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In this article, liposome-based coatings aiming to control drug release from therapeutic soft contact lenses (SCLs) materials are analyzed. A PHEMA based hydrogel material loaded with levofloxacin is used as model system for this research. The coatings are formed by polyelectrolyte layers containing liposomes of 1,2-dimyristoyl-sn-glycero-3- phosphocholine (DMPC) and DMPC1cholesterol (DMPC1 CHOL). The effect of friction and temperature on the drug release is investigated. The aim of the friction tests is to simulate the blinking of the eyelid in order to verify if the SCLs materials coated with liposomes are able to keep their properties, in particular the drug release ability. It was observed that under the study conditions, friction did not affect significantly the drug release from the liposome coated PHEMA material. In contrast, increasing the temperature of release leads to an increase of the drug diffusion rate through the hydrogel. This phenomenon is recorded both in the control and in the coated samples.
In this study, a novel strategy has been developed for the assembly of polyelectrolyte multilayer (PEM) on CaCO3 templates in acidic pH solutions, where consecutive polyelectrolyte layers (heparin/poly(allylamine hydrochloride) or heparin/chitosan) were deposited on PEM hollow microcapsules established previously on CaCO3 templates. The PEM build-up, hollow capsule characterization and successful encapsulation of fluorescein 5(6)-isothiocyanate (FITC)-Dextran by coprecipitation with CaCO3 are demonstrated. Improvement by the removal of CaCO3 core was achieved while the depositions. In the course of the release profile, high retardation for encapsulated FITC-Dextran was observed. The combined shell capsules system is a significant trait that has potential use in tailoring functional layer-by-layer capsules as intelligent drug delivery vehicles where the preliminary in vitro tests showed the responsiveness on the enzymes.
This article covers the design of highly integrated gate drivers and level shifters for high-speed, high power efficiency and dv/dt robustness with focus on automotive applications. With the introduction of the 48 V board net in addition to the conventional 12 V battery, there is an increasing need for fast switching integrated gate drivers in the voltage range of 50 V and above. State-of-the-art drivers are able to switch 50 V in less than 5 ns. The high-voltage electrical drive train demands for galvanic isolated and highly integrated gate drivers. A gate driver with bidirectional signal transmission with a 1 MBit/s amplitude modulation, 10/20 MHz frequency modulation and power transfer over one single transformer will be discussed. The concept of high-voltage charge storing enables an area-efficient fully integrated bootstrapping supply with 70 % less area consumption. EMC is a major concern in automotive. Gate drivers with slope control optimize EMC while maintaining good switching efficiency. A current mode gate driver, which can change its drive current within 10 ns, results in 20 dBuV lower emissions between 7 and 60 MHz and 52 % lower switching loss compared to a conventional constant current gate driver.
Die Organisationsentwicklung hat eine bewegte Geschichte hinter sich und eine aussichtsreiche Zukunft vor sich. Die Kerngedanken der Organisationsentwicklung, die wesentlich durch die Forschungen von Kurt Lewin und Kollegen beeinflusst wurden, haben die theoretischen Vorstellungen über und praktische Handhabung von intentional gesteuerten Veränderungsprozessen wesentlich beeinflusst. Nachdem die Organisationsentwicklung über die Zeit strategischer und pragmatischer geworden ist, droht sie als eigenständige Methode zunehmend unkenntlich zu werden. In diesem Beitrag wird anhand von zwei Thesen argumentiert, dass eine zukunftsfähige Organisationsentwicklung die Grundidee der Partizipation in einer digitalen Arbeitswelt wieder stärken und sich reflektierter als bislang dem paradoxen Verhältnis zwischen Stabilität und Wandel annehmen müsste. Eine Organisationsentwicklung, die sich mit diesen Themen beschäftigt, ist zukunftsfähig und wird wesentlich die Art und Weise prägen, wie in Organisationen Veränderungen gestaltet werden.
The influence of turbidity on the Raman signal strengths of condensed matter is theoretically analyzed and measured with laboratory - scale equipment for remote sensing. The results show the quantitative dependence of back- and forward-scattered signals on the thickness and elastic-scattering properties of matter. In the extreme situation of thin, highly turbid layers, the measured Raman signal strengths exceed their transparent analogs by more than a factor of ten. The opposite behavior is found for thick layers of low turbidity, where the presence of a small amount of scatterers leads to a decrease of the measured signal. The wide range of turbidities appearing in nature is experimentally realized with stacked polymer layers and solid/liquid dispersions, and theoretically modeled by the equation of radiative transfer using the analytical diffusion approximation or random walk simulations.
Green fashion retail
(2017)
This book focuses on sustainability in fashion retail, which is fast becoming the pivot point of future fashion retail strategies. Chapters in the book provide theoretical and practical insight on how going green may positively influence the strategy of fashion retailers and marketers, who have to react to the changing society and customer needs. Structured in four main parts, and based on distinct research questions, readers will be able to dig deep into the individual levers for possible adaptions. It thus provides a solid understanding on how to integrate green aspects into any fashion retailers business model.
The purpose of this paper is to explain the key aspects and growing relevance of sustainability in fashion retail and to evaluate the possibilities of fashion retailers to act sustainable in supply chain management as well as carving out the challenges they have to deal with. The research methodology applied for this purpose is a critical literature review examining books and articles. The findings demonstrate the rising importance of sustainability in fashion retail. In this regard, fashion retailers play a key role and responsibility for sustainability in the fashion supply chain, from the beginning up to the end. This paper mainly analyzes sustainability in the fashion supply chain. It does not analyze topics like second-hand shopping or social media sustainability.
The purpose of this paper is to investigate how the practice of closed-loop production systems (CLPS) is implemented in the fashion industry. This paper offers a critical literature review to present a thorough understanding of the actual status of literature. Subsequently, the paper reveals that CLPS are of great importance. Generally, such systems include different activities that have to be integrated. Critical points are the product acquisition, the recovering process itself and the remarketing to the customer. A lack of reliable data concerning CLPS in the specific case of fashion industry can be identified. Important research fields could be marketing strategies, controlling the acquisition process, evolvement of return technologies and strategies, adaption of recovered products to the mass market, and the development of new technologies concerning recovering processes.
The purpose of this paper is to examine the impact on sustainability of fashion production and consumption in order to discuss what the main lever is to reduce the negative impact. The research methodology applied is a literature review examining academic references. Key findings suggest that fashion production and consumption have a single comparable impact on sustainability. Moreover, as the fashion production follows the demand, the consumer steers the production in a certain direction. Therefore, consumers take over responsibility and need to be informed. To reach a long-term change in the fashion industry, the consumer has to be the focus of the sustainable efforts. Most results in literature were conducted by qualitative research methods, so that further quantitative testing of the results is recommended. Furthermore, most surveys were conducted with young fashion consumers in the EU or UK which does not represent the fashion consumer in general.
The purpose of this paper is to define what impacts sustainable manufacturing standards have for retail brands concerning the communication policy and to find possible solutions of how the companies can deal with them. Therefore, sustainable standards and the impacts on the internal and external communication are described. The enclosed discussion finds possible solutions for the negative impacts. A literature discussion has been conducted to investigate the purpose. Generally, there are many impacts fashion retails have to consider, if they want to transform their company to become more sustainable, because only the impacts on a defined part of the communication policy were huge. A limitation of this paper is that the proposals how retailers could deal with the impacts of the transformation of the company toward more sustainability need further research and tests until they are practicable.