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Hydroxyapatite-modified gelatin bioinks for bone bioprinting

  • In bioprinting approaches, the choice of bioink plays an important role since it must be processable with the selected printing method, but also cytocompatible and biofunctional. Therefore, a crosslinkable gelatin-based ink was modified with hydroxyapatite (HAp) particles, representing the composite buildup of natural bone. The inks’ viscosity was significantly increased by the addition of HAp, making the material processable with extrusion-based methods. The storage moduli of the formed hydrogels rose significantly, depicting improved mechanical properties. A cytocompatibility assay revealed suitable ranges for photoinitiator and HAp concentrations. As a proof of concept, the modified ink was printed together with cells, yielding stable three-dimensional constructs containing a homogeneously distributed mineralization and viable cells.

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Author of HS ReutlingenKluger, Petra
Erschienen in:Bionanomaterials : journal of functional materials, biomechanics, and tissue engineering
Publisher:De Gruyter
Place of publication:Berlin
Document Type:Article
Year of Publication:2016
Tag:additive manufacturing; mineralization; osteoblast differentiation; tissue engineering
Page Number:6
First Page:179
Last Page:184
DDC classes:660 Technische Chemie
Open Access?:Nein
Licence (German):License Logo  Lizenzbedingungen De Gruyter