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Social networks, smart portable devices, Internet of Things (IoT) on base of technologies like analytics for big data and cloud services are emerging to support flexible connected products and agile services as the new wave of digital transformation. Biological metaphors of living and adaptable ecosystems with service-oriented enterprise architectures provide the foundation for self-optimizing and resilient run-time environments for intelligent business services and related distributed information systems. We are extending Enterprise Architecture (EA) with mechanisms for flexible adaptation and evolution of information systems having distributed IoT and other micro-granular digital architecture to support next digitization products, services, and processes. Our aim is to support flexibility and agile transformation for both IT and business capabilities through adaptive digital enterprise architectures. The present research paper investigates additionally decision mechanisms in the context of multi-perspective explorations of enterprise services and Internet of Things architectures by extending original enterprise architecture reference models with state of art elements for architectural engineering and digitization.
Purpose: Human breath analysis is proposed with increasing frequency as a useful tool in clinical application. We performed this study to find the characteristic volatile organic compounds (VOCs) in the exhaled breath of patients with idiopathic pulmonary fibrosis (IPF) for discrimination from healthy subjects. Methods: VOCs in the exhaled breath of 40 IPF patients and 55 healthy controls were measured using a multi-capillary column and ion mobility spectrometer. The patients were examined by pulmonary function tests, blood gas analysis, and serum biomarkers of interstitial pneumonia. Results: We detected 85 VOC peaks in the exhaled breath of IPF patients and controls. IPF patients showed 5 significant VOC peaks; p-cymene, acetoin, isoprene, ethylbenzene, and an unknown compound. The VOC peak of p-cymene was significantly lower (p < 0.001), while the VOC peaks of acetoin, isoprene, ethylbenzene, and the unknown compound were significantly higher (p < 0.001 for all) compared with the peaks of controls. Comparing VOC peaks with clinical parameters, negative correlations with VC (r =−0.393, p = 0.013), %VC (r =−0.569, p < 0.001), FVC (r = −0.440, p = 0.004), %FVC (r =−0.539, p < 0.001), DLco (r =−0.394, p = 0.018), and %DLco (r =−0.413, p = 0.008) and a positive correlation with KL-6 (r = 0.432, p = 0.005) were found for p-cymene. Conclusion: We found characteristic 5 VOCs in the exhaled breath of IPF patients. Among them, the VOC peaks of p-cymene were related to the clinical parameters of IPF. These VOCs may be useful biomarkers of IPF.
This article covers the design of highly integrated gate drivers and level shifters for high-speed, high power efficiency and dv/dt robustness with focus on automotive applications. With the introduction of the 48 V board net in addition to the conventional 12 V battery, there is an increasing need for fast switching integrated gate drivers in the voltage range of 50 V and above. State-of-the-art drivers are able to switch 50 V in less than 5 ns. The high-voltage electrical drive train demands for galvanic isolated and highly integrated gate drivers. A gate driver with bidirectional signal transmission with a 1 MBit/s amplitude modulation, 10/20 MHz frequency modulation and power transfer over one single transformer will be discussed. The concept of high-voltage charge storing enables an area-efficient fully integrated bootstrapping supply with 70 % less area consumption. EMC is a major concern in automotive. Gate drivers with slope control optimize EMC while maintaining good switching efficiency. A current mode gate driver, which can change its drive current within 10 ns, results in 20 dBuV lower emissions between 7 and 60 MHz and 52 % lower switching loss compared to a conventional constant current gate driver.
Afrika ist aufgrund überdurchschnittlicher Wirtschaftswachstumsraten und als die weltweit letzten unbearbeiteten Märkte seit einigen Jahren ein populäres Thema der Wirtschaft. Deutsche Unternehmen sind allerdings mit ihrem Engagement auf den afrikanischen Märkten sehr zurückhaltend. So schwankt der Anteil der deutschen Exporte nach Afrika an den deutschen Gesamtexporten seit zehn Jahren um die zwei Prozent; betrachtet man nur Subsahara‐Afrika, so waren es sogar nur 0,5 % in 2014 (Allafi und Koch 2015, S. 3). Bezüglich der Direktinvestitionen (nur Beteiligungskapital, ohne Direktinvestitionskredite) spielt Afrika eine noch geringere Rolle mit nur 1,5 % aller deutschen Investitionen in 2014, wobei hiervon so gut wie alle nach Nordafrika und Südafrika geflossen sind (Deutsche Bundesbank 2015, S. 12 f.). Neben den Standardgründen wie beispielsweise politischen Risiken, schlechter Infrastruktur, schwacher institutioneller Rahmenbedingungen und Governance‐Problemen (vgl. zum Beispiel World Bank 2016a), ist ein gängiges Markteintrittsproblem die fehlende Verfügbarkeit von lokalen Partnern in den Bereichen Vertrieb, Logistik und teilweise auch Produktion (vgl. zum Beispiel Carlowitz und Röndigs 2016). Aktuell ist ein Markteintritt in Afrika ohne lokalen Partner aufgrund der völlig anderen und schwierigen Rahmenbedingungen fast unmöglich.
This article provides a general overview of the most promising candidates of bio based materials and deals with the most important issues when it comes to their incorporation into PF resins. Due to their abundance on Earth, much knowledge of lignin-based materials has already been gained and uses of lignin in PF resins have been studied for many decades. Other natural polyphenols that are less frequently considered for impregnation are covered as well, as they do also possess some potential for PF substitution.
High quality decorative laminate panels typically consist of two major types of components: the surface layers comprising décor and overlay papers that are impregnated with melamine-based resins, and the core which is made of stacks of kraft papers impregnated with phenolic (PF) resin. The PF-impregnated layers impart superior hydrolytic stability, mechanical strength and fire-resistance to the composite. The manufacturing involves the complex interplay between resin, paper and impregnation/drying processes. Changes in the input variables cause significant alterations in the process characteristics and adaptations of the used materials and specific process conditions may, in turn, be required. This review summarizes the main variables influencing both processability and technological properties of phenolic resin impregnated papers and laminates produced therefrom. It is aimed at presenting the main influences from the involved components (resin and paper), how these may be controlled during the respective process steps (resin preparation and paper production), how they influence the impregnation and lamination conditions, how they affect specific aspects of paper and laminate performance, and how they interact with each other
(synergies).
Characterisation of porous knitted titanium for replacement of intervertebral disc nucleus pulposus
(2017)
Effective restoration of human intervertebral disc degeneration is challenged by numerous limitations of the currently available spinal fusion and arthroplasty treatment strategies. Consequently, use of artificial biomaterial implant is gaining attention as a potential therapeutic strategy. Our study is aimed at investigating and characterizing a novel knitted titanium (Ti6Al4V) implant for the replacement of nucleus pulposus to treat early stages of chronic intervertebral disc degeneration. Specific knitted geometry of the scaffold with a porosity of 67.67 ± 0.824% was used to overcome tissue integration failures. Furthermore, to improve the wear resistance without impairing original mechanical strength, electro-polishing step was employed. Electro-polishing treatment changed a surface roughness from 15.22 ± 3.28 to 4.35 ± 0.87 μm without affecting its wettability which remained at 81.03 ± 8.5°. Subsequently, cellular responses of human mesenchymal stem cells (SCP1 cell line) and human primary chondrocytes were investigated which showed positive responses in terms of adherence and viability. Surface wettability was further enhanced to super hydrophilic nature by oxygen plasma treatment, which eventually caused substantial increase in the proliferation of SCP1 cells and primary chondrocytes. Our study implies that owing to scaffolds physicochemical and biocompatible properties, it could improve the clinical performance of nucleus pulposus replacement.
Dieses Buch beschreibt detailliert die Voraussetzungen und den Prozessablauf von Business Cases. Diese stellen in der Praxis das wichtigste Instrument dar, um unternehmerische Entscheidungen auf ihre Vorteilhaftigkeit zu analysieren. Um einen adäquaten Business Case zu erstellen, reicht allerdings die reine Beherrschung der relevanten Methoden der Investitionsrechnung nicht aus. Andreas Taschner gibt hilfreiche Anleitungen und Tipps zur Methodenwahl und Ergebnisdarstellung und erläutert weitergehende Fragen, wie die Berücksichtigung von Unsicherheit oder die Einbeziehung nicht-monetärer Faktoren. Die Orientierung am idealtypischen Prozess hilft beim Erarbeiten eigener Business Cases und liefert einen Leitfaden für die ersten selbstständigen Arbeiten. Anwendungsbezogene Fragen und Antworten vertiefen die Thematik. „Business Cases“ wendet sich an Unternehmenspraktiker in den Bereichen Investition, Controlling, Planung und Unternehmensführung. Studierende der Wirtschaftswissenschaften an Fachhochschulen und Universitäten, insbesondere mit den Schwerpunkten Controlling und Unternehmensführung, profitieren von der kompakten Wissensvermittlung.
The purpose of this paper is to identify the potential of a fashion fTRACE (ffTRACE) application that gives transparent insight on the supply chain of a fashion item. The research methodology applied to this purpose is a literature review examining academic references. The key findings of this paper are that information plays a major role in the consumer decision process and is therefore beneficial to the demand for sustainable products. Given the right information content in a transparent, credible and understandable way is important. It is found that the functions of such an application would be able to satisfy this consumer demand and therefore has the potential to raise the sales of a sustainable company as well as increase the brand’s awareness and improve its image. While mainly indicating the potentials of the ffTRACE application, their relevance is not examined in this paper.
The purpose of this paper is to investigate the use of sustainable closed-loop supply chain of the fashion brand Filippa K. Information on green fashion has been gathered and a case study approach on the fashion retailer
Filippa K conducted. Results show a switch in knowledge content between a fast fashion supply chain and a sustainable supply chain. Also there is an evolution in sustainability as companies, retailers, and manufactures suffer under pressure from the customers, governments, and the media. Sustainable fashion brands like Filippa K are interested in sharing precise knowledge on variety of aspects linked to the sustainable closed-loop supply chain. This research paper has been limited by less information and unexplored topics in the theme green fashion. This led to the personal critical disputation with the brand Filippa K.