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In this article, liposome-based coatings aiming to control drug release from therapeutic soft contact lenses (SCLs) materials are analyzed. A PHEMA based hydrogel material loaded with levofloxacin is used as model system for this research. The coatings are formed by polyelectrolyte layers containing liposomes of 1,2-dimyristoyl-sn-glycero-3- phosphocholine (DMPC) and DMPC1cholesterol (DMPC1 CHOL). The effect of friction and temperature on the drug release is investigated. The aim of the friction tests is to simulate the blinking of the eyelid in order to verify if the SCLs materials coated with liposomes are able to keep their properties, in particular the drug release ability. It was observed that under the study conditions, friction did not affect significantly the drug release from the liposome coated PHEMA material. In contrast, increasing the temperature of release leads to an increase of the drug diffusion rate through the hydrogel. This phenomenon is recorded both in the control and in the coated samples.
In this study, a novel strategy has been developed for the assembly of polyelectrolyte multilayer (PEM) on CaCO3 templates in acidic pH solutions, where consecutive polyelectrolyte layers (heparin/poly(allylamine hydrochloride) or heparin/chitosan) were deposited on PEM hollow microcapsules established previously on CaCO3 templates. The PEM build-up, hollow capsule characterization and successful encapsulation of fluorescein 5(6)-isothiocyanate (FITC)-Dextran by coprecipitation with CaCO3 are demonstrated. Improvement by the removal of CaCO3 core was achieved while the depositions. In the course of the release profile, high retardation for encapsulated FITC-Dextran was observed. The combined shell capsules system is a significant trait that has potential use in tailoring functional layer-by-layer capsules as intelligent drug delivery vehicles where the preliminary in vitro tests showed the responsiveness on the enzymes.
This article covers the design of highly integrated gate drivers and level shifters for high-speed, high power efficiency and dv/dt robustness with focus on automotive applications. With the introduction of the 48 V board net in addition to the conventional 12 V battery, there is an increasing need for fast switching integrated gate drivers in the voltage range of 50 V and above. State-of-the-art drivers are able to switch 50 V in less than 5 ns. The high-voltage electrical drive train demands for galvanic isolated and highly integrated gate drivers. A gate driver with bidirectional signal transmission with a 1 MBit/s amplitude modulation, 10/20 MHz frequency modulation and power transfer over one single transformer will be discussed. The concept of high-voltage charge storing enables an area-efficient fully integrated bootstrapping supply with 70 % less area consumption. EMC is a major concern in automotive. Gate drivers with slope control optimize EMC while maintaining good switching efficiency. A current mode gate driver, which can change its drive current within 10 ns, results in 20 dBuV lower emissions between 7 and 60 MHz and 52 % lower switching loss compared to a conventional constant current gate driver.
The influence of turbidity on the Raman signal strengths of condensed matter is theoretically analyzed and measured with laboratory - scale equipment for remote sensing. The results show the quantitative dependence of back- and forward-scattered signals on the thickness and elastic-scattering properties of matter. In the extreme situation of thin, highly turbid layers, the measured Raman signal strengths exceed their transparent analogs by more than a factor of ten. The opposite behavior is found for thick layers of low turbidity, where the presence of a small amount of scatterers leads to a decrease of the measured signal. The wide range of turbidities appearing in nature is experimentally realized with stacked polymer layers and solid/liquid dispersions, and theoretically modeled by the equation of radiative transfer using the analytical diffusion approximation or random walk simulations.
The purpose of this paper is to explain the key aspects and growing relevance of sustainability in fashion retail and to evaluate the possibilities of fashion retailers to act sustainable in supply chain management as well as carving out the challenges they have to deal with. The research methodology applied for this purpose is a critical literature review examining books and articles. The findings demonstrate the rising importance of sustainability in fashion retail. In this regard, fashion retailers play a key role and responsibility for sustainability in the fashion supply chain, from the beginning up to the end. This paper mainly analyzes sustainability in the fashion supply chain. It does not analyze topics like second-hand shopping or social media sustainability.
The purpose of this paper is to investigate how the practice of closed-loop production systems (CLPS) is implemented in the fashion industry. This paper offers a critical literature review to present a thorough understanding of the actual status of literature. Subsequently, the paper reveals that CLPS are of great importance. Generally, such systems include different activities that have to be integrated. Critical points are the product acquisition, the recovering process itself and the remarketing to the customer. A lack of reliable data concerning CLPS in the specific case of fashion industry can be identified. Important research fields could be marketing strategies, controlling the acquisition process, evolvement of return technologies and strategies, adaption of recovered products to the mass market, and the development of new technologies concerning recovering processes.
The purpose of this paper is to examine the impact on sustainability of fashion production and consumption in order to discuss what the main lever is to reduce the negative impact. The research methodology applied is a literature review examining academic references. Key findings suggest that fashion production and consumption have a single comparable impact on sustainability. Moreover, as the fashion production follows the demand, the consumer steers the production in a certain direction. Therefore, consumers take over responsibility and need to be informed. To reach a long-term change in the fashion industry, the consumer has to be the focus of the sustainable efforts. Most results in literature were conducted by qualitative research methods, so that further quantitative testing of the results is recommended. Furthermore, most surveys were conducted with young fashion consumers in the EU or UK which does not represent the fashion consumer in general.
The purpose of this paper is to define what impacts sustainable manufacturing standards have for retail brands concerning the communication policy and to find possible solutions of how the companies can deal with them. Therefore, sustainable standards and the impacts on the internal and external communication are described. The enclosed discussion finds possible solutions for the negative impacts. A literature discussion has been conducted to investigate the purpose. Generally, there are many impacts fashion retails have to consider, if they want to transform their company to become more sustainable, because only the impacts on a defined part of the communication policy were huge. A limitation of this paper is that the proposals how retailers could deal with the impacts of the transformation of the company toward more sustainability need further research and tests until they are practicable.
The purpose of this paper is to highlight potentials and limitations of the prosumer concept in fashion retail. The paper illustrates the evolution of prosumption and in which directions the concept is being developed. The primary research is based on a literature review containing different sources of academic and non-academic references. Findings suggest that the prosumer concept is no new phenomenon. Recently, it has moved into the focus of companies that have noted that it is efficient when engaging with customers in order to strengthen their brand loyalty. An increasing number of companies offer innovative business models that underlie the concept. However, lately smart prosuming machines are changing the objectives of the concept. Even if the prosumer concept exists since many years and scholars investigate its potentials continuously, it is the fashion industry that has been researched comparatively little up to now.
The second hand concept indicates a growing trend in clothing recently, leading to growing numbers of second hand shops and developments of new second hand retail forms. This paper concentrates on the current second hand market for fashion products and presents the different motives toward second hand consumption as well as alternative consumption channels for second hand products. The findings of the paper are founded on literature research of academic articles and case studies. Results show that there is a high potential for the second hand market due to the increasing interest of consumers in buying second hand products. The paper concentrates on the second hand market for fashion products in the western society. This means that there was no research on second hand products for disadvantaged people in poor countries. Furthermore, the paper focuses the formal second hand retail channels to see what is already on the market.
The purpose of this paper is to evaluate consisting consumption patterns caused by fast fashion with a new appearing form of consumption and retaining potentials as an alternative as well as sustainable form of fast fashion consumption. This research is set up on a theoretical background of scientific literature including governmental as well as press releases in order to evaluate the status quo of consumption and answering the research question. A new consumption pattern as well as an appearing economy of sharing can be stated including potential aspects of raising businesses and sustainable alternative forms of fast fashion. The framework of the research is limited to the textile and fashion industry in industrialized countries focusing on consumption in the twenty first century.
The purpose of this research is to explore current boundaries of the fashion industry’s second hand market and which solutions and approaches can be adopted from the used-car industry. The paper is based on the study of existing literature which deals with sustainability in combination with second hand markets in general and adaptable features of the used-car industry. Adaptable features are found using the business model canvas. The key finding of this study indicates that the fashion industry faces immense social and environmental challenges which can be partly solved by the development of the second hand market. Used-car industry can be seen as role model for fashion retail. In this study only aspects of used-car distribution are highlighted; therefore, characteristics of the recycling of used cars are not examined.
The purpose of this paper is to study the recycling form of reusing second hand clothing from a conventional fashion brand’s perspective. It should clarify which measures and activities a fashion company needs to integrate in its value chain in order to offer branded second hand merchandise in a self-operated store. The research paper relies on a desk-based research and aims to illustrate the topic by means of a descriptive approach, processing the existing literature. Key findings demonstrate that fashion brands need to integrate complete lifecycle strategies, sustainability communication, and reverse logistics structures, like take-back schemes, for offering second hand clothing. The main limitations evolve from the research design. Further, empirical evidences need to be conducted for a more fundamental understanding of the new business model.
The purpose of this paper is to investigate the use of sustainable closed-loop supply chain of the fashion brand Filippa K. Information on green fashion has been gathered and a case study approach on the fashion retailer
Filippa K conducted. Results show a switch in knowledge content between a fast fashion supply chain and a sustainable supply chain. Also there is an evolution in sustainability as companies, retailers, and manufactures suffer under pressure from the customers, governments, and the media. Sustainable fashion brands like Filippa K are interested in sharing precise knowledge on variety of aspects linked to the sustainable closed-loop supply chain. This research paper has been limited by less information and unexplored topics in the theme green fashion. This led to the personal critical disputation with the brand Filippa K.
This study focuses on the different roles of social media for the promotion of a sustainable lifestyle, behaviour and consumption, especially with regard to the typically non-ethical fashion industry. Research findings include eight roles of social media influencing a sustainable consumption contrary to prior research naming one to five impacts. Results show that social media educates and engages the young and ethically interested target group besides increasing supply chain transparency and brand or theme awareness. Furthermore, social media provides a platform for organisations’ relationship management and social interaction since users get empowered to share experiences which leads to a higher level of trust.
The purpose of this paper is to identify the potential of a fashion fTRACE (ffTRACE) application that gives transparent insight on the supply chain of a fashion item. The research methodology applied to this purpose is a literature review examining academic references. The key findings of this paper are that information plays a major role in the consumer decision process and is therefore beneficial to the demand for sustainable products. Given the right information content in a transparent, credible and understandable way is important. It is found that the functions of such an application would be able to satisfy this consumer demand and therefore has the potential to raise the sales of a sustainable company as well as increase the brand’s awareness and improve its image. While mainly indicating the potentials of the ffTRACE application, their relevance is not examined in this paper.
Since there is no denying that transparency is increasingly central to corporate sustainability, the purpose of this paper is a case study on a company’s attempt to be fully transparent, hence, picking up the existent scholarly conversation about uncompromising supply chain transparency. Literature so far was found to be fairly limited, but, following a trend, has been rising in numbers over recent years. Addressing these shortcomings in the methodology, an in-depth literature review about the multiple dimensions of supply chain transparency has been performed and links within supply networks stressed. On this basis, a case study by exemplary illustrating the fashion label Honestby has been drafted and the effort to become the world’s first 100 % transparent company further examined. Findings are discussed whether more supply chain transparency is desirable in any case, obstacles listed and an outlook for this kind of business model has been drawn. The research is clearly limited by the amount of scholarly literature concerning Honestby in particular. Out of this reason, magazines and journal entries are used as reference as well. Only with the extension of the topic itself to supply chain transparency and the literature review beforehand, the paper gained its necessary academic standard. Concerning implications, it needs to be mentioned that even though Honest by demonstrates to be fully transparent, it was not possible to find any public information about the degree of supplier relationship. In particular, concerning the applied control mechanisms used to exert influence and to balance out the power gradient between company and suppliers.
Social networks, smart portable devices, Internet of Things (IoT) on base of technologies like analytics for big data and cloud services are emerging to support flexible connected products and agile services as the new wave of digital transformation. Biological metaphors of living and adaptable ecosystems with service-oriented enterprise architectures provide the foundation for self-optimizing and resilient run-time environments for intelligent business services and related distributed information systems. We are extending Enterprise Architecture (EA) with mechanisms for flexible adaptation and evolution of information systems having distributed IoT and other micro-granular digital architecture to support next digitization products, services, and processes. Our aim is to support flexibility and agile transformation for both IT and business capabilities through adaptive digital enterprise architectures. The present research paper investigates additionally decision mechanisms in the context of multi-perspective explorations of enterprise services and Internet of Things architectures by extending original enterprise architecture reference models with state of art elements for architectural engineering and digitization.
Social sustainable supply chain management in the textile and apparel industry : a literature review
(2017)
So far, a vast amount of studies on sustainability in supply chain management have been conducted by academics over the last decade. Nevertheless, socially related aspects are still neglected in the related discussion. The primary motivation of the present literature review has arisen from this shortcoming, thus the key purpose of this study is to enrich the discussion by providing a state of-the-art, focusing exclusively on social issues in sustainable supply chain management (SSCM) by considering the textile/apparel sector as the field of application. The authors conduct a literature review, including content analysis which covers 45 articles published in English peer-reviewed journals, and proposes a comprehensive map which integrates the latest findings on socially related practices in the textile/apparel industry with the dominant conceptualization in order to reveal potential research areas in the field. The results show an ongoing lack of investigation regarding the social dimension of the triple bottom line in SSCM. Findings indicate that a company’s internal orientation is the main assisting factor in sustainable supply chain management practices. Further, supplier collaboration and assessment can be interpreted as an offer for suppliers deriving from stakeholders and a focal company’s management of social risk. Nevertheless, suppliers do also face or even create huge barriers in improving their social performance. This calls for more empirical research and qualitative or quantitative survey methods, especially at the supplier level located in developing countries.
Purpose: Human breath analysis is proposed with increasing frequency as a useful tool in clinical application. We performed this study to find the characteristic volatile organic compounds (VOCs) in the exhaled breath of patients with idiopathic pulmonary fibrosis (IPF) for discrimination from healthy subjects. Methods: VOCs in the exhaled breath of 40 IPF patients and 55 healthy controls were measured using a multi-capillary column and ion mobility spectrometer. The patients were examined by pulmonary function tests, blood gas analysis, and serum biomarkers of interstitial pneumonia. Results: We detected 85 VOC peaks in the exhaled breath of IPF patients and controls. IPF patients showed 5 significant VOC peaks; p-cymene, acetoin, isoprene, ethylbenzene, and an unknown compound. The VOC peak of p-cymene was significantly lower (p < 0.001), while the VOC peaks of acetoin, isoprene, ethylbenzene, and the unknown compound were significantly higher (p < 0.001 for all) compared with the peaks of controls. Comparing VOC peaks with clinical parameters, negative correlations with VC (r =−0.393, p = 0.013), %VC (r =−0.569, p < 0.001), FVC (r = −0.440, p = 0.004), %FVC (r =−0.539, p < 0.001), DLco (r =−0.394, p = 0.018), and %DLco (r =−0.413, p = 0.008) and a positive correlation with KL-6 (r = 0.432, p = 0.005) were found for p-cymene. Conclusion: We found characteristic 5 VOCs in the exhaled breath of IPF patients. Among them, the VOC peaks of p-cymene were related to the clinical parameters of IPF. These VOCs may be useful biomarkers of IPF.
This paper investigates the electrothermal stability and the predominant defect mechanism of a Schottky gate AlGaN/GaN HEMT. Calibrated 3-D electrothermal simulations are performed using a simple semiempirical dc model, which is verified against high-temperature measurements up to 440°C. To determine the thermal limits of the safe operating area, measurements up to destruction are conducted at different operating points. The predominant failure mechanism is identified to be hot-spot formation and subsequent thermal runaway, induced by large drain–gate leakage currents that occur at high temperatures. The simulation results and the high temperature measurements confirm the observed failure patterns.
Nenne sie niemals Senioren!
(2017)
In times of dynamic markets, enterprises have to be agile to be able to quickly react to market influences. Due to the increasing digitization of products, the enterprise IT often is affected when business models change. Enterprise Architecture Management (EAM) targets a holistic view of the enterprise’ IT and their relations to the business. However, Enterprise Architectures (EA) are complex structures consisting of many layers, artifacts and relationships between them. Thus, analyzing EA is a very complex task for stakeholders. Visualizations are common vehicles to support analysis. However, in practice visualization capabilities lack flexibility and interactivity. A solution to improve the support of stakeholders in analyzing EAs might be the application of visual analytics. Starting from a systematic literature review, this article investigates the features of visual analytics relevant for the context of EAM.
We present a fully automatic approach to real-time 3D face reconstruction from monocular in-the-wild videos. With the use of a cascaded-regressor-based face tracking and a 3D morphable face model shape fitting, we obtain a semidense 3D face shape. We further use the texture information from multiple frames to build a holistic 3D face representation from the video footage. Our system is able to capture facial expressions and does not require any person specific training. We demonstrate the robustness of our approach on the challenging 300 Videos in the Wild (300- VW) dataset. Our real-time fitting framework is available as an open-source library at http://4dface.org.
It is assumed that more education leads to better understanding of complex systems. Some researchers, however, find indications that simple mechanisms like stocks and flows are not well understood even by people who have passed higher education. In this paper, we test people’s understanding of complex systems with the widely studied stock-and-flow (SF) tasks. SF tasks assess people’s understanding of the interplay between stocks and flows. We investigate SF failure of domain experts and novices in different knowledge domains. In particular, we compare performance on the original study’s bathtub task with the square wave pattern with two alternative cover stories from the engineering and business domains on different groups of business and engineering students from different semesters. Further, we show that, while engineering students perform better than business students, with progressing in higher education, students may lose the capability of dealing with simple SF tasks. We thus find hints on déformation professionelle in higher education.
Nowadays CHP units are discussed for the production of electricity on demand rather than for generation of heat providing electricity as a by-product. By this means, CHP units are capable of satisfying a higher share of the electricity demand on-site and in this new role, CHP units are able to reduce the load on the power grid and to compensate for high fluctuations of solar and wind power.
Evidently, a novel control strategy for CHP units is required in order to shift the operation oriented at the heat demand to an operation led by the electricity demand. Nevertheless, the heat generated by the CHP unit needs to be utilized completely in any case, for maintaining energy as well as economic efficiency. Such a strategy has been developed at Reutlingen University, and it will be presented in the paper. Part of the strategy is an intelligent management for the thermal energy storage (TES) ensuring that the storage is at low level in terms of its heat content just before an electricity demand is calling the CHP unit into operation. Moreover, a proper forecast of both, heat and electricity demand, is incorporated and the requirements of the CHP unit in terms of maintenance and lifetime are considered by limiting the number of starts and stops per unit time and by maintaining a certain minimum length of the operation intervals.
All aspects of this novel control strategy are revealed in the paper, which has been implemented on a controller for further testing at two sites in the field. Results from these tests are given as well as results from a simulation model, which is able to evaluate the performance of the control strategy for an entire year.
THE PROBLEM: Companies create problems for customers and employees when product innovation goes unmanaged. Eventually, excessive operational complexity hurts the bottom line.
THREE SOLUTIONS: Focus on product integration, not product proliferation. Make sure your product developers work closely with customerfacing and operational employees. And settle on a high-level purpose that can guide decision making.
This research is about Omnichannel Retailing and addresses the question how the omnichanneling of retailers in the fashion market can be measured. Our sources will include books, interviews, newspapers and scientific databases.
Omnichanneling is a current topic in the fashion market, retailers all over the world face the question on how to adapt to the challenges Omnichannel Retailing sets. We are going to define what Omnichanneling is by explaining the differences between Multiple-, Multi-, Cross- and Omnichannel Retailing. After we defined omnichanneling itself, we took a set of 26 retailers to evaluate regarding their Omnichannel capabilities. Then we create an index with criteria that can measure the Omnichannel capability of each retailer.
The Omnichannel Score is based on 31 criteria, which analyze the retailers in offline, online, mobile and social aspects enables to see differences between retailers. Our findings were that retailers in the US fashion market are more advanced in Omnichannel Retailing than retailers in the German fashion market. Our top three Omnichannel retailers were Sears with an Omnichannel Score of 91, followed by KOHL’S and Marks&Spencer, both with a Omnichannel Score of 88. The best Omnichannel Retailer from Germany was Adidas with the fourth place and an Omnichannel Score of 81.
There is no doubt that the amplification of channel integration towards an omni-channel structure is a powerful idea whose time has finally come. The digitally cross-linked world postulates all-encompassing, ubiquitous, and unobtrusive future services. In the concomitant, increasingly competitive market, retailers are starting to lay the foundation for omnichannel, meeting the expectations of a digitally cunning audience wanting their shopping experience to be as seamless and uncomplicated as possible. Nevertheless, recent researches show that there are still enough avenues for further research on omnichannel. Until now, the performance of companies was solely considered by experts from a suppliers’ point of view. It would be rather interesting to find out whether the desire to meet the increased cus-tomer expectations is also recognized by the customers themselves. This paper seeks to answering how the purchasing behavior has changed and what customers demand. In addition, it elaborates the opportunities that are promoted by omni-channel. Searching out all the effects, the paper will get to a final step, where it can be attested how the omnichannel performance of fashion and lifestyle retailers can be measured from a consumers’ perspective by developing an exclusive index. The study is confined to four fashion and lifestyle retailers: Hugo Boss AG, Levi Strauss & Co, Pull and Bear as well as COS. Using the scientific method of mystery shopping and a multi-item checklist including 54 key performance indicators, the paper aims to examine to which extend the four selected retailers provide a seamless customer journey, according to the five decision-making phases.
The purpose of this paper is to determine the relevance of social media for luxury brand management. It employs both a multi-methodological approach: After analyzing the online performance of the three luxury brands Burberry, Louis Vuitton and Gucci, the empirical research includes a survey as well as an eye tracking test executed with Tobii Studio. The findings reveal that online and social media have given luxury fashion businesses the opportunity to establish a sustainable interaction with their customers and distinguish themselves from the competition. Still, the online business holds many challenges for luxury companies to overcome. This paper gives instructions as to how social media can be effectively incorporated into a luxury company.
The conventional view of the value-creation chain suggests offering high-value propositions at the product level (in terms of benefits provided by elements of the product) to attain high-value perceptions at the customer level, which should ultimately result in high-value appropriation at the firm level (i.e. relationship, volume, pricing and financial success). This study challenges this view and provides a differentiated understanding of the value creation chain. With a multi-industry sample of 339 companies and a sample of 626 customers to validate managerial assessments, the authors apply a configurational approach to identify whether and to what extent offering high-value propositions at the product level is necessary or sufficient for achieving superior value perceptions at the customer level and high-value appropriation at the firm level. Taking into account the company-internal and company-external environment of the value-creation chain, the study identifies seven value creation chain constellations.
This work presents a spiral antenna array, which can be used in the V- and W-Band. An array equipped with Dolph-Chebychev coefficients is investigated to address issues related to the low gain and side lobe level of the radiating structure. The challenges encountered in this achievement are to provide an antenna that is not only good matched but also presents an appreciable effective bandwidth at the frequency bands of interest. Its radiation properties including the effective bandwidth and the gain are analyzed for the W-Band.
We present a topology of MIMO arrays of inductive antennas exhibiting inherent high crosstalk cancellation capabilities. A single layer PCB is etched into a 3-channels array of emitting/receiving antennas. Once coupled with another similar 3-channels emitter/receiver, we measured an Adjacent Channel Rejection Ratio (ACRR) as high as 70 dB from 150 Hz to 150 kHz. Another primitive device made out of copper wires wound around PVC tubes to form a 2-channels “non-contact slip-ring” exhibited 22 dB to 47 dB of ACRR up to 15MHz. In this paper we introduce the underlying theoretical model behind the crosstalk suppression capabilities of those so-called “Pie-Chart antennas”: an extension of the mutual inductance compensation method to higher number of channels using symmetries. We detail the simple iterative building process of those antennas, illustrate it with numerical analysis and evaluate there effectiveness via real experiments on the 3-channels PCB array and the 2-channels rotary array up to the limit of our test setup. The Pie Chart design is primarily intended as an alternative solution to costly electronic filters or cumbersome EM shields in wireless AND wired applications, but not exclusively.
Energy transfer kinetics in photosynthesis as an inspiration for improving organic solar cells
(2017)
Clues to designing highly efficient organic solar cells may lie in understanding the architecture of light harvesting systems and exciton energy transfer (EET) processes in very efficient photosynthetic organisms. Here, we compare the kinetics of excitation energy tunnelling from the intact phycobilisome (PBS) light harvesting antenna system to the reaction center in photosystem II in intact cells of the cyanobacterium Acaryochloris marina with the charge transfer after conversion of photons into photocurrent in vertically aligned carbon nanotube (va- CNT) organic solar cells with poly(3-hexyl)thiophene (P3HT) as the pigment. We find that the kinetics in electron hole creation following excitation at 600 nm in both PBS and va-CNT solar cells to be 450 and 500 fs, respectively. The EET process has a 3 and 14 ps pathway in the PBS, while in va-CNT solar cell devices, the charge trapping in the CNT takes 11 and 258 ps. We show that the main hindrance to efficiency of va CNT organic solar cells is the slow migration of the charges after exciton formation.
Digitisation forms a part of Industrie 4.0 and is both threatening, but also providing an opportunity to transform business as we know it; and can make entire business models redundant. Although companies might realise the need to digitise, many are unsure of how to start this digital transformation. This paper addresses the problems and challenges faced in digitisation, and develops a model for initialising digital transformation in enterprises. The model is based on a continuous improvement cycle, and also includes triggers for innovative and digital thinking within the enterprise. The model was successfully validated in the German service sector.
Propofol is a commonly used intravenous general anesthetic. Multi-capillary column (MCC) coupled ion-mobility spectrometry (IMS) can be used to quantify exhaled propofol, and thus estimate plasma drug concentration. Here, we present results of the calibration and analytical validation of a MCC/IMS pre-market prototype for propofol quantification in exhaled air.
In vitro cultured cells produce a complex extracellular matrix (ECM) that remains intact after decellularization. The biological complexity derived from the variety of distinct ECM molecules makes these matrices ideal candidates for biomaterials. Biomaterials with the ability to guide cell function are a topic of high interest in biomaterial development. However, these matrices lack specific addressable functional groups, which are often required for their use as a biomaterial. Due to the biological complexity of the cell-derived ECM, it is a challenge to incorporate such functional groups without affecting the integrity of the biomolecules within the ECM. The azide-alkyne cycloaddition (click reaction, Huisgen-reaction) is an efficient and specific ligation reaction that is known to be biocompatible when strained alkynes are used to avoid the use of copper (I) as a catalyst. In our work, the ubiquitous modification of a fibroblast cell-derived ECM with azides was achieved through metabolic oligosaccharide engineering by adding the azide-modified monosaccharide Ac4GalNAz (1,3,4,6 tetra-O-acetyl-N-azidoacetylgalactosamine) to the cell culture medium. The resulting azide-modified network remained intact after removing the cells by lysis and the molecular structure of the ECM proteins was unimpaired after a gentle homogenization process. The biological composition was characterized in order to show that the functionalization does not impair the complexity and integrity of the ECM. The azides within this ‘‘clickECM” could be accessed by small molecules (such as an alkyne modified fluorophore) or by surface-bound cyclooctynes to achieve a covalent coating with clickECM.
Purpose: The purpose of this study was to investigate the value of the web representation of certain fashion hot spots and how these results can be shown on fashion maps in an illustrated way.
Design/methodology/approach: A new ranking was created, which was evaluated with a self-instructed index, to gain solid results. Numbers were collected from Google, Instagram, Facebook, Twitter and web.alert.io. Additionally, fashion maps were created for an illustrative visualization of the results.
Findings: Compared with the ranking of a trend forecasting agency, called Global Language Monitor, which concepted a ranking of non-virtual fashion cities, the web representation and therefore the ranking of the research project, differs mainly in the situation of the cities among the first 10, viz. the rank on which a city occurs, but fewer in the actual cities mentioned.
Research limitations: The research was limited to subjective analysis of data, leading to partly subjective results, as well as the selected number of social media platforms, that had been used.
Originality/value: This is the first study to explore the web representation value of fashion metropolises in comparison to their non-virtual ranking. The results are partly based on results that already existed, concerning transformations of fashion cities or in general which cities own the status of a fashion city.
Purpose: The purpose of this paper is to examine the service of the new business model Curated Shopping in the fashion industry as well as to analyze if the service provides a higher costumer added value in comparison to traditional services in retail stores and e-commerce platforms. It gives implications to curated shop operators how to optimize the service in each stage of the customer buying process.
Design/methodology/approach: The research methodology applied is an empirical study that uses the principal of mystery shopping in order to investigate the provided services during the selling process.
Findings: The study showed that information about the customer should be collected carefully and as holistic as possible in order to assort a suitable outfit. The consumer is able to benefit from the service by saving time and enjoying a stress-free way of shopping. Nevertheless there are limitations in the personal service to give individual and inspiring advice by the curator caused by the physical distance to the customer.
Research limitations: The survey was conducted under 10 mystery shoppers and 4 curated shop operators in Germany, limiting findings to these mystery shoppers and operators.
Practical implications: One implication for the shop operators is to collect consumer information carefully and expand the assortment and brand portfolio in order to provide fashion goods to inspire the consumer. The shop operators are on the right track still there is huge potential to provide a more shopper-oriented service.
Newly developed active pharmaceutical ingredients (APIs) are often poorly soluble in water. As a result the bioavailability of the API in the human body is reduced. One approach to overcome this restriction is the formulation of amorphous solid dispersions (ASDs), e.g., by hot-melt extrusion (HME). Thus, the poorly soluble crystalline form of the API is transferred into a more soluble amorphous form. To reach this aim in HME, the APIs are embedded in a polymer matrix. The resulting amorphous solid dispersions may contain small amounts of residual crystallinity and have the tendency to recrystallize. For the controlled release of the API in the final drug product the amount of crystallinity has to be known. This review assesses the available analytical methods that have been recently used for the characterization of ASDs
and the quantification of crystalline API content. Well established techniques like near- and mid-infrared spectroscopy (NIR and MIR, respectively), Raman spectroscopy, and emerging ones like UV/VIS, terahertz, and ultrasonic spectroscopy are considered in detail. Furthermore, their advantages and limitations are discussed with regard to general practical applicability as process analytical technology (PAT) tools in industrial manufacturing. The review focuses on spectroscopic methods which have been proven as most suitable for in-line and on-line process analytics. Further aspects are spectroscopic techniques that have been or could be integrated into an extruder.
Integrated power semiconductors are often used for applications with cyclic on-chip power dissipation. This leads to repetitive self-heating and thermo-mechanical stress, causing fatigue on the on-chip metallization and possibly destruction by short circuits. Because of this, an accurate simulation of the thermo-mechanical stress is needed already during the design phase to ensure that lifetime requirements are met. However, a detailed thermo mechanical simulation of the device, including the on-chip metallization is prohibitively time-consuming due to its complex structure, typically consisting of many thin metal lines with thousands of vias. This paper introduces a two-step approach as a solution for this problem. First, a simplified but fast simulation is performed to identify the device parts with the highest stress. After, precise simulations are carried out only for them. The applicability of this method is verified experimentally for LDMOS transistors with different metal configurations. The measured lifetimes and failure locations correlate well with the simulations. Moreover, a strong influence of the layout of the on-chip metallization lifetime was observed. This could also be explained with the simulation
method.
Comments on “Solubility parameter of chitin and chitosan”, Carbohydrate Polymers 36 (1998) 121–127
(2017)
Results on the solubility parameters of chitin and chitosan presented in the paper DOI: 10.1016/S0144-8617(98)00020-4 were recalculated and data evaluation was redone. A number of misprints, erroneous calculations and data evaluations were found with respect to Hansen as well as total solubility parameters as derived according to group contribution methods by Hoftyzer-Van Krevelen and Hoy’s system. Revised numerical data are presented.
Wege der Gewinnermittlung
(2017)
Macht ein Unternehmen Gewinn, heißt dies nicht notwendigerweise, dass alles „in trockenen Tüchern“ ist. Die entscheidende Frage ist, wie der Gewinn ermittelt wurde, denn nur mit dem richtigen Verfahren erhält man auch den geeigneten Blickwinkel – auf den Erfolg eines einzelnen Geschäfts, auf den Gewinn einer Periode, auf das Betriebsvermögen, auf die Liquidität oder auf die Bilanz.
EBIT & Co.
(2017)
Eine ganze Reihe von Kennzahlen wird in der Betriebswirtschaftslehre zur Ermittlung und Steuerung des Unternehmensgewinns verwendet. Doch nicht alle eignen sich für denselben Zweck. Je nach Fragestellung sollten unterschiedliche Kennzahlen herangezogen werden. Ihre Interpretation muss nicht zuletzt auch branchenspezifisch erfolgen.
Eine realistische Risikoeinschätzung ist Basis von verantwortungsvollen Unternehmensentscheidungen. Doch wie lassen sich Risiken richtig einschätzen? Verschiedene Instrumente des Risiko-Managements erlauben es, Risiken systematisch zu identifizieren, zu quantifizieren, zu bewerten und zu dokumentieren.
Risiken sind per se nichts Schlechtes, wenn der dadurch erzielte Ertrag für das eingegangene Risiko angemessen ist. Dieser Zusammenhang wird allerdings nicht immer verstanden – einer der Gründe für die Finanzkrise von 2008/09. Die in diesem Beitrag vorgestellten Kennzahlen zeigen, wie man Risiken mit erzielten oder möglichen Erträgen ins Verhältnis setzen kann.
Wer in ein Unternehmen investiert, tut dies, um in Zukunft Geld zu verdienen. Er rechnet mit einer risikoadäquaten Rendite. Die Auswahl der Kennzahlen, die diese Wertsteigerung transparent machen, ist allerdings nicht trivial. Denn von ihnen hängt ab, ob die Unternehmensziele richtig vorgegeben und ob die Anreize für das Management richtig gesetzt werden.
Umsatz und Gewinne stagnieren auf hohem Niveau, und dennoch steigen der Aktienkurs und der Gewinn pro Aktie – eine Entwicklung, die sich etwa bei Apple oder Ebay beobachten lässt. Aktionäre sollten wissen, welche Arithmetik sich hinter solchen Entwicklungen verbirgt und mit welchen Verfahren sie den Unternehmenswert am besten ermitteln können.
Propofol in exhaled breath can be measured and may provide a real-time estimate of plasma concentration. However, propofol is absorbed in plastic tubing, thus estimates may fail to reflect lung/blood concentration if expired gas is not extracted directly from the endotracheal tube.We evaluated exhaled propofol in five ventilated ICU patients who were sedated with propofol. Exhaled propofol was measured once per minute using ion mobility spectrometry. Exhaled air was sampled directly from the endotracheal tube and at the ventilator end of the expiratory side of the anesthetic circuit. The circuit was disconnected from the patient and propofol was washed out with a separate clean ventilator. Propofol molecules, which discharged from the expiratory portion of the breathing circuit, were measured for up to 60 h.We also determined whether propofol passes through the plastic of breathing circuits. A total of 984 data pairs (presented as median values, with 95% confidence interval), consisting of both concentrations were collected. The concentration of propofol sampled near the patient was always substantially higher, at 10.4 [10.25–10.55] versus 5.73 [5.66–5.88] ppb (p<0.001). The reduction in concentration over the breathing circuit tubing was 4.58 [4.48–4.68] ppb, 3.46 [3.21–3.73] in the first hour, 4.05 [3.77–4.34] in the second hour, and 4.01 [3.36–4.40] in the third hour. Out-gassing propofol from the breathing circuit remained at 2.8 ppb after 60 h of washing out. Diffusion through the plastic was not observed. Volatile propofol binds or adsorbs to the plastic of a breathing circuit with saturation kinetics. The bond is reversible so propofol can be washed out from the plastic. Our data confirm earlier findings that accurate measurements of volatile propofol require exhaled air to be sampled as close as possible to the patient.