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The critical process parameters cell density and viability during mammalian cell cultivation are assessed by UV/VIS spectroscopy in combination with multivariate data analytical methods. This direct optical detection technique uses a commercial optical probe to acquire spectra in a label-free way without signal enhancement. For the cultivation, an inverse cultivation protocol is applied, which simulates the exponential growth phase by exponentially replacing cells and metabolites of a growing Chinese hamster ovary cell batch with fresh medium. For the simulation of the death phase, a batch of growing cells is progressively replaced by a batch with completely starved cells. Thus, the most important parts of an industrial batch cultivation are easily imitated. The cell viability was determined by the well-established method partial least squares regression (PLS). To further improve process knowledge, the viability has been determined from the spectra based on a multivariate curve resolution (MCR) model. With this approach, the progress of the cultivations can be continuously monitored solely based on an UV/VIS sensor. Thus, the monitoring of critical process parameters is possible inline within a mammalian cell cultivation process, especially the viable cell density. In addition, the beginning of cell death can be detected by this method which allows us to determine the cell viability with acceptable error. The combination of inline UV/VIS spectroscopy with multivariate curve resolution generates additional process knowledge complementary to PLS and is considered a suitable process analytical tool for monitoring industrial cultivation processes.
Automatic classification of rotating machinery defects using Machine Learning (ML) algorithms
(2020)
Electric machines and motors have been the subject of enormous development. New concepts in design and control allow expanding their applications in different fields. The vast amount of data have been collected almost in any domain of interest. They can be static; that is to say, they represent real-world processes at a fixed point of time. Vibration analysis and vibration monitoring, including how to detect and monitor anomalies in vibration data are widely used techniques for predictive maintenance in high-speed rotating machines. However, accurately identifying the presence of a bearing fault can be challenging in practice, especially when the failure is still at its incipient stage, and the signal-to-noise ratio of the monitored signal is small. The main objective of this work is to design a system that will analyze the vibration signals of a rotating machine, based on recorded data from sensors, in the time/frequency domain. As a consequence of such substantial interest, there has been a dramatic increase of interest in applying Machine Learning (ML) algorithms to this task. An ML system will be used to classify and detect abnormal behavior and recognize the different levels of machine operation modes. The proposed solution can be deployed as predictive maintenance for Industry 4.0.
Power line communications (PLC) reuse the existing power-grid infrastructure for the transmission of data signals. As power line the communication technology does not require a dedicated network setup, it can be used to connect a multitude of sensors and Internet of Things (IoT) devices. Those IoT devices could be deployed in homes, streets, or industrial environments for sensing and to control related applications. The key challenge faced by future IoT-oriented narrowband PLC networks is to provide a high quality of service (QoS). In fact, the power line channel has been traditionally considered too hostile. Combined with the fact that spectrum is a scarce resource and interference from other users, this requirement calls for means to increase spectral efficiency radically and to improve link reliability. However, the research activities carried out in the last decade have shown that it is a suitable technology for a large number of applications. Motivated by the relevant impact of PLC on IoT, this paper proposed a cooperative spectrum allocation in IoT-oriented narrowband PLC networks using an iterative water-filling algorithm.
Our paper gives first answers on a fundamental question: how can the design of architectures of intelligent digital systems and services be accomplished methodologically? Intelligent systems and services are the goals of many current digitalization efforts today and part of massive digital transformation efforts based on digital technologies. Digital systems and services are the foundation of digital platforms and ecosystems. Digtalization disrupts existing businesses, technologies, and economies and promotes the architecture of open environments. This has a strong impact on new value-added opportunities and the development of intelligent digital systems and services. Digital technologies such as artificial intelligence, the Internet of Things, services computing, cloud computing, big data with analytics, mobile systems, and social enterprise networks systems are important enablers of digitalization. The current publication presents our research on the architecture of intelligent digital ecosystems and products and services influenced by the service-dominant logic. We present original methodological extensions and a new reference model for digital architectures with an integral service and value perspective to model intelligent systems and services that effectively align digital strategies and architectures with artificial intelligence as main elements to support intelligent digitalization.
his book highlights new trends and challenges in intelligent systems, which play an important part in the digital transformation of many areas of science and practice. It includes papers offering a deeper understanding of the human-centred perspective on artificial intelligence, of intelligent value co-creation, ethics, value-oriented digital models, transparency, and intelligent digital architectures and engineering to support digital services and intelligent systems, the transformation of structures in digital businesses and intelligent systems based on human practices, as well as the study of interaction and the co-adaptation of humans and systems. All papers were originally presented at the International KES Conference on Human Centred Intelligent Systems 2020 (KES HCIS 2020), held on June 17–19, 2020, in Split, Croatia.
Service Blueprinting
(2020)
Ein Ansatz des Dienstleistungsmanagements, mit dessen Hilfe Gesundheitsleistungen ganz aus Perspektive der behandelten Person und ihrer Customer Journey durch den Leistungsprozess analysiert werden kann, ist das sogenannte Service Blueprinting. Die vorliegende Fallstudie beginnt mit einer kurzen Einführung zur Begründung und zum Vorgehen dieses Ansatzes. Im Anschluss wird der Ansatz anhand der holprigen Customer Journey des imaginären Patienten Torben Schulz im Rahmen einer Bandscheiben-Operation kritisch diskutiert und auf einen Teilaspekt dieser Dienstleistung angewendet.
Die klassischen Vertriebsaufgaben verändern sich intensiv und schnell. Vertriebsmanager benötigen dringend neue strategische Ansätze, wie sie künftig Kundenkontakte gestalten, Distributionskanäle steuern und effektiver verkaufen können. Eine aktuelle Studie gibt Aufschluss, wie sich Unternehmen auf den Strukturwandel einstellen können.
Relationship between a high-performance work system and employee outcomes: a multilevel analysis
(2020)
Although research on high-performance work systems (HPWS) is increasing, there are few studies in which the focus is on whether and how firm-level HPWS affect individual-level employee outcomes. Using social identity theory, we examined the relationship between HPWS and employee outcomes, and the role organizational identification plays as a mediator in this relationship. We used a multilevel research design and collected data at the organizational and individual levels from a sample of 485 employees of 32 companies in Guangdong Province, China. We used Amos 17.0 and hierarchical linear modeling 6.08 software to examine our hypotheses and the theoretical model. Results showed that organizational identification fully mediated the relationship between HPWS and employees’ job performance as well as that between HPWS and their turnover intention. Our findings provide new insights into the relationship between firm-level human resource management and individual-level employee outcomes, and highlight the importance of considering the implementation of HPWS practices to strengthen employees’ identification with the organization and improve their performance.
Aimed at the problem that the accuracy of face image classification in complex environment is not high, a network model F-Net suitable for aesthetic classification of face images is proposed. Based on LeNet-5, the model uses convolutional layers to extract facial image features in complex backgrounds, optimized parameters in the network model, and changes the number of convolutional layers and fully connected layer feature elements in the model. The experimental results show that the F-Net network model proposed in this paper has a face image classifation accuracy of 73% in complex environment background, which is better than other classical convolutional neural network classification models.
In this paper, we address the novel EDP (Expert Design Plan) principle for procedural design automation of analog integrated circuits, which captures the knowledge-based design strategy of human circuit designers in an executable script, making it reusable. We present the EDP Player, which enables the creation and execution of EDPs for arbitrary circuits in the Cadence® Virtuoso® Design Environment. The tool provides a generic version of an instruction set, called EDPL (EDPLanguage), enabling emulation of a typical manual analog sizing flow. To automate the design of a Miller Operational Amplifier and to create variants of a Smart Power IC, several EDPs were implemented using this tool. Employing these EDPs leads to a strong reduction of design time without compromising design quality or reliability.
