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Silicon neurons represent different levels of biological details and accuracies as a trade-off between complexity and power consumption. With respect to this trade-off and high similarity to neuron behaviour models, relaxation-type oscillator circuits often yield a good compromise to emulate neurons. In this chapter, two exemplified relaxation-type silicon neurons are presented that emulate neural behaviour with energy consumption under the scale of nJ/spike. The first proposed fully CMOS relaxation SiN is based on mathematical Izhikevich model and can mimic a broad range of physiologically observable spike patterns. The results of kinds of biologically plausible output patterns and coupling process of two SiNs are presented in 0.35 μm CMOS technology. The second type is a novel ultra-low-frequency hybrid CMOS-memristive SiN based on relaxation oscillators and analog memristive devices. The hybrid SiN directly emulates neuron behaviour in the range of physiological spiking frequencies (less than 100 Hz). The relaxation oscillator is implemented and fabricated in 0.13 μm CMOS technology. An autonomous neuronal synchronization process is demonstrated with two relaxation oscillators coupled by an analog memristive device in the measurement to emulate the synchronous behaviour between spiking neurons.
Purpose
Injury or inflammation of the middle ear often results in the persistent tympanic membrane (TM) perforations, leading to conductive hearing loss (HL). However, in some cases the magnitude of HL exceeds that attributable by the TM perforation alone. The aim of the study is to better understand the effects of location and size of TM perforations on the sound transmission properties of the middle ear.
Methods
The middle ear transfer functions (METF) of six human temporal bones (TB) were compared before and after perforating the TM at different locations (anterior or posterior lower quadrant) and to different degrees (1 mm, ¼ of the TM, ½ of the TM, and full ablation). The sound-induced velocity of the stapes footplate was measured using single-point laser-Doppler-vibrometry (LDV). The METF were correlated with a Finite Element (FE) model of the middle ear, in which similar alterations were simulated.
Results
The measured and calculated METF showed frequency and perforation size dependent losses at all perforation locations. Starting at low frequencies, the loss expanded to higher frequencies with increased perforation size. In direct comparison, posterior TM perforations affected the transmission properties to a larger degree than anterior perforations. The asymmetry of the TM causes the malleus-incus complex to rotate and results in larger deflections in the posterior TM quadrants than in the anterior TM quadrants. Simulations in the FE model with a sealed cavity show that small perforations lead to a decrease in TM rigidity and thus to an increase in oscillation amplitude of the TM mainly above 1 kHz.
Conclusion
Size and location of TM perforations have a characteristic influence on the METF. The correlation of the experimental LDV measurements with an FE model contributes to a better understanding of the pathologic mechanisms of middle-ear diseases. If small perforations with significant HL are observed in daily clinical practice, additional middle ear pathologies should be considered. Further investigations on the loss of TM pretension due to perforations may be informative.
Public enterprises find themselves in increasingly competitive markets, a situation that makes having an entrepreneurial orientation (EO) an urgent need, given that EO is an indispensable driver of performance. Research describes politicians delaying the strategic change of public enterprises when serving as board members, but empirical evidence of the impact of board behavior on EO in public enterprises is lacking. We draw on stakeholder-agency theory (SAT) and resource dependence theory (RDT) and use structural equation modeling (SEM) to investigate survey data collected from 110 German energy suppliers that are majority government owned. Results indicate that board strategy control and board networking do not seem to predict EO on first sight. Closer analysis reveals a board networking–EO relationship depending on ownership structure. Remarkably, we find that it is not the usually suspected local municipal owner who hinders EO in our sample organizations but minority shareholders engaging in board networking activities. The results shed light on the intersection of governance and entrepreneurship with special reference to the fine-grained conceptualization of RDT.
Despite 30 years of Electronic Design Automation, analog IC layouts are still handcrafted in a laborious fashion today due to the complex challenge of considering all relevant design constraints. This paper presents Self-organized Wiring and Arrangement of Responsive Modules (SWARM), a novel approach addressing the problem with a multi-agent system: autonomous layout modules interact with each other to evoke the emergence of overall compact arrangements that fit within a given layout zone. SWARM´s unique advantage over conventional optimization-based and procedural approaches is its ability to consider crucial design constraints both explicitly and implicitly. Several given examples show that by inducing a synergistic flow of self-organization, remarkable layout results can emerge from SWARM’s decentralized decision-making model.