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Als Google vor einigen Jahren begann, seine riesigen Personaldatenbestände auszuwerten, um herauszufinden, welche Eigenschaften gute Führungskräfte ausmachen, betrat es Neuland. Die Ergebnisse legten nahe, die Daten auch für andere personalwirtschaftliche Fragen zu nutzen (vgl. Garvin).
Inzwischen beschäftigen sich nicht nur Technologie-unternehmen wie Google mit Verfahren, die unter dem Schlagwort People Analytics (auch HR Analytics oder Workforce Analytics) intensiv diskutiert und erforscht werden. Dabei werden die umfangreichen Bestände an mitarbeiterbezogenen Daten, die bei der Rekrutierung, bei Mitarbeiterumfragen oder Leistungsbeurteilungen anfallen, systematisch analysiert und für Prognosen genutzt (vgl. Marler/Boudreau, S. 15). Dem liegt die Annahme zugrunde, dass Personalentscheidungen verbessert werden, wenn sie nicht nur auf Intuition und Erfahrung beruhen, sondern zudem auf einem soliden Datenfundament.
The development of new materials that mimic cartilage and its function is an unmet need that will allow replacing the damaged parts of the joints, instead of the whole joint. Polyvinyl alcohol (PVA) hydrogels have raised special interest for this application due to their biocompatibility, high swelling capacity and chemical stability. In this work, the effect of post-processing treatments (annealing, high hydrostatic pressure (HHP) and gamma-radiation) on the performance of PVA gels obtained by cast-drying was investigated and, their ability to be used as delivery vehicles of the anti-inflammatories diclofenac or ketorolac was evaluated. HHP damaged the hydrogels, breaking some bonds in the polymeric matrix, and therefore led to poor mechanical and tribological properties. The remaining treatments, in general, improved the performance of the materials, increasing their crystallinity. Annealing at 150 °C generated the best mechanical and tribological results: higher resistance to compressive and tensile loads, lower friction coefficients and ability to support higher loads in sliding movement. This material was loaded with the anti-inflammatories, both without and with vitamin E (Vit.E) or Vit.E + cetalkonium chloride (CKC). Vit.E + CKC helped to control the release of the drugs which occurred in 24 h. The material did not induce irritability or cytotoxicity and, therefore, shows high potential to be used in cartilage replacement with a therapeutic effect in the immediate postoperative period.
Human bestrophin-1 (hBest1) is a transmembrane Ca2+- dependent anion channel, associated with the transport of Cl−, HCO3- ions, γ-aminobutiric acid (GABA), glutamate (Glu), and regulation of retinal homeostasis. Its mutant forms cause retinal degenerative diseases, defined as Bestrophinopathies. Using both physicochemical - surface pressure/mean molecular area (π/A) isotherms, hysteresis, compressibility moduli of hBest1/sphingomyelin (SM) monolayers, Brewster angle microscopy (BAM) studies, and biological approaches - detergent membrane fractionation, Laurdan (6-dodecanoyl-N,N-dimethyl-2-naphthylamine) and immunofluorescence staining of stably transfected MDCK-hBest1 and MDCK II cells, we report:
1) Ca2+, Glu and GABA interact with binary hBest1/SM monolayers at 35 °C, resulting in changes in hBest1 surface conformation, structure, self-organization and surface dynamics. The process of mixing in hBest1/SM monolayers is spontaneous and the effect of protein on binary films was defined as “fluidizing”, hindering the phase-transition of monolayer from liquid-expanded to intermediate (LE-M) state;
2) in stably transfected MDCK-hBest1 cells, bestrophin-1 was distributed between detergent resistant (DRM) and detergent-soluble membranes (DSM) - up to 30 % and 70 %, respectively; in alive cells, hBest1 was visualized in both liquid-ordered (Lo) and liquid-disordered (Ld) fractions, quantifying protein association up to 35 % and 65 % with Lo and Ld. Our results indicate that the spontaneous miscibility of hBest1 and SM is a prerequisite to diverse protein interactions with membrane domains, different structural conformations and biological functions.
Purpose. To improve the efficiency of the closed-cycle operation of the field-orientation induction machine in dynamic behavior when load conditions are changing, considering the nonlinearities of the main inductance.
Methodology. The optimal control problem is defined as the minimization of the time integral of the energy losses. The algorithm observed in this paper uses the Matlab/Simulink, dSPACE real-time interface, and C language. Handling real-time applications is made in ControlDesk experiment software for seamless ECU development.
Findings. Adiscrete-time model with an integrated predictive control scheme where the optimization is performed online at every sampling step has been developed. The optimal field-producing current trajectory is determined, so that the copper losses are minimized over a wide operational range. Additionally, the comparison of measurement results with conventional methods is provided, which validates the advantages and performance of the control scheme.
Originality. To solve the given problem, the information vector on the current state of the coordinates of the electromechanical system is used to form a controlling influence in the dynamic mode of operation. For the first time, the formation process of controls has considered the current state and the desired future state of the system in the real-time domain.
Practical value. Apredictive iterative approach for optimal flux level of an induction machine is important to generate the required electromagnetic torque and to reduce power losses simultaneously.
The approach of self-organized and autonomous controlled systems offers great potential to meet new requirements for the economical production of customized products with small batch sizes based on a distributed, flexible management of dynamics and complexity within the production and intralogistics system. To support the practical application of self-organization for intralogistics systems, a catalogue of criteria for the evaluation of the self-organization of flexible logistics systems has been developed and validated, which enables the classification of logistics systems as well as the identification and evaluation of corresponding potentials that can be achieved by increasing the degree of self-organization.
Rapidly changing market conditions and global competition are leading to an increasing complexity of logistics systems and require innovative approaches with respect to the organisation and control of these systems. In scientific research, concepts of autonomously controlled logistics systems show a promising approach to meet the increasing requirements for flexible and efficient order processing. In this context, this work aims to introduce a system that is able to adjust order processing dynamically, and optimise intralogistics transportation regarding various generic intralogistics target criteria. The logistics system under consideration consists of various means of transport for autonomous decision-making and fulfilment of transport orders with defined source-sink relationships. The context of this work is set by introducing the Learning Factory Werk 150 with its existing hardware and software infrastructure and its defined target figures to measure the performance of the system. Specifically, the important target figures cost and performance are considered for the transportation system. The core idea of the system’s logic is to solve the problem of order allocation to specific means of transport by linking a Genetic Algorithm with a Multi-Agent System. The implementation of the developed system is described in an application scenario at the learning factory.
Learning factories can complement each other by training different competencies in the field of digitalisation and Industry 4.0. They depict diverse sections of the product development process and focus on various technologies. Within the framework of the International Association of Learning Factories (IALF), the operating organisations of learning factories exchange information on research, training and education. One of the aims is to develop joint projects. The article presents different concepts of cooperation between learning factories while focusing on the improvement of the development of learners competencies e.g. with a broader range of topics. A concept of a joint course between the learning factories in Bochum, Reutlingen and Darmstadt is explained in detail. The three learning factories will be examined with regard to their similarities and differences. The joint course focuses on the target group of students and the topic of digitalisation in the development and production of products. The course and its contents are explained in detail. The new learning approach is evaluated on the basis of feedback from the participants. Finally, challenges resulting from the cooperation between learning factories at different locations and with different operating models will be discussed.
Die Produktindividualisierung, Digitalisierung und Automatisierung der Produktion erfordern eine ständige Anpassung der Produktions- und Intralogistikprozesse. Referenzmodelle unterstützen dabei Produktions- und Fabrikplaner mit Standards, Werkzeugen und vielem mehr. Eine Marktrecherche von Referenzmodellen zeigt erhebliche inhaltliche und methodische Unvollständigkeiten auf. Eine daraus abgeleitete Handlungsempfehlung für die Konstruktion eines Intralogistikreferenzmodells wir vorgestellt.
Melamine-formaldehyde resins are widely used for decorative paper impregnation. Resin properties relevant for impregnation are mainly determined already at the stage of resin synthesis by the applied reaction conditions. Thus, understanding the relationship between reaction conditions and technological properties is important. Response surface methodology based on orthogonal parameter level variations is the most suitable tool to identify and quantify factor effects and deduce causal correlation patterns. Here, two major process factors of MF resin synthesis were systematically varied using such a statistical experimental design. To arrive at resins having a broad range of technological properties, initial pH and M:F ratio were varied in a wide range (pH: 7.9–12.1; M:F ratio: 1:1.5–1:4.5). The impregnation behavior of the resins was modeled using viscosity, penetration rate and residual curing capacity as technological responses. Based on the response surface models, nonlinear and synergistic action of process factors was quantified and a suitable process window for preparing resins with favorable impregnation performance was defined. It was found that low M:F ratios (~1:2–1:2.5) and comparatively high starting pHs (~pH 11) yield impregnation resins with rapid impregnation behavior and good residual curing capacity.