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Milk-run systems are becoming more and more popular when it comes to in-plant material supply. Planning and dimensioning such a system poses challenges, which are difficult to overcome, especially in scenarios characterized by a large number of hard constraints and by well-established processes. This paper is set to ease the task of the planner by presenting an innovative flexible method for the planning and dimensioning of in-plant milk-run systems in high constrained scenarios. After an overview on tugger train systems and existing planning methods, an extensive description of the new method will be given. The new method proposed will be critically analyzed and discussed before suggesting forthcoming research.