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Propofol is an intravenous anesthetic. Currently, it is not possible to routinely measure blood concentration of the drug in real time. However, multi-capillary column ion-mobility spectrometry of exhaled gas can estimate blood propofol concentration.Unfortunately, adhesion of volatile propofol on plastic materials complicates measurements. Therefore, it is necessary to consider the extent to which volatile propofol adheres to various plastics used in sampling tubing. Perfluoralkoxy (PFA), polytetrafluorethylene (PTFE), polyurethane (PUR), silicone, and Tygon tubing were investigated in an experimental setting using a calibration gas generator (HovaCAL). Propofol gas was measured for one hour at 26 °C, 50 °C, and 90 °C tubing temperature. Test tubing segments were then flushed with N2 to quantify desorption. PUR and Tygon sample tubing absorbed all volatile propofol. The silicone tubing reached the maximum propofol concentration after 119 min which was 29 min after propofol gas exposure stopped. The use of PFAor PTFE tubing produced comparable and reasonably accurate propofol measurements. The desaturation time for the PFA was 10 min shorter at 26 °C than for PTFE. PFA tubing thus seems most suitable for measurement of volatile propofol,with PTFE as an alternative.
Though bioprinting is a forward-looking approach in bone tissue engineering, the development of bioinks which are on the one hand processable with the chosen printing technique, and on the other hand possess the relevant mechanical as well as osteoconductive features remains a challenge. In the present study, polymer solutions based on methacrylated gelatin and methacrylated hyaluronic acid modified with hydroxyapatite (HAp) particles (5 wt%) were prepared. Encapsulation of primary human adipose derived stem cells in the HAp-containing gels and culture for 28 d resulted in a storage moduli significantly increased to 126% ± 9.6% compared to the value on day 1 by the sole influence of the HAp. Additional use of osteogenic media components resulted in an increase of storage module up to 199% ± 27.8%. Similarly, the loss moduli was increased to 370% ± 122.1% under the influence of osteogenic media components and HAp. Those changes in rheological material characteristics indicate a distinct change in elastic and viscous hydrogel properties, and are attributed to extensive matrix production in the hydrogels by the encapsulated cells, what could also be proven by staining of bone matrix components like collagen I, fibronectin, alkaline phosphatase and osteopontin. When using the cell-laden polymer solutions as bioinks to build up relevant geometries, the ink showed excellent printability and the printed grid structure's integrity remained intact over a culture time of 28 d. Again, an intense matrix formation as well as upregulation of osteogenic markers by the encapsulated cells could be shown. In conclusion, we demonstrated that our HAp-containing bioinks and hydrogels on basis of methacrylated gelatin and hyaluronic acid are on the one hand highly suitable for the build up of relevant three-dimensional geometries with microextrusion bioprinting, and on the other hand exhibit a significant positive effect on bone matrix development and remodeling in the hydrogels, as indicated by rheological measurements and staining of bone components. This makes the developed composite hydrogels an excellent material for bone bioprinting approaches.
Saving energy and road safety became important in the last decades, hence several driving assistant systems were developed that help to improve the driving behaviour. However, these driving systems cover the area of either energy-efficiency or safety. Furthermore, they do not consider the reaction of the driver to a shown recommendation and the driver stress level. In this paper, the decision process of showing a recommendation to the driver in an energy-efficient and safety relevant driving system is presented. The decision process considers the driver's reaction to a shown recommendation and the driver stress in order to increase the user acceptance and the road safety. The results of the evaluation showed that the driving system was able to show recommendations when needed, while suppressing recommendations when the driver ignored a recommendation repeatedly or when the driver was in stress.
Ziel eines aktuellen Forschungsprojektes an der Hochschule Reutlingen, das gemeinsam mit dem Ingenieurbüro Ganssloser und der Universität Tübingen durchgeführt wird, ist es, Flexibilitäten in Unternehmen, die im Verbund als virtuelles Kraftwerk am Strommarkt agieren, zu erkennen und nutzbar zu machen. Zu diesem Zweck soll eine Steuerbox für Industrie- und Gewerbebetriebe entwickelt werden, die einerseits mit der zentralen Leitwarte des virtuellen Kraftwerks kommuniziert und andererseits die Anlagen des Unternehmens so steuert, dass die zur Verfügung stehenden Flexibilitäten möglichst optimal genutzt werden. Die Hochschule Reutlingen beschäftigt sich innterhalb des Projekts mit der Erkennung und Beschreibung von Flexibilitäten in Unternehmen.
Mit der Energiewende hat die Bundesregierung den Umbau der Energieversorgung begonnen. Da das Gelingen der Energiewende für die Zukunfts- und Wettbewerbsfähigkeit des Wirtschaftsstandorts Deutschland essenziell ist, wurden seitens des Bundesverbandes der deutschen Industrie (BDI) bereits 2013 Impulse für eine smarte Energiewende veröffentlicht, in denen fünf Prinzipien abgeleitet werden, die einen Rahmen für den Diskurs über die zu ergreifenden Maßnahmen setzen. Erneuerbare Energien werden in dem kommenden Jahren die dominierende Stromquelle darstellen. Daraus entstehen neue Herausforderungen. Zu deren Bewältigung hat das Bundeswirtschaftsministerium (BMWi) kürzlich eine 10-Punkte-Agenda (ZPA) für die zentralen Vorhaben der Energiewende vorgelegt. Zu diskutieren ist, inwieweit sie im Einklang mit den fünf Prinzipien des BDI steht und an welchen Stellen Anpassungen notwendig werden, damit der Umbau des Energiesystems erfolgreich gelingen kann.
Um einen Funksensor zum Messen der Windgeschwindigkeit per Energy Harvesting mit Energie zu versorgen, bietet es sich an, das Messsignal selbst zur Energiegewinnung zu nutzen. Mit optimierter Funkübertragung und Energiemanagement lässt sich ein autarker Windstärke-Funksensor realisieren, der ab 2 m/s Windgeschwindigkeiten messen und die Messwerte per Funk übertragen kann.