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Cell-age and cell type-dependent behavior of human vascular cells on micro-structured or soft polymer substrates

  • Increasing number of studies are focused on how adherent cells respond, in vitro, to different properties of a material. Typical properties are the surface chemistry, topographical cues (at the nano- and micro-scale) of the surface, and the substrate stiffness. Cell Response studies are of importance for designing new biomaterials with applications in cell culture technologies, regenerative medicine, or for medical implants. However, only very few studies take the cell age factor, respectively the donor age, into account. In this work, we tested two types of human vascular cells (smooth muscle and endothelial cells) from old and young donors on (a) micro-structured surfaces made of pol (dimethylsiloxane) or on (b) flat polyacrylamide hydrogels with varying stiffnesses. These experiments reveal age-dependent and cell typedependent differences in the cell response to the topography and stiffness, and may establish the Basis for further studies focusing on cell age-dependent responses.

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Author of HS ReutlingenKemkemer, Ralf
Publisher:de Gruyter
Place of publication:Berlin
Document Type:Article
Year of Publication:2014
Issue:s1 : Track D - Cellular, Tissue and Bioengineering
Page Number:4
First Page:S286
Last Page:S289
DDC classes:570 Biowissenschaften, Biologie
Open Access?:Ja
Licence (German):License Logo  Open Access