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Der Beitrag gibt einen Überblick über die Zusammenhänge zwischen Industrie 4.0 und Recht. Ausgangspunkt sind die vertragsrechtlichen Grundlagen mit den Fragen, ob und wie zwischen Maschinen überhaupt Verträge zustande kommen können, wie Industrie 4.0-Verträge vertragstypologisch einzuordnen sind und welche Grenzen bei der Verwendung Allgemeiner Geschäftsbedingungen bestehen können. Anschließend werden die Themen dargestellt, die derzeit die Diskussion um das Haftungsrecht der Industrie 4.0 beherrschen. Im Rahmen des Datenrechts wird geklärt, wem Daten zustehen und wie der Datenschutz geregelt ist. Zudem wird aufgezeigt, welche rechtlichen Vorgaben zur Gewährleistung von IT-Sicherheit im Unternehmen bestehen. Schließlich werden auch arbeitsrechtliche Herausforderungen von Industrie 4.0 angesprochen, wie die zunehmende "Entbetrieblichung", das Aufkommen neuer Beschäftigungsformen, die Forderung nach mehr Flexibilisierung der Arbeitswelt sowie Fragen des Mitbestimmungsrechts.
Die Welt dreht sich immer schneller. Etablierte Firmen, die sinnbildlich für innovative Produkte stehen, werden in kurzer Zeit vom Markt gedrängt und durch disruptive Ansätze aus ihrem Geschäft verdrängt. Inkrementelle Ansätze zur Verbesserung der Produktqualität, zur Reduktion von Herstellkosten und der Fokus auf die Produktionsoptimierung nach dem Individualisierungsprinzip (Losgröße 1) sind keine auf die Zukunft ausgerichtete Zielzustände für Automobilhersteller mehr. Neue Wettbewerber, seien es Softwaregiganten oder agile Startups, treten in den Markt ein. Die traditionelle Massenproduktion des Automotivbereichs kann den sich stetig verändernden Kundenanforderungen nicht mehr länger gerecht werden. Dazu bedarf es Geschäftsmodell-Innovationen, wie beispielsweise digitale Preismodelle oder On-Demand Funktionalitäten.
Die Überlebensfähigkeit von Unternehmen am Markt wird vorrangig durch den Input ihrer Lieferanten getrieben, da dem Einkauf bis zu 50% des prognostizierten Innovationspotenzials zugesprochen wird. Dabei gilt vor allem die digitale Transformation als wesentliche Voraussetzung, um die eigene Wettbewerbsfähigkeit langfristig zu sichern. Der vorliegende Beitrag setzt sich daher mit dem Digitalisierungspotenzial strategischer Lieferantenbeziehungen auseinander. Aufbauend auf einem konzeptionellen Modell des Einkaufs 4.0 werden dessen Erfolgstreiber analysiert. Neben der Optimierung von Einkaufsprozessen durch eProcurementlösungen sollte der Fokus auf der Beziehungspflege zu Lieferanten liegen, um das Potenzial von Einkauf 4.0 vollständig ausschöpfen zu können. Denn nur durch den Aufbau strategischer Wertschöpfungspartnerschaften lässt sich das Erfolgspotenzial des Einkaufs langfristig heben.
Gesellschaftliche und industrielle Trends im Zuge der Digitaliserung induzieren Veränderungsprozesse in der Industrie. Eine hohe Flexibilität und schnelle Entscheidungsfindungsprozesse stellen entscheidende Wettbewerbsvorteile für Unternehmen dar, um zukünftig erfolgreich am Markt agieren zu können. Um dies zu ermöglichen, müssen aggregierte Echtzeitdaten und Prognosen unmittelbar sowohl am Ort der Wertschöpfung als auch dezentral zur Verfügung stehen. Die Entscheidungsunterstützung mit Hilfe geeigneter Visualisierungen ist ein maßgeblicher Bestandteil von Shopfloor Management Systemen. Aufgrund der steigenden Anforderungen wurde das konventionelle und analoge Shopfloor Management in den letzten Jahren verstärkt durch digitale Lösungen ersetzt. Ein ganzheitlicher Shopfloor Management Ansatz, der die Trends und die daraus resultierenden Herausforderungen für die Industrie abdeckt, ist aktuell nicht vorhanden. Zukünftige Shopfloor Management Lösungen sollen diese Lücke schließen. Hierfür wurde ein ganzheitliches System entwickelt, welches Produktionsinformationen in Echtzeit unmittelbar am Shopfloor visualisiert, eine integrierte flexible Planung und Steuerung der Produktion beinhaltet sowie die Mitarbeiterbedürfnisse berücksichtigt. Eine flexible und individuelle Schichtplanung durch die Mitarbeiter und eine umfassende automatische Beanspruchungsbeurteilung sind dazu integriert worden. Zudem ermöglicht das System die Prognose und Visualisierung von Produktionsinformationen und unterstützt die Anwender bei der Durchführung strukturierter Shopfloor-Meetings. Dadurch werden Entscheidungen direkt auf den Ort der Wertschöpfung verlagert.
Es wird erwartet, dass die neuen Technologien rund um die Digitalisierung von Gesellschaft und Geschäftswelt zu revolutionären Veränderungen führen werden. Im Zusammenhang mit produzierenden Unternehmen ist hier von einer möglichen vierten Revolution unter dem Stichwort "Industrie 4.0" die Rede. Eine Frage, die damit aber unmittelbar einhergeht, ist, ob sich infolge dieser Revolution auch Organisations- und Produktionsstrukturen von Unternehmen nicht ebenfalls revolutionär ändern müssen.
Dieser Beitrag geht dieser Frage nach, indem er den momentanen Stand der wissenschaftlichen Diskussion zusammenfasst und anschließend bewertet.
An die Produktionslogistik werden komplexe
Anforderungen gestellt, so dass eine systematische Vorgehensweise zu deren Planung erforderlich ist. Aufgrund der Abhängigkeiten in der Supply Chain muss die Produtkionslogistik immer vom Lieferanten beginnend geplant werden. Trotz der Vielfalt an Planungssystematiken bieten diese alle nur sehr wenig Unterstützung bei der Gestaltung der einzelnen Planungsobjekte in der Logistikkette an, sodass die Planung und Lösungsfindung häufig intuitiv erfolgt und sehr stark vom individuellen Erfahrungswissen des Logistikplaners abhängt. Im Folgenden wird eine Planungssystematik, die auf Morphologien basiert, vorgestellt, die eine durchgängige Planung von Produktionslogistiksystemen ermöglicht und den Planer umgfangreich mit Informationen zu Gestaltungsmöglichkeiten und praktischen Umsetzungen unterstützt.
Die Digitalisierung vrändert die Arbeitsweisen in Unternehmen und damit auch bei der Planung von Fabriken. Am Markt verfügbar sind vielfältige Soft- und Hardwaresysteme für die Digitale Fabrik, die die Fabrikplanung unterstützen und teilweise revolutionieren können. Um dieses Potential zu nutzen, muss aber bekannt sein, was diese Systeme können und wie sie sinnvoll genutzt werden können. Bisherige Fabrikplanungssystematiken haben hierzu keine Unterstützung angeboten, da sie nur das generelle Vorgehen der Fabrikplanung beschreiben, ohne den Zusammenhang zu den sich rasch entwickelnden Soft- und Hardwaresystemen herzustellen. Im Folgenden wird die Entwicklung und Umsetzung eines Planungsvorgehens für die Digitale Fabrikplanung dargestellt, das die Potentiale der Soft- und Hardwaresysteme für die Digitale Fabrik aufgreift und in ein passendes Planungsvorgehensmodell integriert.
The level of automation in intralogistics has steadily increased over recent years. For small and medium-sized enterprises (SMEs), however, the associated digital change is a major challenge. Since most SMEs are facing increasing sales volumes (e.g. due to e-commerce and good overall economy) in combination with decreasing lot sizes due to the market demand for individualized products, SMEs have to find innovative solutions to cope with these challenges in production as well as in logistics. Innovative technologies, like 3D printing technologies for the production for small lot sizes and future-oriented intralogistics technologies can serve as enablers in logistics to realize flexible logistic processes for increasing market requiremments. Considering that, this paper examines innovative and future-oriented technologies for intralogistics such as smart containers, driverless forklift systems, data glasses, smart shelves and smart pallets regarding their potential for SMEs. This explorative research paper shows that digital technologies are already suitable and available for SMEs.However, challenges are still seen in areas like the identification and digitalization potential and the financing of these new projects. The primary reason escpecially for SMEs for this is that they have to make investments based on an economically feasible payback period and less based on prestigious reasons like digitalization flagship projecs done by large corporations. In addition, the identification of feasible starting points for digitalization within intralogistic systems embedded in specific factory processes is a major challenge not only for SMEs.
The success of an autonomous robotic system is influenced by several not easily identifiable interdependent factors. This paper is set to lay the foundation of an integrated approach in order to examine all the parameters and understand their contribution to success. After introducing the problem, two autonomous systems for the process of unloading of containers are presented. Then a recently developed method for modelling and interpreting all the parameters, the STIC analysis, are introduced. The preliminary results of applying such a methodology to a first study case is shortly presented. Future research is in the end recommended in order to prove that this methodology is the only way to overcome barriers to the investment in autonomous systems in the logistics sector.
The increased availability of data gives rise to the use of machine learning methods for purposes like forecasting or quality control in operations management. Practitioners who want to employ these methods are faced with the task of choosing from a large number of available methods. We give an overview of classification methods and available implementations and present considerations for choosing appropriate methods.
What does the factory of tomorrow have to offer for companies? This question and its aspects are the focus of many actual articles and publications. According to Gartner digital twins, one of 2017 strategic technology trends will play a big role for the future of manufacturing. At the moment digital twins are gaining more importance for the industrial application. If companies want to be competitive in the future they have to implement the digital twin in the factories of today. Therefore this paper provides a basic overview of the concept of the smart factory and its requirements. In addition, digital twins are identified as a necessary concept for the evolution of the factory of today.
While academia and industry see large potential for human-robot collaboration (HRC), only a small number of realized HRC application is currently found in industry. To gather more data about current hindrances to wider implementation of collaborative robots, a study among 15 robot manufactureres and 14 system integrators of collaborative robot technology has been conducted through a predesigned questionnaire procedure. Additionally, five industrial users of human-robot collaboration have been interviewed on the main challenges they experienced during the initial implementation process. The quantitative data has been analyzed using the Wilcoxon-Signed-Rank-Test. Accoring to the study participants, the main challenges within the implementation currently are the identification of HRC-suitable processes, the application of relevant safety norms (such as ISO 10218, ISO/TS 15066) and the application-individual risk assessment.
Mature economies which are driven mainly by small and medium sized enterprises (SMEs) are increasingly becoming dependent on material imports. Global material consumption is ever increasing, mainly driven by population increases. Decoupling of material consumption from economic growth is one of the greatest challenges of the 21st century. Within this paper available methods for the assessment of material efficiency on different economic scales are investigated and those detected that are particulary suitable for the use in SMEs. Recommendations for further improvements of the selected tools and an outlook concerning planned research activities in the field of material efficiency in enterprises, supply chains and circular economy aspects are given.
With on-demand access to compute resources, pay-per-use, and elasticity, the cloud evolved into an attractive execution environment for High Performance Computing (HPC). Whereas elasticity, which is often referred to as the most beneficial cloud-specific property, has been heavily used in the context of interactive (multi-tier) applications, elasticity-related research in the HPC domain is still in its infancy. Existing parallel computing theory as well as traditional metrics to analytically evaluate parallel systems do not comprehensively consider elasticity, i.e., the ability to control the number of processing units at runtime. To address these issues, we introduce a conceptual framework to understand elasticity in the context of parallel systems, define the term elastic parallel system, and discuss novel metrics for both elasticity control at runtime as well as the ex post performance evaluation of elastic parallel systems. Based on the conceptual framework, we provide an in depth analysis of existing research in the field to describe the state-of-the art and compile our findings into a research agenda for future research on elastic parallel systems.
Um die ökologischen und ökonomischen Potenzaile der Elektromobilität zu nutzen, setzen kommunale Energieversorger heute auf das Betreiben öffentlicher Ladestationen, den Handel mit Ladestationen und das Bereitstellen spezieller Elektromobilitätstarife; ebenso auf elektrifiziertes Carsharing oder das Vermieten elektrifizierter Fahrzeuge und den Betrieb elektrifizierter Omnibusse im ÖPNV. Auch die Entwicklung und Planung individueller Elektromobilitätskonzepte, teils in Kombination mit Photovoltaikanlage, gehören in einigen Unternehmen zum Portfolio. Für die Zukunft sollten Stadtwerke ihre Aktivitäten im Bereich Elektromobilität an individuell definierten Zielen und Strategien ausrichten.
Candidate experience
(2019)
Die Erfindung betrifft eine Vorrichtung und Verfahren zur Analyse eines Materialstroms S mit einem Einlassbereich E, einem Messbereich M und einen Auslassbereich A sowie mit einer ersten Weiche W1 und einer zweiten Weiche W2 und einem Umlenkbereich U, wobei die beiden Weichen W1, W2 in einem ersten Schaltzustand Z1 einen durchgängigen ersten Materialdurchströmungsraum vom Einlassbereich E über die erste Weiche W1 durch den Messbereich M über die zweite Weiche W2 bis zum Auslassbereich A ausbilden und in einem zweiten Schaltzustand einen durchgängigen zweiten Materialdurchströmungsraum vom Einlassbereich E über die erste Weiche W1 durch den Umkenkbereich U über die zweite Weiche W2 bis zum Auslassbereich A ausbilden.
An apparatus and method for analyzing a flow of material having an inlet region, a measurement range and an outlet region, and having a first diverter and a second diverter, and a deflection area, wherein in a first state of operation, the two diverters form a continuous first material flow space from the inlet region via the first diverter through the measurement range, via the second diverter to the outlet region, and in a second state of operation, form a continuous second material flow space from the inlet region via the first diverter through the deflection area, via the second diverter to the outlet region.
In the last 20 years there have been major advances in autonomous robotics. In IoT (Industry 4.0), mobile robots require more intuitive interaction possibilities with humans in order to expand its field of applications. This paper describes a user-friendly setup, which enables a person to lead the robot in an unknown environment. The environment has to be perceived by means of sensory input. For realizing a cost and resource efficient Follow Me application we use a single monocular camera as low-cost sensor. For efficient scaling of our Simultaneous Localization and Mapping (SLAM) algorithm, we integrate an inertial measurement unit (IMU) sensor. With the camera input we detect and track a person. We propose combining state of the art deep learning with Convolutional Neural Network (CNN) and SLAM algorithms functionality on the same input camera image. Based on the output robot navigation is possible. This work presents the specification, workflow for an efficient development of the Follow Me application. Our application’s delivered point clouds are also used for surface construction. For demonstration, we use our platform SCITOS G5 equipped with the afore mentioned sensors. Preliminary tests show the system works robustly in the wild.
SLAM systems are mainly applied for robot navigation while research on feasibility for motion planning with SLAM for tasks like bin-picking, is scarce. Accurate 3D reconstruction of objects and environments is important for planning motion and computing optimal gripper pose to grasp objects. In this work, we propose the methods to analyze the accuracy of a 3D environment reconstructed using a LSD-SLAM system with a monocular camera mounted onto the gripper of a collaborative robot. We discuss and propose a solution to the pose space conversion problem. Finally, we present several criteria to analyze the 3D reconstruction accuracy. These could be used as guidelines to improve the accuracy of 3D reconstructions with monocular LSD-SLAM and other SLAM based solutions.
We present a new method for detecting gait disorders according to their stadium using cluster methods for sensor data. 21 healthy and 18 Parkinson subjects performed the time up and go test. The time series were segmented into separate steps. For the analysis the horizontal acceleration measured by a mobile sensor system was considered. We used dynamic time warping and hierarchical custering to distinguish the stadiums. A specificity of 92% was achieved.
Auf jeder Stufe der Lebensmittelkette muss von der Herstellung bis zum Inverkehrbringen eine Rückverfolgung der Produkte möglich sein. Erzeuger, Verarbeiter, Transportunternehmen und Händler stehen vor der Herausforderung, Systeme zur Rückverfolgbarkeit effizient in ihre Unternehmensprozesse zu integrieren und gegenseitig zu vernetzen. Für die betriebliche Umsetzung werden die rechtlichen Anforderungen skizziert und die Grundlagen eines Rückverfolgbarkeitssystems vorgestellt.
Research and Development (R&D) is crucial for the growth and future success of research-based pharma companies. To maintain their R&D organisations efficient, pharmaceutical companies started to hedge the potential of open innovation to cut R&D costs and to access external knowledge. These new strategies could be divided into several categories: open source, innovation centres, crowd sourcing and virtual R&D.
Fitting 3D Morphable Face Models (3DMM) to a 2D face image allows the separation of face shape from skin texture, as well as correction for face expression. However, the recovered 3D face representation is not readily amenable to processing by convolutional neural networks (CNN). We propose a conformal mapping from a 3D mesh to a 2D image, which makes these machine learning tools accessible by 3D face data. Experiments with a CNN based face recognition system designed using the proposed representation have been carried out to validate the advocated approach. The results obtained on standard benchmarking data sets show its promise.
Die Auswirkungen der digitalen Revolution sind vielfältig. So gibt es inzwischen immer ausgefeiltere Möglichkeiten, um mit Kunden in den Dialog zu treten. Unternehmen stehen deshalb vor der Herausforderung, die verschiedenen Kanäle und Kontaktpunkte mit ihren Kunden systematisch zu managen. Im Mittelpunkt steht dabei der Informations- und Entscheidungsprozess des Kunden - die Customer Journey. Sie gilt im Marketing als Königsdisziplin, bei der es darum geht, wie man am besten die "Reise des Kunden" erfasst, um Zielgruppen genau an der richtigen Stelle anzusprechen und Budgets gezielt in bestimmte Kanäle zu steuern. Marketing- und Vertriebsverantwortliche müssen sich daher Folgendes fragen: Was erwartet der Endkunde an den verschiedenen Touchpoints und wie sieht seine Customer Journey aus? Wie werden Unternehmen diesen Anforderungen gerecht?
New approaches to respiratory assist: bioengineering an ambulatory, miniaturized bioartificial lung
(2019)
Although state-of-the-art treatments of respiratory failure clearly have made some progress in terms of survival in patients suffering from severe respiratory system disorders, such as acute respiratory distress syndrome (ARDS), they failed to significantly improve the quality of life in patients with acute or chronic lung failure, including severe acute exacerbations of chronic obstructive pulmonary disease or ARDS as well. Limitations of standard treatment modalities, which largely rely on conventional mechanical ventilation, emphasize the urgent, unmet clinical need for developing novel(bio)artificial respiratory assist devices that provide extracorporeal gas exchange with a focus on direct extracorporeal CO2 removal from the blood. In this review, we discuss some of the novel concepts and critical prerequisites for such respiratory lung assist devices that can be used with an adequate safety profile, in the intensive care setting, as well as for long-term domiciliary therapy in patients with chronic ventilatory failure. Specifically, we describe some of the pivotal steps, such as device miniaturization, passivation of the blood-contacting surfaces by chemical surface modifications, or endothelial cell seeding, all of which are required for converting current lung assist devices into ambulatory lung assist device for long-term use in critically ill patients. Finally, we also discuss some of the risks and challenges for the long-term use of ambulatory miniaturized bioartificial lungs.
For the widespread establishment of a circular economy, the acceptance of used products among consumers is a prerequisite. This paper investigates the customer experience of product service systems related to used products (PSSuP), such as renting, remanufacturing, and second-hand models, and aims to point out the offering characteristics that effect customer response and customer engagement. This study was conducted by means of a content analysis-based literature review of 69 empirical PSSuP studies. A frequency analysis of the categories that determine customer experience creation was conducted, as well as a contingency analysis to reveal the interrelationship between these categories. On this basis, the different PSSuP types were compared, and four strategic orientations of customer experience creation in PSSuP are pointed out: price, confidence, convenience, and delight orientation. For each of these strategic orientations, supportive PSSuP offering characteristics are specified. Building on the findings of this study, theoretical and managerial implications for product–service systems marketing are pointed out, and the need for research on the role of information and communication technology as an enabler of customer experience creation in PSSuP is highlighted.
In this exploratory research eight suppliers in the automotive industry are interviewed to measure the application of supply chain finance instruments in their supply chain in the Netherlands and the region of South-West Germany. Current adoption levels and reasons for non adoption are discussed. Based on these indicative results, a set of hypotheses is suggested for further research. The theoretical base of this study is a conceptual model of Supply Chain Finance based on literature research and empirical research in the Netherlands.
Early reduction of risks in a startup or an innovation project is highly important. Appropriate means for risk reduction, such as testing business models with different kinds of experiments exist. However, deciding what to test and how to select the right test, is challenging for many startups and innovation projects. This article presents the so-called Business Experiments Navigator (BEN), a toolkit to assist startup and innovation processes. It compliments other tools such as the Business Model Canvas or the Lean Startup process. The main contribution of BEN is to bridge the gap between the riskiest assumptions of a business model and the multitude of available testing techniques by providing assumption templates. The Business Experiments Navigator has been validated in several workshops. Results show that it creates awareness among the workshop participants that a business model is based on assumptions which impose risks and need to be validated. Further, users of BEN were able to identify relevant assumptions and map different kinds of assumptions to appropriate testing techniques. The process applied in the workshops, as well as the assumption templates, helped the participants understand the main concepts and transfer their learnings, to their own business ideas.
The coculture of osteogenic and angiogenic cells and the resulting paracrine signaling via soluble factors are supposed to be crucial for successfully engineering vascularized bone tissue equivalents. In this study, a coculture system combining primary human adiposederived stem cells (hASCs) and primary human dermal microvascular endothelial cells (HDMECs) within two types of hydrogels based on methacryloyl‐modified gelatin (GM) as three‐dimensional scaffolds was examined for its support of tissue specific cell functions. HDMECs, together with hASCs as supporting cells, were encapsulated in soft GM gels and were indirectly cocultured with hASCs encapsulated in stiffer GM hydrogels additionally containing methacrylate‐modified hyaluronic acid and hydroxyapatite particles. After 14 days, the hASC in the stiffer gels (constituting the “bone gels”) expressed matrix proteins like collagen type I and fibronectin, as well as bone‐specific proteins osteopontin and alkaline phosphatase. After 14 days of coculture with HDMEC‐laden hydrogels, the viscoelastic properties of the bone gels were significantly higher compared with the gels in monoculture. Within the soft vascularization gels, the formed capillary‐like networks were significantly longer after 14 days of coculture than the structures in the control gels. In addition, the stability as well as the complexity of the vascular networks was significantly increased by coculture. We discussed and concluded that osteogenic and angiogenic signals from the culture media as well as from cocultured cell types, and tissue‐specific hydrogel composition all contribute to stimulate the interplay between osteogenesis and angiogenesis in vitro and are a basis for engineering vascularized bone.
This paper investigates the evaluation of dense 3D face reconstruction from a single 2D image in the wild. To this end, we organise a competition that provides a new benchmark dataset that contains 2000 2D facial images of 135 subjects as well as their 3D ground truth face scans. In contrast to previous competitions or challenges, the aim of this new benchmark dataset is to evaluate the accuracy of a 3D dense face reconstruction algorithm using real, accurate and high-resolution 3D ground truth face scans. In addition to the dataset, we provide a standard protocol as well as a Python script for the evaluation. Last, we report the results obtained by three state-of-the-art 3D face reconstruction systems on the new benchmark dataset. The competition is organised along with the 2018 13th IEEE Conference on Automatic Face & Gesture Recognition.
Service robots need to be aware of persons in their vicinity in order to interact with them. People tracking enables the robot to perceive persons by fusing the information of several sensors. Most robots rely on laser range scanners and RGB cameras for this task. The thesis focuses on the detection and tracking of heads. This allows the robot to establish eye contact, which makes interactions feel more natural.
Developing a fast and reliable pose invariant head detector is challenging. The head detector that is proposed in this thesis works well on frontal heads, but is not fully pose-invariant. This thesis further explores adaptive tracking to keep track of heads that do not face the robot. Finally, head detector and adaptive tracker are combined within a new people tracking framework and experiments show its effectiveness compared to a state-of the-art system.
An interactive clothing design and a personalized virtual display with user’s own face are presented in this paper to meet the requirement of personalized clothing customization. A customer interactive clothing design approach based on genetic engineering ideas is analyzed by taking suit as an example. Thus, customers could rearrange the clothing style elements, chose available color, fabric and come up with their own personalized suit style. A web 3D customization prototype system of personalized clothing is developed based on the Unity3D and VR technology. The layout of the structure and functions combined with the flow of the system are given. Practical issues such as 3D face scanning, suit style design, fabric selection, and accessory choices are addressed also. Tests to the prototype system indicate that it could show realistic clothing and fabric effect and offer effective visual and customization experience to users.
Artificial adipose tissue (AT) constructs are urgently needed to treat severe wounds, to replace removed tissue, or for the use as in vitro model to screen for potential drugs or study metabolic pathways. The clinical translation of products is mostly prevented by the absence of a vascular component that would allow a sustainable maintenance and an extension of the construct to a relevant size. With this study, we aimed to evaluate the suitability of a novel material based on bacterial cellulose (CBM) on the defined adipogenic differentiation of human adipose-derived stem cells (ASCs) and the maintenance of the received adipocytes (diffASCs) and human microvascular endothelial cells (mvECs) in mono- and coculture. A slight acceleration of adipogenic differentiation over regular tissue culture polystyrene (TCPS) was seen on CBM under defined conditions, whereas on the maintenance of the generated adipocytes, comparable effects were detected for both materials. CBM facilitated the formation of vascular like structures in monoculture of mvECs, which was not observed on TCPS. By contrast, vascular-like structures were detected in CBM and TCPS in coculture by the presence of diffASCs. Concluding, CBM represents a promising material in vascularized AT engineering with the potential to speed up and simplify the in vitro setup of engineered products.
Jeder weiß, dass die Textil- und Bekleidungsindustrie ein Nachhaltigkeitsproblem hat und es neuer Lösungsansätze bedarf. Auch Konsumenten und deren Verhalten haben einen entscheidenden Einfluss auf die Erfolgsaussichten einer nachhaltigen Entwicklung. Welche Rolle und Bedeutung obliegt jedoch dem einzelnen Mitarbeiter in diesem Prozess? Und welche Handlungsmaßnahmen können daraus abgeleitet werden? Eine empirische Analyse von über 100 internationalen Bekleidungsunternehmen gibt Aufschluss.
Completely defined co-culture of adipogenic differentiated ASCs and microvascular endothelial cells
(2018)
Vascularized adipose tissue models are in high demand as alternatives to animal models to elucidate the mechanisms of widespread diseases, screen for new drugs or assess drug safety levels. Animal-derived sera such as fetal bovine serum (FBS), which are commonly used in these models, are associated with ethical concerns, risk of contaminations and inconsistencies of their composition and impact on cells. In this study, we developed a serum-free, defined co culture medium and implemented it in an adipocyte/endothelial cell (EC) co culture model.
Human adipose-derived stem cells were differentiated under defined conditions (diffASCs) and, like human microvascular ECs (mvECs), cultured in a defined co culture medium in mono-, indirect or direct co-culture for 14 days. The defined co-culture medium was superior when compared to mono-culture media and facilitated the functional maintenance and maturation of diffASCs including perilipin A expression, lipid accumulation, and also glycerol and leptin release. The medium also allowed mvEC maintenance, confirmed by the expression of CD31 and von Willebrand factor (vWF), and by acetylated low density lipoprotein (acLDL) uptake. Thereby, mvECs showed strong dependence on EC-specific factors. Additionally, mvECs formed vascular structures in direct co-culture with diffASCs.
The completely defined co-culture system allows for the serum-free culture of adipocyte/EC co-cultures and thereby represents a valuable and ethically acceptable tool for the culture and study of vascularized adipose tissue models.
To date, special interest has been paid to composite scaffolds based on polymers enriched with hydroxyapatite (HA). However, the role of HA containing different trace elements such as silicate in the structure of a polymer scaffold has not yet been fully explored. Here, we report the potential use of silicate-containing hydroxyapatite (SiHA) microparticles and microparticle aggregates in the predominant range from 2.23 to 12.40 μm in combination with polycaprolactone (PCL) as a hybrid scaffold with randomly oriented and well-aligned microfibers for regeneration of bone tissue. Chemical and mechanical properties of the developed 3D scaffolds were investigated with XRD, FTIR, EDX and tensile testing. Furthermore, the internal structure and surface morphology of the scaffolds were analyzed using synchrotron X-ray μCT and SEM. Upon culturing human mesenchymal stem cells (hMSC) on PCL-SiHA scaffolds, we found that both SiHA inclusion and microfiber orientation affected cell adhesion. The best hMSCs viability was revealed at 10 day for the PCL-SiHA scaffolds with well-aligned structure (~82%). It is expected that novel hybrid scaffolds of PCL will improve tissue ingrowth in vivo due to hydrophilic SiHA microparticles in combination with randomly oriented and well-aligned PCL microfibers, which mimic the structure of extracellular matrix of bone tissue.
Contemporary public enterprises differ from their forebears. Today, they are more similar to private enterprises, receiving far more attention than previously, when privatization processes all over the world were in the spotlight. Furthermore, the broad research stream of entrepreneurship has so far neglected the consideration of public enterprises. To set a future research agenda, the author examines the dispersed literature using an integrative and organizing framework to identify major topics and research findings. This paper reviews articles that investigate the entrepreneurship in contemporary public enterprises. Despite the growing scholarly interest globally, this systematic literature review indicates there is no more than a loose connection between the literature streams of public entrepreneurship and corporate entrepreneurship. Specifically, the review shows that the multidimensional concept of entrepreneurial orientation has thus far been ignored, although autonomy plays a significant role in the literature review, namely in the context of the interference of the public owner. It also reveals other essential research gaps, such as the development of a modern theory of public enterprises. The linked research stream of public-sector corporate entrepreneurship offers a broad area of scholarly research and should encourage further investigation.
Background aims: In vitro engineered adipose tissue is in great demand to treat lost or damaged soft tissue or to screen for new drugs, among other applications.However, today most attempts depend on the use of animal-derived sera. To pave the way for the application of adipose tissue-engineered
products in clinical trials or as reliable and robust in vitro test systems, sera should be completely excluded from the production process. In this study, we aimed to develop an in vitro adipose tissue model in the absence of sera and maintain its function long-term.
Methods: Human adipose tissue-derived stem cells were expanded and characterized in a xeno- and serum-free environment. Adipogenic differentiation was induced using a completely defined medium. Developed adipocytes were maintained in a completely defined maturation medium for additional 28 days. In addition to cell-viability and adherence, adipocyte-specific markers such as perilipin A expression of leptin release were evaluated.
Results: The defined differentiation medium enhanced cell adherence and lipid
accumulation at a significant level compared with the corresponding negative control. The defined maturation medium also significantly supported cell adherence and functional adipocyte maturation during the long-term culture period.
Conclusions: The process described here enables functional adipocyte generation and maintenance without the addition fo unknown or unimal-derived constituents, achieving an important milestone in the introduction of adipose tissue engineered products into clinical trials or in vitro screening.
Bone remodeling can be mimicked in vitro by co-culture models. Based on bone cells, such co-cultures help to study synergistic morphological changes and the impact of materials and applied substances. Hence, we examined the formation of osteoclasts on bovine bone materials to prove the bone resorption functionality of the osteoclasts in three different co-culture set-ups using human monocytes (hMCs) and (I) human mesenchymal stem cells (hMSCs), (II) osteogenic differentiated hMSCs (hOBs), and (III) hOBs in addition of soluble monocyte-colony stimulating factor (M CSF) and cytokine receptor activator of NFkB ligand (RANKL).We detected osteoclast-specific actin morphology, as well as the expression of cathepsin K and CD51/61 in single cells in set-up II and in numerous cells in set-up III. Resorption pits on bone material as characteristic proof of functional osteoclasts were not found in set-up I and II, but we detected such resorption pits in set–up III. We conclude in co culture models without M-CSF and RANKL that monocytes can differentiate into osteoclasts that show the characteristic actin structures and protein expression. However, to receive functional bone resorbing osteoclasts in vitro, the addition of M-CSF and RANKL is needed. Moreover, we suggest the use of bone or bone-like materials for future studies evaluating osteoclastogenesis.
Theory predicts that market‐timing activities bias Jensen's alpha (JA). However, empirical studies have failed to find consistent evidence of this bias. We tackle this puzzle in a nested model analysis and show that the bias contains an exogenous market component that is unrelated to market‐timing skill. In a comprehensive empirical analysis of US mutual funds, we find that the timing‐induced bias in JA is mainly driven by this market component, which is uncorrelated with measured timing activities. Measures of total performance that allow for timing activities are virtually identical to JA, even if timing activities are present in the evaluated fund. Hence, we conclude that JA is a sufficient measure of total performance.
Annotations of subject IDs in images are very important as ground truth for face recognition applications and news retrieval systems. Face naming is becoming a significant research topic in news image indexing applications. By exploiting the uniqueness of name, face naming is transformed to the problem of multiple instance learning (MIL) with exclusive constraint, namely the eMIL problem. First, the positive bags and the negative bags are automatically annotated by a hybrid recurrent convolutional neural network and a distributed affinity propagation cluster. Next, positive instance selection and updating are used to reduce the influence of false-positive bag and to improve the performance. Finally, max exclusive density and iterative Max-ED algorithms are proposed to solve the eMIL problem. The experimental results show that the proposed algorithms achieve a significant improvement over other algorithms.
Nowadays robust, energy-efficient multisensor microsystems often come with heavily restricted power budgets and the characteristic of remaining in certain states for a longer period of time. During this time frame there is no continuous clock signal required which gives the opportunity to suspend the clock until a new transition is requested. In this paper, we present a new topology for on-demand locally clocked finite state machines. The architecture combines a local adaptive clocking approach with synchronous and asynchronous components forming a quasi synchronous system. Using adaptive and local clocking comes with the advantages of reducing the power consumption while saving design effort when no global clock tree is needed. Combining synchronous and asynchronous components is beneficial compared to previous fully asynchronous approaches concerning the design restrictions. The developed topology is verified by the implementation and simulation of a temperature-ADC sensor system realized in a 180 nm process.
We present a compact battery charger topology for weight and cost sensitive applications with an average output current of 9A targeted for 36V batteries commonly found in electric bicycles. Instead of using a conventional boost converter with large DC-link capacitors, we accomplish PFC-functionality by shaping the charging current into a sin²-shape. In addition, a novel control scheme without input-current sensing is introduced. A-priori knowledge is used to implement a feed-forward control in combination with a closed-loop output current control to maintain the target current. The use of a full-bridge/half bridge LLC converter enables operation in a wide input-voltage range.
A fully featured prototype has been built with a peak output power of 1050W. An average output power of 400W was measured, resulting in a power density of 1.8 kW/dm³. At 9A charging current, a power factor of 0.96 was measured and the efficiency exceeds 93% on average with passive rectification.
The impact of pulse charging has been evaluated on a 400Wh battery which was charged with the proposed converter as well as CC-CV-charging for reference. Both charging schemes show similar battery surface temperatures.
Manufacturing has to adapt to changing situations in order to stay competitive.It demands a flexible and easy-to-use integration of production equipment and ICT systems. The contribution of this paper is the presentation of the implementation of the Manufacturing Integration Assistant (MIALinx). The integration steps range from integrating sensors over collecting and rule-based processing of sensor information to the execution of required actions. Furthermore, we describe the implementation of MIALinx by commissioning it in a manufacturing environment to retrofit legacy machines for Industrie 4.0. Finally, we validate the suitability of our approach by applying our solution in a medium-size company.
Defining the antecedents of experience co-creation as applied to alternative consumption models
(2019)
Purpose – The purpose of this paper is to propose a conceptual framework of experience co-creation that captures the multi-dimensionality of this construct, as well as a research process for defining of the antecedents of experience co-creation.
Design/methodology/approach – The framework of experience co-creation was conceptualized by means of a literature review. Subsequently, this framework was used as the conceptual basis for a qualitative content analysis of 66 empirical papers investigating alternative consumption models (ACMs), such as renting, remanufacturing, and second-hand models.
Findings – The qualitative content analysis resulted in 12 categories related to the consumer and 9 related to the ACM offerings that represent the antecedents of experience co-creation. These categories provide evidence that, to a large extent, the developed conceptual framework allows one to capture the multi-dimensionality of the experience co-creation construct.
Research limitations/implications – This study underscores the understanding of experience co-creation as a function of the characteristics of the offering – which are, in turn, a function of the consumers’ motives as determined by their lifeworlds – as well as to service design as an iterative approach to finding, creating and refining service offerings.
Practical implications – The investigation of the antecedents of experience co-creation can enable service providers to determine significant consumer market conditions for forecasting the suitability and viability of their offerings and to adjust their service designs accordingly.
Originality/value – This paper provides a step toward the operationalization of the dimension-related experience co creation construct and presents an approach to defining the antecedents of experience co-creation by considering different research perspectives that can enhance service design research.