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In vitro and ex vivo analysis of collagen foams for soft and hard tissue regeneration

  • Background/Aim: The aim of this study was the conception, production, material analysis and cytocompatibility analysis of a new collagen foam for medical applications. Materials and Methods: After the innovative production of various collagen sponges from bovine sources, the foams were analyzed ex vivo in terms of their structure (including pore size) and in vitro in terms of cytocompatibility according to EN ISO 10993-5/-12. In vitro, the collagen foams were compared with the established soft and hard tissue materials cerabone and Jason membrane (both botiss biomaterials GmbH, Zossen, Germany). Results: Collagen foams with different compositions were successfully produced from bovine sources. Ex vivo, the foams showed a stable and long-lasting primary structure quality with a bubble area of 1,000 to 2,000 μm2. In vitro, all foams showed sufficient cytocompatibility. Conclusion: Collagen sponges represent a promising material for hard and soft tissue regeneration. Future studies could focus on integrating and investigating different additives in the foams.

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Metadaten
Author of HS ReutlingenKrastev, Rumen; Zhao, Cuifeng
URN:urn:nbn:de:bsz:rt2-opus4-35015
DOI:https://doi.org/10.21873/invivo.12536
ISSN:1791-7549
Erschienen in:In vivo : international journal of experimental and clinical pathophysiology and drug research
Publisher:IIAR
Place of publication:Kapandriti, Attiki
Document Type:Journal article
Language:English
Publication year:2021
Tag:collagen; collagen foam; hard tissue; macrophages; soft tissue; tissue regeneration; vascularization
Volume:35
Issue:5
Page Number:9
First Page:2541
Last Page:2549
DDC classes:610 Medizin, Gesundheit
Open access?:Ja
Licence (German):License Logo  Open Access