. Based on the architecture of 3D convolutional neural networks, the proposed deep MRI-iUS registration method has been successfully tested and evaluated on the retrospective evaluation of cerebral tumors (RESECT) dataset. This study showed that our proposed method outperforms other registration methods in previous studies with an average mean squared error (MSE) of 85. Moreover, this method can register three 3D MRI-US pair in less than a second, improving the expected outcomes of brain surgery.
Purpose: Gliomas are the most common and aggressive type of brain tumors due to their infiltrative nature and rapid progression. The process of distinguishing tumor boundaries from healthy cells is still a challenging task in the clinical routine. Fluid attenuated inversion recovery (FLAIR) MRI modality can provide the physician with information about tumor infiltration. Therefore, this paper proposes a new generic deep learning architecture, namely DeepSeg, for fully automated detection and segmentation of the brain lesion using FLAIR MRI data.
Methods: The developed DeepSeg is a modular decoupling framework. It consists of two connected core parts based on an encoding and decoding relationship. The encoder part is a convolutional neural network (CNN) responsible for spatial information extraction. The resulting semantic map is inserted into the decoder part to get the full-resolution probability map. Based on modified U-Net architecture, different CNN models such as residual neural network (ResNet), dense convolutional network (DenseNet), and NASNet have been utilized in this study.
Results: The proposed deep learning architectures have been successfully tested and evaluated on-line based on MRI datasets of brain tumor segmentation (BraTS 2019) challenge, including s336 cases as training data and 125 cases for validation data. The dice and Hausdorff distance scores of obtained segmentation results are about 0.81 to 0.84 and 9.8 to 19.7 correspondingly.
Conclusion: This study showed successful feasibility and comparative performance of applying different deep learning models in a new DeepSeg framework for automated brain tumor segmentation in FLAIR MR images. The proposed DeepSeg is open source and freely available at https://github.com/razeineldin/DeepSeg/.
Accurate and safe neurosurgical intervention can be affected by intra-operative tissue deformation, known as brain-shift. In this study, we propose an automatic, fast, and accurate deformable method, called iRegNet, for registering pre-operative magnetic resonance images to intra-operative ultrasound volumes to compensate for brain-shift. iRegNet is a robust end-to-end deep learning approach for the non-linear registration of MRI-iUS images in the context of image-guided neurosurgery. Pre-operative MRI (as moving image) and iUS (as fixed image) are first appended to our convolutional neural network, after which a non-rigid transformation field is estimated. The MRI image is then transformed using the output displacement field to the iUS coordinate system. Extensive experiments have been conducted on two multi-location databases, which are the BITE and the RESECT. Quantitatively, iRegNet reduced the mean landmark errors from pre-registration value of (4.18 ± 1.84 and 5.35 ± 4.19 mm) to the lowest value of (1.47 ± 0.61 and 0.84 ± 0.16 mm) for the BITE and RESECT datasets, respectively. Additional qualitative validation of this study was conducted by two expert neurosurgeons through overlaying MRI-iUS pairs before and after the deformable registration. Experimental findings show that our proposed iRegNet is fast and achieves state-of-the-art accuracies outperforming state-of-the-art approaches. Furthermore, the proposed iRegNet can deliver competitive results, even in the case of non-trained images as proof of its generality and can therefore be valuable in intra-operative neurosurgical guidance.
Purpose
Artificial intelligence (AI), in particular deep neural networks, has achieved remarkable results for medical image analysis in several applications. Yet the lack of explainability of deep neural models is considered the principal restriction before applying these methods in clinical practice.
Methods
In this study, we propose a NeuroXAI framework for explainable AI of deep learning networks to increase the trust of medical experts. NeuroXAI implements seven state-of-the-art explanation methods providing visualization maps to help make deep learning models transparent.
Results
NeuroXAI has been applied to two applications of the most widely investigated problems in brain imaging analysis, i.e., image classification and segmentation using magnetic resonance (MR) modality. Visual attention maps of multiple XAI methods have been generated and compared for both applications. Another experiment demonstrated that NeuroXAI can provide information flow visualization on internal layers of a segmentation CNN.
Conclusion
Due to its open architecture, ease of implementation, and scalability to new XAI methods, NeuroXAI could be utilized to assist radiologists and medical professionals in the detection and diagnosis of brain tumors in the clinical routine of cancer patients. The code of NeuroXAI is publicly accessible at https://github.com/razeineldin/NeuroXAI.
Automatic segmentation is essential for the brain tumor diagnosis, disease prognosis, and follow-up therapy of patients with gliomas. Still, accurate detection of gliomas and their sub-regions in multimodal MRI is very challenging due to the variety of scanners and imaging protocols. Over the last years, the BraTS Challenge has provided a large number of multi-institutional MRI scans as a benchmark for glioma segmentation algorithms. This paper describes our contribution to the BraTS 2022 Continuous Evaluation challenge. We propose a new ensemble of multiple deep learning frameworks namely, DeepSeg, nnU-Net, and DeepSCAN for automatic glioma boundaries detection in pre-operative MRI. It is worth noting that our ensemble models took first place in the final evaluation on the BraTS testing dataset with Dice scores of 0.9294, 0.8788, and 0.8803, and Hausdorf distance of 5.23, 13.54, and 12.05, for the whole tumor, tumor core, and enhancing tumor, respectively. Furthermore, the proposed ensemble method ranked first in the final ranking on another unseen test dataset, namely Sub-Saharan Africa dataset, achieving mean Dice scores of 0.9737, 0.9593, and 0.9022, and HD95 of 2.66, 1.72, 3.32 for the whole tumor, tumor core, and enhancing tumor, respectively.
Recent advances in artificial intelligence have enabled promising applications in neurosurgery that can enhance patient outcomes and minimize risks. This paper presents a novel system that utilizes AI to aid neurosurgeons in precisely identifying and localizing brain tumors. The system was trained on a dataset of brain MRI scans and utilized deep learning algorithms for segmentation and classification. Evaluation of the system on a separate set of brain MRI scans demonstrated an average Dice similarity coefficient of 0.87. The system was also evaluated through a user experience test involving the Department of Neurosurgery at the University Hospital Ulm, with results showing significant improvements in accuracy, efficiency, and reduced cognitive load and stress levels. Additionally, the system has demonstrated adaptability to various surgical scenarios and provides personalized guidance to users. These findings indicate the potential for AI to enhance the quality of neurosurgical interventions and improve patient outcomes. Future work will explore integrating this system with robotic surgical tools for minimally invasive surgeries.
Intracranial brain tumors are one of the ten most common malignant cancers and account for substantial morbidity and mortality. The largest histological category of primary brain tumors is the gliomas which occur with an ultimate heterogeneous appearance and can be challenging to discern radiologically from other brain lesions. Neurosurgery is mostly the standard of care for newly diagnosed glioma patients and may be followed by radiation therapy and adjuvant temozolomide chemotherapy.
However, brain tumor surgery faces fundamental challenges in achieving maximal tumor removal while avoiding postoperative neurologic deficits. Two of these neurosurgical challenges are presented as follows. First, manual glioma delineation, including its sub-regions, is considered difficult due to its infiltrative nature and the presence of heterogeneous contrast enhancement. Second, the brain deforms its shape, called “brain shift,” in response to surgical manipulation, swelling due to osmotic drugs, and anesthesia, which limits the utility of pre-operative imaging data for guiding the surgery.
Image-guided systems provide physicians with invaluable insight into anatomical or pathological targets based on modern imaging modalities such as magnetic resonance imaging (MRI) and Ultrasound (US). The image-guided toolkits are mainly computer-based systems, employing computer vision methods to facilitate the performance of peri-operative surgical procedures. However, surgeons still need to mentally fuse the surgical plan from pre-operative images with real-time information while manipulating the surgical instruments inside the body and monitoring target delivery. Hence, the need for image guidance during neurosurgical procedures has always been a significant concern for physicians.
This research aims to develop a novel peri-operative image-guided neurosurgery (IGN) system, namely DeepIGN, that can achieve the expected outcomes of brain tumor surgery, thus maximizing the overall survival rate and minimizing post-operative neurologic morbidity. In the scope of this thesis, novel methods are first proposed for the core parts of the DeepIGN system of brain tumor segmentation in MRI and multimodal pre-operative MRI to the intra-operative US (iUS) image registration using the recent developments in deep learning. Then, the output prediction of the employed deep learning networks is further interpreted and examined by providing human-understandable explainable maps. Finally, open-source packages have been developed and integrated into widely endorsed software, which is responsible for integrating information from tracking systems, image visualization, image fusion, and displaying real-time updates of the instruments relative to the patient domain.
The components of DeepIGN have been validated in the laboratory and evaluated in the simulated operating room. For the segmentation module, DeepSeg, a generic decoupled deep learning framework for automatic glioma delineation in brain MRI, achieved an accuracy of 0.84 in terms of the dice coefficient for the gross tumor volume. Performance improvements were observed when employing advancements in deep learning approaches such as 3D convolutions over all slices, region-based training, on-the-fly data augmentation techniques, and ensemble methods.
To compensate for brain shift, an automated, fast, and accurate deformable approach, iRegNet, is proposed for registering pre-operative MRI to iUS volumes as part of the multimodal registration module. Extensive experiments have been conducted on two multi-location databases: the BITE and the RESECT. Two expert neurosurgeons conducted additional qualitative validation of this study through overlaying MRI-iUS pairs before and after the deformable registration. Experimental findings show that the proposed iRegNet is fast and achieves state-of-the-art accuracies. Furthermore, the proposed iRegNet can deliver competitive results, even in the case of non-trained images, as proof of its generality and can therefore be valuable in intra-operative neurosurgical guidance.
For the explainability module, the NeuroXAI framework is proposed to increase the trust of medical experts in applying AI techniques and deep neural networks. The NeuroXAI includes seven explanation methods providing visualization maps to help make deep learning models transparent. Experimental findings showed that the proposed XAI framework achieves good performance in extracting both local and global contexts in addition to generating explainable saliency maps to help understand the prediction of the deep network. Further, visualization maps are obtained to realize the flow of information in the internal layers of the encoder-decoder network and understand the contribution of MRI modalities in the final prediction. The explainability process could provide medical professionals with additional information about tumor segmentation results and therefore aid in understanding how the deep learning model is capable of processing MRI data successfully.
Furthermore, an interactive neurosurgical display has been developed for interventional guidance, which supports the available commercial hardware such as iUS navigation devices and instrument tracking systems. The clinical environment and technical requirements of the integrated multi-modality DeepIGN system were established with the ability to incorporate: (1) pre-operative MRI data and associated 3D volume reconstructions, (2) real-time iUS data, and (3) positional instrument tracking. This system's accuracy was tested using a custom agar phantom model, and its use in a pre-clinical operating room is simulated. The results of the clinical simulation confirmed that system assembly was straightforward, achievable in a clinically acceptable time of 15 min, and performed with a clinically acceptable level of accuracy.
In this thesis, a multimodality IGN system has been developed using the recent advances in deep learning to accurately guide neurosurgeons, incorporating pre- and intra-operative patient image data and interventional devices into the surgical procedure. DeepIGN is developed as open-source research software to accelerate research in the field, enable ease of sharing between multiple research groups, and continuous developments by the community. The experimental results hold great promise for applying deep learning models to assist interventional procedures - a crucial step towards improving the surgical treatment of brain tumors and the corresponding long-term post-operative outcomes.
Vehicles have been so far improved in terms of energy-efficiency and safety mainly by optimising the engine and the power train. However, there are opportunities to increase energy-efficiency and safety by adapting the individual driving behaviour in the given driving situation. In this paper, an improved rule match algorithm is introduced, which is used in the expert system of a human-centred driving system. The goal of the driving system is to optimise the driving behaviour in terms of energy-efficiency and safety by giving recommendations to the driver. The improved rule match algorithm checks the incoming information against the driving rules to recognise any breakings of a driving rule. The needed information is obtained by monitoring the driver, the current driving situation as well as the car, using in-vehicle sensors and serial-bus systems. On the basis of the detected broken driving rules, the expert system will create individual recommendations in terms of energy-efficiency and safety, which will allow eliminating bad driving habits, while considering the driver needs.
Detecting the adherence of driving rules in an energy-efficient, safe and adaptive driving system
(2016)
An adaptive and rule-based driving system is being developed that tries to improve the driving behavior in terms of the energy-efficiency and safety by giving recommendations. Therefore, the driving system has to monitor the adherence of driving rules by matching the rules to the driving behavior. However, existing rule matching algorithms are not sufficient, as the data within a driving system is changing frequently. In this paper a rule matching algorithm is introduced that is able to handle frequently changing data within the context of the driving system. 15 journeys were used to evaluate the performance of the rule matching algorithms. The results showed that the introduced algorithm outperforms existing algorithms in the context of the driving system. Thus, the introduced algorithm is suited for matching frequently changing data against rules with a higher performance, why it will be used in the driving system for the detection of broken energy-efficiency of safety-relevant driving rules.