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Im Frühjahr 1817 unternahm der damalige Professor Friedrich List an der Universität Tübingen eine Reise nach Frankfurt a. M., wo zu dieser Zeit die berühmte Ostermesse stattfand. Dort traf er mit den Anführern der Kaufleute zusammen, die darüber klagten, dass die zaghafte wirtschaftliche Entwicklung unter den vielen Zollschranken und den Billigimporten aus England stark zu leiden habe. Deshalb forderten sie die Abschaffung der Binnenzölle und die Bildung einer Wirtschaftsunion. Im Auftrag der Kaufleute verfasste List seine berühmt gewordene Petition an die Bundesversammlung, die lose Interessenvertretung des Deutschen Bundes in Frankfurt. Als die Petition mit großem Beifall aufgenommen wurde, gründete List im Hochgefühl seines Erfolges spontan den "Allgemeinen Deutschen Handels- und Gewerbsverein" – die erste Interessenvertretung deutscher Kaufleute. Er legte damit den Grundstein für den politischen Prozess zur Gründung des Zollvereins von 1834, der wiederum die Vorstufe zur Gründung des Deutschen Reiches von 1871 bildete. Lists damalige Forderungen sind zurzeit wieder hoch aktuell.
Exogenous factors of influence on exhaled breath analysis by ion-mobility spectrometry (MCC/IMS)
(2019)
The interpretation of exhaled breath analysis needs to address to the influence of exogenous factors, especially to a transfer of confounding analytes by the test persons. A test person who was exposed to a disinfectant had exhaled breath analysis by MCC/IMS (Bioscout®) after different time intervals. Additionally, a new sampling method with inhalation of synthetic air before breath analysis was tested. After exposure to the disinfectant, 3-Pentanone monomer, 3-Pentanone dimer, Hexanal, 3-Pentanone trimer, 2-Propanamine, 1-Propanol, Benzene, Nonanal showed significantly higher intensities, in exhaled breath and air of the examination room, compared to the corresponding baseline measurements. Only one ingredient of the disinfectant (1-Propanol) was identical to the 8 analytes. Prolonging the time intervals between exposure and breath analysis showed a decrease of their intensities. However, the half-time of the decrease was different. The inhalation of synthetic air - more than consequently airing the examination room with fresh air - reduced the exogenous and also relevant endogenous analytes, leading to a reduction and even changing polarity of the alveolar gradient. The interpretation of exhaled breath needs further knowledge about the former residence of the proband and the likelihood and relevance of the inhalation of local, site-specific and confounding exogenous analytes by him. Their inhalation facilitates a transfer to the examination room and a detection of high concentrations in room air and exhaled breath, but also the exhalation of new analytes. This may lead to a misinterpretation of these analytes as endogenous resp. disease-specific ones.
Standardisation of breath sampling is important for application of breath analysis in clinical settings. By studying the effect of room airing on indoor and breath analytes and by generating time series of room air with different sampling intervals we sought to get further insights into room air metabolism, to detect the relevance of exogenous VOCs and to make conclusions about their consideration for the interpretation of exhaled breath. Room air and exhaled breath of a healthy subject were analysed before and after room airing. Furthermore a time series of room air with doors and windows closed was taken over 84 h by an automatic sampling every 180 min. A second times series studied room air analytes over 70 h with samples taken every 16.5 min. For breath and room air measurements an IMS coupled to a multi-capillary column (IMS/MCC) [Bio-Scout® - B&S Analytik GmbH, Dortmund, Germany] was used. The peaks were characterized using the Software Visual Now (B&S Analytik, Dortmund Germany) and identified using the software package MIMA (version 1.1, provided by the Max Planck Institute for Informatics, Saarbrücken, Germany) and the database 20160426_SubstanzDbNIST_122 (B & S Analytik GmbH, Dortmund, Germany). In the morning 4 analytes (Decamethylcylopentasiloxane [541-02-6]; Pentan-2-one [107-87-9] – Dimer; Hexan-1-al [66-25-1]; Pentan-2-one [107-87-9]) – Monomer showed high intensities in the room air and exhaled breath. They were significantly but not equally reduced by room airing. The time series about 84 h showed a time dependent decrease of analytes (limonen-monomer and -dimer; Decamethylcylopentasiloxane, Butan-1-ol, Butan-1-ol) as well as increase (Pentan-2-one [107-87-9] – Dimer). Shorter sampling intervals exhibited circadian variations of analyte concentrations for many analytes. Breath sampling in the morning needs room airing before starting. Then the variation of the intensity of indoor analytes can be kept small. The time series of indoor analytes show, that their intensities have a different behaviour, with time dependent declines, constant increases and circadian variations, dependent on room airing. This has implications on the breath sampling procedure and the intrepretation of exhaled breath.
This study describes a non-contact measuring and system identification procedure for evaluating inhomogeneous stiffness and damping characteristics of the annular ligament in the physiological amplitude and frequency range without the application of large static external forces that can cause unnatural displacements of the stapes. To verify the procedure, measurements were first conducted on a steel beam. Then, measurements on an individual human cadaveric temporal bone sample were performed. The estimated results support the inhomogeneous stiffness and damping distribution of the annular ligament and are in a good agreement with the multiphoton microscopy results which show that the posterior-inferior corner of the stapes footplate is the stiffest region of the annular ligament.
Companies are continuously changing their strategy, processes, and information systems to benefit from the digital transformation. Controlling the digital architecture and governance is the fundamental goal. Enterprise Governance, Risk and Compliance (GRC) systems are vital for managing digital risks threatening in modern enterprises from many different angles. The most significant constituent to GRC systems is the definition of controls that is implemented on different layers of a digital Enterprise Architecture (EA). As part of the compliant aspect of GRC, the effectiveness of these controls is assessed and reported to relevant management bodies within the enterprise. In this paper, we present a metamodel which links controls to the affected elements of a digital EA and supplies a way of expressing associated assessment techniques and results. We complement a metamodel with an expository instantiation of a control compliance cockpit in an international insurance enterprise.
Business process models provide a considerable number of benefits for enterprises and organizations, but the creation of such models is costly and time-consuming, which slows down the organizational adoption of business process modeling. Social paradigms pave new ways for business process modeling by integrating stakeholders and leveraging knowledge sources. However, empirical research about the impact of social paradigms on costs of business process modeling is sparse. A better understanding of their impact could help to reduce the cost of business process modeling and improve decision-making on BPM activities. The paper constributes to this field by reporting about an empirical investigation via survey research on the perceived influence of different cost factors among experts. Our results indicate that different cost components, as well as the use of social paradigms, influence cost.
Due to the consequential impact of technological breakdowns, companies have to be prepared to deal with breakdowns or even better prevent them. In today's information technology, several methods and tools exist to downscale this concern. Therefore, this paper deals with the initial determination of a resilient enterprise architecture supporting predictive maintenance in the information technology domain and furthermore, concerns several mechanisms on how to reactively and proactively secure the state of resiliency on several abstraction levels. The objective of this paper is to give an overview on existing mechanisms for resiliency and to describe the foundation of an optimized approach, combining infrastructure and process mining techniques.
This book contains the proceedings of the KES International conferences on Innovation in Medicine and Healthcare (KES-InMed-19) and Intelligent Interactive Multimedia Systems and Services (KES-IIMSS-19), held on 17–19 June 2019 and co-located in St. Julians, on the island of Malta, as part of the KES Smart Digital Futures 2019 multi theme conference.
The major areas covered by KES-InMed-19 include: Digital IT Architecture in Healthcare; Advanced ICT for Medical and Healthcare; Biomedical Engineering, Trends, Research and Technologies and Healthcare Support System. The major areas covered by KES-IIMSS-19 were: Interactive Technologies; Artificial Intelligence and Data Analytics; Intelligent Services and Architectures and Applications.
This book is of use to researchers in these vibrant areas, managers, industrialists and anyone wishing to gain an overview of the latest research in these fields.
Ziel der Arbeit von Julian Ilg ist die Entwicklung einer systematischen Eignungsanalyse zum Einsatz additiver Fertigungsverfahren im unternehmensspezifischen Kontext. Der Autor fasst die gängigsten additiven Fertigungsverfahren zusammen und liefert einen Überblick über die derzeitige Anwendung dieser Verfahren sowie über die Herausforderungen bei deren Einsatz am Beispiel von Unternehmen aus der Medizintechnik. Basierend auf diesen Erkenntnissen gelingt es dem Autor, interessierten Unternehmen eine quantifizierende Entscheidungshilfe zu liefern, die gleichermaßen sowohl die ingenieurswissenschaftlichen Punkte als auch die wirtschaftlichen Aspekte beim Umstieg vom herkömmlichen Herstellungsverfahren auf additive Fertigungsverfahren berücksichtigt.
Die Zukunftsfähigkeit des Personalmanagements lässt sich daran festmachen, dass in der Organisation qualitativ und quantitativ ausreichend Personal zur Erfüllung des Organisationszwecks in dynamischen Umfeldern zur Verfügung steht. Einen wichtigen Ansatzpunkt stellen die Flexibilisierung der Personalausstattung sowie die institutionelle und strukturelle Öffnung von Organisationen in Richtung mehr Agilität dar. Darauf aufbauend muss das Personalmanagement selbst durch neue Arbeitsweisen und Praktiken innovativer werden und zusätzlich zu seinem stabilen Kern ein zweites agiles Betriebssystem entwickeln. Das zeitlich und strukturell abgestimmte Zusammenspiel des stabilen und agilen Betriebssystems ermöglicht dann die gleichzeitige Nutzung von exploitativen und explorativen Praktiken. Um die Agilitätsagenda des Personalmanagements weiter voranzutreiben, benötigt es einen systematischen Umgang mit der Bedeutung unterschiedlicher Agilitätsdimensionen, die Entwicklung von Instrumenten sowie Zielsetzungen, die ein agiles Personalmanagement verfolgen sollte.