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Polyurethane-bases block copolymers (TPCUs) are block-copolymers with systematically varied soft and hard segments. They have been suggested to serve as material for chondral implants in joint regeneration. Such applications may require the adhesion of chondrocytes to the implant surface, facilitating cell growth while keeping their phenotype. Thus, aims of this work were (1) to modify the surface of soft biostable polyurethane-based model implants (TPCU and TSiPCU) with high-molecular weight hyaluronic acid (HA) using an optimized multistep strategy of immobilization, and (2) to evaluate bioactivity of the modified TPCUs in vitro. Our results show no cytotoxic potential of the TPCUs. HAbioactive molecules (Mw =700kDa) were immobilized onto the polyurethane surface via polyethylenimine (PEI) spacers, and modifications were confirmed by several characterization methods. Tests with porcine chondrocytes indicated the potential of the TPCU-HA for inducing enhanced cell proliferation.
After more than three decades of electronic design automation, most layouts for analog integrated circuits are still handcrafted in a laborious manual fashion today. Obverse to the highly automated synthesis tools in the digital domain (coping with the quantitative difficulty of packing more and more components onto a single chip – a desire well known as More Moore), analog layout automation struggles with the many diverse and heavily correlated functional requirements that turn the analog design problem into a More than Moore challenge. Facing this qualitative complexity, seasoned layout engineers rely on their comprehensive expert knowledge to consider all design constraints that uncompromisingly need to be satisfied. This usually involves both formally specified and nonformally communicated pieces of expert knowledge, which entails an explicit and implicit consideration of design constraints, respectively.
Existing automation approaches can be basically divided into optimization algorithms (where constraint consideration occurs explicitly) and procedural generators (where constraints can only be taken into account implicitly). As investigated in this thesis, these two automation strategies follow two fundamentally different paradigms denoted as top-down automation and bottom-up automation. The major trait of top-down automation is that it requires a thorough formalization of the problem to enable a self-intelligent solution finding, whereas a bottom-up automatism –controlled by parameters– merely reproduces solutions that have been preconceived by a layout expert in advance. Since the strengths of one paradigm may compensate the weaknesses of the other, it is assumed that a combination of both paradigms –called bottom-up meets top-down– has much more potential to tackle the analog design problem in its entirety than either optimization-based or generator-based approaches alone.
Against this background, the thesis at hand presents Self-organized Wiring and Arrangement of Responsive Modules (SWARM), an interdisciplinary methodology addressing the design problem with a decentralized multi-agent system. Its basic principle, similar to the roundup of a sheep herd, is to let responsive mobile layout modules (implemented as context-aware procedural generators) interact with each other inside a user-defined layout zone. Each module is allowed to autonomously move, rotate and deform itself, while a supervising control organ successively tightens the layout zone to steer the interaction towards increasingly compact (and constraint compliant) layout arrangements. Considering various principles of self-organization and incorporating ideas from existing decentralized systems, SWARM is able to evoke the phenomenon of emergence: although each module only has a limited viewpoint and selfishly pursues its personal objectives, remarkable overall solutions can emerge on the global scale.
Several examples exhibit this emergent behavior in SWARM, and it is particularly interesting that even optimal solutions can arise from the module interaction. Further examples demonstrate SWARM’s suitability for floorplanning purposes and its application to practical place-and-route problems. The latter illustrates how the interacting modules take care of their respective design requirements implicitly (i.e., bottom-up) while simultaneously paying respect to high level constraints (such as the layout outline imposed top-down by the supervising control organ). Experimental results show that SWARM can outperform optimization algorithms and procedural generators both in terms of layout quality and design productivity. From an academic point of view, SWARM’s grand achievement is to tap fertile virgin soil for future works on novel bottom-up meets top-down automatisms. These may one day be the key to close the automation gap in analog layout design.
Type 1 diabetes is a chronic and a life threatening disease: an adjusted treatment and a proper management of the disease are crucial to prevent or delay the complications of diabetes. Although during the last decade the development of the artificial pancreas has presented great advances in diabetes care, the multiple daily injections therapy still represents the most widely used treatment option for type 1 diabetes. This work presents the proposal and first development stages of an application focused on guiding patients using the continuous glucose monitors and smart pens together with insulin and carbohydrates recommendations. Our proposal aims to develop a platform to integrate a series of innovative machine learning models and tools rigorously tested together with the use of the latest IoT devices to manage type 1 diabetes. The resulting system actually closes the loop, like the artificial pancreas, but in an intermittent way.
Due to the rising need for palliative care in Russia, it is crucial to provide timely and high-quality solutions for patients, relatives, and caregivers. A methodology for remote monitoring of patients in need of palliative care and the requirements will be developed for a hardware-software complex for remote monitoring of patients' health at home.
The potentials and opportunities created by digitized healthcare can be further customized through smart data processing and analysis using accurate patient information. This development and the associated new treatment concepts basing on digital smart sensors can lead to an increase in motivation by applying gamification approaches. This effect can also be used in the field of medical treatment, e.g. with the help of a digital spirometer combined with an app. In one of our exemplary applications, we show how to control an airplane within an app by breathing respectively inhaling and exhaling. Using this biofeedback within a game allows us to increase the motivation and fun for children that need to perform necessary exercises.
This paper investigates the possibility to effectively monitor and control the respiratory action using a very simple and non invasive technique based on a single lightweight reduced-size wireless surface electromyography (sEMG) sensor placed below the sternum. The captured sEMG signal, due to the critical sensor position, is characterized by a low energy level and it is affected by motion artifacts and cardiac noise. In this work we present a preliminary study performed on adults for assessing the correlation of the spirometry signal and the sEMG signal after the removal of the superimposed heart signal. This study and the related findings could be useful in respiratory monitoring of preterm infants.
During two researches the influence of technologies on sleep were analyzed. The first one is about the effect of light on the circadian rhythm and as consequence on sleep quality of persons in a vegetative state. The second one, which is still running, surveys the influence of several technical tools on the sleep of elderly people living in a nursing home.
In summary, we believe that current “sleep monitoring” consumer devices on the market must undergo a more robust validation process before being made available and distributed in the general public. This is especially noteworthy as there have been first reports in the literature that inaccurate feedback of such consumer devices can worry subjects and may even lead to compromised well-being of the user.
The cloud evolved into an attractive execution environment for parallel applications from the High Performance Computing (HPC) domain. Existing research recognized that parallel applications require architectural refactoring to benefit from cloud-specific properties (most importantly elasticity). However, architectural refactoring comes with many challenges and cannot be applied to all applications due to fundamental performance issues. Thus, during the last years, different cloud migration strategies have been considered for different classes of parallel applications. In this paper, we provide a survey on HPC cloud migration research. We investigate on the approaches applied and the parallel applications considered. Based on our findings, we identify and describe three cloud migration strategies.
