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The article pleads for Education for Sustainable Development (ESD) in the textile and fashion sector and shows possibilities how this can be implemented from elementary school to higher education and vocational training. It begins by highlighting the non-sustainable practices and deficits that can be found in the fashion and textile sector worldwide and explains the sustainability goals in the context of the UN Roadmap ESD for 2030. In order to raise the awareness for sustainability and implement these goals, education is needed. The article introduces the concept of ESD as a guiding principle with the core element design competence, implemented by the interdisciplinary method of Design Thinking (DT). In order to successfully teach the ESD-relevant design competence, various didactic principles are required. It can be shown that they are very similar to the principles and phases of DT. Within a research project DT and its potential for implementing ESD has been investigated in teaching-learning situations at elementary schools as well as in an interdisciplinary seminar for student teachers. These findings have been transferred to the EU project Fashion DIET, which pursues the goal of implementing ESD in the textile and fashion sector. By means of an online pilot workshop, the methods and principles of DT were presented and explained to lecturers, teachers and educators, who gave their feedback on the potential of DT as a method to implement ESD as a guiding principle in their curricula.
Student-faculty interactions that promote learning are essential contributors to student retention, academic success and satisfaction. But the factors that causally initiate and frame these interactions are not well understood. Only if students evaluate these interactions as positive will they seek them. We conducted a survey experiment with students (n = 375) from a tuition-fee-free German business school, using conditional process analysis to assess which factors frame effective interactions. We focus on out-of-classroom standard and non-standard requests that students make to faculty, then investigate how faculty and student gender and students’ academic entitlement influence the interaction. Our study examines how students evaluate the interaction with faculty: when they seek interaction, their expectations of getting their requests approved, and their disappointment when their requests are declined. We find a significant influence of the request type along with moderating effects of faculty gender, student gender and student entitlement, particularly for non-standard work requests. We conclude with policy implications for university management: developing target-group-specific measures that facilitate the desired and positively evaluated student-faculty interactions might benefit all university stakeholders.
For optimization of production processes and product quality, often knowledge of the factors influencing the process outcome is compulsory. Thus, process analytical technology (PAT) that allows deeper insight into the process and results in a mathematical description of the process behavior as a simple function based on the most important process factors can help to achieve higher production efficiency and quality. The present study aims at characterizing a well-known industrial process, the transesterification reaction of rapeseed oil with methanol to produce fatty acid methyl esters (FAME) for usage as biodiesel in a continuous micro reactor set-up. To this end, a design of experiment approach is applied, where the effects of two process factors, the molar ratio and the total flow rate of the reactants, are investigated. The optimized process target response is the FAME mass fraction in the purified nonpolar phase of the product as a measure of reaction yield. The quantification is performed using attenuated total reflection infrared spectroscopy in combination with partial least squares regression. The data retrieved during the conduction of the DoE experimental plan were used for statistical analysis. A non-linear model indicating a synergistic interaction between the studied factors describes the reactor behavior with a high coefficient of determination (R²) of 0.9608. Thus, we applied a PAT approach to generate further insight into this established industrial process.
Intracranial brain tumors are one of the ten most common malignant cancers and account for substantial morbidity and mortality. The largest histological category of primary brain tumors is the gliomas which occur with an ultimate heterogeneous appearance and can be challenging to discern radiologically from other brain lesions. Neurosurgery is mostly the standard of care for newly diagnosed glioma patients and may be followed by radiation therapy and adjuvant temozolomide chemotherapy.
However, brain tumor surgery faces fundamental challenges in achieving maximal tumor removal while avoiding postoperative neurologic deficits. Two of these neurosurgical challenges are presented as follows. First, manual glioma delineation, including its sub-regions, is considered difficult due to its infiltrative nature and the presence of heterogeneous contrast enhancement. Second, the brain deforms its shape, called “brain shift,” in response to surgical manipulation, swelling due to osmotic drugs, and anesthesia, which limits the utility of pre-operative imaging data for guiding the surgery.
Image-guided systems provide physicians with invaluable insight into anatomical or pathological targets based on modern imaging modalities such as magnetic resonance imaging (MRI) and Ultrasound (US). The image-guided toolkits are mainly computer-based systems, employing computer vision methods to facilitate the performance of peri-operative surgical procedures. However, surgeons still need to mentally fuse the surgical plan from pre-operative images with real-time information while manipulating the surgical instruments inside the body and monitoring target delivery. Hence, the need for image guidance during neurosurgical procedures has always been a significant concern for physicians.
This research aims to develop a novel peri-operative image-guided neurosurgery (IGN) system, namely DeepIGN, that can achieve the expected outcomes of brain tumor surgery, thus maximizing the overall survival rate and minimizing post-operative neurologic morbidity. In the scope of this thesis, novel methods are first proposed for the core parts of the DeepIGN system of brain tumor segmentation in MRI and multimodal pre-operative MRI to the intra-operative US (iUS) image registration using the recent developments in deep learning. Then, the output prediction of the employed deep learning networks is further interpreted and examined by providing human-understandable explainable maps. Finally, open-source packages have been developed and integrated into widely endorsed software, which is responsible for integrating information from tracking systems, image visualization, image fusion, and displaying real-time updates of the instruments relative to the patient domain.
The components of DeepIGN have been validated in the laboratory and evaluated in the simulated operating room. For the segmentation module, DeepSeg, a generic decoupled deep learning framework for automatic glioma delineation in brain MRI, achieved an accuracy of 0.84 in terms of the dice coefficient for the gross tumor volume. Performance improvements were observed when employing advancements in deep learning approaches such as 3D convolutions over all slices, region-based training, on-the-fly data augmentation techniques, and ensemble methods.
To compensate for brain shift, an automated, fast, and accurate deformable approach, iRegNet, is proposed for registering pre-operative MRI to iUS volumes as part of the multimodal registration module. Extensive experiments have been conducted on two multi-location databases: the BITE and the RESECT. Two expert neurosurgeons conducted additional qualitative validation of this study through overlaying MRI-iUS pairs before and after the deformable registration. Experimental findings show that the proposed iRegNet is fast and achieves state-of-the-art accuracies. Furthermore, the proposed iRegNet can deliver competitive results, even in the case of non-trained images, as proof of its generality and can therefore be valuable in intra-operative neurosurgical guidance.
For the explainability module, the NeuroXAI framework is proposed to increase the trust of medical experts in applying AI techniques and deep neural networks. The NeuroXAI includes seven explanation methods providing visualization maps to help make deep learning models transparent. Experimental findings showed that the proposed XAI framework achieves good performance in extracting both local and global contexts in addition to generating explainable saliency maps to help understand the prediction of the deep network. Further, visualization maps are obtained to realize the flow of information in the internal layers of the encoder-decoder network and understand the contribution of MRI modalities in the final prediction. The explainability process could provide medical professionals with additional information about tumor segmentation results and therefore aid in understanding how the deep learning model is capable of processing MRI data successfully.
Furthermore, an interactive neurosurgical display has been developed for interventional guidance, which supports the available commercial hardware such as iUS navigation devices and instrument tracking systems. The clinical environment and technical requirements of the integrated multi-modality DeepIGN system were established with the ability to incorporate: (1) pre-operative MRI data and associated 3D volume reconstructions, (2) real-time iUS data, and (3) positional instrument tracking. This system's accuracy was tested using a custom agar phantom model, and its use in a pre-clinical operating room is simulated. The results of the clinical simulation confirmed that system assembly was straightforward, achievable in a clinically acceptable time of 15 min, and performed with a clinically acceptable level of accuracy.
In this thesis, a multimodality IGN system has been developed using the recent advances in deep learning to accurately guide neurosurgeons, incorporating pre- and intra-operative patient image data and interventional devices into the surgical procedure. DeepIGN is developed as open-source research software to accelerate research in the field, enable ease of sharing between multiple research groups, and continuous developments by the community. The experimental results hold great promise for applying deep learning models to assist interventional procedures - a crucial step towards improving the surgical treatment of brain tumors and the corresponding long-term post-operative outcomes.
How mechanical and physicochemical material characteristics influence adipose-derived stem cell fate
(2023)
Adipose-derived stem cells (ASCs) are a subpopulation of mesenchymal stem cells. Compared to bone marrow-derived stem cells, they can be harvested with minimal invasiveness. ASCs can be easily expanded and were shown to be able to differentiate into several clinically relevant cell types. Therefore, this cell type represents a promising component in various tissue engineering and medical approaches (e.g., cell therapy). In vivo cells are surrounded by the extracellular matrix (ECM) that provides a wide range of tissue-specific physical and chemical cues, such as stiffness, topography, and chemical composition. Cells can sense the characteristics of their ECM and respond to them in a specific cellular behavior (e.g., proliferation or differentiation). Thus, in vitro biomaterial properties represent an important tool to control ASCs behavior. In this review, we give an overview of the current research in the mechanosensing of ASCs and current studies investigating the impact of material stiffens, topography, and chemical modification on ASC behavior. Additionally, we outline the use of natural ECM as a biomaterial and its interaction with ASCs regarding cellular behavior.
At the beginning of 2022, Frontiers in Bioengineering and Biotechnology - Biomaterials Section has published a Research Topic on “Functional Surfaces and Biomaterials.” The aim of this Research Topic is to summarize the current state of research and development in the field of functional surfaces and biomaterials with a particular focus on biotechnological and medical applications.
The guest editorial team would like to thank all colleagues from around the world who submitted their reviews and research articles for the Research Topic. By the end of August 2022, we have successfully collected 20 articles by 138 participating authors following the peer review process. We also tried to select manuscripts from different research areas to cover the most relevant Research Topic of interest, from drug delivery systems to bone tissue engineering to biosensors and general aspects in biomedicine. By the end of December, the 20 articles had been viewed for more than 21000 times with downloads more than 4,000 times, and 11 articles have reached more than 1,000 views.
Titanium(IV) surface complexes bearing chelating catecholato ligands for enhanced band-gap reduction
(2023)
Protonolysis reactions between dimethylamido titanium(IV) catecholate [Ti(CAT)(NMe2)2]2 and neopentanol or tris(tert-butoxy)silanol gave catecholato-bridged dimers [(Ti(CAT)(OCH2tBu)2)(HNMe2)]2 and [Ti(CAT){OSi(OtBu)3}2(HNMe2)2]2, respectively. Analogous reactions using the dimeric dimethylamido titanium(IV) (3,6-di-tert-butyl)catecholate [Ti(CATtBu2-3,6)(NMe2)2]2 yielded the monomeric Ti(CATtBu2-3,6)(OCH2tBu)2(HNMe2)2 and Ti(CATtBu2-3,6)[OSi(OtBu)3]2(HNMe2)2. The neopentoxide complex Ti(CATtBu2-3,6)(OCH2tBu)2(HNMe2)2 engaged in further protonolysis reactions with Si–OH groups and was consequentially used for grafting onto mesoporous silica KIT-6. Upon immobilization, the surface complex [Ti(CATtBu2-3,6)(OCH2tBu)2(HNMe2)2]@[KIT-6] retained the bidentate chelating geometry of the catecholato ligand. This convergent grafting strategy was compared with a sequential and an aqueous approach, which gave either a mixture of bidentate chelating species with a bipodally anchored Ti(IV) center along with other physisorbed surface species or not clearly identifiable surface species. Extension of the convergent and aqueous approaches to anatase mesoporous titania (m-TiO2) enabled optical and electronic investigations of the corresponding surface species, revealing that the band-gap reduction is more pronounced for the bidentate chelating species (convergent approach) than for that obtained via the aqueous approach. The applied methods include X-ray photoelectron spectroscopy, ultraviolet photoelectron spectroscopy, and solid-state UV/vis spectroscopy. The energy-level alignment for the surface species from the aqueous approach, calculated from experimental data, accounts for the well-known type II excitation mechanism, whereas the findings indicate a distinct excitation mechanism for the bidentate chelating surface species of the material [Ti(CATtBu2-3,6)(OCH2tBu)2(HNMe2)2]@[m-TiO2].
Purpose
The authors study the valuation effect of corporate diversification in the initial phase of the COVID-19 pandemic in 2020 in Europe.
Design/methodology/approach
Applying a cross-sectional regression model to a sample of public companies headquartered in the European Union, the authors investigate the existence of and the change in a diversification discount between 2018 and 2020. By applying the Excess Q methodology, the authors make an industry adjustment of diversified companies to measure the value effect of corporate diversification.
Findings
The authors find an economically and statistically significant diversification discount that increases from an average Excess Q of −0.05 in 2019 to −0.10 in 2020. The diversified companies' inferior fundamental financial performance in 2020 accompanies the discount. The results deviate from those of previous research, which mostly show a decrease in the diversification discount in economic crises, and thereby, shed doubt on whether diversification provides insurance against pandemic-induced adverse value effects.
Originality/valueThe study distinguishes the role of corporate diversification during recessionary periods by establishing that the valuation effect of diversification depends on the nature of the crisis. The analysis incorporates criticism of previous studies concerning a biased methodology and uniform data source by applying the Excess Q methodology and using FactSet industry segment data.
Polyester fibers are widely employed in a multitude of sectors and applications from the technical textiles to everyday life thanks to their durability, strength, and flexibility. Despite these advantages, polyester lacks in dyeability, adhesion of coating, hydrophilicity, and it is characterized by a low wettability respect to natural fibers. On this regard, beyond the harmful hydrophobic textile finishings of polyester fabrics containing fluorine-compounds, and in order to avoid pre-treatments, such as laser irradiation to improve their surface properties, research is moving towards the development of fluorine-free and safer coatings. In this work, the (3-glycidyloxypropyl)trimethoxysilane (GPTMS) and various long alkyl-chain alkoxysilanes were employed for the fabrication in the presence of a catalyst of a water-based superhydrophobic finishing for polyester fabrics with a simple sol-gel, non-fluorinated, sustainable approach and the dip-pad-dry-cure method. The finished polyester fabrics surface properties were investigated by static and dynamic water repellency tests. Additionally, the resistance to common water-based liquids, abrasion resistance, moisture adsorption, and air permeability measurements were performed. Scanning electron microscopy was employed to examine the micro- and nano-morphology of the functionalized polyester fabrics surfaces. The obtained superhydrophobic finishings displayed high water-based stain resistance as well as good hydrophobicity after different cycles of abrasion.
Unternehmertum spielt sowohl für die Entwicklung afrikanischer Länder eine Rolle, als auch für ausländische Unternehmen mit Markteintrittsplänen. Die infrastrukturellen und institutionellen Rahmenbedingungen für Unternehmertum sind nach wie vor schwierig, wobei aber die fortschreitende Digitalisierung zu einer zunehmend aktiven Start-Up Szene in vielen afrikanischen Ländern führt. Nach wie vor existiert ein Mismatch zwischen den Bereichen in denen Start-Ups entstehen und den Bereichen, wo ausländische Unternehmen Partner für den Markteintritt suchen. Somit bleibt es trotz positiver Entwicklung beim Unternehmertum in absehbarer Zeit schwierig adäquate Partner zu finden.
Artificial intelligence is considered to be a significant technology for driving the future evolution of smart manufacturing environments. At the same time, automated guided vehicles (AGVs) play an essential role in manufacturing systems due to their potential to improve internal logistics by increasing production flexibility. Thereby, the productivity of the entire system relies on the quality of the schedule, which can achieve production cost savings by minimizing delays and the total makespan. However, traditional scheduling algorithms often have difficulties in adapting to changing environment conditions, and the performance of a selected algorithm depends on the individual scheduling problem. Therefore, this paper aimed to analyze the scheduling problem classes of AGVs by applying design science research to develop an algorithm selection approach. The designed artifact addressed a catalogue of characteristics that used several machine learning algorithms to find the optimal solution strategy for the intended scheduling problem. The contribution of this paper is the creation of an algorithm selection method that automatically selects a scheduling algorithm, depending on the problem class and the algorithm space. In this way, production efficiency can be increased by dynamically adapting the AGV schedules. A computational study with benchmark literature instances unveiled the successful implementation of constraint programming solvers for solving JSSP and FJSSP scheduling problems and machine learning algorithms for predicting the most promising solver. The performance of the solvers strongly depended on the given problem class and the problem instance. Consequently, the overall production performance increased by selecting the algorithms per instance. A field experiment in the learning factory at Reutlingen University enabled the validation of the approach within a running production scenario.
Erst die Corona-Pandemie, dann der Krieg in der Ukraine und die Energiekrise. Es scheint als rutschten wir von einer Katastrophe in die andere ohne zu wissen was als Nächstes kommt. Wir müssen uns der Frage stellen, wie wir solchen Krisen zukünftig begegnen können.
Auch die Forscherinnen und Forscher an der Hochschule Reutlingen leisten einen Beitrag dazu, unsere Gesellschaft widerstandsfähiger und robuster zu machen – sei es durch pfiffige Lösungen für die Energiekrise, durch kompetente Beratung zu Ressourceneffizienz und Lieferketten oder durch aktuelle Forschungsansätze zu resilienten IT-Strukturen und einer resilienten Wirtschaft.
Supply chains have evolved into dynamic, interconnected supply networks, which increases the complexity of achieving end-to-end traceability of object flows and their experienced events. With its capability of ensuring a secure, transparent, and immutable environment without relying on a trusted third party, the emerging blockchain technology shows strong potential to enable end-to-end traceability in such complex multitiered supply networks. This paper aims to overcome the limitations of existing blockchain-based traceability architectures regarding their object-related event mapping ability, which involves mapping the creation and deletion of objects, their aggregation and disaggregation, transformation, and transaction, in one holistic architecture. Therefore, this paper proposes a novel ‘blueprint-based’ token concept, which allows clients to group tokens into different types, where tokens of the same type are non-fungible. Furthermore, blueprints can include minting conditions, which, for example, are necessary when mapping assembly processes. In addition, the token concept contains logic for reflecting all conducted object-related events in an integrated token history. Finally, for validation purposes, this article implements the architecture’s components in code and proves its applicability based on the Ethereum blockchain. As a result, the proposed blockchain-based traceability architecture covers all object-related supply chain events and proves its general-purpose end-to-end traceability capabilities of object flows.
Cytocompatibility analyses of new implant materials or biomaterials are not only prescribed by the Medical Device Regulation (MDR), as defined in the DIN ISO Norm 10993-5 and -12, but are also increasingly replacing animal testing. In this context, jellyfish collagen has already been established as an alternative to mammalian collagen in different cell culture conditions, but a lack of knowledge exists about its applicability for cytocompatibility analyses of biomaterials. Thus, the present study was conducted to compare well plates coated with collagen type 0 derived from Rhizostoma pulmo with plates coated with bovine and porcine collagen. The coated well plates were analysed in vitro for their cytocompatibility, according to EN ISO 10993-5/−12, using both L929 fibroblasts and MC3T3 pre-osteoblasts. Thereby, the coated well plates were compared, using established materials as positive controls and a cytotoxic material, RM-A, as a negative control. L929 cells exhibited a significantly higher viability (#### p < 0.0001), proliferation (## p < 0.01), and a lower cytotoxicity (## p < 0.01 and # p < 0.05)) in the Jellagen® group compared to the bovine and porcine collagen groups. MC3T3 cells showed similar viability and acceptable proliferation and cytotoxicity in all collagen groups. The results of the present study revealed that the coating of well plates with collagen Type 0 derived from R. pulmo leads to comparable results to the case of well plates coated with mammalian collagens. Therefore, it is fully suitable for the in vitro analyses of the cytocompatibility of biomaterials or medical devices.
This paper presents a description model for smart, connected devices used in a manufacturing context. Similar to the wide spread adoption of smart products for personal and private usage, recent developments lead to a plethora of devices offering a variety of features and capabilities. Manufacturing companies undergoing digital transformation demand guidance with respect to the systematic introduction of smart, connected devices. The introduction of smart connected devices constitutes a strategic decision cost due to the high future committed cost after introduction and maintaining a smart device fleet by a vendor. This paper aims to support the introduction efforts by classifying the devices and thus helping companies identify their specific requirements for smart, connected devices before initiating widespread procurement. By mapping the features of these devices based on various attributes, allows the clustering of smart, connected devices including a requirement list for their implementation on the shopfloor. Four individual commercially available smart connected devices were analyzed using the description model.
Parallel grippers offer multiple applications thanks to their flexibility. Their application field ranges from aerospace and automotive to medicine and communication technologies. However, the application of grippers has the problem of exhibition wear and errors during the execution of their operation. This affects the performance of the gripper. In this context, the remaining useful life (RUL) defines the remaining lifespan until failure for an asset at a particular time of operation occurs. The exact lifespan of an asset is uncertain, thus the RUL model and estimation must be derived from available sources of information. This paper presents a method for the estimation of the RUL for a two-jaw parallel gripper. After the introduction to the topic, an overview of existing literature and RUL methods are presented. Subsequently, the method for estimating the RUL of grippers is explained. Finally, the results are summarized and discussed before the outlook and further challenges are presented.
In diesem Beitrag wird der Einfluss von Zuschauern nach den pandemiebedingten Geisterspielen auf den Heimvorteil in der ersten Fußball-Bundesliga analysiert. Für die empirische Untersuchung werden die fünf Spielzeiten 2017/18 bis 2021/22 betrachtet. Während in der Geisterspielphase in der Saison 2019/20 der Heimvorteil vollständig verschwindet, steigt der Heimvorteil in der zweiten Geisterspielphase in der Saison 2020/21 mit der Zeit wieder auf vorpandemisches Niveau an. In der Saison 2021/22 ist nach einer kurzen Phase mit eingeschränkten Zuschauerkapazitäten ein signifikant größerer Heimvorteil als in der Zeit vor der Pandemie zu beobachten. Der überdurchschnittlich positive Effekt der Zuschauer in dieser letzten Phase verschwindet mit der Zeit trotz steigender Zuschauerzahlen. Der Einfluss von Fans auf den Heimvorteil ist insgesamt insbesondere auf psychologische Effekte auf die Spieler der Heimmannschaften zurückzuführen.
Artificial Intelligence (AI) in der Markenführung: Künstliche Neuronale Netze zur Markenimagemessung
(2023)
Da Künstliche Neuronale Netze die Modellierung nichtlinearer und vielschichtiger Beziehungen ermöglichen, befasst sich dieser Beitrag mit deren Einsatzmöglichkeiten für die methodisch anspruchsvolle Analyse und Messung des Markenimages. Zur Veranschaulichung des konzeptionellen Ansatzes wird am empirischen Beispiel des Sportartikelherstellers adidas ein mehrschichtiges Künstliches Neuronales Netz zwischen den Bewertungen spezifischer Markenattribute und der Gesamtbewertung der Marke erzeugt. Auf der Grundlage einer Analyse der Verbindungsgewichte des Künstliches Neuronales Netzes wird die Bedeutung verschiedener Markenattribute für die Markenbewertung gemessen, wodurch sich konkrete Implikationen für die Praxis der Markenführung ableiten lassen.
The dawn of the 21st Century has witnessed a tremendous increase in trade pacts among nations, resulting in renewed hopes for sustainable enterprise development in emerging economies worldwide. Ghana and other sub-Saharan African (SSA) countries have signed onto several North-South and South-South free trade agreements with the hope of strengthening their presence in the international trade arena, and to promote economic growth in SSA. For over two decades, however, very little has changed, and many have dashed their high hopes as enterprises continue to struggle in SSA. Not even the African Continental Free Trade Agreement (AfCFTA) could renew the hopes of sceptics. Several studies opined that enterprises in SSA could improve their domestic and international competitiveness by establishing mutually beneficial partnerships with their counterparts from the Global North and South. This study delved into the issues that affect North-South and South-South business collaborations and recommends key success factors that could help promote mutually beneficial cross-border business partnerships. The research includes both literature and empirical information on the key success factors of business partnerships between African enterprises as well as between African enterprises and firms from the Global North. We approached the study qualitatively using a phenomenological research design. Research participants included important stakeholders in Africa and Europe's international trade and sustainable enterprise development ecosystem. The study identified several challenges with the current business collaborations and recommended new ways of making such partnerships more beneficial.