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Polyethylene glycol (PEG) is a widely used modification for drug delivery systems. It reduces undesired interaction with biological components, aggregation of complexes and serves as a hydrophilic linker of ligands for targeted drug delivery. However, PEGylation can also lead to undesired changes in physicochemical characteristics of chitosan/siRNA nanoplexes and hamper gene silencing.
To address this conflicting issue, PEG-chitosan copolymers were synthesized with stepwise increasing degrees of PEG substitution (1.5% to 8.0%). Subsequently formed PEG-chitosan/siRNA nanoplexes were characterized physicochemically and biologically. The results showed that small ratios of chitosan PEGylation did not affect nanoplex stability and density. However, higher PEGylation ratios reduced nanoplex size and charge, as well as cell uptake and final siRNA knockdown efficiency.
Therefore, we recommend fine-tuning of PEGylation ratios to generate PEG-chitosan/siRNA delivery systems with maximum bioactivity. The degree of PEGylation for chitosan/siRNA nanoplexes should be kept low in order to maintain optimal nanoplex efficiency.
In this article, liposome-based coatings aiming to control drug release from therapeutic soft contact lenses (SCLs) materials are analyzed. A PHEMA based hydrogel material loaded with levofloxacin is used as model system for this research. The coatings are formed by polyelectrolyte layers containing liposomes of 1,2-dimyristoyl-sn-glycero-3- phosphocholine (DMPC) and DMPC1cholesterol (DMPC1 CHOL). The effect of friction and temperature on the drug release is investigated. The aim of the friction tests is to simulate the blinking of the eyelid in order to verify if the SCLs materials coated with liposomes are able to keep their properties, in particular the drug release ability. It was observed that under the study conditions, friction did not affect significantly the drug release from the liposome coated PHEMA material. In contrast, increasing the temperature of release leads to an increase of the drug diffusion rate through the hydrogel. This phenomenon is recorded both in the control and in the coated samples.
The internet of things, enterprise social networks, adaptive case management, mobility systems, analytics for big data, and cloud environments are emerging to support smart connected i.e. digital products and services and the digital transformation. Biological metaphors for living and adaptable ecosystems are currently providing the logical foundation for resilient run-time environments with serviceoriented digitization architectures and for self-optimizing intelligent business services and related distributed information systems. We are investigating mechanisms for flexible adaptation and evolution of information systems with digital architecture in the context of the ongoing digital transformation. The goal is to support flexible and agile transformations for both business and related information systems through adaptation and dynamical evolution of their digital architectures. The present research paper investigates mechanisms of decision analytics for digitization architectures, putting a spotlight to internet of things micro-granular architectures, by extending original enterprise architecture reference models with digitization architectures and their multi-perspective architectural decision management.
IT environments that consist of a very large number of rather small structures like microservices, Internet of Things (IoT) components, or mobility systems are emerging to support flexible and agile products and services in the age of digital transformation. Biological metaphors of living and adaptable ecosystems with service-oriented enterprise architectures provide the foundation for self-optimizing, resilient run-time environments and distributed information systems. We are extending Enterprise Architecture (EA) methodologies and models that cover a high degree of heterogeneity and distribution to support the digital transformation and related information systems with micro-granular architectures. Our aim is to support flexibility and agile transformation for both IT and business capabilities within adaptable digital enterprise architectures. The present research paper investigates mechanisms for integrating Microservice Architectures (MSA) by extending original enterprise architecture reference models with elements for more flexible architectural metamodels and EA-mini-descriptions.
The Internet of Things, enterprise social networks, adaptive case management, mobility systems, analytics for big data, and cloud services environments are emerging to support smart connected products and services and the digital transformation. Biological metaphors of living and adaptable ecosystems provide the logical foundation for self-optimizing and resilient run-time environments for intelligent business services and related distributed information systems with service-oriented enterprise architectures. We are investigating mechanisms for flexible adaptation and evolution for the next digital enterprise architecture systems in the context of the digital transformation. Our aim is to support flexibility and agile transformation for both business and related enterprise systems through adaptation and dynamical evolution of digital enterprise architectures. The present research paper investigates digital transformations of business and IT and integrates fundamental mappings between adaptable digital enterprise architectures and service-oriented information systems. We are putting a spotlight with the example domain – Internet of Things.
Digitization is more than using digital technologies to transfer data and perform computations and tasks. Digitization embraces disruptive effects of digital technologies on economy and society. To capture these effects, two perspectives are introduced, the product and the value-creation perspective. In the product perspective, digitization enables the transition from material, static products to interactive and configurable services. In the value-creation perspective, digitization facilitates the transition from centralized, isolated models of value creation, to bidirectional, co-creation oriented approaches of value creation.
Preface of IDEA 2015
(2016)
An enormous amount of data in the context of business processes is stored as images. They contain valuable information for business process management. Up to now this data had to be integrated manually into the business process. By advances of capturing it is possible to extract information from an increasing number of images. Therefore, we systematically investigate the potentials of Image Mining for business process management by a literature research and an in-depth analysis of the business process lifecycle. As a first step to evaluate our research, we developed a prototype for recovering process model information from drawings using Rapidminer.
The Internet of Things (IoT), enterprise social networks, adaptive case management, mobility systems, analytics for big data, and cloud services environments are emerging to support smart connected products and services and the digital transformation. Biological metaphors of living and adaptable ecosystems with service oriented enterprise architectures provide the foundation for self-optimizing and resilient run-time environments for intelligent business services and related distributed information systems. We are investigating mechanisms for flexible adaptation and evolution for the next digital enterprise architecture systems in the context of the digital transformation. Our aim is to support flexibility and agile transformation for both business and related enterprise systems through adaptation and dynamical evolution of digital enterprise architectures. The present research paper investigates mechanisms for decision case management in the context of multi-perspective explorations of enterprise services and Internet of Things architectures by extending original enterprise architecture reference models with state of art elements for architectural engineering for the digitization and architectural decision support.
The digital transformation of our society changes the way we live, work, learn, communicate, and collaborate. The digitization of software-intensive products and services is enabled basically by four megatrends: Cloud computing, big data mobile systems, and social technologies. This disruptive change interacts with all information processes and systems that are important business enablers for the current digital transformation. The internet of things, social collaboration systems for adaptive case management, mobility systems and services for big data in cloud services environments are emerging to support intelligent user-centered and social community systems. Modern enterprises see themselves confronted with an ever growing design space to engineer business models of the future as well as their IT support, respectively. The decision analytics in this field becomes increasingly complex and decision support, particularly for the development and evolution of sustainable enterprise architectures (EA), is duly needed. With the advent of intelligent user-centered and social community systems, the challenging decision processes can be supported in more flexible and intuitive ways. Tapping into these systems and techniques, the engineers and managers of the enterprise architecture become part of a viable enterprise, i.e. a resilient and continuously evolving system that develops innovative business models.