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Das Studienbuch "Internationales Wirtschaftsprivatrecht" stellt die Fortsetzung der in Deutschland existierenden Studienbücher zum nationalen Wirtschaftsprivatrecht dar. Der Ansatz bei diesem Lehrbuch ist es, gerade aus der Sicht von Studierenden der Betriebswirtschaftslehre und Entscheidern aus dem Mittelstand, anhand von wirtschaftswissenschaftlichen Schlagwörtern Problemlösungen aus juristischer Sicht aufzuzeigen. Daher grenzt sich dieses Werk in seiner Grundausrichtung von den typischen am Markt vorhandenen Studienbüchern im Wirtschaftsprivatrecht erheblich ab. Das Studienbuch "Internationales Wirtschaftsprivatrecht" eignet sich besonders für Bachelor- und Master-Studiengänge, in denen verpflichtend Rechtsvorlesungen zu belegen sind; speziell im internationalen Recht. Das betrifft insbesondere BWL-Studiengänge bzw. dazu artverwandte Studiengänge in Deutschland.
In vivo, cells encounter different physical and chemical signals in the extracellular matrix (ECM) which regulate their behavior. Examples of these signals are micro- and nanometer-sized features, the rigidity, and the chemical composition of the ECM. The study of cell responses to such cues is important to understand complex cell functions, some diseases, and is basis for the development of new biomaterials for applications in medical implants or regenerative medicine. Therefore, the development of new methods for surface modifications with controlled physical and chemical features is crucial. In this work, we report a new combination of micelle nanolithography (BCML) and soft micro-lithography, for the production of polyethylene glycol (PEG) hydrogels, with a micro-grooved surface and decoration with hexagonally precisely arranged gold nanoparticles (AU NPs). The Au-NPs are used for binding adhesive ligands in a well-defined density. First tests were performed by culturing human fibroblasts on the gels. Adhesion and alignment of the cells along the parallel grooves of the surface were investigated. The substrates could provide a new platform for studying cell contact guidance by micro structures, and may enable a more precise control of cell behavior by nanometrically controlled surface functionalization.
Increasing number of studies are focused on how adherent cells respond, in vitro, to different properties of a material. Typical properties are the surface chemistry, topographical cues (at the nano- and micro-scale) of the surface, and the substrate stiffness. Cell Response studies are of importance for designing new biomaterials with applications in cell culture technologies, regenerative medicine, or for medical implants. However, only very few studies take the cell age factor, respectively the donor age, into account. In this work, we tested two types of human vascular cells (smooth muscle and endothelial cells) from old and young donors on (a) micro-structured surfaces made of pol (dimethylsiloxane) or on (b) flat polyacrylamide hydrogels with varying stiffnesses. These experiments reveal age-dependent and cell typedependent differences in the cell response to the topography and stiffness, and may establish the Basis for further studies focusing on cell age-dependent responses.
Scanning Near-Field Optical Microscopy (SNOM) has developed during recent decades into a valuable tool to optically image the surface topology of materials with super-resolution. With aperture-based SNOM systems, the resolution scales with the size of the aperture, but also limits the sensitivity of the detection and thus the application for spectroscopic techniques like Raman SNOM. In this paper we report the extension of solid immersion lens (SIL) technology to Raman SNOM. The hemispherical SIL with a tip on the bottom acts as an apertureless dielectric nanoprobe for simultaneously acquiring topographic and spectroscopic information. The SIL is placed between the sample and the microscope objective of a confocal Raman microscope. The lateral resolution in the Raman mode is validated with a cross section of a semiconductor layer system and, at approximately 180 nm, is beyond the classical diffraction limit of Abbe.
In the current study the in vitro outcome of a degradable magnesium alloy (AZ91D) and standard titanium modified by nanostructured-hydroxyapatite (n-HA) coatings concerning cell adhesion and osteogenic differentiation was investigated by direct cell culture. The n-HA modification was prepared via radio-frequency magnetron sputtering deposition and proven by field emission scanning electron microscopy and X-ray powder diffraction patterns revealing a homogenous surface coating. Human mesenchymal stem cell (hMSCs) adhesion was examined after one and 14 days displaying an enhanced initial cell adhesion on the n-HA modified samples. The osteogenic lineage commitment of the cells was determined by alkaline phosphatase (ALP) quantification. On day one n-HA coated AZ91D exhibited a comparable ALP expression to standard tissue culture polystyrene samples. However, after 14 days solely little DNA and ALP amounts were measurable on n-HA coated AZ91D due to the lack of adherent cells. Titanium displayed excellent cell adhesion properties and ALP was detectable after 14 days. An increased pH of the culture was measured for AZ91D as well as for n-HA coated AZ91D. We conclude that n-HA modification improves initial cell attachment on AZ91D within the first 24 h. However, the effect does not ersist for 14 days in in vitro conditions.
Socially interactive robots with human-like speech synthesis and recognition, coupled with humanoid appearance, are an important subject of robotics and artificial intelligence research. Modern solutions have matured enough to provide simple services to human users. To make the interaction with them as fast and intuitive as possible, researchers strive to create transparent interfaces close to human-human interaction. Because facial expressions play a central role in human-human communication, robot faces were implemented with varying degrees of human-likeness and expressiveness. We propose a way to implement a program that believably animates changing facial expressions and allows to influence them via inter-process communication based on an emotion model. This will can be used to create a screen based virtual face for a robotic system with an inviting appearance to stimulate users to seek interaction with the robot.
Die einzelne, allumfassende Managementmethode für ein ganzheitliches Leistungsmanagement gibt es nicht. Vielmehr ist das Zusammenspiel aller erfolgskritischen Managementdisziplinen im Rahmen eines integrativen Managementsystems wichtig, bei dem alle Akteure und Beteiligten auch bei unterschiedlichem Fokus und Sichtweise koordiniert an einem Strang ziehen. Erfolgskritisch ist es jedoch, dass eine unternehmensindividuelle Anpassung mit einem ganzheitlichen Erfahrungshintergrund geplant, komponiert und verzahnt wird. Management Cockpits können als Stufenlösung einen wertvollen Beitrag erbringen, indem sie als Integrationsebene eine Transparenz und Kommunikationsplattform für ein ganzheitliches Leistungsmanagement generieren, selbst wenn die vollständige, fachliche, methodische, prozessuale und technische Integration noch nicht komplett vollzogen bzw. erreicht ist.
Bei weitgehend gleicher Ausstattung und neuen Anforderungen an die Hochschulrechenzentren rücken Kooperationen zunehmend in den Mittelpunkt. Für diese,
auch hochschulartenübergreifende, Kooperationen genügt der klassische informelle Rahmen vielfach nicht mehr. Für eine erfolgreiche Zusammenarbeit sind einige Voraussetzungen zu erfüllen. Rechenzentren treten in neuer Rolle als Provider von Dienstleistungen für Nutzer auch außerhalb ihrer eigenen Hochschule auf. Ebenso
könnten sie sich zukünftig verstärkt in der Nutzerperspektive wiederfinden. IT-Service-Einrichtungen müssen sich ihrer neuen Rolle als Diensteanbieter und Nutzer von Diensten Dritter bewusst werden und diese in ihre Überlegungen für die Ausgestaltung neuer Dienste einfließen lassen.
Adapting characteristics of biomaterials specifically for in vitro and in vivo applications is becoming increasingly important in order to control interactions between material and biological systems. These complex interactions are influenced by surface properties like chemical composition, charge, mechanical and topographic attributes. In many cases it is not useful or even not possible to alter the base material but changing surface, to improve biocompatibility or to make surfaces bioactive, may be achieved by thin coatings. An already established method is the coating with polyelectrolyte multilayers (PEM). To adjust adhesion, proliferation and improve vitality of certain cell types, we modified the roughness of PEM coatings. We included different types nanoparticles (NP’s) in different concentrations into PEM coatings for controlling surface roughness. Surface properties were characterized and the reaction of 3 different cell types on these coatings was tested.
Knee osteoarthritis is a common complication and can lead to total loss of joint function in patients. Treatment by either partial or total knee replacement with appropriate UHMWPE based implantsis highly invasive, may cause complications and may show unsatisfying results. Alternatively, treatment may be done by insertion of an elastic interpositional knee spacer with optimized material characteristics.
We report the development of high performance polyurethane-based polymers modified with bioactive molecules for fabrication of such knee spacers. In order to tailor mechanical and tribological properties and to improve resist to enzymatic degradation we propose a core-shell model for the spacer with specifically adapted properties.