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In the last decade, numerous learning factories for education, training, and research have been built up in industry and academia. In recent years learning factory initiatives were elevated from a local to a European and then to a worldwide level. In 2014 the CIRP Collaborative Working Group (CWG) on Learning Factories enables a lively exchange on the topic "Learning Factories for future oriented research and education in manufacturing". In this paper results of discussions inside the CWG are presented. First, what is meant by the term Learning Factory is outlined. Second, based on the definition a description model (morphology) for learning factories is presented. The morphology covers the most relevant characteristics and features of learning factories in seven dimensions. Third, following the morphology the actual variance of learning factory manifestations is shown in six learning factory application scenarios from industrial training over education to research. Finally, future prospects of the learning factory concept are presented.
Venture capital and the innovative power of a state : econometric study including Google data
(2015)
This article focuses on venture capital investments and the innovative power of a state defined by its public infrastructure. The economic implications are evaluated by estimating several panel regression models. The novelty is twofold: on the one hand the research approach and on the other hand the new data set. The data ranges from 1995 to 2014 and consists of 10 European countries plus the US and Canada. For the first time we include Google search data on Venture Capital. The results show a significant increase in Venture Capital is mainly determined by economic conditions such as real GDP growth. The impact of the innovative power of a state is not significant. We find that Google data is positively related and significant in respect to Venture Capital investments too. Consequently, we confirm that private business investments cannot be created by government policy alone rather via solid macroeconomic conditions.
Background
Alzheimer’s disease (AD) is diagnosed based upon medical history, neuropsychiatric examination, cerebrospinal fluid analysis, extensive laboratory analyses and cerebral imaging. Diagnosis is time consuming and labour intensive. Parkinson’s disease (PD) is mainly diagnosed on clinical grounds.
Objective
The primary aim of this study was to differentiate patients suffering from AD, PD and healthy controls by investigating exhaled air with the electronic nose technique. After demonstrating a difference between the three groups the secondary aim was the identification of specific substances responsible for the difference(s) using ion mobility spectroscopy. Thirdly we analysed whether amyloid beta (Aβ) in exhaled breath was causative for the observed differences between patients suffering from AD and healthy controls.
Methods
We employed novel pulmonary diagnostic tools (electronic nose device/ion-mobility spectrometry) for the identification of patients with neurodegenerative diseases. Specifically, we analysed breath pattern differences in exhaled air of patients with AD, those with PD and healthy controls using the electronic nose device (eNose). Using ion mobility spectrometry (IMS), we identified the compounds responsible for the observed differences in breath patterns. We applied ELISA technique to measure Aβ in exhaled breath condensates.
Results
The eNose was able to differentiate between AD, PD and HC correctly. Using IMS, we identified markers that could be used to differentiate healthy controls from patients with AD and PD with an accuracy of 94%. In addition, patients suffering from PD were identified with sensitivity and specificity of 100%. Altogether, 3 AD patients out of 53 participants were misclassified. Although we found Aβ in exhaled breath condensate from both AD and healthy controls, no significant differences between groups were detected.
Conclusion
These data may open a new field in the diagnosis of neurodegenerative disease such as Alzheimer’s disease and Parkinson’s disease. Further research is required to evaluate the significance of these pulmonary findings with respect to the pathophysiology of neurodegenerative disorders.
Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory disease characterized by incompletely reversible airway obstruction. This clinically heterogeneous group of patients is characterized by different phenotypes. Spirometry and clinical parameters, such as severity of dyspnea and exacerbation frequency, are used to diagnose and assess the severity of COPD. The purpose of this study was to investigate whether volatile organic compounds (VOCs) could be detected in the exhaled breath of patients with COPD and whether these VOCs could distinguish COPD patients from healthy subjects. Moreover, we aimed to investigate whether VOCs could be used as biomarkers for classifying patients into different subgroups of the disease. Ion mobility spectrometry was used to detect VOCs in the exhaled breath of COPD patients. One hundred and thirty-seven peaks were found to have a statistically significant difference between the COPD group and the combined healthy smokers and nonsmoker group. Six of these VOCs were found to correctly discriminate COPD patients from healthy controls with an accuracy of 70%. Only 15 peaks were found to be statistically different between healthy smokers and healthy nonsmokers. Furthermore, by determining the cutoff levels for each VOC peak, it was possible to classify the COPD patients into breathprint subgroups. Forced expiratory volume in 1 second, body mass index, and C-reactive protein seem to play a role in the discrepancies observed in the different breathprint subgroups.
In the luxury Fashion industry, consumers could be categorized into two groups: fashion leader and Fashion follower. Both groups of consumers purchase luxury fashion products aim at satisfying both their functional needs and social needs (i.e., social influence). Thus the demands of both consumer groups are related. In this paper, we construct a model to examine the effects of pricing and online retail service in luxury fashion firms with social influence. To maximize profit, we identify the optimal prices and online retail service when the luxury fashion firms provide the non-differentiated and differentiated online retail services, respectively. More insights are discussed.
Derzeit finden gravierende Veränderungen im Umfeld der Informations- und Kommunikationstechnik statt, die eine große Chance für die optimierte Prozessführung und Wertschöpfung mit darauf abgestimmten vernetzt kommunizierenden Sensoren bieten. Diese Art "smarter" Sensoren stellen Dienste innerhalb eines Netzwerks bereit und nutzen Informationen daraus. Dadurch ergibt sich aktuell die Notwendigkeit, die Anforderungen an Prozesssensoren sowie an deren Kommunikationsfähigkeiten detaillierter zu beschreiben – vom einfachen Temperatursensor bis über heute in Entwicklung befindlichen Messsystemen hinaus –, da diese Technologieentwicklungen rasant voranschreiten. Vernetzte Sensoren sind die Voraussetzung für die Realisierung von Cyberphysischen Produktionssystemen (CPPS) und zukünftiger Automatisierungskonzepte für die Prozessindustrie, wie sie auch durch das Zukunftsprojekt "Industrie 4.0" adressiert werden.
Die Technologie-Roadmap liefert darüber hinaus Perspektiven für Forschungs- und Entwicklungsförderung und gibt Ansätze für die Normungsarbeit. Sie wird damit auch für Politik, Industrieverbände und Gremien von Interesse sein. Wenn sich die Exzellenz der Forschung und das ausgeprägte Know-how der Gerätehersteller und Anwender zu Forschungskonsortien auf Augenhöhe zusammentun und das Wissen gemeinsam vorangebracht wird, kommen faire und gut durchdachte Technologietransferprojekte mit Sicherheit zum Erfolg. Neben der technologischen Weiterentwicklung der Prozesssensoren ist von Herstellern und Anwendern die hohe Verfügbarkeit der komplexen Technologie sicherzustellen, damit weiterhin Vertrauen in die Technik besteht – vom Anwender bis ins Management.
Real Time Charging (RTC) applications that reside in the telecommunications domain have the need for extremely fast database transactions. Today´s providers rely mostly on in-memory databases for this kind of information processing. A flexible and modular benchmark suite specifically designed for this domain provides a valuable framework to test the performance of different DB candidates. Besides a data and a load generator, the suite also includes decoupled database connectors and use case components for convenient customization and extension. Such easily produced test results can be used as guidance for choosing a subset of candidates for further tuning/testing and finally evaluating the database most suited to the chosen use cases. This is why our benchmark suite can be of value for choosing databases for RTC use cases.
Das Provisioning Tool automaIT wurde prototypisch um die Möglichkeit eines Data Discovery erweitert, mit dem Ziel, nicht durch automaIT verwaltete Systeme anbinden und steuern zu können. Daten aus dem Data Discovery werden mittels dem Tool Facter gesammelt und können dynamisch in ausführbare Modelle von automaIT integriert und ausgewertet werden. Dadurch kann der Verlauf weiterer Provisionierungsschritte gesteuert werden, ohne dass es eines manuellen Eingriffs bedarf.
In this paper it is first identified the trade-off among costs, flexibility and performances of autonomous robotic solutions for material handling processes, where adding value with automation is not as trivial as in production processes: hence the requirement for automated solutions to be simple, lean and efficient becomes even stricter. Then a method for modelling and comparing differential performances and costs of manual and autonomous solutions is developed. As a result of the method, a smart man-machine collaborative interface is designed and its impact evaluated on a specific case of study. Results are then generalized and prove the strong conclusions that in unconstrained environments, where full standardization cannot be achieved, the risk of investing in autonomous solutions can only be mitigated by creating a fast and smart man-machine collaborative interface.
According to a recent survey the great majority of players in logistics are planning to adopt one or more robotic solutions until 2019. Technical solutions for automation of processes in logistics are often available as a market-ready product, but the lack of standardization and skepticism towards long term investments are often the reasons why these solutions are not implemented on a large scale. This paper is set to bridge the gap between the world of technologies and the one of applications in order to help investors, robot producers and system integrators to decide on which branch of logistics to set their focus. The three main branches Courier Express Parcel (CEP), contract logistics and production logistics are briefly defined and distinguished through their characteristic factors and parameters. Then a method based on the analysis of three parameters (operative costs, required performance and flexibility) in the three branches is set to identify the most convenient branch of logistics for investing in new technologies, namely the one in which the risk of investment is lower, the return is higher and faster. The conclusion of the method shows that higher labor costs, strict regulations and higher standardization make the production logistics the most suitable branch for investments in emerging automation solutions.