The 20 most recently published documents
In recent years, the development and application of decellularized extracellular matrices (ECMs) for use as biomaterials have grown rapidly. These cell-derived matrices (CDMs) represent highly bioactive and biocompatible materials consisting of a complex assembly of biomolecules. Even though CDMs mimic the natural microenvironment of cells in vivo very closely, they still lack specifically addressable functional groups, which are often required to tailor a biomaterial functionality by bioconjugation. To overcome this limitation, metabolic glycoengineering has emerged as a powerful tool to equip CDMs with chemical groups such as azides. These small chemical handles are known for their ability to undergo bioorthogonal click reactions, which represent a desirable reaction type for bioconjugation. However, ECM insolubility makes its processing very challenging. In this contribution, we isolated both the unmodified ECM and azide-modified clickECM by osmotic lysis. In a first step, these matrices were concentrated to remove excessive water from the decellularization step. Next, the hydrogel-like ECM and clickECM films were mechanically fragmentized, resulting in easy to pipette suspensions with fragment sizes ranging from 7.62 to 31.29 μm (as indicated by the mean d90 and d10 values). The biomolecular composition was not impaired as proven by immunohistochemistry. The suspensions were used for the reproducible generation of surface coatings, which proved to be homogeneous in terms of ECM fragment sizes and coating thicknesses (the mean coating thickness was found to be 33.2 ± 7.3 μm). Furthermore, they were stable against fluid-mechanical abrasion in a laminar flow cell. When primary human fibroblasts were cultured on the coated substrates, an increased bioactivity was observed. By conjugating the azides within the clickECM coatings with alkyne-coupled biotin molecules, a bioconjugation platform was obtained, where the biotin–streptavidin interaction could be used. Its applicability was demonstrated by equipping the bioactive clickECM coatings with horseradish peroxidase as a model enzyme.
Today's pattern making methods for industrial purposes are including construction principles, which are based on mathematical formula and sizing charts. As a result, there are two-dimensional flats, which can be converted into a three-dimensional garment. Because of their high linearity, those patterns are incapable of recreating the complexity of the human body, which results in insufficient fit. Subsequent changes of the pattern require a high degree of experience and lead to an inefficient product development process. It is known that draping allows the development of more complex and demanding patterns, which corresponds more to the actual body shape. Therefore, this method is used in custom tailoring and haute couture to achieve perfect garment fit but is also associated with time.
So, there is the act of defiance to improve the fit of garments, to speed up production but maintain a good value for money. Reutlingen University is therefore working on the development of 3D-modelled body shapes for 3D draping, considering different layers of clothing, such as jackets or coats. For this purpose, 3D modelling is used to develop 3D-bodies that correspond to the finished dimensions of the garment. By flattening of the modelled body, it is then possible to obtain an optimal 2D Pattern of the body. The comparison of the conventional method and the developed method is done by 3D simulation.
Finally, the optical fit test is demonstrated by the simulated basic cuts, that a significantly better body wrapping through the newly developed methodology could be achieved. Unlike in the basic cuts, which were achieved by classical design principles have been created, only a few adjustments are necessary to obtain an optimized basic cut. Also, when considering the body distance, it is shown that the newly developed basic patterns provide a more even enclosure of the body.
The process for the production of customized bras is really challenging. Although the need is very clear, the lingerie industry is currently facing a lack of data, knowledge and expertise for the realization of an automated process chain. Different studies and surveys have shown, that the majority of women wear the incorrect bra size. In addition to aesthetic problems, health risks such as headaches, back problems or digestive problems of the wearers can result from this. An important prerequisite for improvements is the basic knowledge about the female breast, both in terms of body measurements and different breast shapes. The current size systematic for bras only defines a bra size by the relation between bust girth and underbust girth and standardized cup forms do not justice to the high variability of the human body. As the bra type shapes the female breast, basic knowledge about the relation of measurements and shapes from the clothed and the unclothed breast is missing.
In the present project, studies are conducted to explore the female breast and to derive new breast-specific body measurements, different breast shapes and deformation knowledge using existing bras.
Furthermore, an innovative process is being developed that leads from 3D scanning to individual and interactive pattern construction, which allows an automatic pattern creation based on individual body measurements and the influence of different material parameters.
In the course of the presentation, the current project status will be shown and the future developments and project steps will be introduced.
Im Gegensatz etwa zur klassischen Werbung handelt es sich beim Event-Marketing um ein dynamisches Kommunikationsinstrument, das laufend Trends und Neuerungen mit sich bringt. Die vielfältigen Einsatzmöglichkeiten und Potenziale des Event-Marketing ermöglichen es, entsprechend dem momentanen Zeitgeist relevante Zielgruppen zu erreichen, markenrelevante Wirklichkeiten und Erlebniswelten zu generieren, Emotionen und Sympathiewerte zu erzeugen und auf diese Weise eine Bindung zwischen Marke bzw. Unternehmen und Rezipienten herzustellen.
Zielgenau aus dem Hinterhalt
(2020)
Ambush-Marketing löst meistens heftige Reaktionen aus - bei Befürwortern und Gegnern. Die Idee des Ambush-Marketings ist es, von den Erfolgen des Sponsorings zu profitieren, ohne die Pflichten eines offiziellen Sponsors einzugehen. Ambusher besitzen keine Vermarktungsrechte an einer Veranstaltung, bauen aber dennoch durch ihre Marketingmassnahmen eine Verbindung zu einem Event auf. Der Grat zwischen der Verletzung von Sponsoren-Rechten und kreativ-innovativer Kommunikationspolitik ist dabei oft sehr schmal.
Gibt es einen Kauf-Knopf im Gehirn des Konsumenten? Und wenn ja, wie betätigt man diesen? Die Antworten auf diese Fragen könnte das Neuromarketing liefern. Das Neuromarketing ist Bestandteil der Neuroökonomie und eine relativ junge Disziplin an der Schnittstelle von Kognitionswissenschaften, Neurowissenschaften und der Marktforschung. Durch den technologischen Fortschritt können die Neurowissenschaften wichtige Erkenntnisse für das Marketing liefern, insbesondere Einblicke zur Erklärung des Konsumentenverhaltens. Durch den Blick in das Kundengehirn können beispielsweise Handelsunternehmen ihre Kunden gezielter ansprechen und sich so einen Vorteil gegenüber Konkurrenten verschaffen.
This article studies the current debate on Coronabonds and the idea of European public debt in the aftermath of the Corona pandemic. According to the EU-Treaty economic and fiscal policy remains in the sovereignty of Member States. Therefore, joint European debt instruments are risky and trigger moral hazard and free-riding in the Eurozone. We exhibit that a mixture of the principle of liability and control impairs the present fiscal architecture and destabilizes the Eurozone. We recommend that Member States ought to utilize either the existing fiscal architecture available or establish a political union with full sovereignty in Europe. This policy conclusion is supported by the PSPP-judgement of the Federal Constitutional Court of Germany on 5 May 2020. This ruling initiated a lively debate about the future of the Eurozone and Europe in general.
Purpose
Despite growing interest in the intersection of supply chain management (SCM) and management accounting (MA) in the academic debate, there is a lack of understanding regarding both the content and the delimitation of this topic. As of today, no common conceptualization of supply chain management accounting (SCMA) exists. The purpose of this study is to provide an overview of the research foci of SCMA in the scholarly debate of the past two decades. Additionally, it analyzes whether and to what extent the academic discourse of MA in SCs has already found its way into both SCM and MA higher education, respectively.
Design/methodology/approach
A content analysis is conducted including 114 higher education textbooks written in English or in German language.
Findings
The study finds that SC-specific concepts of MA are seldom covered in current textbooks of both disciplines. The authors conclude that although there is an extensive body of scholarly research about SCMA concepts, there is a significant discrepancy with what is taught in higher education textbooks.
Practical implications
There is a large discrepancy between the extensive knowledge available in scholarly research and what we teach in both disciplines. This implies that graduates of both disciplines lack important knowledge and skills in controlling and accounting for SCs. To bring about the necessary change, MA and SCM in higher education must be more integrative.
Originality/value
To the best of the authors knowledge, this study is first of its kind comprising a large textbook sample in both English and German languages. It is the first substantiated assessment of the current state of integration between SCM and MA in higher education.
In Germany, mobility is currently in a state of flux. Since June 2019, electric kick scooters (e-scooters) have been permitted on the roads, and this market is booming. This study employs a user survey to generate new data, supplemented by expert interviews to determine whether such e-scooters are a climate-friendly means of transport. The environmental impacts are quantified using a life cycle assessment. This results in a very accurate picture of e-scooters in Germany. The global warming potential of an e-scooter calculated in this study is 165 g CO2-eq./km, mostly due to material and production (that together account for 73% of the impact). By switching to e-scooters where the battery is swapped, the global warming potential can be reduced by 12%. The lowest value of 46 g CO2-eq./km is reached if all possibilities are exploited and the life span of e-scooters is increased to 15 months. Comparing these emissions with those of the replaced modal split, e-scooters are at best 8% above the modal split value of 39 g CO2-eq./km.
In this work, a brushless, harmonic-excited wound-rotor synchronous machine is investigated which utilizes special stator and rotor windings. The windings magnetically decouple the fundamental torque-producing field from the harmonic field required for the inductive power transfer to the field coil. In contrast to conventional harmonic-excited synchronous machines, the whole winding is utilized for both torque production and harmonic excitation such that no additional copper for auxiliary windings is needed. Different rotor topologies using rotating power electronic components are investigated and their efficiencies have been compared based on Finite-Element calculation and circuit analysis.
Energy efficient electric control of drives is more and more important for electric mobility and manufacturing industries. Online dynamic optimization of induction machines is challenging due to the computational complexity involved and the variable power losses during dynamic operation of induction machines. This paper proposes a simple technique for sub-optimal online loss optimization using rotor flux linkage templates for energy efficient dynamic operation of induction machines. Such a rotor flux linkage template is given by a rotor flux linkage trajectory which is optimal for a specific scenario. This template is calculated in an offline optimization process. For a specific scenario during real time operation the rotor flux linkage is calculated by appropriately scaling the given template.
Steady state efficiency optimization techniques for induction motors are state of the art and various methods have already been developed. This paper provides new insights in the efficiency optimized operation in dynamic regime. The paper proposes an anticipative flux modification in order to decrease losses during torque and speed transients. These trajectories are analyzed based on a numerical study for different motors. Measurement results for one motor are given as well.
The aim of this work was to investigate the mean fill weight control of a continuous capsule-filling process, whether it is possible to derive controller settings from an appendant process model. To that end, a system composed out of fully automated capsule filler and an online gravimetric scale was used to control the filled weight. This setup allows to examine challenges associated with continuous manufacturing processes, such as variations in the amount of active pharmaceutical ingredient (API) in the mixture due to fluctuations of the feeders or due to altered excipient batch qualities. Two types of controllers were investigated: a feedback control and a combination of feedback and feedforward control. Although both of those are common in the industry, determining the optimal parameter settings remains an issue. In this study, we developed a method to derive the control parameters based on process models in order to obtain optimal control for each filled product. Determined via rapid automated process development (RAPD), this method is an effective and fast way of determining control parameters. The method allowed us to optimize the weight control for three pharmaceutical excipients. By conducting experiments, we verified the feasibility of the proposed method and studied the dynamics of the controlled system. Our work provides important basic data on how capsule filler can be implemented into continuous manufacturing systems.
Most antimicrobial peptides (AMPs) and their synthetic mimics (SMAMPs) are thought to act by permeabilizing cell membranes. For antimicrobial therapy, selectivity for pathogens over mammalian cells is a key requirement. Understanding membrane selectivity is thus essential for designing AMPs and SMAMPs to complement classical antibiotics in the future. This study focuses on membrane permeabilization induced by SMAMPs and their selectivity for membranes with different lipid compositions. We measure release and fluorescence lifetime of a self-quenching dye in lipid vesicles. Apart from the dose-response, we quantify the strength of individual leakage events, and, employing cumulative kinetics, categorize permeabilization behavior. We propose that differing selectivities in a series of SMAMPs arise from a combination of the effect of the antimicrobial agent and the susceptibility of the membrane (with a given lipid composition) for certain types of leakage behavior. The unselective and hemolytic SMAMP is found to act mainly by the asymmetry stress mechanism, mediated by hydrophobic insertion of SMAMPs into lipid layers. The more selective SMAMPs induced leakage events occurring stochastically over several hours. Lipid intrinsic properties might additionally amplify the efficiency of leakage events. Leakage behavior changes with both the design of the SMAMP and the lipid composition of the membrane. Understanding how leakage behavior contributes to the selectivity and activity of antimicrobial agents will aid the design and screening of antimicrobials. An understanding of the underlying processes facilitates the comparison of membrane permeabilization across in vitro and in vivo assays.
Digitalization changes the manufacturing dramatically. In regard of employees’ demands, global trends and the technological vision of future factories, automotive manufacturing faces a huge number of diverse challenges. Currently, research focuses on technological aspects of future factories in terms of digitalization. New ways of work and new organizational models for future factories have not been described yet. There are assumptions on how to develop the organization of work in a future factory but up to now, literature shows deficits in scientifically substantiated answers in this research area. Consequently, the objective of this paper is to present an approach on a work organization design for automotive Industry 4.0 manufacturing. Future requirements were analyzed and deducted to criteria that determine future agile organization design. These criteria were then transformed into functional mechanisms, which define the approach for shopfloor organization design
In spite of many studies, knowledge about the fundamental factors influencing adhesion between addition curing silicones and aluminum substrates is very limited. The aim of this publication is to evaluate the influence of the formulation and the surface state of the adherend on bond strength. For this purpose, the composition of an addition curing silicone was systematically varied and the effects on both material and bond properties were examined. Additionally, the influence of surface aging at different humidities (0% r. h., 34% r. h., 82% r. h.) of acid etch pretreated aluminum substrates was considered. It is shown that the mechanical properties of the silicone material can be easily adjusted over a wide range by changing the formulation. Although high tensile strengths up to 9.2 MPa for the silicone material can be achieved, lap-shear strengths remain moderate at approximately 3.5 MPa. Predominant adhesive failures show the limited adhesive strength of the basic formulation without additives. Basic ingredients of addition curing silicones without additives are able to reach a certain adhesive strength. However, this strength was quite limited and adhesion promoters are required to further improve adhesion. The humidity at which the pretreated substrates are stored has an overall minor influence on bond strength. Surprisingly, bond strength tends to increase with the storage time of aluminum substrates despite lower surface energies in comparison to freshly pretreated substrates. All in all, the storage conditions of aluminum had a rather small influence on adhesion, whereas the composition of the silicone adhesive strongly influences bond strength.
In addition to increased safety by detecting possible overload, continuous component monitoring by sensor integration makes the use of fiber reinforced plastics more cost-effective. Since the components are continuously monitored, one can switch from time-based to condition-based maintenance. However, the integration of conventional sensor components causes weak points, as foreign objects are inserted into the reinforcing structure. In this paper, we examine the use of the textile reinforcement as a sensor in itself. We describe how bending sensors can be formed by slightly modifying in the composite’s reinforcement structure. We investigated two different sensor principles. (1) The integration of textile plate capacitors into the structure; (2) The construction of textile piezo elements as part of the reinforcing structure. The bending test results reveal that textile plate capacitors show a load-dependent signal output. The samples with textile piezo elements show a significant increase in signal strength.
Motto der Herbstkonferenz Informatics Inside 2020 ist KInside. Wieder einmal blicken Studierende inside und schauen sich Methoden, Anwendungen und Zusammenhänge genauer an. Die Beiträge sind vielfältig und entsprechend dem Studiengang human-centered. Es ist der Anspruch, dass sich die Themen um die Bedürfnisse der Menschen drehen und eingesetzte Methoden kein Selbstzweck sind, sondern am Nutzen für den Menschen gemessen werden.
